Maternal treatment of rats with the new pyridoindole antioxidant during pregnacy and lactation resulting in improved offspring hippocampal resistance to ischemia in vitro

Neuroendocrinology Letters

Volumn 31, Issue 3, 2010, Pages 348-352

  Gáspárová, Zdenka ^a   Šnirc, Vladimír ^a   Štolc, Svorad ^a,b   Dubovický, Michal ^a   Mach, Mojmír ^a   Ujházy, Eduard ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Biont as   (Slovakia)

Author keywords

Electrophysiology; Hippocampus; Ischemia; Neuroprotection; Pyridoindole antioxidant; Rat

Indexed keywords

ANTIOXIDANT; CARBOLINE DERIVATIVE; SME1EC2; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; EVOKED CORTICAL RESPONSE; FEMALE; HIPPOCAMPUS; LACTATION; NEWBORN; NONHUMAN; PREGNANCY; PROGENY; RAT; REOXYGENATION; ANIMAL; BREEDING; DRUG EFFECTS; IN VITRO STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PRENATAL EXPOSURE; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; FEMALE; HIPPOCAMPUS; IN VITRO TECHNIQUES; INDOLES; LACTATION; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; PYRIDINES; RATS; RATS, WISTAR;

EID: 77955464267     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 60Co opens the blood-brain barrier for drugs in rats. Experientia. 46: 1017-1020.
2. Bourre JM (2004). The role of nutritional factors on the structure and function of the brain: an update on dietary requirements. [Article in French] Rev Neurol (Paris). 160: 767-792.
3. Castro DJ, Yu Z, Lohr CV, Pereira CB, Giovanini JN, Fischer KA, Orner GA, Dashwood RH, Williams DE (2008). Chemoprevention dibenzo[a,1]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis. 29: 1581-1586.
4. Cederberg J, Simán CM, Eriksson UJ (2001). Combined treatment with vitamin E and vitamin C decreases oxidative stress and improve fetal outcome in experimental diabetic pregnancy. Pediatr Res. 49: 755-762. (Pubitemid 32522048)
5. Chen CS, Squire JA, Wells PG (2009). Reduced tumorigenesis in p53 knockout mice exposed in utero to low-dose vitamin-E. Cancer. 115: 1563-1575.
6. Chen W, Ostrowski RP, Obenaus A, Zhang JH (2009). Prodeath or prosurvival: two faces of hypoxia inducible factor-1 in perinatal brain injury. Exp Neurol. 216: 7-15.
7. Edwards J, Grange LL, Wang M, Reyes E (2000). Fetoprotectivity of the flavanolignan compound siliphos against ethanol-induced toxicity. Phytother. 14: 517-521.
8. Gáspárová Z, Štolc S, Šnirc V (2006). In vitro physiological evidence of enhanced neuroprotective and antioxidant action of 2,3-dihydromelatonin: a melatonin analogue. Pharmacol Res. 53: 22-27.
9. 2A adenosine receptors in rat hippocampus under ischemia in vitro. Pharmacol Rep. 60: 353-360.
10. Gáspárová Z, Janega P, Babál P, Šnirc V, Štolc S, Mach M, Ujházy E (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuroendocrinol Lett. 30: 574-581.
11. Gazzolo D, Abella R, Marioni E, di Iorio R, Li Volti G, Galvano F, Frigiola A, Temporini F, Moresco L, Colvicchi M, Sabatini M, Ricotti A, Strozzi MC, Crivelli S, Risso FM, Sannia A, Florio P (2009). New markers of neonatal neurology. J Matern Fetal Neonat Med. 22 Supp 13: 57-61.
12. He Z, Yu S, Mei G, Zheng M, Wang M, Dai Y, Tang B, Li N (2008). Maternally transmitted milk containing recombinant human catalase provides protection against oxidation for mouse offspring during lactation. Free Radic Biol Med. 45: 1135-1142.
13. Horáková L, Štolc S (1998). Antioxidant and pharmacodynamic effect of pyridoindole stobadine. Gen Pharmacol. 30: 627-638.
14. Kinalski M, Sledziewski A, Telejko B, Zarzycki W, Kinalska I (1999). Antioxidant therapy and streptozotocin-induced diabetes in pregnant rats. Acta Diabetol. 36: 113-117.
15. La Grande L, Wang M, Watkins R, Ortiz D, Sanchez ME, Konst J, Lee C, Reyes E (1999). Protective effect of flavonoid mixture, Silymarin, on fetal rat brain and liver. J Ethnopharmacol. 65: 53-61.
16. Laptook AR, Corbett RJ (2002). The effects of temperature on hypoxic-ischemic injury. Clin Perinatol. 29: 623-649.
17. Laurberg P, Nohr SB, Pedersen KM, Fuglsang E (2004). Iodine nutrition in breast-fed infants is impaired by maternal smoking. J. Clin Endocrinol Metab. 89: 181-187. (Pubitemid 38183879)
18. Mach M, Dubovický M, Navarová J, Brucknerová I, Ujházy E (2009). Experimental modeling of hypoxia in pregnancy and early postnatal life. Interdisc Toxicol, 2: 28-32.
19. Marosi M, Rákos G, Robotka H, Németh H, Sas K, Kis Z, Farkas T, Lur G, Vécsei L, Toldi J (2006). Hippocampal (CA1) activities in Wistar rats from different vendors. Fundamental difference in acute ischemia. J Neurosci Methods. 156: 231-235.
20. Mitchell JJ, Paiva M, Heaton MB (1999). The antioxidants vitamin E and beta carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol. 17: 163-168.
21. Mutter J, Naumann J, Schneider R, Walach H, Haley B (2005). Mercury and autism: accelerating evidence? Neuro Endocrinnol Lett. 26: 439-446.
22. Nakai A, Taniuchi Y, Asakura H, Oya A, Yokota A, Koshino T, Araki T (2001). Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria. Am J Obstet Gynecol. 184: 731-735.
23. Okatani Y, Wakatsuki A, Kaneda C (2000). Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. J Pineal Res. 28: 89-96. (Pubitemid 30125173)
24. Sharma P, Mishra KP (2006). Aluminium-induced maternal and developmental toxicity and oxidative stress in rat brain: response to combined administration of Tiron and glutathione. Reprod Toxicol. 21: 313-321.
25. Šoltés L, Bezek Š, Ujházy E, Bauer V (2000). Extraction and chromatographic separation methods in pharmacokinetics studies of Stobadine - an indole-related antioxidant and free-radical scavenger. Biomed Chromatogr. 14: 188-201.
26. Štolc S, Šnirc V, Májeková M, Gáspárová Z, Gajdošiková A, Štvrtina S (2006). Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. Cell Mol Neurobiol. 26: 1493-1502.
27. Štolc S, Šnirc V, Gajdošiková A, Gajdošik A, Gáspárová Z, Ondrejičková O, Sotníková R, Viola A, Rapta P, Jariabka P, Syneková I, Vajdová M, Zacharová S, Nemček V, Krchnárová V (2008). New pyridoindoles with antioxidant and neuroprotective actions. In Trends in pharmacological research, ed. V. Bauer, Institute of Experimental Pharmacology, Bratislava, Slovakia, pp. 118-136.
28. Tanaka H (1997). Maternal environment and developmental damage. [Article in Japanese] No To Hattatsu. 29: 183-189.
29. Towfighi J, Mauger D, Vannucci RC, Vannucci SJ (1997). Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res Dev Brain Res. 100: 149-160.
30. Trnovec T, Kállay Z, Bezek Š (1990). Effects of ionizing radiation on the blood brain barrier permeability to pharmacologically active substances. Int J Radiat Oncol Biol Phys. 19: 1581-1587.
31. Ujházy E, Dubovický M, Faberová V, Zemánek M, Šoltés, L, Gajdošík A, Eybl V (2000). Placental transfer of the antioxidant stobadine at different gestational stages in rabbits. Methods Find Exp Clin Pharmacol. 22: 683-688. (Pubitemid 32216823)
32. Ujházy E, Dubovický M, Ponechalová V, Navarová J, Brucknerová J, Šnirc V, Mach M (2008). Prenatal developmental toxicity study of the pyridoindole antioxidant SMe1EC2 in rats. Neuroendocrinol Lett. 29: 639-643.
33. Viana M, Barbas C, Castro M, Herrera E, Bonet B (1999). Alpha-tocopherol concentration in fetal and maternal tissues of pregnant rats supplemented with alpha-tocopherol. Ann Nutr Metab. 43: 107-112. (Pubitemid 29373688)
34. Vlkolinský R, Štolc S (1999). Effects of stobadine, melatonin, and other antioxidants on hypoxia/reoxygenation-induced synaptic transmission failure in rat hippocampal slices. Brain Res. 850: 118-26.
35. Wise-Faberowski L, Robinson PN, Rich S, Warner DS (2009). Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition. Anest Analg. 109: 205-210.
36. Zhao P, Zuo Z (2005). Prenatal hypoxia-induced adaptation and neuroprotection that is inducible nitric oxide synthase-dependent. Neurobiol Dis. 20: 871-880. (Pubitemid 41619362)