Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: A novel preventive strategy for posttraumatic stress disorder?

BioPsychoSocial Medicine

Volumn 5, Issue , 2011, Pages

  Matsuoka, Yutaka ^a,b,c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION DISASTER MEDICAL CENTER   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79551685494     PISSN: None     EISSN: 17510759     Source Type: Journal    
DOI: 10.1186/1751-0759-5-3     Document Type: Review

References (86)

1. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005, 62:617-627. 10.1001/archpsyc.62.6.617, 2847357, 15939839.
2. Yehuda R. Post-traumatic stress disorder. N Engl J Med 2002, 346:108-114. 10.1056/NEJMra012941, 11784878.
3. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997, 349:1498-1504. 10.1016/S0140-6736(96)07492-2, 9167458.
4. MacKenzie EJ, Rivara FP, Jurkovich GJ, Nathens AB, Frey KP, Egleston BL, Salkever DS, Scharfstein DO. A national evaluation of the effect of trauma-center care on mortality. N Engl J Med 2006, 354:366-378. 10.1056/NEJMsa052049, 16436768.
5. Mayou R, Bryant B, Ehlers A. Prediction of psychological outcomes one year after a motor vehicle accident. Am J Psychiatry 2001, 158:1231-1238. 10.1176/appi.ajp.158.8.1231, 11481156.
6. Zatzick DF, Rivara FP, Nathens AB, Jurkovich GJ, Wang J, Fan MY, Russo J, Salkever DS, Mackenzie EJ. A nationwide US study of post-traumatic stress after hospitalization for physical injury. Psychol Med 2007, 37:1469-1480. 10.1017/S0033291707000943, 17559704.
7. Shalev AY, Freedman S, Peri T, Brandes D, Sahar T, Orr SP, Pitman RK. Prospective study of posttraumatic stress disorder and depression following trauma. Am J Psychiatry 1998, 155:630-637.
8. O'Donnell ML, Creamer M, Pattison P. Posttraumatic Stress Disorder and Depression Following Trauma: Understanding Comorbidity. Am J Psychiatry 2004, 161:1390-1396.
9. Hamanaka S, Asukai N, Kamijo Y, Hatta K, Kishimoto J, Miyaoka H. Acute stress disorder and posttraumatic stress disorder symptoms among patients severely injured in motor vehicle accidents in Japan. Gen Hosp Psychiatry 2006, 28:234-241. 10.1016/j.genhosppsych.2006.02.007, 16675367.
10. Schnyder U, Moergeli H, Klaghofer R, Buddeberg C. Incidence and prediction of posttraumatic stress disorder symptoms in severely injured accident victims. Am J Psychiatry 2001, 158:594-599. 10.1176/appi.ajp.158.4.594, 11282694.
11. Schnyder U, Wittmann L, Friedrich-Perez J, Hepp U, Moergeli H. Posttraumatic stress disorder following accidental injury: rule or exception in Switzerland?. Psychother Psychosom 2008, 77:111-118. 10.1159/000112888, 18230944.
12. Matsuoka Y, Nishi D, Nakajima S, Kim Y, Homma M, Otomo Y. Incidence and prediction of psychiatric morbidity after a motor vehicle accident in Japan: The Tachikawa Cohort of Motor Vehicle Accident Study. Crit Care Med 2008, 36:74-80. 10.1097/01.CCM.0000291650.70816.D6, 18090377.
13. Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ. Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. General Hospital Psychiatry 2008, 30:421-434. 10.1016/j.genhosppsych.2008.05.006, 2572638, 18774425.
14. Pitman RK, Delahanty DL. Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr 2005, 10:99-106.
15. Roberts NP, Kitchiner NJ, Kenardy J, Bisson JI. Systematic Review and Meta-Analysis of Multiple-Session Early Interventions Following Traumatic Events. Am J Psychiatry 2009, 166:293-301. 10.1176/appi.ajp.2008.08040590, 19188285.
16. Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, Barnoud D, Bleichner G, Bruel C, Choukroun G, et al. A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med 2007, 356:469-478. 10.1056/NEJMoa063446, 17267907.
17. Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry 2002, 51:189-192. 10.1016/S0006-3223(01)01279-3, 11822998.
18. Vaiva G, Ducrocq F, Jezequel K, Averland B, Lestavel P, Brunet A, Marmar CR. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiatry 2003, 54:947-949. 10.1016/S0006-3223(03)00412-8, 14573324.
19. Schelling G, Briegel J, Roozendaal B, Stoll C, Rothenhausler HB, Kapfhammer HP. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry 2001, 50:978-985. 10.1016/S0006-3223(01)01270-7, 11750894.
20. Schelling G, Kilger E, Roozendaal B, de Quervain DJ, Briegel J, Dagge A, Rothenhausler HB, Krauseneck T, Nollert G, Kapfhammer HP. Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Biol Psychiatry 2004, 55:627-633. 10.1016/j.biopsych.2003.09.014, 15013832.
21. Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, Inokuchi K. Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 2009, 139:814-827. 10.1016/j.cell.2009.10.020, 19914173.
22. O'Donnell ML, Creamer M, Pattison P, Atkin C. Psychiatric Morbidity Following Injury. Am J Psychiatry 2004, 161:507-514.
23. Hepp U, Moergeli H, Buchi S, Bruchhaus-Steinert H, Kraemer B, Sensky T, Schnyder U. Post-traumatic stress disorder in serious accidental injury: 3-year follow-up study. The British Journal of Psychiatry 2008, 192:376-383. 10.1192/bjp.bp.106.030569, 18450664.
24. Bryant RA, O'Donnell ML, Creamer M, McFarlane AC, Clark CR, Silove D. The Psychiatric Sequelae of Traumatic Injury. Am J Psychiatry 2010, 167:312-320. 10.1176/appi.ajp.2009.09050617, 20048022.
25. Matsuoka Y, Nishi D, Yonemoto N, Nakajima S, Kim Y. Towards an explanation of inconsistent rates of posttraumatic stress disorder across different countries: infant mortality rate as a marker of social circumstances and basic population health. Psychother Psychosom 2010, 79:56-57. 10.1159/000259418, 19923876.
26. Schnyder U, Moergeli H, Trentz O, Klaghofer R, Buddeberg C. Prediction of psychiatric morbidity in severely injured accident victims at one-year follow-up. Am J Respir Crit Care Med 2001, 164:653-656.
27. O'Donnell ML, Creamer M, Bryant RA, Schnyder U, Shalev A. Posttraumatic disorders following injury: an empirical and methodological review. Clin Psychol Rev 2003, 23:587-603.
28. Holbrook TL, Hoyt DB, Stein MB, Sieber WJ. Perceived threat to life predicts posttraumatic stress disorder after major trauma: risk factors and functional outcome. J Trauma 2001, 51:287-292. discussion 292-283, 10.1097/00005373-200108000-00010, 11493786.
29. Holbrook TL, Hoyt DB, Stein MB, Sieber WJ. Gender differences in long-term posttraumatic stress disorder outcomes after major trauma: women are at higher risk of adverse outcomes than men. J Trauma 2002, 53:882-888. 10.1097/00005373-200211000-00012, 12435938.
30. Bryant RA, Creamer M, O'Donnell M, Silove D, McFarlane AC. A Multisite Study of Initial Respiration Rate and Heart Rate as Predictors of Posttraumatic Stress Disorder. J Clin Psychiatry 2008, 69:1694-1701. 10.4088/JCP.v69n1104, 19014750.
31. Zatzick DF, Russo J, Pitman RK, Rivara F, Jurkovich G, Roy-Byrne P. Reevaluating the association between emergency department heart rate and the development of posttraumatic stress disorder: A public health approach. Biol Psychiatry 2005, 57:91-95. 10.1016/j.biopsych.2004.10.005, 15607305.
32. Holbrook TL, Galarneau MR, Dye JL, Quinn K, Dougherty AL. Morphine Use after Combat Injury in Iraq and Post-Traumatic Stress Disorder. N Engl J Med 2010, 362:110-117. 10.1056/NEJMoa0903326, 20071700.
33. Bryant RA, Creamer M, O'Donnell M, Silove D, McFarlane AC. A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. Biol Psychiatry 2009, 65:438-440. 10.1016/j.biopsych.2008.10.032, 19058787.
34. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci 2007, 10:1116-1124. 10.1038/nn1944, 2444035, 17726478.
35. McGaugh JL. Memory-a century of consolidation. Science 2000, 287:248-251. 10.1126/science.287.5451.248, 10634773.
36. Nemeroff CB, Bremner JD, Foa EB, Mayberg HS, North CS, Stein MB. Posttraumatic stress disorder: A state-of-the-science review. Journal of Psychiatric Research 2006, 40:1-21. 10.1016/j.jpsychires.2005.07.005, 16242154.
37. Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. Biol Psychiatry 2006, 60:376-382. 10.1016/j.biopsych.2006.06.004, 16919525.
38. Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, et al. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 2001, 32:911-926. 10.1016/S0896-6273(01)00523-2, 11738035.
39. Aimone JB, Wiles J, Gage FH. Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci 2006, 9:723-727. 10.1038/nn1707, 16732202.
40. Pitman RK. Post-traumatic stress disorder, hormones, and memory. Biol Psychiatry 1989, 26:221-223. 10.1016/0006-3223(89)90033-4, 2545287.
41. Stangl D, Thuret S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr 2009, 4:271-282. 10.1007/s12263-009-0134-5, 2775886, 19685256.
42. Zhao C, Deng W, Gage FH. Mechanisms and Functional Implications of Adult Neurogenesis. Cell 2008, 132:645-660. 10.1016/j.cell.2008.01.033, 18295581.
43. Ross BM, Seguin J, Sieswerda LE. Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?. Lipids Health Dis 2007, 6:21. 10.1186/1476-511X-6-21, 2071911, 17877810.
44. Parker G, Gibson NA, Brotchie H, Heruc G, Rees A-M, Hadzi-Pavlovic D. Omega-3 Fatty Acids and Mood Disorders. Am J Psychiatry 2006, 163:969-978. 10.1176/appi.ajp.163.6.969, 16741195.
45. Beltz BS, Tlusty MF, Benton JL, Sandeman DC. Omega-3 fatty acids upregulate adult neurogenesis. Neurosci Lett 2007, 415:154-158. 10.1016/j.neulet.2007.01.010, 1892224, 17240063.
46. Wu A, Ying Z, Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004, 21:1457-1467. 10.1089/neu.2004.21.1457, 15672635.
47. Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 2008, 155:751-759. 10.1016/j.neuroscience.2008.05.061, 18620024.
48. Calderon F, Kim HY. Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem 2004, 90:979-988. 10.1111/j.1471-4159.2004.02520.x, 15287904.
49. Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006, 139:991-997. 10.1016/j.neuroscience.2006.01.021, 16527422.
50. Venna VR, Deplanque D, Allet C, Belarbi K, Hamdane M, Bordet R. PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. Psychoneuroendocrinology 2009, 34:199-211. 10.1016/j.psyneuen.2008.08.025, 18848400.
51. Katoh-Semba R, Takeuchi IK, Semba R, Kato K. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. J Neurochem 1997, 69:34-42. 10.1046/j.1471-4159.1997.69010034.x, 9202291.
52. Hashimoto K. Brain-derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions. Psychiatry and Clinical Neurosciences 2010, 64:341-357. 10.1111/j.1440-1819.2010.02113.x, 20653908.
53. Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol 2005, 192:348-356. 10.1016/j.expneurol.2004.11.016, 15755552.
54. Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, et al. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol 2007, 5:e297. 10.1371/journal.pbio.0050297, 2071943, 18001149.
55. Conklin SM, Gianaros PJ, Brown SM, Yao JK, Hariri AR, Manuck SB, Muldoon MF. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neuroscience Letters 2007, 421:209-212. 10.1016/j.neulet.2007.04.086, 17574755.
56. McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand NM. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2007, 62:17-24. 10.1016/j.biopsych.2006.08.026, 17188654.
57. Bossini L, Tavanti M, Calossi S, Lombardelli A, Polizzotto NR, Galli R, Vatti G, Pieraccini F, Castrogiovanni P. Magnetic resonance imaging volumes of the hippocampus in drug-naive patients with post-traumatic stress disorder without comorbidity conditions. J Psychiatr Res 2008, 42:752-762. 10.1016/j.jpsychires.2007.08.004, 17892884.
58. Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB. MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. Am J Psychiatry 1995, 152:973-981.
59. Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Mazure C, Capelli S, McCarthy G, Innis RB, Charney DS. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report. Biol Psychiatry 1997, 41:23-32. 10.1016/S0006-3223(96)00162-X, 8988792.
60. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, Pitman RK. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience 2002, 5:1242-1247. 10.1038/nn958, 2819093, 12379862.
61. Gurvits TV, Shenton ME, Hokama H, Ohta H, Lasko NB, Gilbertson MW, Orr SP, Kikinis R, Jolesz FA, McCarley RW, Pitman RK. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry 1996, 40:1091-1099. 10.1016/S0006-3223(96)00229-6, 2910907, 8931911.
62. Karl A, Schaefer M, Malta LS, Dorfel D, Rohleder N, Werner A. A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 2006, 30:1004-1031. 10.1016/j.neubiorev.2006.03.004, 16730374.
63. Kitayama N, Vaccarino V, Kutner M, Weiss P, Bremner JD. Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord 2005, 88:79-86. 10.1016/j.jad.2005.05.014, 16033700.
64. Smith ME. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 2005, 15:798-807. 10.1002/hipo.20102, 15988763.
65. Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B. Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med 1997, 27:951-959. 10.1017/S0033291797005242, 9234472.
66. Villarreal G, Hamilton DA, Petropoulos H, Driscoll I, Rowland LM, Griego JA, Kodituwakku PW, Hart BL, Escalona R, Brooks WM. Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biol Psychiatry 2002, 52:119-125. 10.1016/S0006-3223(02)01359-8, 12114003.
67. Wignall EL, Dickson JM, Vaughan P, Farrow TF, Wilkinson ID, Hunter MD, Woodruff PW. Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder. Biol Psychiatry 2004, 56:832-836. 10.1016/j.biopsych.2004.09.015, 15576059.
68. Winter H, Irle E. Hippocampal volume in adult burn patients with and without posttraumatic stress disorder. Am J Psychiatry 2004, 161:2194-2200. 10.1176/appi.ajp.161.12.2194, 15569889.
69. Woon FL, Hedges DW. Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus 2008, 18:729-736. 10.1002/hipo.20437, 18446827.
70. Wang Z, Neylan TC, Mueller SG, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. Magnetic Resonance Imaging of Hippocampal Subfields in Posttraumatic Stress Disorder. Arch Gen Psychiatry 2010, 67:296-303. 10.1001/archgenpsychiatry.2009.205, 2848481, 20194830.
71. Bonne O, Brandes D, Gilboa A, Gomori JM, Shenton ME, Pitman RK, Shalev AY. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am J Psychiatry 2001, 158:1248-1251. 10.1176/appi.ajp.158.8.1248, 2819102, 11481158.
72. Carrion VG, Weems CF, Eliez S, Patwardhan A, Brown W, Ray RD, Reiss AL. Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biol Psychiatry 2001, 50:943-951. 10.1016/S0006-3223(01)01218-5, 11750890.
73. De Bellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM, Frustaci K, Ryan ND. Developmental traumatology. Part II: Brain development. Biol Psychiatry 1999, 45:1271-1284. 10.1016/S0006-3223(99)00045-1, 10349033.
74. De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, Moritz G. Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry 2002, 52:1066-1078. 10.1016/S0006-3223(02)01459-2, 12460690.
75. Fennema-Notestine C, Stein MB, Kennedy CM, Archibald SL, Jernigan TL. Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biol Psychiatry 2002, 52:1089-1101. 10.1016/S0006-3223(02)01413-0, 12460692.
76. Golier JA, Yehuda R, De Santi S, Segal S, Dolan S, de Leon MJ. Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder. Psychiatry Res 2005, 139:53-64. 10.1016/j.pscychresns.2005.02.007, 15939577.
77. Pederson CL, Maurer SH, Kaminski PL, Zander KA, Peters CM, Stokes-Crowe LA, Osborn RE. Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse. J Trauma Stress 2004, 17:37-40. 10.1023/B:JOTS.0000014674.84517.46, 15027791.
78. Matsuoka Y, Yamawaki S, Inagaki M, Akechi T, Uchitomi Y. A volumetric study of amygdala in cancer survivors with intrusive recollections. Biol Psychiatry 2003, 54:736-743. 10.1016/S0006-3223(02)01907-8, 14512214.
79. Nakano T, Wenner M, Inagaki M, Kugaya A, Akechi T, Matsuoka Y, Sugahara Y, Imoto S, Murakami K, Uchitomi Y. Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors. Am J Psychiatry 2002, 159:2087-2093. 10.1176/appi.ajp.159.12.2087, 12450961.
80. Matsuoka Y, Nagamine M, Mori E, Imoto S, Kim Y, Uchitomi Y. Left Hippocampal Volume Inversely Correlates With Enhanced Emotional Memory in Healthy Middle-Aged Women. J Neuropsychiatry Clin Neurosci 2007, 19:335-338.
81. Bossini L, Tavanti M, Lombardelli A, Calossi S, Polizzotto NR, Galli R, Vatti G, Pieraccini F, Castrogiovanni P. Changes in hippocampal volume in patients with post-traumatic stress disorder after sertraline treatment. J Clin Psychopharmacol 2007, 27:233-235. 10.1097/01.jcp.0000264979.09862.a8, 17414261.
82. Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 2003, 54:693-702. 10.1016/S0006-3223(03)00634-6, 14512209.
83. Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hashimoto K, Hamazaki T. Omega-3 fatty acids for secondary prevention of posttraumatic stress disorder after accidental injury: An open-label pilot study. J Clin Psychopharmacol 2010, 30:217-219. 10.1097/JCP.0b013e3181d48830, 20520307.
84. Matsuoka Y, Nishi D, Nakajima S, Yonemoto N, Hashimoto K, Noguchi H, Homma M, Otomo Y, Kim Y. The Tachikawa cohort of motor vehicle accident study investigating psychological distress: design, methods and cohort profiles. Soc Psychiatry Psychiatr Epidemiol 2009, 44:341.
85. Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hamazaki T, Hashimoto K. Potential role of BDNF in the omega-3 fatty acid supplementation to prevent posttraumatic distress after accidental injury: An open-label pilot study. Psychothear Psychosom
86. Peters J, Dieppa-Perea LM, Melendez LM, Quirk GJ. Induction of Fear Extinction with Hippocampal-Infralimbic BDNF. Science 2010, 328:1288-1290. 10.1126/science.1186909, 20522777.