Nanoparticles as contrast agents for in-vivo bioimaging: Current status and future perspectives

Analytical and Bioanalytical Chemistry

Volumn 399, Issue 1, 2011, Pages 3-27

  Hahn, Megan A ^a   Singh, Amit K ^b   Sharma, Parvesh ^a   Brown, Scott C ^a   Moudgil, Brij M ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida   (United States)

Author keywords

Characterization; Clinical; In vivo imaging; Multifunctional; Nanoparticles; Theranostic

Indexed keywords

BINDING CAPACITIES; BIO-IMAGING; BIOIMAGING TECHNIQUES; BROAD SPECTRUM; CIRCULATION TIME; CLINICAL; COMPUTED TOMOGRAPHY; CONTRAST AGENT; CURRENT STATUS; EMERGING TECHNOLOGIES; FATE AND TRANSPORT; FUTURE PERSPECTIVES; IMAGING APPLICATIONS; IN-VIVO; IN-VIVO IMAGING; MEDICAL DIAGNOSTICS; METAL OXIDES; MULTIFUNCTIONAL; MULTIMERIC; NEAR-INFRARED FLUORESCENCE; PHOTO-ACOUSTIC IMAGING; PHYSICOCHEMICAL PROPERTY; THERANOSTIC;

BIOMATERIALS; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; RESONANCE; ULTRASONIC APPLICATIONS;

COMPUTERIZED TOMOGRAPHY;

CONTRAST MEDIUM; DIAGNOSTIC AGENT; NANOPARTICLE;

ANIMAL; CHEMISTRY; DIAGNOSTIC IMAGING; HUMAN; INSTRUMENTATION; METHODOLOGY; NANOTECHNOLOGY; REVIEW;

ANIMALS; CONTRAST MEDIA; DIAGNOSTIC IMAGING; HUMANS; NANOPARTICLES; NANOTECHNOLOGY;

EID: 79451473831     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4207-5     Document Type: Review

References (229)

1. P Tallury K Payton S Santra 2008 Silica-based multimodal/multifunctional nanoparticles for bioimaging and biosensing applications Nanomed 3 4 579 592 1:CAS:528:DC%2BD1cXhtVWnsL7M
2. TF Massoud SS Gambhir 2003 Molecular imaging in living subjects: seeing fundamental biological processes in a new light Genes Dev 17 545 580 1:CAS:528:DC%2BD3sXisVejurY%3D
3. P Debbage W Jaschke 2008 Molecular imaging with nanoparticles: giant roles for dwarf actors Histochem Cell Biol 130 845 875 1:CAS:528: DC%2BD1cXht1eit7zJ
4. V Ntziachristos 2010 Going deeper than microscopy: the optical imaging frontier in biology Nat Methods 7 8 603 614 1:CAS:528:DC%2BC3cXpsFWktrw%3D
5. AltInoǧlu EI, Adair JH (2010) Near infrared imaging with nanoparticles. Wiley Interdiscip Rev: Nanomed Nanobiotechnol 2(5):461-477
6. X He K Wang Z Cheng 2010 In vivo near-infrared fluorescence imaging of cancer with nanoparticle-based probes Wiley Interdiscip Rev: Nanomed Nanobiotechnol 2 4 349 366 1:CAS:528:DC%2BC3cXosFCmtb0%3D
7. MK So C Xu AM Loening SS Gambhir J Rao 2006 Self-illuminating quantum dot conjugates for in-vivo imaging Nat Biotechnol 22 339 343
8. S Kim YT Lim EG Soltesz AM De Grand J Lee A Nakayama JA Parker T Mihaljevic RG Laurence DM Dor LH Cohn MG Bawendi JV Frangioni 2004 Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping Nat Biotechnol 22 1 93 97 1:CAS:528:DC%2BD2cXls1ej
9. 2 core/shell nanoparticles and the applications for in vivo NIR detection Adv Mater 20 4118 4123 1:CAS:528:DC%2BD1cXhsVartbfP
10. SA Hilderbrand F Shao C Salthouse U Mahmood R Weissleder 2009 Upconverting luminescent nanomaterials: application to in vivo bioimaging Chem Commun 28 4188 4190
11. DK Chatterjee AJ Rufaihah Y Zhang 2008 Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals Biomaterials 29 937 943 1:CAS:528:DC%2BD2sXhsVGltbjL
12. 3+ nanocrystals Nano Res 3 317 325 1:CAS:528:DC%2BC3cXmslOitL0%3D
13. 3 nanoparticles J Phys Conf Ser 191 012002
14. PK Bachmann H Hummel T Jüstel J Merikhi CR Ronda V Weiler 2008 Near-infrared luminescent nanomaterials for in-vivo optical imaging J Nanophotonics 2 021920
15. K Welsher Z Liu SP Sherlock JT Robinson Z Chen D Daranciang H Dai 2009 A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice Nat Nanotechnol 4 773 780 1:CAS:528:DC%2BD1MXhtlygsLfJ
16. Y-P Sun B Zhou Y Lin W Wang KAS Fernando P Pathak MJ Meziani BA Harruff X Wang H Wang PG Luo H Yang ME Kose B Chen LM Veca S-Y Xie 2006 Quantum-sized carbon dots for bright and colorful photoluminescence J Am Chem Soc 128 24 7756 7757 1:CAS:528:DC%2BD28XkvVehur0%3D
17. ST Yang X Wang HF Wang FS Lu PJG Luo L Cao MJ Meziani JH Liu YF Liu M Chen YP Huang YP Sun 2009 Carbon dots as nontoxic and high-performance fluorescence imaging agents J Phys Chem C 113 42 18110 18114 1:CAS:528:DC%2BD1MXhtFynsbbE
18. L Cao X Wang MJ Meziani F Lu H Wang PG Luo Y Lin BA Harruff LM Veca D Murray S-Y Xie Y-P Sun 2007 Carbon dots for multiphoton bioimaging J Am Chem Soc 129 37 11318 11319 1:CAS:528:DC%2BD2sXpsFCjtb8%3D
19. S-T Yang L Cao PG Luo F Lu X Wang H Wang MJ Meziani Y Liu G Qi Y-P Sun 2009 Carbon dots for optical imaging in vivo J Am Chem Soc 131 11308 11309 1:CAS:528:DC%2BD1MXovF2lsLg%3D
20. AS Barnard 2009 Diamond standard in diagnostics: nanodiamond biolabels make their mark Analyst 134 1751 1764 1:CAS:528:DC%2BD1MXhtVSms7jO
21. Eİ AltInoǧlu TJ Russin JM Kaiser BM Barth PC Eklund M Kester JH Adair 2008 Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in-vivo imaging of human breast cancer ACS Nano 2 10 2075 2084
22. J-H Park L Gu G von Maltzahn E Ruoslahti SN Bhatia MJ Sailor 2009 Biodegradable luminescent porous silicon nanoparticles for in vivo applications Nat Mater 8 331 336 1:CAS:528:DC%2BD1MXjsFKntbo%3D
23. MF Kircher R Weissleder L Josephson 2004 A dual fluorochrome probe for imaging proteases Bioconjug Chem 15 2 242 1:CAS:528:DC%2BD2cXhs1Wmtr0%3D
24. J Rao A Dragulescu-Andrasi H Yao 2007 Fluorescence imaging in vivo: recent advances Curr Opin Biotechnol 18 17 25 1:CAS:528:DC%2BD2sXhvVyis7o%3D
25. NC Deliolanis J Dunham T Wurdinger J-L Figueiredo BA Tannous V Ntziachristos 2009 In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography J Biomed Opt 14 3 030509
26. A Garofalakis G Zacharakis H Meyer EN Economou C Mamalaki J Papamatheakis D Kioussis V Ntziachristos J Ripoll 2007 Three-dimensional in-vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography Mol Imaging 6 2 96 107
27. A Martin J Aguirre A Sarasa-Renedo D Tsoukatou A Garofalakis H Meyer C Mamalaki J Ripoll AM Planas 2008 Imaging changes in lymphoid organs in vivo after brain ischemia with three-dimensional fluorescence molecular tomography in transgenic mice expressing green fluorescent protein in T lymphocytes Mol Imaging 7 4 157 167 1:CAS:528:DC%2BD1MXhslelsQ%3D%3D
28. O Khullar JV Frangioni M Grinstaff YL Colson 2009 Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light Seminars Thorac Cardiovasc Surg 21 4 309 315
29. G Ravizzini B Turkbey T Barrett H Kobayashi PL Choyke 2009 Nanoparticles in sentinel lymph node mapping Wiley Interdiscip Rev: Nanomed Nanobiotechnol 1 610 623 1:CAS:528:DC%2BC3cXmtVSru74%3D
30. HB Na T Hyeon 2009 Nanostructured t1MRI contrast agents J Mater Chem 19 35 6267 6273 1:CAS:528:DC%2BD1MXhtVeiurjL
31. HB Na IC Song T Hyeon 2009 Inorganic nanoparticles for MRI contrast agents Adv Mater 21 21 2133 2148 1:CAS:528:DC%2BD1MXntVGqu78%3D
32. C Corot P Robert JM Idee M Port 2006 Recent advances in iron oxide nanocrystal technology for medical imaging Adv Drug Delivery Rev 58 14 1471 1504 1:CAS:528:DC%2BD28Xht1KmtLbP
33. RC Semelka TKG Helmberger 2001 Contrast agents for MR imaging of the liver Radiology 218 1 27 38 1:STN:280:DC%2BD3MzitFCmtg%3D%3D
34. FA Jaffer P Libby R Weissleder 2006 Molecular and cellular imaging of atherosclerosis - emerging applications J Am Coll Cardiol 47 7 1328 1338 1:CAS:528:DC%2BD28XjtFGgurY%3D
35. DE Sosnovik M Nahrendorf R Weissleder 2008 Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications Basic Res Cardiol 103 2 122 130 1:CAS:528:DC%2BD1cXksF2qtLc%3D
36. R Weissleder MJ Pittet 2008 Imaging in the era of molecular oncology Nature 452 7187 580 589 1:CAS:528:DC%2BD1cXktFCgt7Y%3D
37. FA Jaffer P Libby R Weissleder 2007 Molecular imaging of cardiovascular disease Circulation 116 9 1052 1061
38. AH Lu EL Salabas F Schuth 2007 Magnetic nanoparticles: synthesis, protection, functionalization, and application Angew Chem Int Ed 46 8 1222 1244 1:CAS:528:DC%2BD2sXitF2lurs%3D
39. CH Cunningham T Arai PC Yang MV McConnell JM Pauly SM Conolly 2005 Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles Magn Reson Med 53 5 999 1005 1:CAS:528:DC%2BD2MXksFGmtro%3D
40. Y Suzuki CH Cunningham KI Noguchi IY Chen IL Weissman AC Yeung RC Robbins PC Yang 2008 In vivo serial evaluation of superparamagnetic iron-oxide labeled stem cells by off-resonance positive contrast Magn Reson Med 60 6 1269 1275 1:CAS:528:DC%2BD1MXjs1WltA%3D%3D
41. A Senpan SD Caruthers I Rhee NA Mauro DPJ Pan G Hu MJ Scott RW Fuhrhop PJ Gaffney SA Wickline GM Lanzat 2009 Conquering the dark side: colloidal iron oxide nanoparticles ACS Nano 3 12 3917 3926 1:CAS:528:DC%2BD1MXhsVSgtLnF
42. C Alric J Taleb G Le Duc C Mandon C Billotey A Le Meur-Herland T Brochard F Vocanson M Janier P Perriat S Roux O Tillement 2008 Gadolinium chelate coated gold nanoparticles as contrast agents for both x-ray computed tomography and magnetic resonance imaging J Am Chem Soc 130 18 5908 5915 1:CAS:528: DC%2BD1cXksFykurs%3D
43. E Terreno DD Castelli A Viale S Aime 2010 Challenges for molecular magnetic resonance imaging Chem Rev 110 5 3019 3042 1:CAS:528: DC%2BC3cXltFChurw%3D
44. LM Manus DJ Mastarone EA Waters XQ Zhang EA Schultz-Sikma KW MacRenaris D Ho TJ Meade 2010 Gd(III)-nanodiamond conjugates for MRI contrast enhancement Nano Lett 10 2 484 489 1:CAS:528:DC%2BD1MXhs1Srur3E
45. KML Taylor JS Kim WJ Rieter H An WL Lin WB Lin 2008 Mesoporous silica nanospheres as highly efficient MRI contrast agents J Am Chem Soc 130 7 2154 2155 1:CAS:528:DC%2BD1cXps1Khsg%3D%3D
46. JM Shin RM Anisur MK Ko GH Im JH Lee IS Lee 2009 Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery Angew Chem Int Ed 48 2 321 324 1:CAS:528:DC%2BD1MXhtFChtLs%3D
47. S Viswanathan Z Kovacs KN Green SJ Ratnakar AD Sherry 2010 Alternatives to gadolinium-based metal chelates for magnetic resonance imaging Chem Rev 110 5 2960 3018 1:CAS:528:DC%2BC3cXkvVahsr0%3D
48. MA Bouchiat TR Carver CM Varnum 1960 Nuclear polarization in He-3 gas induced by optical pumping and dipolar exchange Phys Rev Lett 5 8 373 375 1:CAS:528:DyaF3MXhsVWnt7c%3D
49. AM Oros NJ Shah 2004 Hyperpolarized xenon in NMR and MRI Phys Med Biol 49 20 R105 R153 1:CAS:528:DC%2BD2cXhtVWrs7vL
50. AD Sherry M Woods 2008 Chemical exchange saturation transfer contrast agents for magnetic resonance imaging Ann Rev Biomed Eng 10 391 411 1:CAS:528:DC%2BD1cXhtVGru7bO
51. ME Phelps 2000 Positron emission tomography provides molecular imaging of biological processes Proc Natl Acad Sci USA 97 16 9226 9233 1:CAS:528:DC%2BD3cXls12ksb8%3D
52. PW Miller NJ Long R Vilar AD Gee 2008 Synthesis of C-11, F-18, O-15, and N-13 radiolabels for positron emission tomography Angew Chem Int Ed 47 47 8998 9033 1:CAS:528:DC%2BD1cXhsVCnsrfP
53. C Sioka A Fotopoulos A Kyritsis 2010 Recent advances in PET imaging for evaluation of Parkinson's disease Eur J Nucl Med Mol Imaging 37 8 1594 1603
54. PA Jarzyna A Gianella T Skajaa G Knudsen LH Deddens DP Cormode ZA Fayad WJM Mulder 2010 Multifunctional imaging nanoprobes Wiley Interdiscip Rev: Nanomed Nanobiotechnol 2 138 150 1:CAS:528:DC%2BC3cXmtVSru7s%3D
55. M Nahrendorf H Zhang S Hembrador P Panizzi DE Sosnovik E Aikawa P Libby FK Swirski R Weissleder 2008 Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis Circulation 117 379 387 1:CAS:528: DC%2BD1cXlvV2isA%3D%3D
56. DW Townsend 2001 A combined PET/CT scanner: the choices J Nucl Med 42 3 533 534 1:STN:280:DC%2BD3MvjsFKlsw%3D%3D
57. Chung D, Kang K, Jeon Y, Kim Y, Alothman ZA, Ahmed AYH, Choi K, Aimajid AM, Piao J, Alothman AA, Quan B (2010) Fluorescent silica nanoparticle with radioactive tag and the detecting method of PET and fluorescent dual imaging using thereof. International Patent WO 2010/030120
58. R Kumar I Roy TY Ohulchanskky LA Vathy EJ Bergey M Sajjad PN Prasad 2010 In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles ACS Nano 4 2 699 708 1:CAS:528: DC%2BC3cXot1Knsg%3D%3D
59. K Chen Z-B Li H Wang W Cai X Chen 2008 Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots Eur J Nucl Med Mol Imaging 35 2235 2244 1:CAS:528:DC%2BD1cXhsVyls73E
60. J Xie K Chen J Huang S Lee J Wang J Gao X Li 2010 PET/NIRF/MRI triple functional iron oxide nanoparticles Biomaterials 31 3016 3022 1:CAS:528:DC%2BC3cXit1SgtLs%3D
61. GJ Strijkers WJM Mulder GAF van Tilborg K Nicolay 2007 MRI contrast agents: current status and future perspectives Anticancer Agents Med Chem 7 3 291 305 1:CAS:528:DC%2BD2sXksVWhur8%3D
62. SR Cherry AY Louie RE Jacobs 2008 The integration of positron emission tomography with magnetic resonance imaging Proc IEEE 96 3 416 438 1:CAS:528:DC%2BD1cXjt1Wiur8%3D
63. HPW Schlemmer BJ Pichler M Schmand Z Burbar C Michel R Ladebeck K Jattke D Townsend C Nahmias PK Jacob WD Heiss CD Claussen 2008 Simultaneous MR/PET imaging of the human brain: feasibility study Radiology 248 3 1028 1035
64. SY Hong G Tobias KT Al-Jamal B Ballesteros H Ali-Boucetta S Lozano-Perez PD Nellist RB Sim C Finucane SJ Mather MLH Green K Kostarelos BG Davis 2010 Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging Nat Mater 9 485 490 1:CAS:528:DC%2BC3cXmtlWrurY%3D
65. SM Seltzer MJ Berger 1985 Bremsstrahlung spectra from electron interactions with screened atomic-nuclei and orbital electrons Nucl Instrum Methods Phys Res Sect B 12 1 95 134
66. Carlsson GA (1985) Theoretical basis for dosimetry. In: Kase KR, Bajrngard BE, Attix FH (eds) The dosimetry of ionizing radiation, vol 1. Academic Press, Orlando, pp 1-75
67. N Becker D Liebermann H Wesch G Van Kaick 2008 Mortality among Thorotrast-exposed patients and an unexposed comparison group in the German Thorotrast study Eur J Cancer 44 9 1259 1268 1:CAS:528:DC%2BD1cXmsFKqu7w%3D
68. de Vries A, Custers E, Lub J, van den Bosch S, Nicolay K, Grüll H Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents. Biomaterials 31 (25):6537-6544
69. WH Kong WJ Lee ZY Cui KH Bae TG Park JH Kim K Park SW Seo 2007 Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging Biomaterials 28 36 5555 5561 1:CAS:528:DC%2BD2sXht1WqtbfN
70. DB Elrod R Partha D Danila SW Casscells JL Conyers 2009 An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid Nanomedicine 5 1 42 45 1:CAS:528: DC%2BC3cXmtVChtQ%3D%3D
71. Skajaa T, Cormode DP, Falk E, Mulder WJ, Fisher EA, Fayad ZA High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis. Arteriosclerosis Thromb Vasc Biol 30 (2):169-176
72. GS Gazelle GL Wolf GL McIntire ER Bacon G Na EF Halpern JL Toner 1995 Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits Acad Radiol 2 8 700 704 1:STN:280:DyaK1c%2FotVyqtQ%3D%3D
73. GL McIntire ER Bacon JL Toner JB Cornacoff PE Losco KJ Illig KJ Nikula BA Muggenburg L Ketai 1998 Pulmonary delivery of nanoparticles of insoluble, iodinated CT x-ray contrast agents to lung draining lymph nodes in dogs J Pharm Sci 87 11 1466 1470 1:CAS:528:DyaK1cXltVWgsrY%3D
74. F Hyafil JC Cornily JE Feig R Gordon E Vucic V Amirbekian EA Fisher V Fuster LJ Feldman ZA Fayad 2007 Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography Nat Med 13 5 636 641 1:CAS:528:DC%2BD2sXkvVOhu7k%3D
75. JL Van Herck GRY De Meyer W Martinet RA Salgado B Shivalkar R De Mondt H Van De Ven A Ludwig P Van Der Veken L Van Vaeck H Bult AG Herman CJ Vrints 2010 Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits Basic Res Cardiol 105 1 51 59
76. A Galperin D Margel J Baniel G Dank H Biton S Margel 2007 Radiopaque iodinated polymeric nanoparticles for x-ray imaging applications Biomaterials 28 30 4461 4468 1:CAS:528:DC%2BD2sXovFSqtrw%3D
77. H Aviv S Bartling F Kieslling S Margel 2009 Radiopaque iodinated copolymeric nanoparticles for x-ray imaging applications Biomaterials 30 29 5610 5616 1:CAS:528:DC%2BD1MXpvFCgu78%3D
78. A Ashokan D Menon S Nair M Koyakutty 2010 A molecular receptor targeted, hydroxyapatite nanocrystal based multi-modal contrast agent Biomaterials 31 9 2606 2616 1:CAS:528:DC%2BC3cXptlyltg%3D%3D
79. PA Jackson WN Rahman CJ Wong T Ackerly M Geso 2009 Potential dependent superiority of gold nanoparticles in comparison to iodinated contrast agents Eur J Radiol 75 1 104 109
80. D Kim S Park JH Lee YY Jeong S Jon 2007 Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging J Am Chem Soc 129 24 7661 7665 1:CAS:528:DC%2BD2sXmtVyhsrc%3D (Pubitemid 46981930)
81. C Kojima Y Umeda M Ogawa A Harada Y Magata K Kono 2010 X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer Nanotechnology 21 24 245104
82. R Popovtzer A Agrawal NA Kotov A Popovtzer J Balter TE Carey R Kopelman 2008 Targeted gold nanoparticles enable molecular CT imaging of cancer Nano Lett 8 12 4593 4596 1:CAS:528:DC%2BD1cXhtlemtrnN
83. M Xiao J Nyagilo V Arora P Kulkarni DS Xu XK Sun DP Dave 2010 Gold nanotags for combined multi-colored Raman spectroscopy and x-ray computed tomography Nanotechnology 21 3 035101
84. B Aydogan J Li T Rajh A Chaudhary SJ Chmura C Pelizzari C Wietholt M Kurtoglu P Redmond 2010 AuNP-DG: Deoxyglucose-labeled gold nanoparticles as x-ray computed tomography contrast agents for cancer imaging Mol Imaging Biol 10.1007/s11307-010-0299-8
85. E Boote G Fent V Kattumuri S Casteel K Katti N Chanda R Kannan K Katti R Churchill 2010 Gold nanoparticle contrast in a phantom and juvenile swine: models for molecular imaging of human organs using x-ray computed tomography Acad Radiol 17 4 410 417
86. QY Cai SH Kim KS Choi SY Kim SJ Byun KW Kim SH Park SK Juhng KH Yoon 2007 Colloidal gold nanoparticles as a blood-pool contrast agent for x-ray computed tomography in mice Investig Radiol 42 12 797 806 1:CAS:528:DC%2BD2sXhtlSmu7rE
87. IC Sun DK Eun JH Na S Lee IJ Kim IC Youn CY Ko HS Kim D Lim K Choi PB Messersmith TG Park SY Kim IC Kwon K Kim CH Ahn 2009 Heparin-coated gold nanoparticles for liver-specific CT imaging Chemistry 15 48 13341 13347 1:CAS:528:DC%2BD1MXhsFGrtb%2FO
88. YS Park A Kasuya A Dmytruk N Yasuto M Takeda N Ohuchi Y Sato K Tohji M Uo F Watari 2007 Concentrated colloids of silica-encapsulated gold nanoparticles: colloidal stability, cytotoxicity, and x-ray absorption J Nanosci Nanotechnol 7 8 2690 2695 1:CAS:528:DC%2BD2sXot1ent70%3D
89. YS Park LM Liz-Marzan A Kasuya Y Kobayashi D Nagao M Konno S Mamykin A Dmytruk M Takeda N Ohuchi 2006 X-ray absorption of gold nanoparticles with thin silica shell J Nanosci Nanotechnol 6 11 3503 3506 1:CAS:528:DC%2BD28XhtlWgsLvO
90. R Guo H Wang C Peng MW Shen MJ Pan XY Cao GX Zhang XY Shi 2010 X-ray attenuation property of dendrimer-entrapped gold nanoparticles J Phys Chem C 114 1 50 56 1:CAS:528:DC%2BD1MXhsFGku7zK
91. M Lijowski S Caruthers G Hu HY Zhang MJ Scott T Williams T Erpelding AH Schmieder G Kiefer G Gulyas PS Athey PJ Gaffney SA Wickline GM Lanza 2009 High sensitivity high-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model Investig Radiol 44 1 15 22 1:CAS:528:DC%2BD1MXht1ent70%3D
92. CJ Xu GA Tung SH Sun 2008 Size and concentration effect of gold nanoparticles on x-ray attenuation as measured on computed tomography Chem Mater 20 13 4167 4169 1:CAS:528:DC%2BD1cXms12iuro%3D
93. HM Garnica-Garza 2009 Contrast-enhanced radiotherapy: feasibility and characteristics of the physical absorbed dose distribution for deep-seated tumors Phys Med Biol 54 18 5411 5425 1:STN:280:DC%2BD1Mrps1ejtQ%3D%3D
94. SJ McMahon MH Mendenhall S Jain F Currell 2008 Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles Phys Med Biol 53 20 5635 5651
95. O Rabin J Manuel Perez J Grimm G Wojtkiewicz R Weissleder 2006 An x-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles Nat Mater 5 2 118 122 1:CAS:528:DC%2BD28XptFOgsg%3D%3D
96. M Ajeesh BF Francis J Annie PRH Varma 2010 Nano iron oxide-hydroxyapatite composite ceramics with enhanced radioopacity J Mater Sci Mater Med 21 5 1427 1434 1:CAS:528:DC%2BC3cXlvVGqtrg%3D
97. S Santra RP Bagwe D Dutta JT Stanley GA Walter W Tan BM Moudgil RA Mericle 2005 Synthesis and characterization of fluorescent, radio-opaque, and paramagnetic silica nanoparticles for multimodal bioimaging applications Adv Mater 17 18 2165 2169 1:CAS:528:DC%2BD2MXhtVKqsb3K
98. PA Dayton JJ Rychak 2007 Molecular ultrasound imaging using microbubble contrast agents Frontiers Biosci 12 5124 5142 1:CAS:528:DC%2BD2sXosF2qsb4%3D
99. R Gessner PA Dayton 2010 Advances in molecular imaging with ultrasound Mol Imaging 9 3 117 127
100. GM Lanza DR Abendschein CS Hall MJ Scott DE Scherrer A Houseman JG Miller SA Wickline 2000 In vivo molecular imaging of stretch-induced tissue factor in carotid arteries with ligand-targeted nanoparticles J Am Soc Echocardiogr 13 6 608 614 1:STN:280:DC%2BD3czptFSjsg%3D%3D
101. BE Oeffinger MA Wheatley 2004 Development and characterization of a nano-scale contrast agent Ultrasonics 42 1-9 343 347 1:CAS:528: DC%2BD2cXislWjurk%3D
102. R Cavalli A Bisazza P Giustetto A Civra D Lembo G Trotta C Guiot M Trotta 2009 Preparation and characterization of dextran nanobubbles for oxygen delivery Int J Pharm 381 2 160 165 1:CAS:528:DC%2BD1MXhtFOrsbbN
103. R Cavalli A Bisazza A Rolfo S Balbis D Madonnaripa I Caniggia C Guiot 2009 Ultrasound-mediated oxygen delivery from chitosan nanobubbles Int J Pharm 378 1-2 215 217 1:CAS:528:DC%2BD1MXovFOjsr8%3D
104. TL Hwang YK Lin CH Chi TH Huang JY Fang 2009 Development and evaluation of perfluorocarbon nanobubbles for apomorphine delivery J Pharm Sci 98 10 3735 3747 1:CAS:528:DC%2BD1MXhtVKhsrzK
105. N Rapoport Z Gao A Kennedy 2007 Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy J Natl Cancer Inst 99 4 1095 1106 1:CAS:528:DC%2BD2sXpsVKmtbo%3D
106. MS Hughes JN Marsh CS Hall RW Fuhrhop EK Lacy GM Lanza SA Wickline 2005 Acoustic characterization in whole blood and plasma of site-targeted nanoparticle ultrasound contrast agent for molecular imaging J Acoust Soc Am 117 2 964 972 1:CAS:528:DC%2BD2MXhtValsrc%3D
107. OM Mukdadi HB Kim J Hertzberg R Shandas 2004 Numerical modeling of microbubble backscatter to optimize ultrasound particle image velocimetry imaging: initial studies Ultrasonics 42 10 1111 1121
108. J Liu AL Levine JS Mattoon M Yamaguchi RJ Lee X Pan TJ Rosol 2006 Nanoparticles as image enhancing agents for ultrasonography Phys Med Biol 51 2179 2189 1:CAS:528:DC%2BD28XltlKhs7Y%3D
109. K Tachibana LB Feril Y Ikeda-Dantsuji 2008 Sonodynamic therapy Ultrasonics 48 4 253 259 1:CAS:528:DC%2BD1cXpsVKmu7Y%3D
110. LV Wang 2009 Multiscale photoacoustic microscopy and computed tomography Nat Photonics 3 9 503 509 1:CAS:528:DC%2BD1MXhtVGgs7jK
111. MH Xu LHV Wang 2006 Photoacoustic imaging in biomedicine Rev Sci Instrum 77 4 041101
112. XM Yang EW Stein S Ashkenazi LHV Wang 2009 Nanoparticles for photoacoustic imaging Wiley Interdiscip Rev: Nanomed Nanobiotechnol 1 4 360 368 1:CAS:528:DC%2BC3cXmtVSrtLo%3D
113. Wang LV, H-i Wu (2007) Biomedical optics: Principles and imaging. Wiley-Interscience, NJ
114. SA Ermilov T Khamapirad A Conjusteau MH Leonard R Lacewell K Mehta T Miller AA Oraevsky 2009 Laser optoacoustic imaging system for detection of breast cancer J Biomed Opt 14 2 024007
115. RA Kruger DR Reinecke GA Kruger 1999 Thermoacoustic computed tomography-technical considerations Med Phys 26 9 1832 1837 1:STN:280: DyaK1MvjtlKqsg%3D%3D
116. RGM Kolkman E Hondebrink W Steenbergen TG van Leeuwen FFM de Mul 2004 Photoacoustic imaging of blood vessels with a double-ring sensor featuring a narrow angular aperture J Biomed Opt 9 6 1327 1335
117. RO Esenaliev AA Karabutov AA Oraevsky 1999 Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors IEEE J Sel Top Quantum Electron 5 4 981 988 1:CAS:528:DyaK1MXntVWruro%3D
118. AA Oraevsky SA Ermilov A Conjusteau T Miller RR Gharieb R Lacewell K Mehta EG Radulescu D Herzog S Thompson A Stein M McCorvey P Otto T Khamapirad 2007 Initial clinical evaluation of laser optoacoustic imaging system for diagnostic imaging of breast cancer Breast Cancer Res Treat 106 S47
119. RI Siphanto KK Thumma RGM Kolkman TG van Leeuwen FFM de Mul JW van Neck LNA van Adrichem W Steenbergen 2005 Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis Opt Express 13 1 89 95 1:STN:280:DC%2BD1MzotlaitQ%3D%3D
120. XD Wang XY Xie GN Ku LHV Wang 2006 Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography J Biomed Opt 11 2 024015
121. KH Song EW Stein JA Margenthaler LV Wang 2008 Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model J Biomed Opt 13 5 054033
122. JJ Yao K Maslov S Hu LHV Wang 2009 Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo J Biomed Opt 14 5 054049
123. M Pramanik M Swierczewska D Green B Sitharaman LV Wang 2009 Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent J Biomed Opt 14 3 034018
124. XD Wang YJ Pang G Ku XY Xie G Stoica LHV Wang 2003 Noninvasive laser-induced photoacoustic tomography for structural and functional in-vivo imaging of the brain Nat Biotechnol 21 7 803 806 1:CAS:528:DC%2BD3sXkvFertbg%3D
125. Q Zhang N Iwakuma P Sharma BM Moudgil C Wu J McNeill H Jiang SR Grobmyer 2009 Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography Nanotechnology 20 395102 1:STN:280: DC%2BD1MngtVCrtw%3D%3D
126. A Agarwal SW Huang M O'Donnell KC Day M Day N Kotov S Ashkenazi 2007 Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging J Appl Phys 102 6 064701
127. YS Chen W Frey S Kim K Homan P Kruizinga K Sokolov S Emelianov 2010 Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy Opt Express 18 9 8867 8877 1:CAS:528: DC%2BC3cXlsl2ktLk%3D
128. KH Song CH Kim CM Cobley YN Xia LV Wang 2009 Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model Nano Lett 9 1 183 188 1:CAS:528:DC%2BD1cXhsVyrtL3P
129. S Mallidi T Larson J Tam PP Joshi A Karpiouk K Sokolov S Emelianov 2009 Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer Nano Lett 9 8 2825 2831 1:CAS:528:DC%2BD1MXotV2mtLw%3D
130. W Lu Q Huang KB Geng XX Wen M Zhou D Guzatov P Brecht R Su A Oraevsky LV Wang C Li 2010 Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres Biomaterials 31 9 2617 2626 1:CAS:528: DC%2BC3cXptlyltA%3D%3D
131. ML Li JC Wang JA Schwartz KL Gill-Sharp G Stoica LHV Wang 2009 In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature J Biomed Opt 14 1 010507
132. YW Wang XY Xie XD Wang G Ku KL Gill DP O'Neal G Stoica LV Wang 2004 Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain Nano Lett 4 9 1689 1692 1:CAS:528:DC%2BD2cXmsVSkt7Y%3D (Pubitemid 39297446)
133. LS Bouchard MS Anwar GL Liu B Hann ZH Xie JW Gray XD Wang A Pines FF Chen 2009 Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles Proc Natl Acad Sci USA 106 11 4085 4089 1:CAS:528: DC%2BD1MXjslCht7s%3D
134. P Sharma SC Brown N Bengtsson Q Zhang GA Walter SR Grobmyer S Santra H Jiang EW Scott BM Moudgil 2008 Gold-speckled multimodal nanoparticles for noninvasive bioimaging Chem Mater 20 6087 6094 1:CAS:528:DC%2BD1cXhtFSmt7%2FF
135. DPJ Pan M Pramanik A Senpan S Ghosh SA Wickline LV Wang GM Lanza 2010 Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons Biomaterials 31 14 4088 4093 1:CAS:528:DC%2BC3cXjtFKisrk%3D
136. S Kalele SW Gosavi J Urban SK Kulkarni 2006 Nanoshell particles: synthesis, properties and applications Curr Sci 91 8 1038 1052 1:CAS:528:DC%2BD28XhtlSksLzK
137. XH Huang S Neretina MA El-Sayed 2009 Gold nanorods: from synthesis and properties to biological and biomedical applications Adv Mater 21 48 4880 4910 1:CAS:528:DC%2BD1MXhs1WltL3F
138. XJ Ji RP Shao AM Elliott RJ Stafford E Esparza-Coss JA Bankson G Liang ZP Luo K Park JT Markert C Li 2007 Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy J Phys Chem C 111 17 6245 6251 1:CAS:528: DC%2BD2sXjvFKnsL4%3D
139. DP O'Neal LR Hirsch NJ Halas JD Payne JL West 2004 Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles Cancer Lett 209 2 171 176
140. LR Hirsch RJ Stafford JA Bankson SR Sershen B Rivera RE Price JD Hazle NJ Halas JL West 2003 Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance Proc Natl Acad Sci USA 100 23 13549 13554 1:CAS:528:DC%2BD3sXptFOit7k%3D
141. G von Maltzahn JH Park A Agrawal NK Bandaru SK Das MJ Sailor SN Bhatia 2009 Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas Cancer Res 69 9 3892 3900
142. R Eisler 2003 Chrysotherapy: a synoptic review Inflamm Res 52 12 487 501 1:CAS:528:DC%2BD2cXjvVyjsLk%3D
143. CJ Murphy AM Gole JW Stone PN Sisco AM Alkilany EC Goldsmith SC Baxter 2008 Gold nanoparticles in biology: beyond toxicity to cellular imaging Acc Chem Res 41 12 1721 1730 1:CAS:528:DC%2BD1cXhtVSrtLvF
144. YS Chen YC Hung I Liau GS Huang 2009 Assessment of the in vivo toxicity of gold nanoparticles Nanoscale Res Lett 4 8 858 864 1:CAS:528: DC%2BD1MXoslKisLY%3D
145. E Boisselier D Astruc 2009 Gold nanoparticles in nanomedicine: Preparations, imaging, diagnostics, therapies and toxicity Chem Soc Rev 38 6 1759 1782 1:CAS:528:DC%2BD1MXmsVSms7k%3D
146. JR Cole NA Mirin MW Knight GP Goodrich NJ Halas 2009 Photothermal efficiencies of nanoshells and nanorods for clinical therapeutic applications J Phys Chem C 113 28 12090 12094 1:CAS:528:DC%2BD1MXnt1Wrur8%3D
147. W Eck G Craig A Sigdel G Ritter LJ Old L Tang MF Brennan PJ Allen MD Mason 2008 PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue ACS Nano 2 11 2263 2272 1:CAS:528:DC%2BD1cXhtlaktLvI
148. WC Huang PJ Tsai YC Chen 2007 Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria Nanomedicine 2 6 777 787 1:CAS:528:DC%2BD1cXitlWgu7Y%3D
149. D Pissuwan CH Cortie SM Valenzuela MB Cortie 2007 Gold nanosphere-antibody conjugates for hyperthermal therapeutic applications Gold Bull 40 2 121 129 1:CAS:528:DC%2BD2sXptlKktrw%3D
150. MP Melancon W Lu Z Yang R Zhang Z Cheng AM Elliot J Stafford T Olson JZ Zhang C Li 2008 In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy Mol Cancer Ther 7 6 1730 1739 1:CAS:528:DC%2BD1cXnsVSkurk%3D
151. AM Elliott RJ Stafford J Schwartz J Wang AM Shetty C Bourgoyne P O'Neal JD Hazle 2007 Laser-induced thermal response and characterization of nanoparticles for cancer treatment using magnetic resonance thermal imaging Med Phys 34 7 3102 3108 1:CAS:528:DC%2BD2sXnsFWlurY%3D (Pubitemid 47019830)
152. IH El-Sayed XH Huang MA El-Sayed 2005 Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer Nano Lett 5 5 829 834 1:CAS:528:DC%2BD2MXjt1SmtLg%3D
153. K Sokolov M Follen J Aaron I Pavlova A Malpica R Lotan R Richards-Kortum
154. D Yelin D Oron S Thiberge E Moses Y Silberberg 2003 Multiphoton plasmon-resonance microscopy Opt Express 11 12 1385 1391
155. TS Troutman JK Barton M Romanowski 2007 Optical coherence tomography with plasmon resonant nanorods of gold Opt Lett 32 11 1438 1440
156. DC Adler SW Huang R Huber JG Fujimoto 2008 Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography Opt Express 16 7 4376 4393 1:CAS:528:DC%2BD1cXlt1Ontbw%3D
157. YT Lim MY Cho JK Kim S Hwangbo BH Chung 2007 Plasmonic magnetic nanostructure for bimodal imaging and photonic-based therapy of cancer cells Chembiochem 8 18 2204 2209 1:CAS:528:DC%2BD1cXltlentLc%3D
158. A Maltzahn GVC J Park R Ramanathan MJ Sailor TA Hatton SN Bhatia 2009 SERS-coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating Adv Mater 21 31 3175 3180
159. RT Zaman P Diagaradjane JC Wang J Schwartz N Rajaram KL Gill-Sharp SH Cho HG Rylander JD Payne S Krishnan JW Tunnell 2008 In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy IEEE J Sel Top Quantum Electron 13 6 1715 1720
160. XD Wang G Ku MA Wegiel DJ Bornhop G Stoica LHV Wang 2004 Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent Opt Lett 29 7 730 732
161. M Hu JY Chen ZY Li L Au GV Hartland XD Li M Marquez YN Xia 2006 Gold nanostructures: Engineering their plasmonic properties for biomedical applications Chem Soc Rev 35 11 1084 1094 1:CAS:528:DC%2BD28XhtFSgtL%2FK
162. M Eghtedari A Oraevsky JA Copland NA Kotov A Conjusteau M Motamedi 2007 High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system Nano Lett 7 7 1914 1918 1:CAS:528: DC%2BD2sXmsVaisL4%3D
163. PC Li CRC Wang DB Shieh CW Wei CK Liao C Poe S Jhan AA Ding YN Wu 2008 In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods Opt Express 16 23 18605 18615 1:CAS:528:DC%2BD1cXhsVOhsL%2FO
164. PC Li CW Wei CK Liao CD Chen KC Pao CRC Wang YN Wu DB Shieh 2007 Photoacoustic imaging of multiple targets using gold nanorods IEEE Trans Ultrason Ferroelectr Freq Control 54 8 1642 1647
165. KH Song C Kim K Maslov LV Wang 2009 Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes Eur J Radiol 70 2 227 231
166. K Kim SW Huang S Ashkenazi M O'Donnell A Agarwal NA Kotov MF Denny MJ Kaplan 2007 Photoacoustic imaging of early inflammatory response using gold nanorods Appl Phys Lett 90 22 223901
167. CK Liao SW Huang CW Wei PC Li 2007 Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system J Biomed Opt 12 6 064006
168. DL Chamberland A Agarwal N Kotov JB Fowlkes PL Carson X Wang 2008 Photoacoustic tomography of joints aided by an Etanercept-conjugated gold nanoparticle contrast agent - an ex vivo preliminary rat study Nanotechnology 19 9 095101
169. EC Cho C Kim F Zhou CM Cobley KH Song JY Chen ZY Li LHV Wang YN Xia 2009 Measuring the optical absorption cross sections of Au-Ag nanocages and Au nanorods by photoacoustic imaging J Phys Chem C 113 21 9023 9028 1:CAS:528:DC%2BD1MXltlKksLg%3D
170. XM Yang SE Skrabalak ZY Li YN Xia LHV Wang 2007 Photoacoustic tomography of a rat cerebral cortex in vivo with Au nanocages as an optical contrast agent Nano Lett 7 12 3798 3802 1:CAS:528:DC%2BD2sXhtlaisb3K
171. M Foldvari M Bagonluri 2008 Carbon nanotubes as functional excipients for nanomedicines: I. Pharmaceutical properties Nanomed Nanotechnol Biol Med 4 3 173 182 1:CAS:528:DC%2BC3cXmtVCmsw%3D%3D
172. M Foldvari M Bagonluri 2008 Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues Nanomed Nanotechnol Biol Med 4 3 183 200 1:CAS:528:DC%2BC3cXmtVCmsA%3D%3D
173. H Hong T Gao WB Cai 2009 Molecular imaging with single-walled carbon nanotubes Nano Today 4 3 252 261 1:CAS:528:DC%2BC3cXltFGms7Y%3D
174. M Pramanik LV Wang 2009 Thermoacoustic and photoacoustic sensing of temperature J Biomed Opt 14 5 054024
175. MJ O'Connell SM Bachilo CB Huffman VC Moore MS Strano EH Haroz KL Rialon PJ Boul WH Noon C Kittrell JP Ma RH Hauge RB Weisman RE Smalley 2002 Band gap fluorescence from individual single-walled carbon nanotubes Science 297 5581 593 596
176. S Berciaud L Cognet P Poulin RB Weisman B Lounis 2007 Absorption spectroscopy of individual single-walled carbon nanotubes Nano Lett 7 5 1203 1207 1:CAS:528:DC%2BD2sXjsVahtLs%3D
177. A De La Zerda C Zavaleta S Keren S Vaithilingam S Bodapati Z Liu J Levi BR Smith TJ Ma O Oralkan Z Cheng XY Chen HJ Dai BT Khuri-Yakub SS Gambhir 2008 Carbon nanotubes as photoacoustic molecular imaging agents in living mice Nat Nanotechnol 3 9 557 562
178. LZ Xiang Y Yuan D Xing ZM Ou SH Yang FF Zhou 2009 Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor J Biomed Opt 14 2 021008
179. M Pramanik KH Song M Swierczewska D Green B Sitharaman LHV Wang 2009 In vivo carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node Phys Med Biol 54 11 3291 3301
180. JW Kim EI Galanzha EV Shashkov HM Moon VP Zharov 2009 Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents Nat Nanotechnol 4 10 688 694 1:CAS:528:DC%2BD1MXht1aqsLvJ
181. EI Galanzha EV Shashkov T Kelly JW Kim LL Yang VP Zharov 2009 In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells Nat Nanotechnol 4 12 855 860 1:CAS:528:DC%2BD1MXhsFagsrjK
182. A de la Zerda ZA Liu S Bodapati R Teed S Vaithilingam BT Khuri-Yakub XY Chen HJ Dai SS Gambhir 2010 Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice Nano Lett 10 6 2168 2172
183. P Sharma S Brown G Walter S Santra B Moudgil 2006 Nanoparticles for bioimaging Adv Colloid Interface Sci 123 471 485
184. G Ku LHV Wang 2005 Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent Opt Lett 30 5 507 509
185. T Desmettre JM Devoisselle S Mordon 2000 Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography Surv Ophthalmol 45 1 15 27 1:STN:280:DC%2BD3cvktVyhsQ%3D%3D
186. S Mordon JM Devoisselle S Soulie-Begu T Desmettre 1998 Indocyanine green: physicochemical factors affecting its fluorescence in vivo Microvasc Res 55 2 146 152 1:CAS:528:DyaK1cXisFOqsrc%3D
187. B Zhang B Yan 2010 Analytical strategies for characterizing the surface chemistry of nanoparticles Anal Bioanal Chem 396 973 982 1:CAS:528: DC%2BD1MXpt1Ogu70%3D
188. DR Boverhof RM David 2010 Nanomaterial characterization: considerations and needs for hazard assessment and safety evaluation Anal Bioanal Chem 396 953 961 1:CAS:528:DC%2BD1MXhtFaqtL7E
189. B Fadeel AE Garcia-Bennett 2010 Better safe than sorry: understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications Adv Drug Delivery Rev 62 362 374 1:CAS:528:DC%2BC3cXit1OntL8%3D
190. KW Powers M Palazuelos BM Moudgil SM Roberts 2007 Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies Nanotoxicology 1 1 42 51 1:CAS:528:DC%2BD2sXms1Krt78%3D
191. KW Powers SC Brown VB Krishna SC Wasdo BM Moudgil SM Roberts 2006 Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation Toxicol Sci 90 2 296 303 1:CAS:528:DC%2BD28Xit1Ons7o%3D
192. G Oberdörster E Oberdörster J Oberdörster 2007 Concepts of nanoparticle dose metric and response metric Environ Health Perspect 115 A290
193. G Oberdörster J Ferin BE Lehnert 1994 Correlation between particle size, in vivo particle persistence, and lung injury Environ Health Perspect 102 173 179
194. G Oberdörster V Stone K Donaldson 2007 Toxicology of nanoparticles: a historical perspective Nanotoxicology 1 2 25
195. V Stone H Johnston RPF Schins 2009 Development of in vitro systems for nanotoxicology: methodological considerations Crit Rev Toxicol 39 7 613 626 1:CAS:528:DC%2BD1MXptlOlurY%3D
196. SE McNeil 2009 Nanoparticle therapeutics: a personal perspective Wiley Interdiscip Rev: Nanomed Nanobiotechnol 1 264 271 1:CAS:528:DC%2BD1MXotlalsbw%3D
197. L Wang MB O'Donoghue W Tan 2006 Nanoparticles for multiplex diagnostics and imaging Nanomedicine 1 4 413 426 1:CAS:528:DC%2BD2sXhsV2htb4%3D
198. M Lewin N Carlesso CH Tung XW Tang D Cory DT Scadden R Weissleder 2000 Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells Nat Biotechnol 18 4 410 414 1:CAS:528: DC%2BD3cXis1Gmt7s%3D
199. L Jiancheng L Zhenhua A He 2003 Research on refractive index distribution in biological tissues Proc SPIE 4876 103 108
200. Sharma P, Singh A, Brown SC, Bengtsson N, Walter GA, Grobmyer SR, Iwakuma N, Santra S, Scott EW, Moudgil BM (2010) Multimodal nanoparticulate bioimaging contrast agents. In: Cancer nanotechnology: Methods and protocols, vol 624. Methods in molecular biology. Springer, Secaucus, NJ, pp 67-81
201. J Kim Y Piao T Hyeon 2009 Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy Chem Soc Rev 38 2 372 390 1:CAS:528:DC%2BD1MXksVSntLo%3D
202. A Louie 2010 Multimodality imaging probes: design and challenges Chem Rev 110 5 3146 3195 1:CAS:528:DC%2BC3cXjtFOqsr4%3D
203. LE Jennings NJ Long 2009 'two is better than one'-probes for dual-modality molecular imaging Chem Commun 24 3511 3524
204. C Catana YB Wu MS Judenhofer JY Qi BJ Pichler SR Cherry 2006 Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner J Nucl Med 47 12 1968 1976
205. SR Cherry 2006 The 2006 Henry N. Wagner lecture: of mice and men (and positrons) - advances in PET imaging technology J Nucl Med 47 11 1735 1745 1:CAS:528:DC%2BD28Xht1Gru7zE
206. SR Cherry 2001 Fundamentals of positron emission tomography and applications in preclinical drug development J Clin Pharm 41 5 482 491 1:CAS:528:DC%2BD3MXjvVaksbw%3D
207. HY Lee Z Li K Chen AR Hsu CJ Xu J Xie SH Sun XY Chen 2008 PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles J Nucl Med 49 8 1371 1379 1:CAS:528:DC%2BD1cXhtVCqs7rO
208. TD Tran SD Caruthers M Hughes JN Marsh T Cyrus PM Winter AM Neubauer SA Wickline GM Lanza 2007 Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics Int J Nanomed 2 4 515 526 1:CAS:528:DC%2BD1cXhtFKrsbc%3D
209. 18F labeled nanoparticles for in vivo PET-CT imaging Bioconjug Chem 20 2 397 401 1:CAS:528:DC%2BD1MXksVyquw%3D%3D
210. DW Hwang HY Ko S-K Kim D Kim DS Lee S Kim 2009 Development of a quadruple imaging modality by using nanoparticles Chemistry 15 9387 9393 1:CAS:528:DC%2BD1MXhtFGlu7bN
211. AM Gobin MH Lee NJ Halas WD James RA Drezek JL West 2007 Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy Nano Lett 7 7 1929 1934 1:CAS:528:DC%2BD2sXmtVyht7c%3D
212. SE Skrabalak J Chen L Au X Lu X Li Y Xia 2007 Gold nanocages for biomedical applications Adv Mater 19 20 3177 3184 1:CAS:528:DC%2BD2sXht12jt7vN
213. NWS Kam M O'Connell JA Wisdom HJ Dai 2005 Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction Proc Natl Acad Sci USA 102 33 11600 11605 1:CAS:528:DC%2BD2MXpsFGgsbs%3D
214. JR McCarthy FA Jaffer R Weissleder 2006 A macrophage-targeted theranostic nanoparticle for biomedical applications Small 2 8-9 983 987 1:CAS:528:DC%2BD28XosVehu7g%3D
215. J Lu M Liong JI Zink F Tamanoi 2007 Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs Small 3 8 1341 1346 1:CAS:528:DC%2BD2sXpt1aqtLg%3D
216. PP Adiseshaiah JB Hall SE McNeil 2009 Nanomaterial standards for efficacy and toxicity assessment Wiley Interdiscip Rev: Nanomed Nanobiotechnol 2 99 112
217. Cancer trends progress report (2009-2010) National Cancer Institute, http://progressreport.cancer.gov/doc-detail.asp?pid=1&did=2007&chid= 75&coid=726&mid=. Accessed 10 Aug 2010
218. NCI funded research portfolio (2009) National Cancer Institute, http://fundedresearch.cancer.gov/search/funded;jsessionid= 107562A56E42858129D2785D47CEDE77?action=full&fy=PUB2009&type=site. Accessed 10 Aug 2010
219. Estimates of funding for various research, condition, and disease categories (RCDC) (2010) National Institutes of Health, http://report.nih.gov/ rcdc/categories/. Accessed 10 Aug 2010
220. SL Chen FM Hoehne AE Giuliano 2007 The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis Ann Surg Oncol 14 12 3378 3384
221. DL Morton AJ Cochran JF Thompson R Elashoff R Essner EC Glass N Mozzillo OE Nieweg DF Roses HJ Hoekstra CP Karakousis DS Reintgen BJ Coventry HJ Wang 2005 Sentinel node biopsy for early-stage melanoma - accuracy and morbidity in MSLT-I, an international multicenter trial Ann Surg 242 3 302 313
222. CP Adams VV Brantner 2006 Estimating the cost of new drug development: is it really 802 million? Health Aff 25 2 420 428
223. R Bawa 2008 Nanoparticle-based therapeutics in humans: a survey Nanotechnol Law Bus 5 2 135 155
224. Nanotechnology task force (2006) U.S. Food and Drug Administration, http://www.fda.gov/ScienceResearch/SpecialTopics/Nanotechnology/default.htm. Accessed 10 Aug 2010
225. Sosnovik D, Weissleder R (2005) Magnetic resonance and fluorescence based molecular imaging technologies. In: Rudin M (ed) Progress in drug research, vol 62. Progress in drug research. Birkhauser, Switzerland, pp 83-115
226. M Baker 2010 The whole picture Nature 463 977 980 1:CAS:528: DC%2BC3cXitFemtLw%3D
227. H Kobayashi Y Hama Y Koyama T Barrett CAS Regino Y Urano PL Choyke 2007 Simultaneous multicolor imaging of five different lymphatic basins using quantum dots Nano Lett 7 6 1711 1716 1:CAS:528:DC%2BD2sXls1Oru7s%3D
228. Y-w Jun Y-M Huh C J-s J-H Lee H-T Song YS KimKim K-S Kim J-S Shin J-S Suh J Cheon 2005 Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging J Am Chem Soc 127 16 5732 5733 1:CAS:528:DC%2BD2MXivVert7o%3D
229. Y-w Jun JH Lee J Cheon 2008 Chemical design of nanoparticle probes for high-performance magnetic resonance imaging Angew Chem Int Ed 47 28 5122 5135 1:CAS:528:DC%2BD1cXos1Gkuro%3D