Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1- propenes as a new class of anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1328-1348

  McNamara, Yvonne M ^a   Cloonan, Suzanne M ^a   Knox, Andrew J S ^a   Keating, John J ^a,c   Butler, Stephen G ^a   Peters, Günther H ^b   Meegan, Mary J ^a   Williams, D Clive ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

4 Methylthioamphetamine (4 MTA); Apoptosis; Burkitt's lymphoma; Cancer; Nitrostyrene; Programmed cell death; Serotonin transporter (SERT)

Indexed keywords

1 (4 CHLOROPHENYL) 3 (2,4 DICHLOROPHENYL) 2 NITRO 1 PROPENE; 1 (4 CHLOROPHENYL) 3 (4 METHYLTHIOPHENYL) 2 NITRO 1 PROPENE; 1 (4 METHYLTHIOPHENYL) 3 (4 CHLOROPHENYL) 2 NITRO 1 PROPENE; 1,3 BIS(3,4 METHYLENEDIOXY) 2 PROPANOL; 1,3 BIS(3,4 METHYLENEDIOXY) 2 PROPANONE OXIME; 1,3 BIS(4 BROMOPHENYL) 2 NITRO 1 PROPENE; 1,3 BIS(4 CHLOROPHENYL) 2 NITRO 1 PROPENE; 1,3 BIS(4 CHLOROPHENYL) 2 PROPANAMINE; 1,3 BIS(4 FLUOROPHENYL) 2 NITRO 1 PROPENE; 1,3 BIS(4 METHOXYPHENYL) 2 PROPANAMINE; 2 (3,4 METHYLENEDIOXYBENZYL) 3 (3,4 METHYLENEDIOXYPHENYL)AZIRIDINE; 2 (N FORMYL N METHYL)AMINO 1,3 BIS(3,4 METHYLENEDIOXYPHENYL); 2 N ACETYLAMINO 1,3 BIS(3,4 METHYLENEDIOXYPHENYL)PROPANE; 2 N ETHYLAMINO 1,3 BIS(3,4 METHYLENEDIOXYPHENYL)PROPANE; 2 N FORMYLAMINO 1,3 BIS(3,4 METHOXYPHENYL)PROPANE; 2 N METHYLAMINO 1,3 BIS(3,4 METHYLENEDIOXYPHENYL) PROPANE; 4 (3,4 METHYLENEDIOXYBENZYL) 5 (3,4 METHYLENEDIOXYMETHYLENEDIOXYPHENYL)PYRIMIDINE; 4 (4 METHYLTHIOBENZYL) 5 (4 METHYLTHIOPHENYL)PYRIMIDINE; AMPHETAMINE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE; CITALOPRAM; DOPAMINE TRANSPORTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORADRENALIN TRANSPORTER; PACLITAXEL; PROTEIN TYROSINE PHOSPHATASE; SEROTONIN TRANSPORTER; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BURKITT LYMPHOMA; CANCER CELL CULTURE; CELL DEATH; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL; PERIPHERAL BLOOD MONONUCLEAR CELL;

ALKENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BURKITT LYMPHOMA; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; NITRO COMPOUNDS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 79551503694     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.054     Document Type: Article

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