Innate signaling in otitis media: Pathogenesis and recovery

Current Allergy and Asthma Reports

Volumn 11, Issue 1, 2011, Pages 78-84

  Leichtle, Anke ^a   Lai, Yuping ^b   Wollenberg, Barbara ^a   Wasserman, Stephen I ^c   Ryan, Allen F ^c  

^a UNIVERSITY OF LÜBECK   (Germany)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Innate immunity; Otitis media; Pathogenesis; TLR; TNF

Indexed keywords

ANTIBIOTIC AGENT; CXCL2 CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL INFECTION; CONVALESCENCE; CYTOKINE PRODUCTION; DRUG TREATMENT FAILURE; EPITHELIUM HYPERPLASIA; GENE DELETION; GENETIC POLYMORPHISM; HUMAN; IMMUNOPATHOGENESIS; INFECTION RESISTANCE; INNATE IMMUNITY; LEUKOCYTE FUNCTION; MIDDLE EAR MUCOSA; NONHUMAN; OTITIS MEDIA; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CHILD; CYTOKINES; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; IMMUNITY, INNATE; MICE; OTITIS MEDIA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79551546993     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-010-0158-3     Document Type: Article

References (46)

1. World Health Organization: World Bank. 1993. World Development Report 1993: Investing in Health. New York: Oxford University Press; 1993.
2. C Infante-Rivard A Fernandez 1993 Otitis media in children: frequency, risk factors, and research avenues Epidemiol Rev 15 444 465 1:STN:280: DyaK2c3ivFWquw%3D%3D 8174666
3. JO Klein 2000 The burden of otitis media Vaccine 1 S2 S8 10.1016/S0264-410X(00)00271-1 (Pubitemid 32121713)
4. JW Seibert CJ Danner 2006 Eustachian tube function and the middle ear Otolaryngol Clin North Am 39 1221 1235 10.1016/j.otc.2006.08.011 17097443 (Pubitemid 44692764)
5. EM Mandel WJ Doyle B Winther, et al. 2008 The incidence, prevalence and burden of OM in unselected children aged 1-8 years followed by weekly otoscopy through the "common cold" season Int J Pediatr Otorhinolaryngol 72 491 499 10.1016/j.ijporl.2007.12.008 18272237
6. E Leibovitz 2006 Acute otitis media in children aged less than 2 years: drug treatment issues Paediatr Drugs 8 337 346 10.2165/00148581-200608060-00002 17154641 (Pubitemid 44912718)
7. E Leibovitz 2007 The challenge of recalcitrant acute otitis media: pathogens, resistance, and treatment strategy Pediatr Infect Dis J 26 S8 S11 10.1097/INF.0b013e318154b24a 18049381
8. E Leibovitz MR Jacobs R Dagan 2004 Haemophilus influenzae: a significant pathogen in acute otitis media Pediatr Infect Dis J 23 1142 1152 15626953
9. K Takeda T Kaisho S Akira 2003 Toll-like receptors Annu Rev Immunol 21 335 376 1:CAS:528:DC%2BD3sXjtF2isrg%3D 10.1146/annurev.immunol.21.120601.141126 12524386 (Pubitemid 37174535)
10. R Medzhitov 2001 Toll-like receptors and innate immunity Nat Rev Immunol 1 135 145 1:CAS:528:DC%2BD38XlvF2qu74%3D 10.1038/35100529 11905821
11. CW Wieland S Florquin NA Maris, et al. 2005 The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signalling is important in clearing nontypeable Haemophilus influenzae from the mouse lung J Immunol 175 6042 6049 1:CAS:528:DC%2BD2MXhtFahurbE 16237099
12. M Leendertse RJ Willems IA Giebelen, et al. 2008 TLR2-dependent MyD88 signalling contributes to early host defense in murine Enterococcus faecium peritonitis J Immunol 180 4865 4874 1:CAS:528:DC%2BD1cXjsVKqt7o%3D 18354210
13. E Mandel ML Casselbrant 2004 Antibiotics for otitis media with effusion Minerva Pediatr 56 481 495 1:STN:280:DC%2BD2cvptVyntQ%3D%3D 15459573
14. LC Johnston HM Feldman JL Paradise, et al. 2004 Tympanic membrane abnormalities and hearing levels at the ages of 5 and 6 years in relation to persistent otitis media and tympanostomy tube insertion in the first 3 years of life: a prospective study incorporating a randomized clinical trial Pediatrics 114 e58 e67 10.1542/peds.114.1.e58 15231974
15. CM Alper B Winther EM Mandel, et al. 2007 Temporal relationships for cold-like illnesses and otitis media in sibling pairs Pediatr Infect Dis J 26 778 781 10.1097/INF.0b013e318124aa31 17721370 (Pubitemid 47329846)
16. AF Ryan A Catanzaro SI Wasserman, et al. 1986 Complement depletion reduces immunologically mediated middle ear effusion and inflammation Clin Immunol Immunopathol 40 410 421 1:STN:280:DyaL283nt1Onuw%3D%3D 10.1016/0090-1229(86)90185-6 3731540 (Pubitemid 16041140)
17. NW Palm R Medzhitov 2009 Pattern recognition receptors and control of adaptive immunity Immunol Rev 227 221 233 1:CAS:528:DC%2BD1MXhsFGls73I 10.1111/j.1600-065X.2008.00731.x 19120487 This is an excellent overview of the topic
18. R Medzithov P Preston-Hurlburt CA Janeway Jr 1997 A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 394 397 10.1038/41131 (Pubitemid 27334820)
19. B Beutler 2004 Inferences, questions and possibilities in TLR signaling Nature 430 257 263 1:CAS:528:DC%2BD2cXlsVGjt7g%3D 10.1038/nature02761 15241424 (Pubitemid 38902439)
20. T Shuto H Xu B Wang, et al. 2001 Activation of NF-kappa B by nontypeable Haemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells Proc Natl Acad Sci U S A 98 8774 8779 1:CAS:528: DC%2BD3MXls1Witbo%3D 10.1073/pnas.151236098 11438700 (Pubitemid 32678103)
21. G Trinchieri A Sher 2007 Cooperation of Toll-like receptor signals in innate immune defence Nat Rev Immunol 7 179 190 1:CAS:528:DC%2BD2sXitVGrtbc%3D 10.1038/nri2038 17318230
22. ER Leake K Holmes DJ Lim, et al. 1994 Peptidoglycan isolated from nontypeable Haemophilus influenzae induces experimental otitis media in the chinchilla J Infect Dis 170 1532 1538 1:CAS:528:DyaK2MXivFansbw%3D 7995993
23. TF DeMaria MA Apicella WA Nichols, et al. 1997 Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media Infect Immun 65 4431 4435 1:CAS:528:DyaK2sXntlSgsLY%3D 9353016
24. M Emonts RH Veenhoven SP Wiertsema, et al. 2007 Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media Pediatrics 120 814 823 10.1542/peds.2007-0524 17908769 (Pubitemid 47549570)
25. SP Wiertsema SK Khoo G Baynam, et al. 2006 Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses Clin Vaccine Immunol 13 892 897 1:CAS:528:DC%2BD28XosFCrsbw%3D 10.1128/CVI.00100-06 16893989 (Pubitemid 44409628)
26. T Watanabe H Jono J Han, et al. 2004 Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha Proc Natl Acad Sci U S A 101 3563 3568 1:CAS:528:DC%2BD2cXisFWmtrk%3D 10.1073/pnas. 0400557101 14993593 (Pubitemid 38338235)
27. R Chen JH Lim H Jono, et al. 2004 Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways Biochem Biophys Res Commun 324 1087 1094 1:CAS:528:DC%2BD2cXos1Klt7g%3D 10.1016/j.bbrc.2004.09. 157 15485666 (Pubitemid 39361620)
28. T Hirano S Kodama K Fujita, et al. 2007 Role of Toll-like receptor 4 in innate immune responses in a mouse model of acute otitis media FEMS Immunol Med Microbiol 49 75 83 1:CAS:528:DC%2BD2sXhvVOitL4%3D 10.1111/j.1574-695X.2006. 00186.x 17266713 (Pubitemid 46160589)
29. M Hernandez A Leichtle K Pak, et al. 2008 Myeloid differentiation primary response gene 88 is required for the resolution of otitis media J Infect Dis 198 1862 1869 10.1086/593213 18986247
30. A Leichtle M Hernandez K Pak, et al. 2009 TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media Innate Immun 15 205 215 1:CAS:528:DC%2BD1MXhtVyiur%2FJ 10.1177/1753425909103170 19586996
31. A Catanzaro A Ryan S Batcher SI Wasserman 1991 The response to human rIL-1, rIL-2 and rTNF in the middle ear of guinea pigs Laryngoscope 101 271 275 1:STN:280:DyaK3M7lsFKksQ%3D%3D 10.1288/00005537-199103000-00008 2000014
32. EJ Jeon YS Park YC Choi, et al. 2001 Effect of inhibitor of tumor necrosis factor-alpha on experimental otitis media with effusion Ann Otol Rhinol Laryngol 110 917 921 1:STN:280:DC%2BD3Mrmt1ymtQ%3D%3D 11642423
33. DH Lee YS Park TT Jung, et al. 2001 Effect of tumor necrosis factor-alpha on experimental otitis media with effusion Laryngoscope 111 728 733 1:CAS:528:DC%2BD3MXjtFWhsbk%3D 10.1097/00005537-200104000-00030 11359148
34. KH Kim YS Park EJ Jeon, et al. 2006 Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion Ann Otol Rhinol Laryngol 115 617 623 16944661
35. YS Park HJ Auo EJ Jeon, et al. 2006 Effect of tumor necrosis factor-alpha and oxatomide on immune mediated otitis media Laryngoscope 116 1642 1646 1:CAS:528:DC%2BD28XptFWjurw%3D 10.1097/01.mlg.0000232545.08028.b3 16954996 (Pubitemid 44368087)
36. JA Patel S Nair K Revai, et al. 2006 Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media Pediatrics 118 2273 2279 10.1542/peds.2006-0764 17142509 (Pubitemid 46397564)
37. H Jono JH Lim LF Chen, et al. 2004 NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway J Biol Chem 279 36171 36174 1:CAS:528: DC%2BD2cXmvFCnt7s%3D 10.1074/jbc.M406638200 15226292 (Pubitemid 39128950)
38. H Takahashi T Tashiro M Miyazaki, et al. 2002 An essential role of macrophage protein 1 alpha/CCL3 on the expression of host's innate immunities against infectious complications J Leukoc Biol 72 1190 1197 1:CAS:528: DC%2BD3sXhtF2lsA%3D%3D 12488501
39. F Montecucco S Steffens F Burger, et al. 2008 Tumor necrosis factor-alpha induces integrin CD11b/CD18 (Mac-1) up- regulation and migration to the CC chemokine CCL3 (MIP-1 alpha) on human neutrophils through defined signaling pathways Cell Signal 20 557 568 1:CAS:528:DC%2BD1cXptlCruw%3D%3D 10.1016/j.cellsig.2007.11.008 18164590
40. L Otonello F Montecucco M Bertolotto, et al. 2005 CCL3 (MIP-1 alpha) induces in vitro migration of GM-CSF primed human neutrophils via CCR5-dependent activation of ERK 1-2 Cell Signal 17 355 363 10.1016/j.cellsig.2004.08.002 (Pubitemid 39574696)
41. HD Broxmeyer B Sheery L Lu, et al. 1989 Myelopoeitic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/ macrophage progenitor cells J Exp Med 170 1583 1594 1:CAS:528:DyaK3cXlvVCi 10.1084/jem.170.5.1583 2478652
42. A Leichtle M Hernandez J Ebmeyer, et al. 2010 CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- Mice J Immunol 184 3087 3097 1:CAS:528:DC%2BC3cXis1yitr0%3D 10.4049/jimmunol.0901167 20164426 This article discusses a possible new treatment of OM
43. B Lemaitre E Nicolas L Michaut, et al. 1996 The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 973 983 1:CAS:528:DyaK28XlvV2nsLY%3D 10.1016/S0092-8674(00)80172-5 8808632 (Pubitemid 26336801)
44. JH Fritz SE Girardin 2005 How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals J Endotoxin Res 11 390 394 1:CAS:528:DC%2BD2MXhtleku7jL 16303096
45. J Fan RS Frey AB Malik 2003 TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase J Clin Invest 112 1234 1243 1:CAS:528:DC%2BD3sXotlWisL8%3D 14561708
46. Y Lai A Di Nardo T Nakatsuji, et al. 2009 Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury Nat Med 15 1377 1382 1:CAS:528:DC%2BD1MXhsFWksbrO 10.1038/nm.2062 19966777