Cbl-b regulates airway mucosal tolerance to aeroallergen

Clinical and Experimental Allergy

Volumn 41, Issue 3, 2011, Pages 434-442

  Oh, S Y ^a   Park, J U ^a   Zheng, T ^a   Kim, Y K ^a   Wu, F ^a   Cho, S H ^a   Barber, D ^b   Penninger, J ^c   Zhu, Z ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

Author keywords

Aeroallergen; Allergic inflammation; Asthma; Cbl b; Ubiquitin E3 ligase

Indexed keywords

ADAPTOR PROTEIN; ALLERGEN; AUTACOID; EOTAXIN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PROTEIN CBLB; RANTES; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; ENVIRONMENTAL EXPOSURE; EOSINOPHIL; HOMEOSTASIS; HYPERPLASIA; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; LUNG PARENCHYMA; LYMPHOCYTE; MOUSE; MUCUS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; RESPIRATORY TRACT MUCOSA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLERGENS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; PNEUMONIA; PROTO-ONCOGENE PROTEINS C-CBL; RESPIRATORY MUCOSA;

EID: 79551641951     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2010.03593.x     Document Type: Article

References (36)

1. Cutz E, Levison H, Cooper DM. Ultrastructure of airways in children with asthma. Histopathology 1978; 2:407-21.
2. Bochner BS, Undem BJ, Lichtenstein LM. Immunological aspects of allergic asthma. Annu Rev Immunol 1994; 12: 295-335.
3. Wills-Karp M, Luyimbazi J, Xu X et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:2258-61.
4. Grunig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261-3.
5. Magnan AO, Mely LG, Camilla CA et al. Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma. Am J Respir Crit Care Med 2000; 161:1790-6.
6. Cho SH, Stanciu LA, Holgate ST, Johnston SL. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+and CD8+T cells in atopic asthma. Am J Respir Crit Care Med 2005; 171:224-30.
7. Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med 2001; 344:655-64.
8. Walker LS, Abbas AK. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2002; 2:11-9.
9. Schwartz RH. T cell anergy. Annu Rev Immunol 2003; 21:305-34.
10. Heissmeyer V, Macian F, Im SH et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 2004; 5:255-65.
11. Jeon MS, Atfield A, Venuprasad K et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 2004; 21:167-77.
12. Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 1995; 10:2367-77.
13. Thien CB, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001; 2:294-307.
14. Chiang YJ, Kole HK, Brown K et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000; 403:216-20.
15. Bachmaier K, Krawczyk C, Kozieradzki I et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000; 403:211-6.
16. Krawczyk C, Bachmaier K, Sasaki T et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 2000; 13:463-73.
17. Fang D, Liu YC. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2001; 2:870-5.
18. Zhang R, Zhang N, Mueller DL. Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansion. J Immunol 2008; 181:5331-9.
19. Kitaura Y, Jang IK, Wang Y et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007; 26:567-78.
20. Wohlfert EA, Callahan MK, Clark RB. Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. J Immunol 2004; 173:1059-65.
21. Gustin SE, Thien CB, Langdon WY. Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells. J Immunol 2006; 177:5980-9.
22. Zhang J, Chiang YJ, Hodes RJ, Siraganian RP. Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor. J Immunol 2004; 173:1811-8.
23. Hirasaka K, Kohno S, Goto J et al. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 2007; 56:2511-22.
24. Kim YK, Oh SY, Jeon SG et al. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 2007; 178:5375-82.
25. Zhu Z, Homer RJ, Wang Z et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103:779-88.
26. Zheng T, Zhu Z, Wang Z et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest 2000; 106:1081-93.
27. Oh SY, Zheng T, Kim YK et al. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol 2009; 40:568-74.
28. Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-51.
29. Finkelman FD, Goroff DK, Fultz M, Morris SC, Holmes JM, Mond JJ. Polyclonal activation of the murine immune system by an antibody to IgD. X. Evidence that the precursors of IgG1-secreting cells are newly generated membrane IgD+B cells rather than the B cells that are initially activated by anti-IgD antibody. J Immunol 1990; 145:3562-9.
30. Stavnezer J. Regulation of antibody production and class switching by TGF-beta. J Immunol 1995; 155:1647-51.
31. Snapper CM, Waegell W, Beernink H, Dasch JR. Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro. J Immunol 1993; 151:4625-36.
32. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7:145-73.
33. Kim YS, Hong SW, Choi JP et al. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol 2009; 183:5113-20.
34. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 2009; 180:720-30.
35. Hanlon A, Jang S, Salgame P. Cbl-b differentially regulates activation-induced apoptosis in T helper 1 and T helper 2 cells. Immunology 2005; 116:507-12.
36. Tsitoura DC, DeKruyff RH, Lamb JR, Umetsu DT. Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells. J Immunol 1999; 163:2592-600.