Prenatal developmental toxicity study of the pyridoindole antioxidant SMe1EC2 in rats

Neuroendocrinology Letters

Volumn 29, Issue 5, 2008, Pages 639-643

  Ujházy, Eduard ^a   Dubovický, Michal ^a   Ponechalová, Veronika ^b   Navarová, Jana ^a   Brucknerová, Ingrid ^c   Šnirc, Vladimír ^a   Mach, Mojmír ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Department of Pharmaceutical Analysis and Nuclear Pharmacy   (Slovakia)

^c Bratislava   (Slovakia)

Author keywords

Embryo; Fetus; Hypoxia ischemia; Oxidative stress; Pyridoindole derivative; Rat; Teratogenicity

Indexed keywords

2 ETHOXYCARBONYL 8 METHOXY 2,3,4,4A,5,9B HEXAHYDRO 1H PYRIDO [4,3B] INDOLINIUM CHLORIDE; ANTIOXIDANT; CARBOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FEMALE; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; GESTATION PERIOD; MALE; MORPHOLOGY; NONHUMAN; RAT; TERATOGENESIS; TOXICITY TESTING; WISTAR RAT;

EID: 57149122315     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Balonová T, Zeljenková D, Ďurišová M, Nosál' R, Jakubovský J, Líška J, Štolc S (1991). Reproductive toxicity studies with cis(-)- 2,3,4,4a,5,9-b-hexahydro-2,8-dimethyl-1H-pyrido-(4,3-b)indole dipalmitate in rats. Arzneim-Forsch/Drug Res 41: 1-5.
2. Barker SD (1998). In utero programming of chronic disease. Clin Sci (Lond) 95: 115-28.
3. Barkov NK (1973). On the mechanism of action of carbidine. Phramcol Toxicol 36:154-7 (in Russian).
4. Bezek S, Ujházy E, Mach M, Navarová J, Dubovický M (2008). Developmental origin of chronic diseases: Toxicological Implications. Interdisciplinary Toxicology 1(2): 29-31.
5. Chaudhari T, McGuire W (2008). Allopurinol preventive effects in mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. Cochrane Database Syst Rev 16: CD 006817.
6. Cohen-Keren M, Koren G (2003). Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implication to humans. Neurotoxicol Teratol 25: 1-9.
7. Dennery PA (2007). Effects of oxidative stress on embryonic development. Birth Defect Res (Part C) 81: 155-62.
8. Dubovický M, Ujházy E, Kovačovský P, Rychlík I, Janšák J (1999). Evaluation of long-term administration of the antioxidant stobadine on exploratory behavior in rats of both genders. J Appl Toxicol 19: 431-436.
9. Gajdošíkova A, Ujházy E, Gajdošík A, Chalupa I, Blaško M, Tomáškova A, Líška J, Dubovický M, Bauer V (1995). Chronic toxicity and micronucleus assay of the new cardioprotective agent stobadine in rats. Arzneim-Forsch/Drug Res 45: 531-536.
10. Hansen JM (2006). Oxidative stress as a mechanism of teratogenesis. Birth Defect Res (Part C) 78: 293-307.
11. Horáková L, Štolc S (1998). Antioxidant and pharmacodynamic effects of pyridoindole stobadine. A review. Gen Pharmacol 30: 789-799.
12. Lorke D (1977). Evaluation of skeleton. In Methods in prenatal toxicology (eds Neubert D, Merker H-J, Kwasigroch TE). Georg Thieme Publisher Stuttgart, 145-52.
13. Mach M, Dubovický M, Navarová J, Kovačovský P, Ujházy E (2006). Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study. Neuroendocrinol Lett 27(Suppl 2): 69-73.
14. Mach M, Ujházy E, Dubovický M, Kovačovský P, Navarová J (2005). High-dose vitamin E supplementation in phenytoin-induced intrauterine hypoxia: teratological study. Biologia 60 (Suppl 17): 45-49.
15. Martin MM, Hurley LS (1977). Effect of large amounts of vitamin E during pregnancy and lactation. Am J Clin Nutr 30: 1629-37.
16. Miháliková K, Ujházy E, Braxatorisová E, Kučera P (1993). Comparative teratological study of stobadin in vitro and in vivo. Toxicol In vitro 7: 803-7.
17. Navarová J, Schmidtová M, Ujházy E, Dubovický M, Mach M (2006). Selected biochemical variables in a model of neonatal anoxia in rats. Neuroendocrinol Lett 27(Suppl 2): 78-81.
18. OECD (1981). Guidelines for testing of chemicals, No. 414.
19. Palmer AK (1997). Incidence of sporadic malformations, anomalies and variations in random bred animals. In Methods in prenatal toxicology (eds Neubert D, Merker H-J, Kwasigroch TE). Georg Thieme Publisher Stuttgart, 52-71.
20. Saugstad OD (2005). Oxidative stress in the newborn - a 30-year perspective. Biol Neonate 88: 228-36.
21. Saugstad OD (1990). Oxygen toxicity in the neonatal period. Acta Paediatr Scand 79: 881-92.
22. Štolc S, Šnirc V, Gajdošíková A, Gajdošík A, Gásparová Z, Ondrejičková O, Sotniková R, Viola A, Rapta P, Jariabka P, Syneková I, Vajdová M, Zacharová S, Nemček V, Krchnárová V (2008). New pyridoindoles with antioxidant and neuroprotective actions. In Trends in pharmacological research (eds Bauer V, Dubovický M, Kouřilová M, Mach M, Navarová J, Nosár R, Sotníková R). Institute of Experimental Pharmacology SAS, Bratislava, Slovakia, 118-36.
23. Štolc S, Šnirc V, Májeková M, Gáspárová Z, Gajdošíková A, Štvrtina S (2006). Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. Cell Mol Neurobiol 26: 1495-1504.
24. Ujházy E, Dubovický M, Balonová T, Janšák J, Zeljenková D (1994). Teratological assessment of stobadine after single and repeated administration in mice. J Appl Toxicol 14: 357-63.
25. Ujházy E, Dubovický M, Balonová T, Janšák J (1999). Teratological study of the antoxidant stobadine in rats. Gen Physiol Biophys (Focus Issue) 18: 171-6.
26. Ujházy E, Schmidtová M, Dubovický M, Navarová J, Brucknerová I, Mach M (2006). Neurobehavioural changes in rats after neonatal anoxia: effect of antioxidant stobadine pretreatment. Neuroendocrinol Lett 27(Suppl 2): 82-85.
27. Wilson JG (1965). Methods for administering agents and detecting malformations in experimental animals. In Teratology, Principles and Techniques (eds Wilson JG, Warkany J). Chicago University of Chicago Press, 262-77.