Regio- and stereoselective oxidation of propranolol enantiomers by human CYP2D6, cynomolgus monkey CYP2D17 and marmoset CYP2D19

Chemico-Biological Interactions

Volumn 189, Issue 3, 2011, Pages 146-152

  Narimatsu, Shizuo ^a   Nakata, Toshiyuki ^a   Shimizudani, Takeshi ^a   Nagaoka, Kenjiro ^a   Nakura, Hironori ^a   Masuda, Kazufumi ^b   Katsu, Takashi ^a   Koeda, Akiko ^c   Naito, Shinsaku ^d   Yamano, Shigeru ^e   Miyata, Atsuro ^f   Hanioka, Nobumitsu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b SHUJITSU UNIVERSITY   (Japan)

^c N   (Japan)

^d OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^e FUKUOKA UNIVERSITY   (Japan)

^f KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

CYP2D17; CYP2D19; CYP2D6; Propranolol enantiomer; Regioselectivity; Stereoselectivity

Indexed keywords

4 HYDROXYPROPRANOLOL; 5 HYDROXYPROPRANOLOL; CYTOCHROME P450 2D; CYTOCHROME P450 2D17; CYTOCHROME P450 2D19; CYTOCHROME P450 2D6; LEUCINE; N DEISOPROPYLDISOPROPRANOLOL; PROPRANOLOL; UNCLASSIFIED DRUG; VALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALLITRICHINAE; CONTROLLED STUDY; DRUG OXIDATION; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HAPLORHINI; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN EXPRESSION; STEREOCHEMISTRY; YEAST CELL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CALLITHRIX; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP2D6; HUMANS; KINETICS; LEUCINE; MACACA FASCICULARIS; MICROSOMES, LIVER; OXIDATION-REDUCTION; PROPRANOLOL; STEREOISOMERISM; SUBSTRATE SPECIFICITY; VALINE;

ANIMALIA; MACACA FASCICULARIS; MARMOSETS;

EID: 79551533310     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.12.014     Document Type: Article

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