Mechanistic model of G-protein signal transduction. Determinants of efficacy and effect of precoupled receptors

Biochemical Pharmacology

Volumn 53, Issue 4, 1997, Pages 519-530

  Shea, Lonnie ^a   Linderman, Jennifer J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

diffusion; efficacy; mathematical model; precoupling; receptor states; switching

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR; DOBUTAMINE; EPHEDRINE; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; ORCIPRENALINE; SALBUTAMOL; ZINTEROL;

ANIMAL CELL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MEMBRANE TRANSPORT; MODEL; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; HUMANS; MATHEMATICS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; ORGAN SPECIFICITY; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0031581813     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00768-X     Document Type: Article

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