The perplexing case of the geranylgeranyl transferase-deficient mouse

Journal of Clinical Investigation

Volumn 121, Issue 2, 2011, Pages 510-513

  Philips, Mark R ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOKINE; GERANYLTRANSFERASE; PHYTOENE SYNTHASE; RHO FACTOR;

AMINO ACID SEQUENCE; ARTHRITIS; CELL FUNCTION; CELL MEMBRANE; CYTOSKELETON; ENZYME SUBSTRATE; INFLAMMATION; INFLAMMATORY CELL; MACROPHAGE; METHYLATION; NONHUMAN; NOTE; PRENYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; FARNESYLTRANSTRANSFERASE; MACROPHAGES; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PRENYLATION; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 79551560265     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45952     Document Type: Note

References (25)

1. Esteban LM, et al. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol. 2001;21(5):1444-1452.
2. Shull MM, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inf lammatory disease. Nature. 1992;359(6397):693-699.
3. Khan OM, et al. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest. 2011;121(2):628-639.
4. Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci. 2005;118(Pt 5):843-846.
5. Wright LP, Philips MR. Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J Lipid Res. 2006;47(5):883-891.
6. Willumsen BM, Cox AD, Solski PA, Der CJ, Buss JE. Novel determinants of H-Ras plasma membrane localization and transformation. Oncogene. 1996;13(9):1901-1909.
7. Allal C, et al. RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription. J Biol Chem. 2000;275(40):31001-31008.
8. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247-69.
9. Roberts AW, et al. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 1999;10(2):183-196.
10. Sjogren AM, et al. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007;117(5):1294-304.
11. Bustelo XR. Regulatory and signaling properties of the Vav family. Mol Cell Biol. 2000;20(5):1461-1477.
12. Michiels F, et al. Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. J Cell Biol. 1997;137(2):387-398. (Pubitemid 27181292)
13. Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR. Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and rhoGDI binding. J Cell Biol. 2001;152(1):111-126.
14. Hoffman GR, Nassar N, Cerione RA. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoG-DI. Cell. 2000;100(3):345-356.
15. Molnar G, Dagher MC, Geiszt M, Settleman J, Ligeti E. Role of prenylation in the interaction of Rho-family small GTPases with GTPase activating proteins. Biochemistry. 2001;40(35):10542-10549. (Pubitemid 32821159)
16. Yeung T, et al. Receptor activation alters inner surface potential during phagocytosis. Science. 2006;313(5785):347-351.
17. Michaelson D, et al. Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol. 2008;181(3):485-496.
18. Sung PJ, Rodrigues AB, Kleinberger A, Quatela S, Bach EA, Philips MR. Cytosolic ras supports eye development in Drosophila. Mol Cell Biol. 2010;30(24):5649-5657.
19. Reid TS, Terry KL, Casey PJ, Beese LS. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004;343(2):417-433.
20. Bos JL, et al. The role of Rap1 in integrin-mediated cell adhesion. Biochem Soc Trans. 2003;31(pt 1):83-86.
21. Li Y, et al. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007;179(12):8322-8331.
22. Cope AP, Schulze-Koops H, Aringer M. The central role of T cells in rheumatoid arthritis. Clin Exp Rheumatol. 2007;25(5 suppl 46):S4-S11.
23. Whyte DB, et al. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem. 1997;272(22):14459- 14464.
24. Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009;29(8):2254-2263.
25. Philips MR, Cox AD. Geranylgeranyltransferase I as a target for anti-cancer drugs. J Clin Invest. 2007;117(5):1223-1225.