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Volumn 6, Issue 1, 2011, Pages 20-26

The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis

Author keywords

Calcium sensitizer; Caspase 3; Patents; Protection; TUNEL staining

Indexed keywords

DOBUTAMINE; FAS LIGAND; LEVOSIMENDAN; PLACEBO; TROPONIN C;

EID: 79551665968     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489011794578482     Document Type: Article
Times cited : (12)

References (101)
  • 2
    • 0031976338 scopus 로고    scopus 로고
    • Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting
    • Lilleberg J, Nieminen MS, Akkila J, Heikkila L, Kuitunen A, Lehtonen L, et al. Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J 1998; 19: 660-668.
    • (1998) Eur Heart J , vol.19 , pp. 660-668
    • Lilleberg, J.1    Nieminen, M.S.2    Akkila, J.3    Heikkila, L.4    Kuitunen, A.5    Lehtonen, L.6
  • 3
    • 23644460318 scopus 로고    scopus 로고
    • Calcium sensitizer agents: A new class of inotropic agents in the treatment of decompensated heart failure
    • Perrone SV, Kaplinsky EJ. Calcium sensitizer agents: A new class of inotropic agents in the treatment of decompensated heart failure. Int J Cardiol 2005; 103: 248-255.
    • (2005) Int J Cardiol , vol.103 , pp. 248-255
    • Perrone, S.V.1    Kaplinsky, E.J.2
  • 4
    • 9444292903 scopus 로고    scopus 로고
    • The contractile apparatus as a target for drugs against heart failure: Interaction of levosimendan, a calcium sensitiser, with cardiac troponin C
    • Sorsa T, Pollesello P, Solaro RJ. The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin C. Mol Cell Biochem 2004; 266: 87-107.
    • (2004) Mol Cell Biochem , vol.266 , pp. 87-107
    • Sorsa, T.1    Pollesello, P.2    Solaro, R.J.3
  • 5
    • 0035544376 scopus 로고    scopus 로고
    • Mechanism of action of Ca2+ sensitizers--update 2001
    • Endoh M. Mechanism of action of Ca2+ sensitizers--update 2001. Cardiovasc Drugs Ther 2001; 15: 397-403.
    • (2001) Cardiovasc Drugs Ther , vol.15 , pp. 397-403
    • Endoh, M.1
  • 6
    • 17644369589 scopus 로고    scopus 로고
    • Pharmacological mechanisms contributing to the clinical efficacy of levosimendan
    • Papp Z, Csapo K, Pollesello P, Haikala H, Edes I. Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. Cardiovasc Drug Rev 2005; 23: 71-98.
    • (2005) Cardiovasc Drug Rev , vol.23 , pp. 71-98
    • Papp, Z.1    Csapo, K.2    Pollesello, P.3    Haikala, H.4    Edes, I.5
  • 9
    • 16344362711 scopus 로고    scopus 로고
    • Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake
    • Michaels AD, McKeown B, Kostal M, Vakharia KT, Jordan MV, Gerber IL, et al. Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake. Circulation 2005; 111: 1504-1509.
    • (2005) Circulation , vol.111 , pp. 1504-1509
    • Michaels, A.D.1    McKeown, B.2    Kostal, M.3    Vakharia, K.T.4    Jordan, M.V.5    Gerber, I.L.6
  • 10
    • 0034739460 scopus 로고    scopus 로고
    • Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators
    • Slawsky MT, Colucci WS, Gottlieb SS, Greenberg BH, Haeusslein E, Hare J, et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators. Circulation 2000; 102: 2222-2227.
    • (2000) Circulation , vol.102 , pp. 2222-2227
    • Slawsky, M.T.1    Colucci, W.S.2    Gottlieb, S.S.3    Greenberg, B.H.4    Haeusslein, E.5    Hare, J.6
  • 11
  • 14
    • 0031935492 scopus 로고    scopus 로고
    • Calcium sensitising agents in heart failure
    • Mathew L, Katz SD. Calcium sensitising agents in heart failure. Drugs Aging 1998; 12: 191-204.
    • (1998) Drugs Aging , vol.12 , pp. 191-204
    • Mathew, L.1    Katz, S.D.2
  • 15
    • 0030998587 scopus 로고    scopus 로고
    • New inotropic concepts: Rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors
    • Holubarsch C. New inotropic concepts: Rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors. Cardiology 1997; 88 (Suppl 2): 12-20.
    • (1997) Cardiology , vol.88 , Issue.2 , pp. 12-20
    • Holubarsch, C.1
  • 16
    • 0345367424 scopus 로고    scopus 로고
    • Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: Dependency of external work and forceon muscle length, heart rate and inotropic stimulation
    • Holubarsch C, Ludemann J, Wiessner S, Ruf T, Schulte-Baukloh H, Schmidt-Schweda S, et al. Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: Dependency of external work and forceon muscle length, heart rate and inotropic stimulation. Cardiovasc Res 1998; 37: 46-57.
    • (1998) Cardiovasc Res , vol.37 , pp. 46-57
    • Holubarsch, C.1    Ludemann, J.2    Wiessner, S.3    Ruf, T.4    Schulte-Baukloh, H.5    Schmidt-Schweda, S.6
  • 17
    • 4644227135 scopus 로고    scopus 로고
    • Levosimendan, a new calcium-sensitizing inotrope for heart failure
    • Ng TM. Levosimendan, a new calcium-sensitizing inotrope for heart failure. Pharmacotherapy 2004; 24: 1366-1384.
    • (2004) Pharmacotherapy , vol.24 , pp. 1366-1384
    • Ng, T.M.1
  • 18
    • 0034039813 scopus 로고    scopus 로고
    • Acute effects of a single low oral dose of pimobendan on left ventricular systolic and diastolic function in patients with congestive heart failure
    • Ishiki R, Ishihara T, Izawa H, Nagata K, Hirai M, Yokota M. Acute effects of a single low oral dose of pimobendan on left ventricular systolic and diastolic function in patients with congestive heart failure. J Cardiovasc Pharmacol 2000; 35: 897-905.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 897-905
    • Ishiki, R.1    Ishihara, T.2    Izawa, H.3    Nagata, K.4    Hirai, M.5    Yokota, M.6
  • 19
    • 0029742865 scopus 로고    scopus 로고
    • Effect of pimobendan on exercise capacity in patients with heart failure: Main results from the Pimobendan in Congestive Heart Failure (PICO) trial
    • Lubsen J, Just H, Hjalmarsson AC, La Framboise D, Remme WJ, Heinrich-Nols J, et al. Effect of pimobendan on exercise capacity in patients with heart failure: Main results from the Pimobendan in Congestive Heart Failure (PICO) trial. Heart 1996; 76: 223-231.
    • (1996) Heart , vol.76 , pp. 223-231
    • Lubsen, J.1    Just, H.2    Hjalmarsson, A.C.3    la Framboise, D.4    Remme, W.J.5    Heinrich-Nols, J.6
  • 20
    • 34247857479 scopus 로고    scopus 로고
    • Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE Randomized Trial
    • Mebazaa A, Nieminen MS, Packer M, Cohen-Solal A, Kleber FX, Pocock SJ, et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE Randomized Trial. JAMA 2007; 297: 1883-1891.
    • (2007) JAMA , vol.297 , pp. 1883-1891
    • Mebazaa, A.1    Nieminen, M.S.2    Packer, M.3    Cohen-Solal, A.4    Kleber, F.X.5    Pocock, S.J.6
  • 23
    • 56049125762 scopus 로고    scopus 로고
    • Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: Basic considerations
    • Monassier JP. Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: Basic considerations. Arch Cardiovasc Dis 2008; 101: 491-500.
    • (2008) Arch Cardiovasc Dis , vol.101 , pp. 491-500
    • Monassier, J.P.1
  • 24
    • 57849088252 scopus 로고    scopus 로고
    • Reperfusion injury in acute myocardial infarction: From bench to cath lab. Part II: Clinical issues and therapeutic options
    • Monassier JP. Reperfusion injury in acute myocardial infarction: From bench to cath lab. Part II: Clinical issues and therapeutic options. Arch Cardiovasc Dis 2008; 101: 565-575.
    • (2008) Arch Cardiovasc Dis , vol.101 , pp. 565-575
    • Monassier, J.P.1
  • 25
    • 70349567942 scopus 로고    scopus 로고
    • Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury
    • Scheiermann C, Colom B, Meda P, Patel NS, Voisin MB, Marrelli A, et al. Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol 2009; 29: 1509-1515.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1509-1515
    • Scheiermann, C.1    Colom, B.2    Meda, P.3    Patel, N.S.4    Voisin, M.B.5    Marrelli, A.6
  • 26
    • 34548147767 scopus 로고    scopus 로고
    • Protocols and mechanisms for remote ischemic preconditioning: A novel method for reducing ischemia reperfusion injury
    • Kanoria S, Jalan R, Seifalian AM, Williams R, Davidson BR. Protocols and mechanisms for remote ischemic preconditioning: A novel method for reducing ischemia reperfusion injury. Transplantation 2007; 84: 445-458.
    • (2007) Transplantation , vol.84 , pp. 445-458
    • Kanoria, S.1    Jalan, R.2    Seifalian, A.M.3    Williams, R.4    Davidson, B.R.5
  • 27
    • 3843094875 scopus 로고    scopus 로고
    • Potassium-specific effects of levosimendan on heart mitochondria
    • Kopustinskiene DM, Pollesello P, Saris NE. Potassium-specific effects of levosimendan on heart mitochondria. Biochem Pharmacol 2004; 68: 807-812.
    • (2004) Biochem Pharmacol , vol.68 , pp. 807-812
    • Kopustinskiene, D.M.1    Pollesello, P.2    Saris, N.E.3
  • 30
    • 0033553475 scopus 로고    scopus 로고
    • + channels and myocardial preconditioning
    • + channels and myocardial preconditioning. Circ Res 1999; 84: 973-979.
    • (1999) Circ Res , vol.84 , pp. 973-979
    • Gross, G.J.1    Fryer, R.M.2
  • 33
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier P, Finch A, Evan G. Apoptosis in development. Nature 2000; 407: 796-801.
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 34
    • 0032885388 scopus 로고    scopus 로고
    • Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
    • Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 1999; 68: 383-424.
    • (1999) Annu Rev Biochem , vol.68 , pp. 383-424
    • Earnshaw, W.C.1    Martins, L.M.2    Kaufmann, S.H.3
  • 35
    • 0034641898 scopus 로고    scopus 로고
    • CD95's deadly mission in the immune system
    • Krammer PH. CD95's deadly mission in the immune system. Nature 2000; 407: 789-795.
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 36
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15: 2922-2933.
    • (2001) Genes Dev , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 37
    • 0037213368 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
    • Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003; 39: 615-647.
    • (2003) Mol Immunol , vol.39 , pp. 615-647
    • Borner, C.1
  • 38
    • 0034016574 scopus 로고    scopus 로고
    • Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition
    • Patterson SD, Spahr CS, Daugas E, Susin SA, Irinopoulou T, Koehler C, et al. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition. Cell Death Differ 2000; 7: 137-144.
    • (2000) Cell Death Differ , vol.7 , pp. 137-144
    • Patterson, S.D.1    Spahr, C.S.2    Daugas, E.3    Susin, S.A.4    Irinopoulou, T.5    Koehler, C.6
  • 40
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 41
    • 21144476976 scopus 로고    scopus 로고
    • Volatile anesthetics induce caspase-dependent, mitochondriamediated apoptosis in human T lymphocytes in vitro
    • Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, et al. Volatile anesthetics induce caspase-dependent, mitochondriamediated apoptosis in human T lymphocytes in vitro. Anesthesiology 2005; 102: 1147-1147.
    • (2005) Anesthesiology , vol.102 , pp. 1147-1147
    • Loop, T.1    Dovi-Akue, D.2    Frick, M.3    Roesslein, M.4    Egger, L.5    Humar, M.6
  • 42
    • 25144460454 scopus 로고    scopus 로고
    • Cardioprotection: A new paradigm in the management of acute heart failure syndromes
    • Maytin M, Colucci WS. Cardioprotection: A new paradigm in the management of acute heart failure syndromes. Am J Cardiol 2005; 96: 26G-31G.
    • (2005) Am J Cardiol , vol.96
    • Maytin, M.1    Colucci, W.S.2
  • 54
    • 0028339593 scopus 로고
    • Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts
    • Rump AF, Acar D, Rosen R, Klaus W. Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts. Pharmacol Toxicol 1994; 74: 244-248.
    • (1994) Pharmacol Toxicol , vol.74 , pp. 244-248
    • Rump, A.F.1    Acar, D.2    Rosen, R.3    Klaus, W.4
  • 56
    • 0032846862 scopus 로고    scopus 로고
    • The effects of levosimendan on the left ventricular function and protein phosphorylation in post-ischemic guinea pig hearts
    • Kristof E, Szigeti G, Papp Z, Bodi A, Ball NA, Walsh RA, et al. The effects of levosimendan on the left ventricular function and protein phosphorylation in post-ischemic guinea pig hearts. Basic Res Cardiol 1999; 94: 223-230.
    • (1999) Basic Res Cardiol , vol.94 , pp. 223-230
    • Kristof, E.1    Szigeti, G.2    Papp, Z.3    Bodi, A.4    Ball, N.A.5    Walsh, R.A.6
  • 57
    • 0032780899 scopus 로고    scopus 로고
    • Levosimendan: Effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart
    • du Toit EF, Muller CA, McCarthy J, Opie LH. Levosimendan: Effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart. J Pharmacol Exp Ther 1999; 290: 505-514.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 505-514
    • du Toit, E.F.1    Muller, C.A.2    McCarthy, J.3    Opie, L.H.4
  • 58
    • 0033959417 scopus 로고    scopus 로고
    • Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels
    • Kersten JR, Montgomery MW, Pagel PS, Warltier DC. Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels. Anesth Analg 2000; 90: 5-11.
    • (2000) Anesth Analg , vol.90 , pp. 5-11
    • Kersten, J.R.1    Montgomery, M.W.2    Pagel, P.S.3    Warltier, D.C.4
  • 59
    • 0034769061 scopus 로고    scopus 로고
    • Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model
    • du Toit E, Hofmann D, McCarthy J, Pineda C. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart 2001; 86: 81-87.
    • (2001) Heart , vol.86 , pp. 81-87
    • du Toit, E.1    Hofmann, D.2    McCarthy, J.3    Pineda, C.4
  • 60
    • 4344631942 scopus 로고    scopus 로고
    • Effect of levosimendan on balance between ATP production and consumption in isolated perfused guinea-pig heart before ischemia or after reperfusion
    • Eriksson O, Pollesello P, Haikala H. Effect of levosimendan on balance between ATP production and consumption in isolated perfused guinea-pig heart before ischemia or after reperfusion. J Cardiovasc Pharmacol 2004; 44: 316-321.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 316-321
    • Eriksson, O.1    Pollesello, P.2    Haikala, H.3
  • 61
    • 33845641680 scopus 로고    scopus 로고
    • Effects of levosimendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model
    • Busk M, Maeng M, Kristensen J, Berg JS, Mortensen UM, Nielsen TT, et al. Effects of levosimendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model. Cardiovasc Drugs Ther 2006; 20: 335-342.
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 335-342
    • Busk, M.1    Maeng, M.2    Kristensen, J.3    Berg, J.S.4    Mortensen, U.M.5    Nielsen, T.T.6
  • 62
    • 33750630750 scopus 로고    scopus 로고
    • Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model
    • Lepran I, Pollesello P, Vajda S, Varro A, Papp JG. Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model. J Cardiovasc Pharmacol 2006; 48: 148-152.
    • (2006) J Cardiovasc Pharmacol , vol.48 , pp. 148-152
    • Lepran, I.1    Pollesello, P.2    Vajda, S.3    Varro, A.4    Papp, J.G.5
  • 63
    • 33749007990 scopus 로고    scopus 로고
    • Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusioninduced arrhythmias in dogs
    • Papp JG, Pollesello P, Varro AF, Vegh AS. Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusioninduced arrhythmias in dogs. J Cardiovasc Pharmacol Ther 2006; 11: 129-135.
    • (2006) J Cardiovasc Pharmacol Ther , vol.11 , pp. 129-135
    • Papp, J.G.1    Pollesello, P.2    Varro, A.F.3    Vegh, A.S.4
  • 64
    • 33947137368 scopus 로고    scopus 로고
    • Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction
    • Missant C, Rex S, Segers P, Wouters PF. Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. Crit Care Med 2007; 35: 707-715.
    • (2007) Crit Care Med , vol.35 , pp. 707-715
    • Missant, C.1    Rex, S.2    Segers, P.3    Wouters, P.F.4
  • 67
    • 42949135943 scopus 로고    scopus 로고
    • A role for the RISK pathway and K(ATP) channels in pre- and postconditioning induced by levosimendan in the isolated guinea pig heart
    • du Toit EF, Genis A, Opie LH, Pollesello P, Lochner A. A role for the RISK pathway and K(ATP) channels in pre- and postconditioning induced by levosimendan in the isolated guinea pig heart. Br J Pharmacol 2008; 154: 41-50.
    • (2008) Br J Pharmacol , vol.154 , pp. 41-50
    • du Toit, E.F.1    Genis, A.2    Opie, L.H.3    Pollesello, P.4    Lochner, A.5
  • 69
    • 34748901360 scopus 로고    scopus 로고
    • Pharmacological preconditioning by levosimendan is mediated by inducible nitric oxide synthase and mitochondrial KATP channel activation in the in vivo anesthetized rabbit heart model
    • Das B, Sarkar C. Pharmacological preconditioning by levosimendan is mediated by inducible nitric oxide synthase and mitochondrial KATP channel activation in the in vivo anesthetized rabbit heart model. Vascul Pharmacol 2007; 47: 248-256.
    • (2007) Vascul Pharmacol , vol.47 , pp. 248-256
    • Das, B.1    Sarkar, C.2
  • 74
    • 72249117543 scopus 로고    scopus 로고
    • Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs
    • Metzsch C, Linner R, Steen S, Liao Q, Algotsson L. Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs. Acta Anaesthesiol Scand 2010; 54: 103-10.
    • (2010) Acta Anaesthesiol Scand , vol.54 , pp. 103-110
    • Metzsch, C.1    Linner, R.2    Steen, S.3    Liao, Q.4    Algotsson, L.5
  • 75
    • 46749126210 scopus 로고    scopus 로고
    • Protection of the spinal cord from ischemia: Comparative effects of levosimendan and iloprost
    • Lafci B, Yasa H, Ilhan G, Ortac R, Yilik L, Kestelli M, et al. Protection of the spinal cord from ischemia: Comparative effects of levosimendan and iloprost. Eur Surg Res 2008; 41:1-7.
    • (2008) Eur Surg Res , vol.41 , pp. 1-7
    • Lafci, B.1    Yasa, H.2    Ilhan, G.3    Ortac, R.4    Yilik, L.5    Kestelli, M.6
  • 76
  • 77
    • 43049119601 scopus 로고    scopus 로고
    • Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: A rabbit model
    • Yasa H, Yakut N, Emrecan B, Ergunes K, Ortac R, Karahan N, et al. Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: A rabbit model. J Surg Res 2008; 147: 138-142.
    • (2008) J Surg Res , vol.147 , pp. 138-142
    • Yasa, H.1    Yakut, N.2    Emrecan, B.3    Ergunes, K.4    Ortac, R.5    Karahan, N.6
  • 78
    • 41849106827 scopus 로고    scopus 로고
    • The influence of levosimendan and iloprost on renal ischemiareperfusion: An experimental study
    • Yakut N, Yasa H, Bahriye Lafci B, Ortac R, Tulukoglu E, et al. The influence of levosimendan and iloprost on renal ischemiareperfusion: An experimental study. Interact Cardiovasc Thorac Surg 2008; 7: 235-239.
    • (2008) Interact Cardiovasc Thorac Surg , vol.7 , pp. 235-239
    • Yakut, N.1    Yasa, H.2    Bahriye, L.B.3    Ortac, R.4    Tulukoglu, E.5
  • 80
    • 77955714479 scopus 로고    scopus 로고
    • Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model
    • Ozturk T, Gok S, Nese N. Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model. J Cardiothorac Vasc Anesth 2010; 24: 624-628.
    • (2010) J Cardiothorac Vasc Anesth , vol.24 , pp. 624-628
    • Ozturk, T.1    Gok, S.2    Nese, N.3
  • 81
    • 77951294283 scopus 로고    scopus 로고
    • Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs
    • Grossini E, Caimmi PP, Platini F, Molinari C, Uberti F, Cattaneo M, et al. Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs. Cardiovasc Drugs Ther 2010; 24: 5-15.
    • (2010) Cardiovasc Drugs Ther , vol.24 , pp. 5-15
    • Grossini, E.1    Caimmi, P.P.2    Platini, F.3    Molinari, C.4    Uberti, F.5    Cattaneo, M.6
  • 82
    • 70350442289 scopus 로고    scopus 로고
    • Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats
    • Louhelainen M, Vahtola E, Forsten H, Merasto S, Kyto V, Finckenberg P, et al. Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats. J Hypertens 2009; 27: 2094-2107.
    • (2009) J Hypertens , vol.27 , pp. 2094-2107
    • Louhelainen, M.1    Vahtola, E.2    Forsten, H.3    Merasto, S.4    Kyto, V.5    Finckenberg, P.6
  • 83
    • 0033939131 scopus 로고    scopus 로고
    • Effect of a calcium-sensitizing agent, levosimendan, on the postcardioplegic inotropic response of the myocardium
    • Lochner A, Colesky F, Genade S. Effect of a calcium-sensitizing agent, levosimendan, on the postcardioplegic inotropic response of the myocardium. Cardiovasc Drugs Ther 2000; 14: 271-281.
    • (2000) Cardiovasc Drugs Ther , vol.14 , pp. 271-281
    • Lochner, A.1    Colesky, F.2    Genade, S.3
  • 84
    • 0036987560 scopus 로고    scopus 로고
    • Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts
    • Koksal C, Suzer O, Bozkurt AK, Koseoglu S. Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts. Acta Med (Hradec Kralove) 2002; 45: 93-97.
    • (2002) Acta Med (Hradec Kralove) , vol.45 , pp. 93-97
    • Koksal, C.1    Suzer, O.2    Bozkurt, A.K.3    Koseoglu, S.4
  • 85
    • 14944348020 scopus 로고    scopus 로고
    • Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction
    • Huang L, Weil MH, Tang W, Sun S, Wang J. Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction. Crit Care Med 2005; 33: 487-491.
    • (2005) Crit Care Med , vol.33 , pp. 487-491
    • Huang, L.1    Weil, M.H.2    Tang, W.3    Sun, S.4    Wang, J.5
  • 86
    • 23944504020 scopus 로고    scopus 로고
    • Levosimendan improves postresuscitation myocardial dysfunction after betaadrenergic blockade
    • Wang J, Weil MH, Tang W, Sun S, Huang L. Levosimendan improves postresuscitation myocardial dysfunction after betaadrenergic blockade. J Lab Clin Med 2005; 146: 179-183.
    • (2005) J Lab Clin Med , vol.146 , pp. 179-183
    • Wang, J.1    Weil, M.H.2    Tang, W.3    Sun, S.4    Huang, L.5
  • 87
    • 26844579375 scopus 로고    scopus 로고
    • Levosimendan improves postresuscitation outcomes in a rat model of CPR
    • Huang L, Weil MH, Sun S, Cammarata G, Cao L, Tang W. Levosimendan improves postresuscitation outcomes in a rat model of CPR. J Lab Clin Med 2005; 146: 256-261.
    • (2005) J Lab Clin Med , vol.146 , pp. 256-261
    • Huang, L.1    Weil, M.H.2    Sun, S.3    Cammarata, G.4    Cao, L.5    Tang, W.6
  • 88
    • 34547829784 scopus 로고    scopus 로고
    • Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest
    • Koudouna E, Xanthos T, Bassiakou E, Goulas S, Lelovas P, Papadimitriou D, et al. Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest. Acta Anaesthesiol Scand 2007; 51: 1123-1129.
    • (2007) Acta Anaesthesiol Scand , vol.51 , pp. 1123-1129
    • Koudouna, E.1    Xanthos, T.2    Bassiakou, E.3    Goulas, S.4    Lelovas, P.5    Papadimitriou, D.6
  • 89
    • 74449087114 scopus 로고    scopus 로고
    • Reducing mortality in cardiac surgery with levosimendan: A meta-analysis of randomized controlled trials
    • Landoni G, Mizzi A, Biondi-Zoccai G, Bruno G, Bignami E, Corno L, et al. Reducing mortality in cardiac surgery with levosimendan: A meta-analysis of randomized controlled trials. J ardiothorac Vasc Anesth 2010; 24: 51-57.
    • (2010) J Ardiothorac Vasc Anesth , vol.24 , pp. 51-57
    • Landoni, G.1    Mizzi, A.2    Biondi-Zoccai, G.3    Bruno, G.4    Bignami, E.5    Corno, L.6
  • 90
    • 0036764821 scopus 로고    scopus 로고
    • Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebocontrolled, double-blind study (RUSSLAN)
    • Moiseyev VS, Poder P, Andrejevs N, Ruda MY, Golikov AP, Lazebnik LB, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebocontrolled, double-blind study (RUSSLAN). Eur Heart J 2002; 23: 1422-1432.
    • (2002) Eur Heart J , vol.23 , pp. 1422-1432
    • Moiseyev, V.S.1    Poder, P.2    Andrejevs, N.3    Ruda, M.Y.4    Golikov, A.P.5    Lazebnik, L.B.6
  • 91
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • Sonntag S, Sundberg S, Lehtonen LA, Kleber FX. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 2004; 43: 2177-2182.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.A.3    Kleber, F.X.4
  • 92
    • 33646873253 scopus 로고    scopus 로고
    • Preconditioning effects of levosimendan in coronary artery bypass grafting-a pilot study
    • Tritapepe L, De Santis V, Vitale D, Santulli M, Morelli A, Nofroni I, et al. Preconditioning effects of levosimendan in coronary artery bypass grafting-a pilot study. Br J Anaesth 2006; 96: 694-700.
    • (2006) Br J Anaesth , vol.96 , pp. 694-700
    • Tritapepe, L.1    de Santis, V.2    Vitale, D.3    Santulli, M.4    Morelli, A.5    Nofroni, I.6
  • 94
    • 31944443341 scopus 로고    scopus 로고
    • Effects of levosimendan on left ventricular diastolic function after primary angioplasty for acute anterior myocardial infarction: A Doppler echocardiographic study
    • De Luca L, Sardella G, Proietti P, Battagliese A, Benedetti G, Di Roma A, et al. Effects of levosimendan on left ventricular diastolic function after primary angioplasty for acute anterior myocardial infarction: A Doppler echocardiographic study. J Am Soc Echocardiogr 2006; 19: 172-177.
    • (2006) J Am Soc Echocardiogr , vol.19 , pp. 172-177
    • de Luca, L.1    Sardella, G.2    Proietti, P.3    Battagliese, A.4    Benedetti, G.5    Di Roma, A.6
  • 95
    • 2342505687 scopus 로고    scopus 로고
    • Effects of levosimendan on circulating proinflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure
    • Parissis JT, Adamopoulos S, Antoniades C, Kostakis G, Rigas A, Kyrzopoulos S, et al. Effects of levosimendan on circulating proinflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure. Am J Cardiol 2004; 93: 1309-1312.
    • (2004) Am J Cardiol , vol.93 , pp. 1309-1312
    • Parissis, J.T.1    Adamopoulos, S.2    Antoniades, C.3    Kostakis, G.4    Rigas, A.5    Kyrzopoulos, S.6
  • 96
    • 33751190290 scopus 로고    scopus 로고
    • Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    • Trikas A, Antoniades C, Latsios G, Vasiliadou K, Karamitros I, Tousoulis D, et al. Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure. Eur J Heart Fail 2006; 8: 804-809.
    • (2006) Eur J Heart Fail , vol.8 , pp. 804-809
    • Trikas, A.1    Antoniades, C.2    Latsios, G.3    Vasiliadou, K.4    Karamitros, I.5    Tousoulis, D.6
  • 97
    • 33745168603 scopus 로고    scopus 로고
    • Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure
    • Adamopoulos S, Parissis JT, Iliodromitis EK, Paraskevaidis I, Tsiapras D, Farmakis D, et al. Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure. Am J Cardiol 2006; 98: 102-106.
    • (2006) Am J Cardiol , vol.98 , pp. 102-106
    • Adamopoulos, S.1    Parissis, J.T.2    Iliodromitis, E.K.3    Paraskevaidis, I.4    Tsiapras, D.5    Farmakis, D.6
  • 98
    • 33750120771 scopus 로고    scopus 로고
    • Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation
    • Krumnikl JJ, Toller WG, Prenner G, Metzler H. Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation. Acta Anaesthesiol Scand 2006; 50: 768-770.
    • (2006) Acta Anaesthesiol Scand , vol.50 , pp. 768-770
    • Krumnikl, J.J.1    Toller, W.G.2    Prenner, G.3    Metzler, H.4
  • 99
    • 77951175499 scopus 로고    scopus 로고
    • Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction
    • Papadopoulos G, Baikoussis NG, Tzimas P, Siminelakis SN, Karanikolas M. Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction. J Cardiothorac Surg 2010; 5: 9.
    • (2010) J Cardiothorac Surg , vol.5 , pp. 9
    • Papadopoulos, G.1    Baikoussis, N.G.2    Tzimas, P.3    Siminelakis, S.N.4    Karanikolas, M.5
  • 101
    • 36749091743 scopus 로고    scopus 로고
    • New pharmacologic options in the treatment of acute coronary syndromes and myocardial ischemia-reperfusion injury: Potential role of levosimendan
    • Garcia-Gonzalez MJ, Dominguez-Rodriguez A, Abreu-Gonzalez P. New pharmacologic options in the treatment of acute coronary syndromes and myocardial ischemia-reperfusion injury: Potential role of levosimendan. Minerva Cardioangiol 2007; 55: 625-635.
    • (2007) Minerva Cardioangiol , vol.55 , pp. 625-635
    • Garcia-Gonzalez, M.J.1    Dominguez-Rodriguez, A.2    Abreu-Gonzalez, P.3


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