Nano Anti-Cancer drugs: Pros and cons and future perspectives

Current Cancer Drug Targets

Volumn 11, Issue 2, 2011, Pages 131-134

  Ali, I ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

Future perspectives; Nano anti cancer drugs; Pros and cons; Special features; Toxicities

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; LIPOSOME; NANO ANTICANCER DRUG; NANOPARTICLE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD TOXICITY; CANCER RESISTANCE; CYTOTOXICITY; DNA DRUG COMPLEX; DRUG RESEARCH; ENVIRONMENTAL PROTECTION; FLU LIKE SYNDROME; HUMAN; IMMUNOTOXICITY; LUNG FIBROSIS; MULTIDRUG RESISTANCE;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; HUMANS; NANOMEDICINE; NANOSTRUCTURES;

EID: 79551615052     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800911794328457     Document Type: Article

References (38)

1. Feynman, R. P. There's plenty of room at the bottom. Eng. Sci. (Cal Tech) 1960, 23, 22-36.
2. Drexler, K. E. Engines of creation: the coming era of nanotechnology. New York: Anchor Press/Doubleday; 1986.
3. Freitas, R. A. Jr. Nanomedicine. Basic capabilities. Landes. Biosci. 1999, Vol. 1.
4. Nanomedicine: Grounds for optimism, and a call for papers. Lancet 2003, 362, 673.
5. Freitas, R. A. Jr. The future of nanofabrication and molecular scale devices in nano-medicine. Stud. Health Technol. Inform. 2002, 80, 45-59.
6. Bogunia-Kubik, K.; Sugisaka, M. From molecular biology to nanotechnology and nano-medicine. Biosystems 2002, 65, 123-138.
7. Haberzettl, C. A. Nanomedicine: Destination or journey? Nanotechnology 2002, 13, 9-13.
8. Emerich, D. F.; Thanos, C. G. Nanotechnology and medicine. Expert Opin. Biol. Ther. 2003, 3, 655-663.
9. Maruyama, K. In vivo targeting by liposomes. Biol. Pharm. Bull. 2000, 23, 791-799.
10. Mayer, L. D.; Shabbits, J. A. The role of liposomal drug delivery in molecular and pharmacological strategies to overcome multidrug resistance. Cancer Metastasis Rev. 2001, 20, 87-93.
11. Sonoda, T.; Kobayashi, H.; Kaku, T.; Hirakawa, T.; Nakano, H. Expression of angiogenesis factors in monolayer culture, multicellular spheroid and in vivo transplanted tumor by human ovarian cancer cell lines. Can. Lett. 2003, 196, 229-237.
12. Jackson, T. L.; Byrne H. M. A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy. Math. Biosci. 2000, 164, 17-38.
13. Song, H.; He, R.; Wang, K.; Ruan, J.; Bao, C.; Li, N.; Ji, J.; Cui, D. Anti-HIF-1-alpha antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials 2010, 31, 2302-23112.
14. Verbridge, S. S.; Chandler, E. M.; Fischbach, C. Tissue-engineered three-dimensional tumor models to study tumor angiogenesis. Tissue Eng. Part A 2010, 16, 2147-2152.
15. Moghimi, S. M.; Szebeni, J. Stealth liposomes and long circulating nanoparticles: Critical issues in pharmacokinetics, opsonization and protein binding properties. Prog. Lipid Res. 2003, 42, 463-478.
16. Sinek, J.; Frieboes, H. B.; Zheng, X.; Cristini V. Chemotherapy simulations demonstrate fundamental transport limitations involving nanoparticles. Biomed. Microdevices. 2004, 6, 297-309.
17. Ito, A.; Matsuoka, F.; Honda, H.; Kobayashi, T. Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles. Can. Gene Ther. 2003, 10, 918-925.
18. Elamanchili, P.; Diwan, M.; Cao, M.; Samuel, J. Characterization of poly (D,L-lactic-coglycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine 2004, 22, 2406-2412.
19. Cui, Z.; Hsu, C. H.; Mumper, R. J. Physical characterization and macrophage cell uptake of mannan-coated nanoparticles. Drug Dev. Ind. Pharm. 2003, 29, 689-700.
20. Sayes, C. M.; Fortner, J. D.; Guo, W.; Lyon, D.; Boyd, A. M.; Ausman, K. D.; Tao, Y. J.; Sitharaman, B.; Wilson, L. J.; Hughes, J. B.; West, J. L.; Colvin, V. L. The differential cytotoxicity of water- soluble fullerenes. Nano Lett. 2004, 4, 1881-1887.
21. Lockman, P. R.; Koziara, J. M.; Mumper, R. J.; Allen, D. D. Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J. Drug Target 2004, 12, 635-641.
22. Chiu-Wing, L.; James, J. T.; McCluskey, R.; Hunter, R.L. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 2004, 77, 126-134.
23. Warheit, D. B.; Laurence, B. R.; Reed, K. L.; Roach, D. H.; Reynolds, G. A.; Webb, T. R. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 2004, 77, 117-125.
24. Xie, G.; Sun, J.; Zhong, G.; Shi, L.; Zhang, D. Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch. Toxicol. 2010, 84, 183-190.
25. Tang, J.; Xiong, L.; Wang, S.; Wang, J.; Liu, L.; Li, J.; Yuan, F.; Xi, T. Distribution, translocation and accumulation of silver nanoparticles in rats. J. Nanosci. Nanotechnol. 2009, 9, 4924-4932.
26. Cho, M.; Cho, W. S.; Choi, M.; Kim, S. J.; Han, B. S.; Kim, S. H.; Kim, H. O.; Sheen, Y. Y.; Jeong, J. The impact of size on tissue distribution and elimination by single intravenous injection of silica nano-particles. Toxicol. Lett. 2009, 189, 177-183.
27. Senior, J. H.; Trimble, K. R.; Maskiewicz, R. Interaction of positively- charged liposomes with blood: implications for their application in vivo. Biochim. Biophys. Acta 1991, 1070, 173-179.
28. Sakurai, F.; Nishioka, T.; Saito, H.; Baba, T.; Okuda, A.; Matsumoto, O.; Taga, T.; Yamashita, F.; Takakura, Y.; Hashida, M. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther. 2001, 8, 677-686.
29. Oyewumi, M. O.; Yokel, R. A.; Jay, M.; Coakley, T.; Mumper, R. J. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumorbearing mice. J. Control Release 2004, 95, 613-626.
30. Richardson, S. C.; Kolbe, H. V.; Duncan, R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int. J. Pharm. 1999, 178, 231-243.
31. Tousignant, J. D.; Gates, A. L.; Ingram, L. A.; Johnson, C. L.; Nietupski, J. B.; Cheng, S. H.; Eastman, S. J.; Scheule, R. K. Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice. Hum. Gene Ther. 2000, 11, 2493-2513.
32. Zhang, J. S.; Liu, F.; Huang, L. Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity. Adv. Drug. Deliv. Rev. 2005, 57, 689-698.
33. Alton, E. W.; Stern, M.; Farley, R.; Jaffe, A.; Chadwick, S. L.; Phillips, J.; Davies, J.; Smith, S. N.; Browning, J.; Davies, M. G.; Hodson, M. E.; Durham, S. R.; Li, D.; Jeffery, P. K.; Scallan, M.; Balfour, R.; Eastman, S. J.; Cheng, S. H.; Smith, A. E.; Meeker, D.; Geddes, D. M. Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo- controlled trial. Lancet 1999, 353, 947-954.
34. Mnyusiwalla, A.; Daar A. S.; Singer P. A. Mind the gap: Science and ethics in nanotechnology. Nanotechnol. 2003, 14, 9-13.
35. Bartlett, D. W.; Davis, M. E. Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug. Chem. 2007, 18, 456-468.
36. Song, E.; Zhu, P.; Lee, S.K.; Chowdhury, D.; Kussman, S.; Dykxhoorn, D. M.; Feng, Y.; Palliser, D.; Weiner, D. B.; Shankar, P.; Marasco, W. A.; Lieberman, J. Antibody mediated in vivo delivery of small interfering. RNAs via cell-surface receptors. Nat. Biotechnol. 2005, 23, 709-717.
37. Hong, S.; Leroueil, P. R.; Majoros, I. J.; Orr, B. G.; Baker, J. R. Jr.; Banaszak Holl, M. M. The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chem. Biol. 2007, 14, 107-115.
38. Feng, S. S.; Chien, S. Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases. Chem. Eng. Sci. 2003, 58, 4087-4114.