Determination of the biological activity and structure activity relationships of drugs based on the highly cytotoxic duocarmycins and CC-1065

Toxins

Volumn 1, Issue 2, 2009, Pages 134-150

  Tietze, Lutz F ^a   Krewer, Birgit ^a   von Hof, J Marian ^a   Frauendorf, Holm ^a   Schuberth, Ingrid ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

ADEPT; anticancer agents; cancer therapy; CC 1065; cytotoxicity; DNA alkylation; duocarmycins; electrospray mass spectrometry; HPLC; oligonucleotides; structure activity relationship

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; DNA; PRODRUG;

DRUG DESIGN; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; DNA; DRUG DESIGN; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84979815381     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins1020134     Document Type: Article

References (0)