Oxidative stress induced by the Fe2+/ascorbic acid system or model ischemia in vitro: Effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue

Interdisciplinary Toxicology

Volumn 3, Issue 4, 2010, Pages 122-126

  Gáspárová, Zdenka ^a   Ondrejickova O ^a   Gajdošíková, Alena ^a   Gajdošík, Andrej ^a   Šnirc, Vladimír ^a   Štolc, Svorad ^a,b  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Biont as   (Slovakia)

Author keywords

antioxidants; brain cortex; hippocampus; population spike; protein carbonyls

Indexed keywords

ASCORBIC ACID; CARBOLINE DERIVATIVE; CARBONYL DERIVATIVE; CARVEDILOL; FERROUS ION; REACTIVE OXYGEN METABOLITE; SME1EC2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN HOMOGENATE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; HIPPOCAMPUS; IN VITRO STUDY; MALE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; RAT;

RATTUS;

EID: 79551601421     PISSN: 13376853     EISSN: 13379569     Source Type: Journal    
DOI: 10.2478/v10102-010-0051-x     Document Type: Article

References (26)

1. Balu M, Sangeetha P, Murali G, Panneerselvam C. (2005). Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. Int J Dev Neurosci 23: 501-507 (Pubitemid 41138141)
2. Blackburn AC, Doe WF, Buffinton GD. (1999). Protein carbonyl formation on mucosal proteins in vitro and in dextran sulfate-induced colitis. Free Radic Biol Med 27: 262-270
3. Brunetti L, Menghini L, Orlando G, Recinella L, Leone S, Epifano F, Lazzarin F, Chiavaroli A, Ferrante C, Vacca M. (2009). Antioxidant effects of garlic in young and aged rat brain in vitro. J Med Food 12: 1166-1169
4. Carreira RS, Monteiro P, Goncalves LM, Providencia LA. (2006). Carvedilol: just another beta-blocker or a powerful cardioprotector? Cardiovasc Hematol Disord Drug Targets 6: 257-266
5. Desole MS, Esposito G, Enrico P, Miele M, Fresu L, De Natale G, Miele E, Grella G. (1993). Effects of ageing on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat. Neurosci Lett 159: 143-146
6. Gáspárová Z, Štolc S, Šnirc V. (2006). In vitro physiological evidence of enhanced neuroprotective and antioxidant action of 2,3-dihydromelatonin: a melatonin analogue. Pharmacol Res 53: 22-27
7. Gáspárová Z, Janega P, Babál P, Šnirc V, Štolc S, Mach M, Ujházy E. (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuro Endocrinol Lett 30: 574-581
8. Gáspárová Z, Šnirc V, Štolc S, DubovickÝ M. Mach M, Ujházy E. (2010). Maternal treatment of rats with the new pyridoindole antioxidant during pregnancy and lactation resulting in improved offspring hippocampal resistance to ischemia in vitro. NeuroEndocrinol Lett 31: 348-352
9. Gleibus G, Lippa CF. (2007). The influence of beta-blockers on delayed memory function in people with cognitive function impairment. Am J Alzheimers Dis Other Demen 22: 57-61
10. Horáková L, Štolc S. (1998). Antioxidant and pharmacodynamic effect of pyridoindole stobadine. Gen Pharmacol 30: 627-638 (Pubitemid 28167763)
11. Levine RL, Garland D, Oliver CN, Amici A, Climent I., Lenz AG, Ahn BW, Shaltiel S, Stadtman ER. (1990). Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186: 464-478
12. +channel modulator and glutamate transport inhibitor. Neurosci Lett 171: 77-80
13. Oliviera PJ, Esteves T, Rolo AP, Palmeira CM, Moreno AJ. (2004). Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism. Cardivasc Toxicol 4: 11-20
14. Oliviera PJ, Goncalves L., Monteiro P., Providencia LA, Moreno AJ. (2005). Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria? Curr Vasc Pharmacol 3: 147-158
15. Prakash AK, Kumar A. (2009). Effect of chronic treatment of carvedilol on oxidative stress in an intracerebroventricular streptozotocin induced model of dementia in rats. J Pharm Pharmacol 61: 1665-1672
16. Rabasseda X. (1998). Carvedilol: an effextive antihypertensive drug with antiischemic/ antioxidant cardioprotective properties. Drugs Today (Barc) 34: 905-926
17. Ruffolo RR Jr, Gellai M., Hieble JP, Willette RN, Nichols AJ. (1990). The pharmacology of carvedilol. Eur. J Clin Pharmacol 38: Suppl 2, S82-88
18. Squier TC. (2001). Oxidative stress and protein aggregation during biological aging. Exp Gerontol 36: 1539-1550
19. Strosznajder RP, Jesko H, Dziewulska J. (2005). Effetc of carvedilol on neuronal survival and poly(ADP-ribose) polymerase activity in hippocampus after transient forebrain ischemia. Acta Neurobiol Exp 65: 137-144
20. Sumien H, Heinrich KR, Sohal RS, Forster MJ. (2004). Short-term vitamin E intake fails to improve cognitive or psychomotor performance of aged mice. Free Radic Biol Med 36: 1424-1433
21. Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Pratico D. (2004). Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimeŕs disease. FASEB J 18: 323-325
22. Štolc S, Šnirc V, Májeková M, Gáspárová Z, GajdoŠíková A, Štvrtina S (2006). Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress,Cell Mol Neurobiol. 26:1493-1502.
23. Štolc S, Šnirc V, GajdoŠíková A, GajdoŠík A, Gáspárová Z, Ondrejiè ková O, Sotníková R, Viola A, Rapta P, Jariabka P, Syneková I, Vajdová M, Zacharová S, Nemèek V, Krchnárová V (2008). New pyridoindoles with antioxidant and neuroprotective actions, Trends in pharmacological research (V. Bauer, ed.)118-136, Institute of Experimental Pharmacology, Bratislava, Slovakia.
24. Ujházy E, DubovickÝ M, Ponechalová V, Navarová J, Brucknerová J, Šnirc V, Mach M. (2008). Prenatal developmental toxicity study of the pyridolindole antioxidant SMe1EC2 in rats. Neuro Endocrinol Lett 29: 639-643
25. VlkolinskÝ R, Štolc S. (1999). Effects of stobadine, melatonin, and other antioxidants on hypoxia / reoxygenation-induced synaptic transmission failure in rat hippocampal slices. Brain Res 850: 118-126
26. von Gall C, Weaver DR. (2008). Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus. Neurobiol Aging 29: 464-470