Cytochrome p450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 2, 2001, Pages 479-488

  Yaghi, Asma ^a   Webb, Christopher D ^a   Scott, Jeremy A ^a   Mehta, Sanjay ^a   Bend, John R ^a   Mccormack, David G ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; DRUG METABOLITE; EPOXYICOSATRIENOIC ACID; HEME OXYGENASE; HYDROXYICOSATETRAENOIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC ACID; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; POTASSIUM CHLORIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GRAM NEGATIVE INFECTION; IN VITRO STUDY; LUNG BLOOD VESSEL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS; PULMONARY ARTERY; RAT;

ANIMALS; ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; HEME OXYGENASE (DECYCLIZING); HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; LUNG; MALE; MICROSOMES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROBENZENES; PNEUMONIA, BACTERIAL; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PSEUDOMONAS INFECTIONS; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES;

EID: 0035028830     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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