The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN-γ production of patients and their household contacts

Annals of the New York Academy of Sciences

Volumn 1153, Issue , 2009, Pages 247-255

  Bozza, Veronica ^a   D'Attilio, Luciano ^a   Didoli, Griselda ^a   Santucci, Natalia ^a   Nannini, Luis ^b   Bogue, Cristina ^c   Del Rey, Adriana ^d   Besedovsky, Hugo ^d   Bay, Maria Luisa ^a   Bottasso, Oscar ^a,e  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b Pulmonary Section   (Argentina)

^c Hospital I Carrasco   (Argentina)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Cortisol; Dehydroepiandrosterone; Household contacts; Immunoendocrine interactions; Interferon ; Tuberculosis

Indexed keywords

GAMMA INTERFERON; HYDROCORTISONE; MYCOBACTERIUM ANTIGEN; PRASTERONE;

ADULT; AGED; CELL CULTURE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 60349105175     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03976.x     Document Type: Conference Paper

References (24)

1. World Health. Organization Global tuberculosis control: surveillance, planning, financing. WHO report 2006. http://www.who.int/entity/tb/publications/ global-report/2006/pdf/full-report-correctedversion.pdf
2. Bloom, B.R. & C.J. Murray. 1992. Tuberculosis: commentary on a re-emergent killer. Science 257 : 1055 1064.
3. Comstock, G.W. 1982. Epidemiology of tuberculosis. Am. Rev. Respir. Dis. 125 : 8 15.
4. Flynn, J.L. 2004. Immunology of tuberculosis and implications in vaccine development. Tuberculosis 84 : 93 101.
5. Bottasso, O., M.L. Bay, H. Besedovsky, et al. 2007. The immuno-endocrine component in the pathogenesis of tuberculosis. Scand. J. Immunol. 66 : 166 175.
6. Besedovsky, H. & A. del Rey. 1996. Immune-neuro-endocrine interactions: facts and hypothesis. Endocr. Rev. 17 : 64 95.
7. Turnbull, A.V. & C.L. Rivier. 1999. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiological Rev. 79 : 1 71.
8. Elenkov, I.J. & G.P. Chrousos. 1999. Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol. Metab. 10 : 359 368.
9. Dillon, J. 2005. dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders. Curr. Drug Targets Inflamm. Allergy 4 : 377 385.
10. Mahuad, C., M.L. Bay, M.A. Farroni, et al. 2004. Cortisol and dehydroepiandrosterone affect the response of peripheral blood mononuclear cells to mycobacterial antigens during tuberculosis. Scand. J. Immunol. 60 : 639 646.
11. del Rey, A., C.V. Mahuad, V.V. Bozza, et al. 2007. Endocrine and cytokine responses in humans with pulmonary tuberculosis. Brain Behav. Immun. 21 : 171 179.
12. Morrison, J., M. Pai & P.C. Hopewell. 2008. Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infec. Dis. 8 : 359 368.
13. 3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57 : 159 163.
14. Denis, M. 1991. Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol. Clin. Exp. Immunol. 84 : 200 208.
15. Miyaura, H. & M. Iwata. 2002. Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J. Immunol. 168 : 1087 1094.
16. Ramirez, F., D.J. Fowell, M. Puklavec, et al. 1996. Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro. J. Immunol. 156 : 2406 2412.
17. Padgett, D.A., J.F. Sheridan, R. Loria. 1995. Steroid hormone regulation of a polyclonal Th2 immune response. Ann. N. Y. Acad. Sci. 774 : 323 325.
18. Hennebold J.D. & R.A. Daynes. 1994. Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 135 : 67 75.
19. Demissie, A., M. Abebe, A. Aseffa, et al. 2004. Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4δ2. J. Immunol. 172 : 6938 6943.
20. Doherty, T.M., A. Demissie, J. Olob, et al. 2002. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J. Clin. Microbiol. 40 : 704 706.
21. Harari, A., F. Vallelian, P.R. Meylan, et al. 2005. Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J. Immunol. 174 : 1037 1045.
22. Younes, S.A., B. Yassine-Diab, A.R. Dumont, et al. 2003. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J. Exp. Med. 198 : 1909 1922.
23. Millington, K.A., J.A. Innes, S. Hackforth, et al. 2007. Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J. Immunol. 178 : 5217 5226.
24. Correa, R., A. Harari, F. Vallelian, et al. 2007. Functional patterns of HIV-1-specific CD4 T-cell responses in children are influenced by the extent of virus suppression and exposure. AIDS 21 : 23 30.