메뉴 건너뛰기




Volumn 162, Issue 5, 2011, Pages 1029-1044

Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

Author keywords

agonist efficacy; GDP binding; muscarinic acetylcholine receptors

Indexed keywords

CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SULFUR 35; TRITIUM;

EID: 79551486842     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01081.x     Document Type: Article
Times cited : (18)

References (32)
  • 1
    • 33751119043 scopus 로고    scopus 로고
    • The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic
    • Abdulaev NG, Ngo T, Ramon E, Brabazon DM, Marino JP, Ridge KD, (2006). The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic. Biochemistry 45: 12986-12997.
    • (2006) Biochemistry , vol.45 , pp. 12986-12997
    • Abdulaev, N.G.1    Ngo, T.2    Ramon, E.3    Brabazon, D.M.4    Marino, J.P.5    Ridge, K.D.6
  • 2
    • 72149097863 scopus 로고    scopus 로고
    • Guide to receptors and channels (GRAC)
    • 4th edn.
    • Alexander SPH, Mathie A, Peters JA, (2009). Guide to receptors and channels (GRAC). 4th edn. Br J Pharmacol 158 (Suppl. 1): S1-S254.
    • (2009) Br J Pharmacol , vol.158 , Issue.1 SUPPL.
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 3
    • 0023205408 scopus 로고
    • An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover
    • Ashkenazi A, Winslow JW, Peralta EG, Peterson GL, Schimerlik MI, Capon DJ, et al. (1987). An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science 238: 672-675.
    • (1987) Science , vol.238 , pp. 672-675
    • Ashkenazi, A.1    Winslow, J.W.2    Peralta, E.G.3    Peterson, G.L.4    Schimerlik, M.I.5    Capon, D.J.6
  • 4
    • 0018134270 scopus 로고
    • The binding of agonists to brain muscarinic receptors
    • Birdsall NJ, Burgen AS, Hulme EC, (1978). The binding of agonists to brain muscarinic receptors. Mol Pharmacol 14: 723-736.
    • (1978) Mol Pharmacol , vol.14 , pp. 723-736
    • Birdsall, N.J.1    Burgen, A.S.2    Hulme, E.C.3
  • 5
    • 0029020344 scopus 로고
    • Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3′,5′-cyclic monophosphate accumulation in Chinese hamster ovary cells
    • Burford NT, Tobin AB, Nahorski SR, (1995). Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3′,5′-cyclic monophosphate accumulation in Chinese hamster ovary cells. J Pharmacol Exp Ther 274: 134-142.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 134-142
    • Burford, N.T.1    Tobin, A.B.2    Nahorski, S.R.3
  • 6
    • 0031037633 scopus 로고    scopus 로고
    • Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins
    • Burstein ES, Spalding TA, Brann MR, (1997). Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol Pharmacol 51: 312-319.
    • (1997) Mol Pharmacol , vol.51 , pp. 312-319
    • Burstein, E.S.1    Spalding, T.A.2    Brann, M.R.3
  • 7
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Cheng Y, Prusoff WH, (1973). Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22: 3099-3108.
    • (1973) Biochem Pharmacol , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 8
    • 0032586641 scopus 로고    scopus 로고
    • Determination of [35S]guanosine-5′-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay
    • DeLapp NW, McKinzie JH, Sawyer BD, Vandergriff A, Falcone J, McClure D, et al. (1999). Determination of [35S]guanosine-5′-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. J Pharmacol Exp Ther 289: 946-955.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 946-955
    • Delapp, N.W.1    McKinzie, J.H.2    Sawyer, B.D.3    Vandergriff, A.4    Falcone, J.5    McClure, D.6
  • 9
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
    • De Lean A, Stadel JM, Lefkowitz RJ, (1980). A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem 255: 7108-7117.
    • (1980) J Biol Chem , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 10
    • 0023958554 scopus 로고
    • Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
    • Ehlert FJ, (1988). Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol 33: 187-194.
    • (1988) Mol Pharmacol , vol.33 , pp. 187-194
    • Ehlert, F.J.1
  • 11
    • 0022876166 scopus 로고
    • The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins
    • Ferguson KM, Higashijima T, Smigel MD, Gilman AG, (1986). The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem 261: 7393-7399.
    • (1986) J Biol Chem , vol.261 , pp. 7393-7399
    • Ferguson, K.M.1    Higashijima, T.2    Smigel, M.D.3    Gilman, A.G.4
  • 12
    • 0024603349 scopus 로고
    • Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles
    • Florio VA, Sternweis PC, (1989). Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles. J Biol Chem 264: 3909-3915.
    • (1989) J Biol Chem , vol.264 , pp. 3909-3915
    • Florio, V.A.1    Sternweis, P.C.2
  • 13
    • 0022838315 scopus 로고
    • Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go)
    • Haga K, Haga T, Ichiyama A, (1986). Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go). J Biol Chem 261: 10133-10140.
    • (1986) J Biol Chem , vol.261 , pp. 10133-10140
    • Haga, K.1    Haga, T.2    Ichiyama, A.3
  • 14
    • 28644443374 scopus 로고    scopus 로고
    • Dynamics of receptor/G protein coupling in living cells
    • Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M, (2005). Dynamics of receptor/G protein coupling in living cells. EMBO J 24: 4106-4114.
    • (2005) EMBO J , vol.24 , pp. 4106-4114
    • Hein, P.1    Frank, M.2    Hoffmann, C.3    Lohse, M.J.4    Bünemann, M.5
  • 15
    • 0037329292 scopus 로고    scopus 로고
    • Structure and activation of muscarinic acetylcholine receptors
    • Hulme EC, Lu ZL, Saldanha JW, Bee MS, (2003). Structure and activation of muscarinic acetylcholine receptors. Biochem Soc Trans 31: 29-34.
    • (2003) Biochem Soc Trans , vol.31 , pp. 29-34
    • Hulme, E.C.1    Lu, Z.L.2    Saldanha, J.W.3    Bee, M.S.4
  • 16
    • 0029417130 scopus 로고
    • Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists
    • Jakubík J, Bačáková L, el-Fakahany EE, Tuček S, (1995). Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS Lett 377: 275-279.
    • (1995) FEBS Lett , vol.377 , pp. 275-279
    • Jakubík, J.1    Bačáková, L.2    El-Fakahany, E.E.3    Tuček, S.4
  • 18
    • 1842333847 scopus 로고    scopus 로고
    • Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors
    • Jakubík J, Bačáková L, El-Fakahany EE, Tuček S, (1997). Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol 52: 172-179.
    • (1997) Mol Pharmacol , vol.52 , pp. 172-179
    • Jakubík, J.1    Bačáková, L.2    El-Fakahany, E.E.3    Tuček, S.4
  • 19
    • 33746238100 scopus 로고    scopus 로고
    • Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors
    • Jakubík J, El-Fakahany EE, Doležal V, (2006). Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors. Mol Pharmacol 70: 656-666.
    • (2006) Mol Pharmacol , vol.70 , pp. 656-666
    • Jakubík, J.1    El-Fakahany, E.E.2    Doležal, V.3
  • 20
    • 34547157646 scopus 로고    scopus 로고
    • Receptor-mediated activation of heterotrimeric G-proteins: Current structural insights
    • Johnston CA, Siderovski DP, (2007). Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Mol Pharmacol 72: 219-230.
    • (2007) Mol Pharmacol , vol.72 , pp. 219-230
    • Johnston, C.A.1    Siderovski, D.P.2
  • 21
    • 0043235844 scopus 로고    scopus 로고
    • Ligand-selective receptor conformations revisited: The promise and the problem
    • Kenakin T, (2003). Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol Sci 24: 346-354.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 346-354
    • Kenakin, T.1
  • 22
    • 0018862848 scopus 로고
    • A quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modeling of ligand binding data
    • Kent RS, De Lean A, Lefkowitz RJ, (1980). A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol Pharmacol 17: 14-23.
    • (1980) Mol Pharmacol , vol.17 , pp. 14-23
    • Kent, R.S.1    De Lean, A.2    Lefkowitz, R.J.3
  • 23
    • 0035079910 scopus 로고    scopus 로고
    • 2 acetylcholine receptors on the synthesis of cyclic amp in CHO cells: Dependence on time, receptor density and receptor agonists
    • Michal P, Lysíková M, Tuček S, (2001). Dual effects of muscarinic M(2) acetylcholine receptors on the synthesis of cyclic AMP in CHO cells: dependence on time, receptor density and receptor agonists. Br J Pharmacol 132: 1217-1228. (Pubitemid 32234705)
    • (2001) British Journal of Pharmacology , vol.132 , Issue.6 , pp. 1217-1228
    • Michal, P.1    Lysikova, M.2    Tucek, S.3
  • 24
    • 33846446407 scopus 로고    scopus 로고
    • Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins
    • Michal P, El-Fakahany EE, Doležal V, (2007). Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins. J Pharmacol Exp Ther 320: 607-614.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 607-614
    • Michal, P.1    El-Fakahany, E.E.2    Doležal, V.3
  • 25
    • 37549016836 scopus 로고    scopus 로고
    • Heterotrimeric G protein activation by G-protein-coupled receptors
    • Oldham WM, Hamm HE, (2008). Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9: 60-71.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 60-71
    • Oldham, W.M.1    Hamm, H.E.2
  • 26
    • 0034996884 scopus 로고    scopus 로고
    • Functional differences between full and partial agonists: Evidence for ligand-specific receptor conformations
    • Seifert R, Wenzel-Seifert K, Gether U, Kobilka BK, (2001). Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations. J Pharmacol Exp Ther 297: 1218-1226.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1218-1226
    • Seifert, R.1    Wenzel-Seifert, K.2    Gether, U.3    Kobilka, B.K.4
  • 27
    • 0031581813 scopus 로고    scopus 로고
    • Mechanistic model of G-protein signal transduction. Determinants of efficacy and effect of precoupled receptors
    • Shea L, Linderman JJ, (1997). Mechanistic model of G-protein signal transduction. Determinants of efficacy and effect of precoupled receptors. Biochem Pharmacol 53: 519-530.
    • (1997) Biochem Pharmacol , vol.53 , pp. 519-530
    • Shea, L.1    Linderman, J.J.2
  • 28
    • 0026466773 scopus 로고
    • Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins
    • Shiozaki K, Haga T, (1992). Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins. Biochemistry 31: 10634-10642.
    • (1992) Biochemistry , vol.31 , pp. 10634-10642
    • Shiozaki, K.1    Haga, T.2
  • 29
    • 0027491658 scopus 로고
    • G-protein alpha o subunit: Mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity
    • Thomas TC, Schmidt CJ, Neer EJ, (1993). G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity. Proc Natl Acad Sci U S A 90: 10295-10298.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10295-10298
    • Thomas, T.C.1    Schmidt, C.J.2    Neer, E.J.3
  • 30
    • 0025352919 scopus 로고
    • Partial agonist effects on the interaction between the atrial muscarinic receptor and the inhibitory guanine nucleotide-binding protein in a reconstituted system
    • Tota MR, Schimerlik MI, (1990). Partial agonist effects on the interaction between the atrial muscarinic receptor and the inhibitory guanine nucleotide-binding protein in a reconstituted system. Mol Pharmacol 37: 996-1004.
    • (1990) Mol Pharmacol , vol.37 , pp. 996-1004
    • Tota, M.R.1    Schimerlik, M.I.2
  • 31
    • 0033794067 scopus 로고    scopus 로고
    • Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins
    • Wenzel-Seifert K, Seifert R, (2000). Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins. Mol Pharmacol 58: 954-966.
    • (2000) Mol Pharmacol , vol.58 , pp. 954-966
    • Wenzel-Seifert, K.1    Seifert, R.2
  • 32
    • 0030938936 scopus 로고    scopus 로고
    • G-protein-coupled receptors: Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition
    • Wess J, (1997). G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB J 11: 346-354.
    • (1997) FASEB J , vol.11 , pp. 346-354
    • Wess, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.