The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching

International Immunology

Volumn 8, Issue 10, 1996, Pages 1503-1510

  Jabara, Haifa H ^a,b   Geha, Raif S ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD40L; IgE; Isotype switching; Toxic shock syndrome toxin 1

Indexed keywords

B LYMPHOCYTE ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN SUBCLASS; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; SUPERANTIGEN; TOXIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOXIC SHOCK SYNDROME;

EID: 0029838834     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.10.1503     Document Type: Article

References (50)

1. Vercelli, D. and Geha, R. S. 1992. Regulation of isotype switching. Curr. Opin. Immunol. 4:794.
2. Sutton, B. J., and Gould, H. J. 1993. The human IgE network. Nature 366:421.
3. Punonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N. J., Menon, S., Zurawski, G., de Waal Malefyt, R. and de Vries, J. E. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl Acad. Sci. USA 90:3730.
4. Defrance, T., Carayon, P., Billian, G., Guillemot, J.-C., Minty, A., Caput, D. and Ferrara, P. 1994. Interleukin 13 is a B cell stimulating factor. J. Exp. Med. 179:135.
5. Jabara, H. H., Fu, S. M., Geha, R. S. and Vercelli, D. 1990. CD40 and IgE: synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172:1861.
6. Marshall, L. S., Aruffo, A., Ledbetter, J. A. and Noelle, R. J. 1993. The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39. J. Clin. Immunol. 13:165.
7. Thyphronitis, G., Tsokos, G. C., June, C. H., Levine, A. D. and Finkelman, F. D. 1989. IgE Secretion by Epstein-Barr Virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon γ. Proc. Natl Acad. Sci. USA 86:5580.
8. Wu, C. Y., Sarfati, M., Heusser, C., Fournier, S., Rubio-Trujillo, M., Peleman, R. and Delespesse, G. 1991. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes. J. Clin. Invest. 87:870.
9. Jabara, H. H., Ahern, D. J., Vercelli, D. and Geha, R. S. 1991. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J. Immunol. 147:1557.
10. Fanslow, W. C., Andersen, D. M., Grabstein, K. H., Clark, E. A., Cosman, D. and Armitage, R. J. 1992. Soluble forms of CD40 inhibit biologic responses of human B cells. J. Immunol. 149:655.
11. Spriggs, M. K., Armitage, R. J., Strockbine, L., Clifford, K. N., Macduff, B. M., Sato, T. A., Maliszewski, C. R. and Fanslow, W. C. 1992. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 176:1543.
12. Banchereau, J., Bazan, F., Blanchard, D., Briere, F., Galizzi, J. P., van Kooten, C., Liu, Y. J. Roussel, F. and Saeland, S. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
13. Ramesh, N., Fuleihan, R. and Geha, R. S. 1994. Molecular pathology of X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Immunol. Rev. 138:87.
14. Castigli, E., Alt, F., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A. K. and Geha, R. S. 1994. CD40 deficient mice generated by RAG-2 deficient blastocyst complementation. Proc. Natl Acad. Sci. USA 91:12135.
15. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. and Kikutani, H. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
16. Xu, J., Foy, T. M., Laman, J. D., Dunn, J. J., Waldschmidt, T. J., Elsemore, J., Noelle, R. J. and Flavell, R. A. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
17. Chatila, T., and Geha, R. S. 1993. Signal transduction by microbial superantigens via MHC class II molecules. Immunol. Rev. 131:43
18. Kappler, J., Kotzin, B., Herron, L., Gelfand, E. W., Bigler, R. D., Boylston, A., Carrel, S., Posnett, D. N., Choi, Y. and Marrack, P. 1989. Vβ-specific Stimulation of human T cells by staphylococcal toxins, Science 244:811.
19. Mourad, W., Scholl, P., Diez, A., Geha, R. and Chatila, T. 1989. The staphylococcal toxin TSST-1 triggers B cell proliferation and differentiation via MHC unrestricted cognate T/B cell interaction. J. Exp. Med. 170:2011.
20. Tumang, J. R., Cherniack, E. P., Gietl, D. M., Cole, B. C., Russo, C., Crow, M. K. and Friedman, S. M. 1991. T helper cell-dependent, microbial superantigen-induced murine B cell activation: polyclonal and antigen-specific antibody responses. J. Immunol. 147:432.
21. Stohl, W., Elliott, J. E. and Linsley, P. 1994. Human T cel dependent B cell differentiation induced by staphylococcal superantigens. J. Immunol. 153:117.
22. + T cells that induces contact-dependent B cell differentiation (help) J. Exp. Med. 175:1091.
23. Vercelli, D., Jabara, H.H., Arai, K. and Geha, R. S. 1989. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J. Exp. Med. 169:1295.
24. Umetsu, D. T., Yunis, E. J., Matsui, Y., Jabara, H. H. and Geha, R. S. 1985. HLA-DR4 associated alloreactivity of an HLA-DR3 restricted human tetanus toxoid specific T cell clone: Inhibition of both reactivities by an alloantiserum. Eur. J. Immunol. 15:356.
25. Lane, P., Traunecker, A., Hubele, S., Inui, S., Lanzavecchia, A. and Gray. D. 1992. Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J. Immunol. 22:2573.
26. Choi, Y., Lafferty, J. A., Clements, J. R., Todd, J. K., Gelfand, E. W., Kappler, J., Marrack, P. and Kotzin, B. L. 1990. Selective expansion of T cells expressing Vβ2 in toxic shock syndrome. J. Exp. Med. 172:981.
27. + T cells that react with toxic-shock syndrome toxin-1. Eur J. Immunol. 22:2749.
28. Jupin, C., Anderson, S., Damais, C., Alouf, J. E. and Parant, M. 1988. Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and γ interferon. J. Exp. Med. 167:752.
29. + T cells. J. Immunol. 148:2291.
30. Xu, L. and Rothman, P. 1994. IFN-γ represses ε germline transcription and subsequently down-regulates switch recombination to ε. Int. Immunol. 6:515.
31. 2. Proc. Natl Acad. Sci. USA 85:6880.
32. Vercelli, D., Jabara, H. H., Arai, K., Yokota, T. and Geha, R. S. 1989. Endogenous IL-6 plays an obligatory role in IL-4 induced human IgE synthesis. Eur. J. Immunol. 19:1419.
33. Fuleihan, R., Mourad, W., Geha, R. S. and Chatila, T. 1991 Engagement of MHC-class II molecules by the staphylococcal exotoxin TSST-1 delivers a progression signal to mitogen activated B cells. J. Immunol. 146:1661.
34. Fuleihan, R., Spertini, F., Geha, R. S. and Chatila, T. 1992. Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands. J. Immunol. 149:1853.
35. Bartlett, W. C., McCann, J., Shepherd, D. M., Roy, M. and Noelle, R. J. 1990. Cognate interactions between helper T cells and B cells. J. Immunol. 145:3956.
36. Durie, F. H., Foy, T. M., Masters, S. R., Laman, J. D. and Noelle, R. J. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 15:406.
37. Hofer, M. F., Lester, M. R. and Leung, D. Y. M. 1995. Effect of staphylococcal toxic shock syndrome toxin 1 (TSST-1) on IgE synthesis in atopic dermatitis (A.D.). J. Allergy Clin. Immunol. 95:334.
38. Punnonen, J., Malefyt, R. d. W., van Vlasselaer, P., Gauchat, J.-F. and de Vries, J. E. 1993. IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes. J. Immunol. 151:1280.
39. Finkelman, F. D., Svetic, A., Gresser, I., Snapper, C., Holmes, J., Trotta, P. P., Katona, I. M. and Gause, W. C. 1991. Regulation by interferon α of immunoglobulin isotype selection and lymphokine production in mice. J. Exp. Med. 174:1179.
40. Kimata, H., Yoshida, A., Ishioka, C., Lindley, I. and Mikawa, H. 1992. Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. J. Exp. Med. 176:1227.
41. Drynda, A., Konig, B., Binventre, P. F. and Konig, W. 1995. Role of carboxy-terminal site of TSST-1 in eliciting immune responses of human peripheral blood mononuclear cells. Infect. Immun. 63:1095.
42. Jabara, H. H., Loh, R., Ramesh, N., Vercelli, D. and Geha, R. S. 1993. Sequential switching from μ to ε via γ4 in human B cells stimulated with IL-4 and hydrocortisone. J. Immunol. 151:4528.
43. Shapira S., Jabara, H., Thienes, C., Ahern, D., Veecelli, D., Gould, H. and Geha, R. 1991 Deletional switch recombination occurs in IL-4 induced isotype switching to IgE expression in human B cells Proc. Natl Acad. Sci. USA 147:7528
44. Mourad W., Geha, R. S. and Chatila, T. 1990. Engagement of major histocompatibility complex class II molecules induces sustained, LFA-1 dependent cell adhesion. J. Exp. Med. 172:1513.
45. Leung, D. Y. M., Harbeck, R., Bina, P., Reiser, R. F., Yang, E., Norris, D. A., Hanifin, J. M. and Sampson, H. A. 1993. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis: evidence for a new group of allergens. J. Clin. Invest. 92:1374.
46. Leung, D. Y. M. and Geha, R. S. 1986. Immunoregulatory abnormalities in atopic dermatitis. Clin. Rev. Allergy 4:67.
47. Armerding, D., van Reijsen C. F., Hren, A. and Mudd, G. C. 1993. Induction of IgE and IgG1 in human B cell cultures with staphylococcal superantigens; role of helper T cell interactions, resistance to interferon-gamma. Immunobiology 188:259.
48. Jujo, K., Renz, H., Abe, J., Gelfand, E. W. and Leung, D. Y. M. 1992. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J. Allergy Clin. Immunol. 90:323
49. Sager, N., Feldmann, A., Schilling, G., Kreitsch, P. and Neumann, C. 1992. House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin. Immunol. 89:801.
50. + allergen specific T lymphocytes in atopic dermatitis lesional skin. J. Invest. Dermatol. 97:389.