Leucine acutely reverses burn-induced alterations in translation initiation in heart

Shock

Volumn 22, Issue 4, 2004, Pages 326-332

  Lang, Charles H ^a   Deshpande, Nobuko ^a   Frost, Robert A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

4E BP1; elF4E; elF4G; Heart; mTOR; S6; S6K1; Thermal injury

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4G; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; REPRESSOR PROTEIN; RIBOSOMAL PROTEIN S6K1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SURFACE; BURN; CONTROLLED STUDY; DRUG MECHANISM; FEEDING; HEART DISEASE; HEART MUSCLE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; RAT; RNA TRANSLATION; SCALD; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; THERMAL INJURY; TRANSLATION INITIATION; TRANSLATION REGULATION;

ADMINISTRATION, ORAL; ANIMALS; BURNS; CARRIER PROTEINS; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEUCINE; MALE; MYOCARDIUM; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

EID: 7944236989     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000136096.03931.ed     Document Type: Article

References (33)

1. Ramzy PI, Barret JP, Herndon DN: Thermal injury. Crit Care Clin 15:333-352, 1999.
2. Mass DL, White J, Horton JW: IL-1 beta and 1L-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma. Shock 18:360-366, 2002.
3. Maass DL, Hybki DP, White J, Horton JW: The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution to burn-related cardiac contractile dysfunction. Shock 17:293-299, 2002.
4. Horton JW, White DJ: Cardiac responses to burn injury in young and adult guinea pigs. Shock 12:280-287, 1999.
5. Horton JW, Lin C, Maass D: Burn trauma and tumor necrosis factor alpha alter calcium handling by cardiomyocytes. Shock 10:270-277, 1998.
6. Huang Y-S, Yang Z-C, Yan B-G, Yan J-M, Chen F-M, Crowther RS, Li A: Pathogenesis of early cardiac myocyte damage after severe burn. J Trauma 46:428-432, 1999.
7. Lang CH, Frost RA, Vary TC: Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation. Am J Physiol Regul Integr Comp Physiol 286:R740-R750, 2004.
8. Russo LA, Morgan HE: Control of protein synthesis and ribosome formation in rat heart. Diabetes Metab Rev 5:31-47, 1989.
9. Lang CH, Frost RA, Jefferson LS, Kimball SR, Vary TC: Endotoxin-induced changes in muscle protein synthesis is associated with changes in eIF2B, eIF4E and IGF-I. Am J Physiol Endocrinol Metab 278:E1133-E1143, 2000.
10. Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC: TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab 282:E336-E347, 2002.
11. Shah OJ, Anthony JC, Kimball SR, Jefferson LS: 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am J Physiol Endocrinol Metab 279:E715-E729, 2000.
12. Cooney RN, Kimball SR, Vary TC: Regulation of skeletal muscle protein turnover during sepsis: mechanisms and mediators. Shock 7:1-16, 1997.
13. Pain VM: Initiation of protein synthesis in mammalian cells. Biochem J 235:625-637, 1986.
14. Avruch J, Belham C, Weng Z, Hara K, Yonezawa K: The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog Mol Subcell Biol 26:115-154, 2001.
15. Dufner A, Thomas G: Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 253:100-109, 1999.
16. Jefferson LS, Kimball SR: Amino acid regulation of gene expression. J Nutr 131 (Suppl 9):2460S-2468S, 2486S-2487S, 2001.
17. Lynch CJ: Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr 131:861S-865S, 2001.
18. Chua B, Siehl DL, Morgan HE: Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart. J Biol Chem 254:8358-8362, 1979.
19. Morgan HE, Earl DCN, Broadus A, Wolpert EB, Gieger KE, Jefferson LS: Regulation of protein synthesis in heart muscle. 1. Effect of amino acid levels on protein synthesis. J Biol Chem 246:2152-2162, 1971.
20. Morgan HE, Jefferson LS, Wolpert EB, Rannels DE: Regulation of protein synthesis in heart muscle. II. Effect of amino acid levels and insulin on ribosomal aggregation. J Biol Chem 246:2163-2170, 1971.
21. Li JB, Jefferson LS: Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim Biophys Acta 544:351-359, 1978.
22. Anthony JC, Anthony TG, Layman DK: Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr 129:1102-1106, 1999.
23. Lang CH, Liu X, Nystrom GJ, Frost RA: Acute response of IGF-I and IGF binding proteins induced by thermal injury. Am J Physiol Endocrinol Metab 278:E1087-E1096, 2000.
24. Lang CH, Frost RA, Deshpande N, Kumar V, Jefferson LS, Kimball SR: Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab 285:E1205-E1215, 2003.
25. Morley SJ, Curtis PS, Pain VM: Translation's mystery factor begins to yield its secrets. RNA 3:1085-1104, 1997.
26. Jurasinski C, Gray K, Vary TC: Modulation of skeletal muscle protein synthesis by amino acids and insulin during sepsis. Metabolism 44:1130-1138, 1995.
27. Lang CH, Kumar V, Liu X, Frost RA, Vary TC: IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication. Alcohol Clin Exp Res 27:485-494, 2003.
28. Tuxworth WJ, Wada H, Ishibashi Y, McDermott PJ: Role of load in regulating eIF-4F complex formation in adult feline cardiocytes. Am J Physiol Heart Circ Physiol 277:H1273-H1282, 1999.
29. Saghir AN, Tuxworth WJ, Hagedorn CH, McDermott PJ: Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein synthesis rates. Biochem J 356:557-566, 2001.
30. Hara K, Kazuyoshi K, Weng Q-P, Kozlowski MT, Belha G, Avruch J: Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273:14484-14494, 1998.
31. Bark TH, McNurlan MA, Lang CH, Garlick PJ: Increased protein synthesis after acute IGF-I or insulin infusion is localized to muscle in mice. Am J Physiol Endocrinol Metab 275:E180-E193, 1998.
32. Weng QP, Kozlowski M, Belham C, Zhang A, Comb MJ, Avruch J: Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J Biol Chem 273:16621-16629, 1998.
33. Raught B, Gingras A-C, Gygi SP, Imatake H, Morino S, Gradi A, Aebersold R, Sonenberg N: Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J 19:434-444, 2000.