Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted α-alkylthioamphetamines

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 4009-4031

  Cloonan, Suzanne M ^a   Keating, John J ^a   Corrigan, Desmond ^a   O'Brien, John E ^a   Kavanagh, Pierce V ^b   Williams, D Clive ^a   Meegan, Mary J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

4 Methylthioamphetamine (4 MTA); Clandestine synthesises; Impurity profiling; Leuckart reaction; Toxicity profiling

Indexed keywords

4 METHYLTHIOAMPHETAMINE; AMPHETAMINE DERIVATIVE; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DRUG ISOLATION; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; NEUROBLASTOMA CELL; NEUROTOXICITY; SUBSTITUTION REACTION; SYNTHESIS;

AMPHETAMINES; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; HUMANS; METHAMPHETAMINE; NEURONS; PHENETHYLAMINES; SULFUR;

EID: 77953233295     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.022     Document Type: Article

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