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Volumn 290, Issue 2, 1999, Pages 505-514

Levosimendan: Effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart

Author keywords

[No Author keywords available]

Indexed keywords

LACTATE DEHYDROGENASE; LACTIC ACID; LEVOSIMENDAN;

EID: 0032780899     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (101)

References (38)
  • 1
    • 0026748339 scopus 로고
    • Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning
    • Auchampach JA, Maruyama M, Cavero I, Garrett J and Gross J (1992) Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. Circulation 86:311-319.
    • (1992) Circulation , vol.86 , pp. 311-319
    • Auchampach, J.A.1    Maruyama, M.2    Cavero, I.3    Garrett, J.4    Gross, J.5
  • 2
    • 0022624277 scopus 로고
    • Reversal of dysfunction in postischaemic stunned myocardium by epinephrine and postextrasystolic potentiation
    • Becker LC, Levine JH, DiPaula AF, Gaurnieri T and Aversano T (1986) Reversal of dysfunction in postischaemic stunned myocardium by epinephrine and postextrasystolic potentiation. J Am Coll Cardiol 7:580-589.
    • (1986) J Am Coll Cardiol , vol.7 , pp. 580-589
    • Becker, L.C.1    Levine, J.H.2    DiPaula, A.F.3    Gaurnieri, T.4    Aversano, T.5
  • 3
    • 0028991696 scopus 로고
    • ATP channel openers protect against increased cytosolic calcium during ischemia and reperfusion
    • ATP channel openers protect against increased cytosolic calcium during ischemia and reperfusion. J Mol Cell Cardiol 27:1809-1817.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 1809-1817
    • Behling, R.W.1    Malone, H.J.2
  • 4
    • 0025061752 scopus 로고
    • Mechanism of myocardial stunning
    • Bolli R (1990) Mechanism of myocardial stunning. Circulation 82:723-738.
    • (1990) Circulation , vol.82 , pp. 723-738
    • Bolli, R.1
  • 5
    • 0024261077 scopus 로고
    • Role of calcium ions in reperfusion arrhythmias: Relevance to pharmacologic intervention
    • Coetzee WA and Opie LH (1988) Role of calcium ions in reperfusion arrhythmias: Relevance to pharmacologic intervention. Cardiovasc Drugs Ther 2:623-636.
    • (1988) Cardiovasc Drugs Ther , vol.2 , pp. 623-636
    • Coetzee, W.A.1    Opie, L.H.2
  • 6
    • 0026012567 scopus 로고
    • ATP-regulated channels protect the myocardium against ischemia/reperfusion damage
    • Cole WC, McPherson CD and Sontag D (1991) ATP-regulated channels protect the myocardium against ischemia/reperfusion damage. Circ Res 69:571-581.
    • (1991) Circ Res , vol.69 , pp. 571-581
    • Cole, W.C.1    McPherson, C.D.2    Sontag, D.3
  • 7
    • 0031934731 scopus 로고    scopus 로고
    • Effects of nitrovasodilators and inhibitors of nitric oxide synthase on ischemic and reperfusion function of the rat isolated hearts
    • Du Toit EF, McCarthy J, Miyashiro J, Opie LH and Brunner F (1998) Effects of nitrovasodilators and inhibitors of nitric oxide synthase on ischemic and reperfusion function of the rat isolated hearts. Br J Pharmacol 123:1159-1167.
    • (1998) Br J Pharmacol , vol.123 , pp. 1159-1167
    • Du Toit, E.F.1    McCarthy, J.2    Miyashiro, J.3    Opie, L.H.4    Brunner, F.5
  • 8
    • 0026561493 scopus 로고
    • Modulation of the severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at the onset of reperfusion
    • Du Toit EF and Opie LH (1992) Modulation of the severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at the onset of reperfusion. Circ Res 70:960-967.
    • (1992) Circ Res , vol.70 , pp. 960-967
    • Du Toit, E.F.1    Opie, L.H.2
  • 9
    • 0027372323 scopus 로고
    • + exchanger in reperfusion stunning in the isolated rat heart
    • + exchanger in reperfusion stunning in the isolated rat heart. J Cardiovasc Pharmacol 22:877-883.
    • (1993) J Cardiovasc Pharmacol , vol.22 , pp. 877-883
    • Du Toit, E.F.1    Opie, L.H.2
  • 10
    • 0029061923 scopus 로고
    • Effect of levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and calcium sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart
    • Edes I, Kiss E, Kitada Y, Powers F, Papp J, Kranias E and Solaro RJ (1995) Effect of levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and calcium sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circ Res 77:107-113.
    • (1995) Circ Res , vol.77 , pp. 107-113
    • Edes, I.1    Kiss, E.2    Kitada, Y.3    Powers, F.4    Papp, J.5    Kranias, E.6    Solaro, R.J.7
  • 11
    • 0027409532 scopus 로고
    • The pharmacology of ATP-sensitive potassium channels
    • Edwards G and Weston AH (1993) The pharmacology of ATP-sensitive potassium channels. Annu Rev Pharmacol Toxicol 33:597-637.
    • (1993) Annu Rev Pharmacol Toxicol , vol.33 , pp. 597-637
    • Edwards, G.1    Weston, A.H.2
  • 12
    • 0021332816 scopus 로고
    • Comparative effects of calcium channel blocking agents and varying extracellular calcium concentrations on hypoxia/ reoxygenation and ischemia/reperfusion induced cardiac injury
    • Fitzpatrick DB and Karmazyn M (1984) Comparative effects of calcium channel blocking agents and varying extracellular calcium concentrations on hypoxia/ reoxygenation and ischemia/reperfusion induced cardiac injury. J Pharmacol Exp Ther 228:761-768.
    • (1984) J Pharmacol Exp Ther , vol.228 , pp. 761-768
    • Fitzpatrick, D.B.1    Karmazyn, M.2
  • 13
    • 85047680849 scopus 로고
    • Effects of potassium channel modulation during global-ischemia in the isolated rat heart with and without cardioplegia
    • Galinanes M, Shattock MJ and Hearse DJ (1992) Effects of potassium channel modulation during global-ischemia in the isolated rat heart with and without cardioplegia. Cardiovasc Res 26:1063-1068.
    • (1992) Cardiovasc Res , vol.26 , pp. 1063-1068
    • Galinanes, M.1    Shattock, M.J.2    Hearse, D.J.3
  • 14
    • 4244120031 scopus 로고    scopus 로고
    • Calcium-sensitising drug reduces energy cost for excitation-contraction coupling in the failing heart, but not in the normal heart
    • Goto Y, Katsuya H, Takasago T, Saeki A and Nishioka T (1996) Calcium-sensitising drug reduces energy cost for excitation-contraction coupling in the failing heart, but not in the normal heart. Circulation 94(Suppl 8):I545.
    • (1996) Circulation , vol.94 , Issue.SUPPL. 8
    • Goto, Y.1    Katsuya, H.2    Takasago, T.3    Saeki, A.4    Nishioka, T.5
  • 15
    • 85047679591 scopus 로고
    • Protective effects of ATP sensitive potassium channel openers in models of myocardial ischemia
    • Grover GJ (1994) Protective effects of ATP sensitive potassium channel openers in models of myocardial ischemia. Cardiovasc Res 28:778-782.
    • (1994) Cardiovasc Res , vol.28 , pp. 778-782
    • Grover, G.J.1
  • 16
    • 0025358820 scopus 로고
    • The protective effect of cromakalim and pinacidil on reperfusion function and infarct size in the isolated perfused rat hearts and anaesthetised dogs
    • Grover GJ, Dzwonczyk S, Parham CS and Sleph PG (1990) The protective effect of cromakalim and pinacidil on reperfusion function and infarct size in the isolated perfused rat hearts and anaesthetised dogs. Cardiovasc Drugs Ther 4:465-474.
    • (1990) Cardiovasc Drugs Ther , vol.4 , pp. 465-474
    • Grover, G.J.1    Dzwonczyk, S.2    Parham, C.S.3    Sleph, P.G.4
  • 17
    • 0026095089 scopus 로고
    • Cardioprotective effects of the potassium channel opener chromakalim: Stereo-selectivity and effect on myocardial adenine nucleotides
    • Grover GJ, Newburger J and Slegh PG (1991) Cardioprotective effects of the potassium channel opener chromakalim: Stereo-selectivity and effect on myocardial adenine nucleotides. J Pharmacol Exp Ther 257:156-162.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 156-162
    • Grover, G.J.1    Newburger, J.2    Slegh, P.G.3
  • 18
    • 0030955524 scopus 로고    scopus 로고
    • The role of cAMP- and cGMP-dependent protein kinase in the cardiac actions of the calcium sensitizer, levosimendan
    • Haikala H, Kaheinen P, Levijoki J and Linden I-B (1997) The role of cAMP- and cGMP-dependent protein kinase in the cardiac actions of the calcium sensitizer, levosimendan. Cardiovasc Res 34:536-546.
    • (1997) Cardiovasc Res , vol.34 , pp. 536-546
    • Haikala, H.1    Kaheinen, P.2    Levijoki, J.3    Linden, I.-B.4
  • 19
    • 0029098682 scopus 로고
    • Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan
    • Haikala H, Kaivola J, Nissenen E, Wall P, Levijoki J and Linden I-B (1995a) Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. Cell Cardiol 27:1859-1866.
    • (1995) Cell Cardiol , vol.27 , pp. 1859-1866
    • Haikala, H.1    Kaivola, J.2    Nissenen, E.3    Wall, P.4    Levijoki, J.5    Linden, I.-B.6
  • 20
  • 22
    • 0344999956 scopus 로고
    • Effects of pinacidil combined with potassium cardioplegia on myocardial viability in hypothermic global ischemia followed by perfusion
    • Hosoda H, Sunamori M, Watanabe M and Suzuki A (1992) Effects of pinacidil combined with potassium cardioplegia on myocardial viability in hypothermic global ischemia followed by perfusion. J Mol Cell Cardiol 24(Suppl 1):S76.
    • (1992) J Mol Cell Cardiol , vol.24 , Issue.SUPPL. 1
    • Hosoda, H.1    Sunamori, M.2    Watanabe, M.3    Suzuki, A.4
  • 23
    • 0019520073 scopus 로고
    • Beneficial effects of amnirone on myocardial oxygen consumption during acute left ventricular failure in dogs
    • Jentzer JH, Lejemtel TH, Sonnenblick EH and Kirk ES (1981) Beneficial effects of amnirone on myocardial oxygen consumption during acute left ventricular failure in dogs. Am J Cardiol 48:75-83.
    • (1981) Am J Cardiol , vol.48 , pp. 75-83
    • Jentzer, J.H.1    Lejemtel, T.H.2    Sonnenblick, E.H.3    Kirk, E.S.4
  • 24
    • 0024465125 scopus 로고
    • Direct measurement of intracellular calcium transients during hypoxia, ischemia and reperfusion in the intact mammalian heart
    • Kihara Y, Grossman W and Morgan JP (1989) Direct measurement of intracellular calcium transients during hypoxia, ischemia and reperfusion in the intact mammalian heart. Circ Res 65:1029-1044.
    • (1989) Circ Res , vol.65 , pp. 1029-1044
    • Kihara, Y.1    Grossman, W.2    Morgan, J.P.3
  • 25
    • 0025230883 scopus 로고
    • Excitation-contraction coupling in post-ischaemic myocardium. Does the failure of activator calcium transients underlie stunning?
    • Kusuoka H, Koretsune Y, Chacko VP, Weisfeldt ML and Marban E (1990) Excitation-contraction coupling in post-ischaemic myocardium. Does the failure of activator calcium transients underlie stunning? Circ Res 66:1268-1276.
    • (1990) Circ Res , vol.66 , pp. 1268-1276
    • Kusuoka, H.1    Koretsune, Y.2    Chacko, V.P.3    Weisfeldt, M.L.4    Marban, E.5
  • 28
    • 0026747161 scopus 로고
    • Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: Implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors
    • Lubbe W, Podzuweit T and Opie LH (1992) Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: Implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors. J Am Coll Cardiol 19:1622-1633.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 1622-1633
    • Lubbe, W.1    Podzuweit, T.2    Opie, L.H.3
  • 29
    • 0025195094 scopus 로고
    • j in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as to the study of ischemia and reperfusion
    • j in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as to the study of ischemia and reperfusion. Circ Res 66:1255-1267.
    • (1990) Circ Res , vol.66 , pp. 1255-1267
    • Marban, E.1    Kitikaze, M.2    Koretsune, Y.3    Yue, D.T.4    Chacko, V.P.5    Pike, M.M.6
  • 32
    • 0022636689 scopus 로고
    • Inodilators
    • Opie LH (1986) Inodilators. Lancet 1:1336.
    • (1986) Lancet , vol.1 , pp. 1336
    • Opie, L.H.1
  • 33
    • 0028339593 scopus 로고
    • Functional and anti-ischemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts
    • Rump A, Acar D, Rosen R and Klaus W (1994) Functional and anti-ischemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts. Pharmacol Toxicol 74:244-248.
    • (1994) Pharmacol Toxicol , vol.74 , pp. 244-248
    • Rump, A.1    Acar, D.2    Rosen, R.3    Klaus, W.4
  • 34
    • 0027493105 scopus 로고
    • Beneficial effects of amnrinone on the size of acute regional ischemia in isolated rabbit hearts
    • Rump A, Rosen R, Sigmund B, Fuchs J, Dhein S and Klaus W (1993) Beneficial effects of amnrinone on the size of acute regional ischemia in isolated rabbit hearts. J Cardiothorac Vasc Anesth 7:573-578.
    • (1993) J Cardiothorac Vasc Anesth , vol.7 , pp. 573-578
    • Rump, A.1    Rosen, R.2    Sigmund, B.3    Fuchs, J.4    Dhein, S.5    Klaus, W.6
  • 35
    • 0023257084 scopus 로고
    • Elevation of cytosolic free calcium concentration early in myocardial ischemia in perfused rat hearts
    • Steenbergen C, Murphy E, Levy L and London RE (1987) Elevation of cytosolic free calcium concentration early in myocardial ischemia in perfused rat hearts. Circ Res 60:700-707.
    • (1987) Circ Res , vol.60 , pp. 700-707
    • Steenbergen, C.1    Murphy, E.2    Levy, L.3    London, R.E.4
  • 36
    • 0029095970 scopus 로고
    • 2+ current in rat ventricular myocytes
    • 2+ current in rat ventricular myocytes. Circ Res 77:803-812.
    • (1995) Circ Res , vol.77 , pp. 803-812
    • Sumii, K.1    Sperelakis, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.