-
1
-
-
0037273839
-
Pharmacotherapeutic approaches for decompensated heart failure: A role for the calcium sensitiser, levosimendan?
-
Greenberg B, Borghi C, Perrone S. Pharmacotherapeutic approaches for decompensated heart failure: a role for the calcium sensitiser, levosimendan? Eur J Heart Fail 2003;5:13-21.
-
(2003)
Eur J Heart Fail
, vol.5
, pp. 13-21
-
-
Greenberg, B.1
Borghi, C.2
Perrone, S.3
-
2
-
-
0029609859
-
Will calcium sensitizers play a role in the treatment of heart failure?
-
Nielsen-Kudsk JE, Aldershvile J. Will calcium sensitizers play a role in the treatment of heart failure? J Cardiovasc Pharmacol 1995;26(suppl 1):S77-84.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, Issue.1 SUPPL.
-
-
Nielsen-Kudsk, J.E.1
Aldershvile, J.2
-
3
-
-
0034878357
-
Inotropic therapy for heart failure: An evidence-based approach
-
Felker GM, O'Connor CM. Inotropic therapy for heart failure: an evidence-based approach. Am Heart J 2001;142:393-401.
-
(2001)
Am Heart J
, vol.142
, pp. 393-401
-
-
Felker, G.M.1
O'Connor, C.M.2
-
4
-
-
0037181515
-
Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial
-
Cuffe MS, Califf RM, Adams KF Jr, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 2002;287:1541-7.
-
(2002)
JAMA
, vol.287
, pp. 1541-1547
-
-
Cuffe, M.S.1
Califf, R.M.2
Adams Jr., K.F.3
-
5
-
-
0026072848
-
Effect of oral milrinone on mortality in severe chronic heart failure
-
The PROMISE study research group
-
Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE study research group. N Engl J Med 1991;325:1468-75.
-
(1991)
N Engl J Med
, vol.325
, pp. 1468-1475
-
-
Packer, M.1
Carver, J.R.2
Rodeheffer, R.J.3
-
6
-
-
8244241095
-
Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure
-
Second prospective randomised study of ibopamine on mortality and efficacy (PRIME II) investigators
-
Hampton JR, van Veldhuisen DJ, Kleber FX, et al. Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure. Second prospective randomised study of ibopamine on mortality and efficacy (PRIME II) investigators. Lancet 1997;349:971-7.
-
(1997)
Lancet
, vol.349
, pp. 971-977
-
-
Hampton, J.R.1
Van Veldhuisen, D.J.2
Kleber, F.X.3
-
7
-
-
0001915433
-
Mechanisms of cardiac contraction and relaxation
-
Braunwald E, ed. Philadelphia: WB Saunders Company
-
Opie L. Mechanisms of cardiac contraction and relaxation. In: Braunwald E, ed. Heart disease. A textbook of cardiovascular medicine, 5th ed. Philadelphia: WB Saunders Company, 1997:360-93.
-
(1997)
Heart Disease. A Textbook of Cardiovascular Medicine, 5th Ed.
, pp. 360-393
-
-
Opie, L.1
-
8
-
-
0032145260
-
Cellular and molecular aspects of contractile dysfunction in heart failure
-
Mittmann C, Eschenhagen T, Scholz H. Cellular and molecular aspects of contractile dysfunction in heart failure. Cardiovasc Res 1998;39:267-75.
-
(1998)
Cardiovasc Res
, vol.39
, pp. 267-275
-
-
Mittmann, C.1
Eschenhagen, T.2
Scholz, H.3
-
9
-
-
0001229903
-
Alterations in calcium handling in cardiac hypertrophy and heart failure
-
Balke CW, Shorofsky SR. Alterations in calcium handling in cardiac hypertrophy and heart failure. Cardiovasc Res 1998;37:290-9.
-
(1998)
Cardiovasc Res
, vol.37
, pp. 290-299
-
-
Balke, C.W.1
Shorofsky, S.R.2
-
10
-
-
0033804245
-
Abnormalities of calcium cycling in the hypertrophied and failing heart
-
Houser S, Piancentino V, Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol 2000;32:1595-607.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 1595-1607
-
-
Houser, S.1
Piancentino, V.2
Weisser, J.3
-
11
-
-
0028791569
-
Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension
-
Haikala H, Levijoki J, Linden IB. Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension. J Mol Cell Cardiol 1995;27:2155-65.
-
(1995)
J Mol Cell Cardiol
, vol.27
, pp. 2155-2165
-
-
Haikala, H.1
Levijoki, J.2
Linden, I.B.3
-
12
-
-
0029061923
-
2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart
-
2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circ Res 1995;77:107-13.
-
(1995)
Circ Res
, vol.77
, pp. 107-113
-
-
Edes, I.1
Kiss, E.2
Kitada, Y.3
-
13
-
-
0028172183
-
2+ sensitizer, levosimendan, to recombinant human cardiac troponin C: A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study
-
2+ sensitizer, levosimendan, to recombinant human cardiac troponin C: a molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study. J Biol Chem 1994;269:28584-90.
-
(1994)
J Biol Chem
, vol.269
, pp. 28584-28590
-
-
Pollesello, P.1
Ovaska, M.2
Kaivola, J.3
-
14
-
-
0029098682
-
Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan
-
Haikala H, Kaivola J, Nissinen E, Wall P, Levijoki J, Linden IB. Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. J Mol Cell Cardiol 1995;27:1859-66.
-
(1995)
J Mol Cell Cardiol
, vol.27
, pp. 1859-1866
-
-
Haikala, H.1
Kaivola, J.2
Nissinen, E.3
Wall, P.4
Levijoki, J.5
Linden, I.B.6
-
15
-
-
0030974966
-
Mechanisms of the contractile effects of levosimendan in the mammalian heart
-
Boknik P, Neumann J, Kaspareit G, et al. Mechanisms of the contractile effects of levosimendan in the mammalian heart. J Pharmacol Exp Ther 1997;280:277-83.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 277-283
-
-
Boknik, P.1
Neumann, J.2
Kaspareit, G.3
-
16
-
-
0030955524
-
The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan
-
Haikala H, Kaheinen P, Levijoki J, Linden IB. The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan. Cardiovasc Res 1997;34:536-46.
-
(1997)
Cardiovasc Res
, vol.34
, pp. 536-546
-
-
Haikala, H.1
Kaheinen, P.2
Levijoki, J.3
Linden, I.B.4
-
17
-
-
0032541979
-
Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
-
Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium. Circulation 1998;98:2141-7.
-
(1998)
Circulation
, vol.98
, pp. 2141-2147
-
-
Hasenfuss, G.1
Pieske, B.2
Castell, M.3
Kretschmann, B.4
Maier, L.S.5
Just, H.6
-
18
-
-
0028922806
-
Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation
-
Haikala H, Nissinen E, Etemadzadeh E, Levijoki J, Linden IB. Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation. J Cardiovasc Pharmacol 1995;25:794-801.
-
(1995)
J Cardiovasc Pharmacol
, vol.25
, pp. 794-801
-
-
Haikala, H.1
Nissinen, E.2
Etemadzadeh, E.3
Levijoki, J.4
Linden, I.B.5
-
19
-
-
0027942068
-
Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs
-
Pagel PS, Harkin CP, Hettrick DA, Warltier DC. Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs. Anesthesiology 1994;81:974-87.
-
(1994)
Anesthesiology
, vol.81
, pp. 974-987
-
-
Pagel, P.S.1
Harkin, C.P.2
Hettrick, D.A.3
Warltier, D.C.4
-
20
-
-
0029097331
-
Systemic and coronary hemodynamic actions and left ventricular functional effects of levosimendan in conscious dogs
-
Harkin CP, Pagel PS, Tessmer JP, Warltier DC. Systemic and coronary hemodynamic actions and left ventricular functional effects of levosimendan in conscious dogs. J Cardiovasc Pharmacol 1995;26:179-88.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, pp. 179-188
-
-
Harkin, C.P.1
Pagel, P.S.2
Tessmer, J.P.3
Warltier, D.C.4
-
21
-
-
0141621300
-
Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery
-
Pataricza J, Krassoi I, Hohn J, Kun A, Papp J. Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery. Cardiovasc Drugs Ther 2003;17:115-21.
-
(2003)
Cardiovasc Drugs Ther
, vol.17
, pp. 115-121
-
-
Pataricza, J.1
Krassoi, I.2
Hohn, J.3
Kun, A.4
Papp, J.5
-
22
-
-
0036258593
-
An analysis of responses to levosimendan in the pulmonary vascular bed of the cat
-
De Witt BJ, Ibrahim IN, Bayer E, et al. An analysis of responses to levosimendan in the pulmonary vascular bed of the cat. Anesth Analg 2002;94:1427-33.
-
(2002)
Anesth Analg
, vol.94
, pp. 1427-1433
-
-
De Witt, B.J.1
Ibrahim, I.N.2
Bayer, E.3
-
24
-
-
0031958567
-
Coronary vasorelaxant effect of levosimendan, a new inodilator with calcium-sensitizing properties
-
Gruhn N, Nielsen-Kudsk JE, Theilgaard S, Bang L, Diesen SP, Aldershvile J. Coronary vasorelaxant effect of levosimendan, a new inodilator with calcium-sensitizing properties. J Cardiovasc Pharmacol 1998;31:741-9.
-
(1998)
J Cardiovasc Pharmacol
, vol.31
, pp. 741-749
-
-
Gruhn, N.1
Nielsen-Kudsk, J.E.2
Theilgaard, S.3
Bang, L.4
Diesen, S.P.5
Aldershvile, J.6
-
25
-
-
0032911582
-
Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization
-
Bowman P, Haikala H, Paul RJ. Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization. J Pharmacol Exp Ther 1999;288:316-25.
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 316-325
-
-
Bowman, P.1
Haikala, H.2
Paul, R.J.3
-
27
-
-
0343049171
-
Comparison of the vasorelaxing effect of cromakalim and the new inodilator, levosimendan, in human isolated portal vein
-
Pataricza J, Hohn J, Petri A, Balogh A, Papp J. Comparison of the vasorelaxing effect of cromakalim and the new inodilator, levosimendan, in human isolated portal vein. J Pharm Pharmacol 2000;52:213-17.
-
(2000)
J Pharm Pharmacol
, vol.52
, pp. 213-217
-
-
Pataricza, J.1
Hohn, J.2
Petri, A.3
Balogh, A.4
Papp, J.5
-
28
-
-
0035088001
-
Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels
-
Kaheinen P, Pollesello P, Levijoki J, Haikala H. Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels. J Cardiovasc Pharmacol 2001;37:367-74.
-
(2001)
J Cardiovasc Pharmacol
, vol.37
, pp. 367-374
-
-
Kaheinen, P.1
Pollesello, P.2
Levijoki, J.3
Haikala, H.4
-
29
-
-
0028245011
-
A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts
-
Rump AF, Acar D, Klaus W. A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts. Br J Pharmacol 1994;112:757-62.
-
(1994)
Br J Pharmacol
, vol.112
, pp. 757-762
-
-
Rump, A.F.1
Acar, D.2
Klaus, W.3
-
30
-
-
0028339593
-
Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts
-
Rump AF, Acar D, Rosen R, Klaus W. Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts. Pharmacol Toxicol 1994;74:244-8.
-
(1994)
Pharmacol Toxicol
, vol.74
, pp. 244-248
-
-
Rump, A.F.1
Acar, D.2
Rosen, R.3
Klaus, W.4
-
31
-
-
0030857836
-
Intracoronary levosimendan enhances contractile function of stunned myocardium
-
Jamali IN, Kersten JR, Pagel PS, Hettrick DA, Warltier DC. Intracoronary levosimendan enhances contractile function of stunned myocardium. Anesth Analg 1997;85:23-9.
-
(1997)
Anesth Analg
, vol.85
, pp. 23-29
-
-
Jamali, I.N.1
Kersten, J.R.2
Pagel, P.S.3
Hettrick, D.A.4
Warltier, D.C.5
-
32
-
-
0030434483
-
Effects of levosimendan on myocardial contractility and oxygen consumption
-
Todaka K, Wang J, Yi GH, et al. Effects of levosimendan on myocardial contractility and oxygen consumption. J Pharmacol Exp Ther 1996;279:120-7.
-
(1996)
J Pharmacol Exp Ther
, vol.279
, pp. 120-127
-
-
Todaka, K.1
Wang, J.2
Yi, G.H.3
-
33
-
-
0029583354
-
Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics
-
Hasenfuss G, Pieske B, Kretschmann B, Holubarsch C, Alpert NR, Just H. Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics. J Cardiovasc Pharmacol 1995;26(suppl 1):S45-51.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, Issue.1 SUPPL.
-
-
Hasenfuss, G.1
Pieske, B.2
Kretschmann, B.3
Holubarsch, C.4
Alpert, N.R.5
Just, H.6
-
34
-
-
0032780899
-
Levosimendan: Effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart
-
Du Toit EF, Muller CA, McCarthy J, Opie LH. Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart. J Pharmacol Exp Ther 1999;290:505-14.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 505-514
-
-
Du Toit, E.F.1
Muller, C.A.2
McCarthy, J.3
Opie, L.H.4
-
35
-
-
0033959417
-
Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels
-
Kersten JR, Montgomery MW, Pagel PS, Warltier DC. Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels. Anesth Analg 2000;90:5-11.
-
(2000)
Anesth Analg
, vol.90
, pp. 5-11
-
-
Kersten, J.R.1
Montgomery, M.W.2
Pagel, P.S.3
Warltier, D.C.4
-
36
-
-
0034769061
-
Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model
-
du Toit E, Hofmann D, McCarthy J, Pineda C. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart 2001;86:81-7.
-
(2001)
Heart
, vol.86
, pp. 81-87
-
-
Du Toit, E.1
Hofmann, D.2
McCarthy, J.3
Pineda, C.4
-
37
-
-
0034648108
-
Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium
-
Takahashi R, Talukder MA, Endoh M. Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium. Eur J Pharmacol 2000;400:103-12.
-
(2000)
Eur J Pharmacol
, vol.400
, pp. 103-112
-
-
Takahashi, R.1
Talukder, M.A.2
Endoh, M.3
-
38
-
-
12944316443
-
Effects of OR-1896, an active metabolite of levosimendan, on contractile force and aequorin light transients in intact rabbit ventricular myocardium
-
Takahashi R, Talukder MA, Endoh M. Effects of OR-1896, an active metabolite of levosimendan, on contractile force and aequorin light transients in intact rabbit ventricular myocardium. J Cardiovasc Pharmacol 2000;36:118-25.
-
(2000)
J Cardiovasc Pharmacol
, vol.36
, pp. 118-125
-
-
Takahashi, R.1
Talukder, M.A.2
Endoh, M.3
-
39
-
-
0036033594
-
2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium
-
2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium. Naunyn Schmiedebergs Arch Pharmacol 2002;366:440-8.
-
(2002)
Naunyn Schmiedebergs Arch Pharmacol
, vol.366
, pp. 440-448
-
-
Takahashi, R.1
Endoh, M.2
-
40
-
-
0036137181
-
Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure
-
Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol 2002;42:43-51.
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 43-51
-
-
Kivikko, M.1
Antila, S.2
Eha, J.3
Lehtonen, L.4
Pentikainen, P.J.5
-
41
-
-
0027987504
-
Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers
-
Lilleberg J, Antila S, Karlsson M, Nieminen MS, Pentkainen PJ. Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers. Clin Pharmacol Ther 1994;56:554-63.
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 554-563
-
-
Lilleberg, J.1
Antila, S.2
Karlsson, M.3
Nieminen, M.S.4
Pentkainen, P.J.5
-
42
-
-
0029585067
-
Pharmacokinetics of levosimendan in healthy volunteers and patients with congestive heart failure
-
Sandell EP, Hayha M, Antila S, et al. Pharmacokinetics of levosimendan in healthy volunteers and patients with congestive heart failure. J Cardiovasc Pharmacol 1995;26(suppl 1):S57-62.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, Issue.1 SUPPL.
-
-
Sandell, E.P.1
Hayha, M.2
Antila, S.3
-
43
-
-
0036795429
-
Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure
-
Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. Int J Clin Pharmacol Ther 2002;40:465-71.
-
(2002)
Int J Clin Pharmacol Ther
, vol.40
, pp. 465-471
-
-
Kivikko, M.1
Antila, S.2
Eha, J.3
Lehtonen, L.4
Pentikainen, P.J.5
-
44
-
-
0004938880
-
The effects of severe congestive heart failure on the pharmacokinetics of levosimendan
-
Sandell E, Aalto T, Antila S, et al. The effects of severe congestive heart failure on the pharmacokinetics of levosimendan [abstr]. EurJ Clin Pharmacol 1997;52(suppl):55.
-
(1997)
EurJ Clin Pharmacol
, vol.52
, Issue.SUPPL.
, pp. 55
-
-
Sandell, E.1
Aalto, T.2
Antila, S.3
-
45
-
-
0038818406
-
The effects of renal failure on the pharmacokinetics of levosimendan
-
1st congress of the European association for clinical pharmacology and therapeutics, Paris, France, September 27-30, 1995
-
Sandell E, Antila S, Koistinen H, Pentikainen P. The effects of renal failure on the pharmacokinetics of levosimendan [abstr]. Therapie 1995;1st congress of the European association for clinical pharmacology and therapeutics, Paris, France, September 27-30, 1995:495.
-
(1995)
Therapie
, pp. 495
-
-
Sandell, E.1
Antila, S.2
Koistinen, H.3
Pentikainen, P.4
-
46
-
-
0004966620
-
Pharmacokinetics and safety profile of levosimendan in pediatric patients evaluated for cardiac surgery
-
Turanlahti M, Antila S, Rantanen S, Lehtonen L. Pharmacokinetics and safety profile of levosimendan in pediatric patients evaluated for cardiac surgery [abstr]. Intensive Care Med 1999;25(suppl):S72.
-
(1999)
Intensive Care Med
, vol.25
, Issue.SUPPL.
-
-
Turanlahti, M.1
Antila, S.2
Rantanen, S.3
Lehtonen, L.4
-
48
-
-
0028143958
-
Haemodynamic dose-efficacy of levosimendan in healthy volunteers
-
Lilleberg J, Sundberg S, Hayha M, Akkila J, Nieminen MS. Haemodynamic dose-efficacy of levosimendan in healthy volunteers. Eur J Clin Pharmacol 1994;47:267-74.
-
(1994)
Eur J Clin Pharmacol
, vol.47
, pp. 267-274
-
-
Lilleberg, J.1
Sundberg, S.2
Hayha, M.3
Akkila, J.4
Nieminen, M.S.5
-
49
-
-
0029038397
-
Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men
-
Sundberg S, Lilleberg J, Nieminen MS, Lehtonen L. Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men. Am J Cardiol 1995;75:1061-6.
-
(1995)
Am J Cardiol
, vol.75
, pp. 1061-1066
-
-
Sundberg, S.1
Lilleberg, J.2
Nieminen, M.S.3
Lehtonen, L.4
-
50
-
-
0030909430
-
Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers
-
Ukkonen H, Saraste M, Akkila J, et al. Myocardial efficiency during calcium sensitization with levosimendan: a noninvasive study with positron emission tomography and echocardiography in healthy volunteers. Clin Pharmacol Ther 1997;61:596-607.
-
(1997)
Clin Pharmacol Ther
, vol.61
, pp. 596-607
-
-
Ukkonen, H.1
Saraste, M.2
Akkila, J.3
-
51
-
-
0032771929
-
Levosimendan enhances cardiac performance after cardiopulmonary bypass: A prospective, randomized placebo-controlled trial
-
Nijhawan N, Nicolosi AC, Montgomery MW, Aggarwal A, Pagel PS, Warltier DC. Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol 1999;34:219-28.
-
(1999)
J Cardiovasc Pharmacol
, vol.34
, pp. 219-228
-
-
Nijhawan, N.1
Nicolosi, A.C.2
Montgomery, M.W.3
Aggarwal, A.4
Pagel, P.S.5
Warltier, D.C.6
-
52
-
-
0031976338
-
Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting
-
Lilleberg J, Nieminen MS, Akkila J, et al. Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J 1998;19:660-8.
-
(1998)
Eur Heart J
, vol.19
, pp. 660-668
-
-
Lilleberg, J.1
Nieminen, M.S.2
Akkila, J.3
-
53
-
-
0029558280
-
Dose-range study of a new calcium sensitizer, levosimendan, in patients with left ventricular dysfunction
-
Lilleberg J, Sundberg S, Nieminen MS. Dose-range study of a new calcium sensitizer, levosimendan, in patients with left ventricular dysfunction. J Cardiovasc Pharmacol 1995;26(suppl 1):S63-9.
-
(1995)
J Cardiovasc Pharmacol
, vol.26
, Issue.1 SUPPL.
-
-
Lilleberg, J.1
Sundberg, S.2
Nieminen, M.S.3
-
54
-
-
0034739460
-
Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure
-
Study investigators
-
Slawsky MT, Colucci WS, Gottlieb SS, et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study investigators. Circulation 2000;102:2222-7.
-
(2000)
Circulation
, vol.102
, pp. 2222-2227
-
-
Slawsky, M.T.1
Colucci, W.S.2
Gottlieb, S.S.3
-
55
-
-
0034669441
-
Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure
-
Nieminen MS, Akkila J, Hasenfuss G, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000;36:1903-12.
-
(2000)
J Am Coll Cardiol
, vol.36
, pp. 1903-1912
-
-
Nieminen, M.S.1
Akkila, J.2
Hasenfuss, G.3
-
56
-
-
0036764821
-
Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: A randomized, placebo-controlled, double-blind study (RUSSLAN)
-
Moiseyev VS, Poder P, Andrejevs N, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: a randomized, placebo-controlled, double-blind study (RUSSLAN). Eur Heart J 2002;23:1422-32.
-
(2002)
Eur Heart J
, vol.23
, pp. 1422-1432
-
-
Moiseyev, V.S.1
Poder, P.2
Andrejevs, N.3
-
57
-
-
0037142946
-
Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomised double-blind trial
-
Follath F, Cleland JG, Just H, et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 2002;360:196-202.
-
(2002)
Lancet
, vol.360
, pp. 196-202
-
-
Follath, F.1
Cleland, J.G.2
Just, H.3
-
58
-
-
0037422531
-
Sustained hemodynamic effects of intravenous levosimendan
-
Kivikko M, Lehtonen L, Colucci WS. Sustained hemodynamic effects of intravenous levosimendan. Circulation 2003;107:81-6.
-
(2003)
Circulation
, vol.107
, pp. 81-86
-
-
Kivikko, M.1
Lehtonen, L.2
Colucci, W.S.3
-
59
-
-
0033696857
-
Myocardial efficiency during levosimendan infusion in congestive heart failure
-
Ukkonen H, Saraste M, Akkila J, et al. Myocardial efficiency during levosimendan infusion in congestive heart failure. Clin Pharmacol Ther 2000;68:522-31.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 522-531
-
-
Ukkonen, H.1
Saraste, M.2
Akkila, J.3
-
60
-
-
0012323490
-
Levosimendan, a calcium sensitizer and potassium channel opener, is safe and improves left ventricular function in acute myocardial infarction
-
Luotolahti M, Lammintausta O, Ukkonen H, et al. Levosimendan, a calcium sensitizer and potassium channel opener, is safe and improves left ventricular function in acute myocardial infarction. Circulation 1998;98(suppl):1105-6.
-
(1998)
Circulation
, vol.98
, Issue.SUPPL.
, pp. 1105-1106
-
-
Luotolahti, M.1
Lammintausta, O.2
Ukkonen, H.3
-
61
-
-
0001783305
-
Effects of the calcium sensitizer levosimendan on stunned myocardium after percutaneous transluminal coronary angioplasty
-
Sonnatag S, Opitz C, Wellnhofer E, et al. Effects of the calcium sensitizer levosimendan on stunned myocardium after percutaneous transluminal coronary angioplasty [abstr]. Eur Heart J 2000;21(suppl):40.
-
(2000)
Eur Heart J
, vol.21
, Issue.SUPPL.
, pp. 40
-
-
Sonnatag, S.1
Opitz, C.2
Wellnhofer, E.3
-
62
-
-
2942619175
-
Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: Results with levosimendan in the REVIVE-1 study
-
Packer M, Colucci WS, Fisher L, et al. Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: results with levosimendan in the REVIVE-1 study [abstr]. J Card Fail 2003;9(suppl):S61.
-
(2003)
J Card Fail
, vol.9
, Issue.SUPPL.
-
-
Packer, M.1
Colucci, W.S.2
Fisher, L.3
-
63
-
-
0033600141
-
Dose-ranging and safety with intravenous levosimendan in low-output heart failure: Experience in three pilot studies and outline of the levosimendan infusion versus dobutamine (LIDO) trial
-
Follath F, Hinkka H, Jager D, et al. Dose-ranging and safety with intravenous levosimendan in low-output heart failure: experience in three pilot studies and outline of the levosimendan infusion versus dobutamine (LIDO) trial. Am J Cardiol 1999;83:I21-5.
-
(1999)
Am J Cardiol
, vol.83
-
-
Follath, F.1
Hinkka, H.2
Jager, D.3
-
64
-
-
4644283758
-
CASINO results: Should docs gamble on levosimendan?
-
Heartwire. New Orleans, LA
-
Heartwire. CASINO results: Should docs gamble on levosimendan? American College of Cardiology News. New Orleans, LA: theheart.org; 2004.
-
(2004)
American College of Cardiology News
-
-
-
65
-
-
0037276509
-
Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: An analysis based on the international LIDO trial
-
Cleland JG, Takala A, Apajasalo M, Zethraeus N, Kobelt G. Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial. Eur J Heart Fail 2003;5:101-8.
-
(2003)
Eur J Heart Fail
, vol.5
, pp. 101-108
-
-
Cleland, J.G.1
Takala, A.2
Apajasalo, M.3
Zethraeus, N.4
Kobelt, G.5
-
66
-
-
0033600153
-
Effects of intravenous levosimendan on plasma neurohormone levels in patients with heart failure: Relation to hemodynamic response
-
Nicklas J, Monsur J, Bleske B. Effects of intravenous levosimendan on plasma neurohormone levels in patients with heart failure: relation to hemodynamic response. Am J Cardiol 1999;83:I12-15.
-
(1999)
Am J Cardiol
, vol.83
-
-
Nicklas, J.1
Monsur, J.2
Bleske, B.3
-
67
-
-
0000754346
-
The positive inotropic agent levosimendan mediates increased cardiac output with progression of sympathovagal imbalance in patients with heart failure
-
Binkley P, Nunziata E, Hatten P, Leier C. The positive inotropic agent levosimendan mediates increased cardiac output with progression of sympathovagal imbalance in patients with heart failure [abstr]. Circulation 2000;102(suppl II):II-720.
-
(2000)
Circulation
, vol.102
, Issue.2 SUPPL.
-
-
Binkley, P.1
Nunziata, E.2
Hatten, P.3
Leier, C.4
-
68
-
-
0033600110
-
Effects of levosimendan on cardiac arrhythmia: Electrophysiologic and ambulatory electrocardiographic findings in phase II and phase III clinical studies in cardiac failure
-
Singh B, Lilleberg J, Sandell E, Ylonen V, Lehtonen L, Toivonen L. Effects of levosimendan on cardiac arrhythmia: electrophysiologic and ambulatory electrocardiographic findings in phase II and phase III clinical studies in cardiac failure. Am J Cardiol 1999;83:I16-20.
-
(1999)
Am J Cardiol
, vol.83
-
-
Singh, B.1
Lilleberg, J.2
Sandell, E.3
Ylonen, V.4
Lehtonen, L.5
Toivonen, L.6
-
69
-
-
0034126327
-
Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function
-
Toivonen L, Viitasalo M, Sundberg S, Akkila J, Lehtonen L. Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function. J Cardiovasc Pharmacol 2000;35:664-9.
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, pp. 664-669
-
-
Toivonen, L.1
Viitasalo, M.2
Sundberg, S.3
Akkila, J.4
Lehtonen, L.5
-
70
-
-
0029995121
-
Haemodynamic interactions of a new calcium sensitizing drug levosimendan and captopril
-
Antila S, Eha J, Heinpalu M, et al. Haemodynamic interactions of a new calcium sensitizing drug levosimendan and captopril. Eur J Clin Pharmacol 1996;49:451-8.
-
(1996)
Eur J Clin Pharmacol
, vol.49
, pp. 451-458
-
-
Antila, S.1
Eha, J.2
Heinpalu, M.3
-
71
-
-
0001314147
-
No pharmacodynamic interactions between a new calcium sensitizing drug levosimendan and a calcium antagonist drug felodipine
-
Lehtonen L, Antila S, Eha J. No pharmacodynamic interactions between a new calcium sensitizing drug levosimendan and a calcium antagonist drug felodipine [abstr]. Eur J Clin Pharmacol 1997;52(suppl):136.
-
(1997)
Eur J Clin Pharmacol
, vol.52
, Issue.SUPPL.
, pp. 136
-
-
Lehtonen, L.1
Antila, S.2
Eha, J.3
-
72
-
-
0034032582
-
Haemodynamic interactions between the novel calcium sensitiser levosimendan and isosorbide-5-mononitrate in healthy subjects
-
Sundberg S, Lehtonen L. Haemodynamic interactions between the novel calcium sensitiser levosimendan and isosorbide-5-mononitrate in healthy subjects. Eur J Clin Pharmacol 2000;55:793-9.
-
(2000)
Eur J Clin Pharmacol
, vol.55
, pp. 793-799
-
-
Sundberg, S.1
Lehtonen, L.2
-
73
-
-
0036032273
-
The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects
-
Lehtonen L, Sundberg S. The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects. Eur J Clin Pharmacol 2002;58:449-52.
-
(2002)
Eur J Clin Pharmacol
, vol.58
, pp. 449-452
-
-
Lehtonen, L.1
Sundberg, S.2
-
74
-
-
0034469050
-
Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarin
-
Antila S, Jarvinen A, Honkanen T, Lehtonen L. Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarin. Eur J Clin Pharmacol 2000;56:705-10.
-
(2000)
Eur J Clin Pharmacol
, vol.56
, pp. 705-710
-
-
Antila, S.1
Jarvinen, A.2
Honkanen, T.3
Lehtonen, L.4
-
75
-
-
0031596437
-
The CYP3A4 inhibitor itraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan
-
Antila S, Honkanen T, Lehtonen L, Neuvonen PJ. The CYP3A4 inhibitor itraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan. Int J Clin Pharmacol Ther 1998;36:446-9.
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, pp. 446-449
-
-
Antila, S.1
Honkanen, T.2
Lehtonen, L.3
Neuvonen, P.J.4
-
76
-
-
0030759526
-
Studies on psychomotoric effects and pharmacokinetic interactions of the new calcium sensitizing drug levosimendan and ethanol
-
Antila S, Jarvinen A, Akkila J, Honkanen T, Karlsson M, Lehtonen L. Studies on psychomotoric effects and pharmacokinetic interactions of the new calcium sensitizing drug levosimendan and ethanol. Arzneimittelforschung 1997;47:816-20.
-
(1997)
Arzneimittelforschung
, vol.47
, pp. 816-820
-
-
Antila, S.1
Jarvinen, A.2
Akkila, J.3
Honkanen, T.4
Karlsson, M.5
Lehtonen, L.6
|