-
1
-
-
0025913487
-
Identification and characterization of protein products of the cot oncogene with serine kinase activity
-
Aoki M, Akiyama T, Miyoshi J, Toyoshima K. (1991). Identification and characterization of protein products of the cot oncogene with serine kinase activity. Oncogene 6: 1515-1519.
-
(1991)
Oncogene
, vol.6
, pp. 1515-1519
-
-
Aoki, M.1
Akiyama, T.2
Miyoshi, J.3
Toyoshima, K.4
-
2
-
-
0038112098
-
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
-
Beinke S, Deka J, Lang V, Belich MP, Walker PA, Howell S et al. (2003). NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol Cell Biol 23: 4739-4752.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4739-4752
-
-
Beinke, S.1
Deka, J.2
Lang, V.3
Belich, M.P.4
Walker, P.A.5
Howell, S.6
-
3
-
-
6344264987
-
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105
-
Beinke S, Robinson MJ, Hugunin M, Ley SC. (2004). Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol 24: 9658-9667.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9658-9667
-
-
Beinke, S.1
Robinson, M.J.2
Hugunin, M.3
Ley, S.C.4
-
4
-
-
0033611544
-
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
-
Belich MP, Salmeró n A, Johnston LH, Ley SC. (1999). TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Nature 397: 363-368.
-
(1999)
Nature
, vol.397
, pp. 363-368
-
-
Belich, M.P.1
Salmerón, A.2
Johnston, L.H.3
Ley, S.C.4
-
5
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M et al. (1993). Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178: 1223-1230.
-
(1993)
J Exp Med
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hubbard, B.R.5
Murphy, M.6
-
6
-
-
12444250688
-
Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo
-
Cataisson C, Pearson AJ, Torgerson S, Nedospasov SA, Yuspa SH. (2005). Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo. J Immunol 174: 1686-1692.
-
(2005)
J Immunol
, vol.174
, pp. 1686-1692
-
-
Cataisson, C.1
Pearson, A.J.2
Torgerson, S.3
Nedospasov, S.A.4
Yuspa, S.H.5
-
7
-
-
0030902506
-
Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation
-
Ceci JD, Patriotis CP, Tsatsanis C, Makris AM, Kovatch R, Swing DA et al. (1997). Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev 11: 688-700.
-
(1997)
Genes Dev
, vol.11
, pp. 688-700
-
-
Ceci, J.D.1
Patriotis, C.P.2
Tsatsanis, C.3
Makris, A.M.4
Kovatch, R.5
Swing, D.A.6
-
9
-
-
0033970230
-
Multiple mitogenactivated protein kinase signaling pathways connect the Cot oncoprotein to the c-jun promoter and to cellular transformation
-
Chiariello M, Marinissen MJ, Gutkind JS. (2000). Multiple mitogenactivated protein kinase signaling pathways connect the Cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol 20: 1747-1758.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1747-1758
-
-
Chiariello, M.1
Marinissen, M.J.2
Gutkind, J.S.3
-
10
-
-
0029898839
-
Amount of interleukin 12 available at the tumor site is critical for tumor regression
-
Colombo MP, Vagliani M, Spreafico F, Parenza M, Chiodoni C, Melani C et al. (1996). Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res. 56: 2531-2534.
-
(1996)
Cancer Res
, vol.56
, pp. 2531-2534
-
-
Colombo, M.P.1
Vagliani, M.2
Spreafico, F.3
Parenza, M.4
Chiodoni, C.5
Melani, C.6
-
11
-
-
0037180757
-
Inflammation and cancer
-
Coussens LM, Werb Z. (2002). Inflammation and cancer. Nature 420: 860-867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
12
-
-
30144443269
-
Paradoxical roles of the immune system during cancer development
-
de Visser KE, Eichten A, Coussens LM. (2006). Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6: 24-37.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 24-37
-
-
De Visser, K.E.1
Eichten, A.2
Coussens, L.M.3
-
13
-
-
0021711179
-
DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
-
DiGiovanni J, Prichett WP, Decina PC, Diamond L. (1984). DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O- tetradecanoylphorbol-13-acetate. Carcinogenesis 5: 1493-1498.
-
(1984)
Carcinogenesis
, vol.5
, pp. 1493-1498
-
-
Digiovanni, J.1
Prichett, W.P.2
Decina, P.C.3
Diamond, L.4
-
14
-
-
17744371331
-
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH et al. (2000). TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103: 1071-1083.
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
Ceci, J.D.2
Tsatsanis, C.3
Kontoyiannis, D.4
Stamatakis, K.5
Lin, J.H.6
-
15
-
-
34547863906
-
The high-risk benign tumor: Evidence from the two-stage skin cancer model and relevance for human cancer
-
Glick A, Ryscavage A, Perez-Lorenzo R, Hennings H, Yuspa S, Darwiche N. (2007). The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer. Mol Carcinog 46: 605-610.
-
(2007)
Mol Carcinog
, vol.46
, pp. 605-610
-
-
Glick, A.1
Ryscavage, A.2
Perez-Lorenzo, R.3
Hennings, H.4
Yuspa, S.5
Darwiche, N.6
-
16
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
Griner EM, Kazanietz MG. (2007). Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281-294.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
17
-
-
33750514341
-
Inhibition of Tpl2 kinase and TNFalpha production with quinoline- 3-carbonitriles for the treatment of rheumatoid arthritis
-
Hu Y, Green N, Gavrin LK, Janz K, Kaila N, Li HQ et al. (2006). Inhibition of Tpl2 kinase and TNFalpha production with quinoline- 3-carbonitriles for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett 16: 6067-6072.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 6067-6072
-
-
Hu, Y.1
Green, N.2
Gavrin, L.K.3
Janz, K.4
Kaila, N.5
Li, H.Q.6
-
18
-
-
0035110896
-
Protein kinase C-epsilon transgenic mice: A unique model for metastatic squamous cell carcinoma
-
Jansen AP, Verwiebe EG, Dreckschmidt NE, Wheeler DL, Oberley TD, Verma AK. (2001). Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res 61: 808-812.
-
(2001)
Cancer Res
, vol.61
, pp. 808-812
-
-
Jansen, A.P.1
Verwiebe, E.G.2
Dreckschmidt, N.E.3
Wheeler, D.L.4
Oberley, T.D.5
Verma, A.K.6
-
19
-
-
67650874081
-
Cancer Statistics 2008
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. (2009). Cancer Statistics 2008. CA Cancer J Clin 59: 225-249.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
20
-
-
0036316344
-
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
-
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A. (2002). Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22: 5962-5974.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5962-5974
-
-
Kane, L.P.1
Mollenauer, M.N.2
Xu, Z.3
Turck, C.W.4
Weiss, A.5
-
21
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression
-
Karin M. (2006). Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
22
-
-
35548950622
-
Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis
-
Kimura YN, Watari K, Fotovati A, Hosoi F, Yasumoto K, Izumi H et al. (2007). Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. Canc Sci 98: 2009-2018.
-
(2007)
Canc Sci
, vol.98
, pp. 2009-2018
-
-
Kimura, Y.N.1
Watari, K.2
Fotovati, A.3
Hosoi, F.4
Yasumoto, K.5
Izumi, H.6
-
23
-
-
43149084824
-
Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice
-
Lichti U, Anders J, Yuspa SH. (2008). Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc 3: 799-810.
-
(2008)
Nat Protoc
, vol.3
, pp. 799-810
-
-
Lichti, U.1
Anders, J.2
Yuspa, S.H.3
-
24
-
-
0032983865
-
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
-
Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N et al. (1999). Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 5: 828-831.
-
(1999)
Nat Med
, vol.5
, pp. 828-831
-
-
Moore, R.J.1
Owens, D.M.2
Stamp, G.3
Arnott, C.4
Burke, F.5
East, N.6
-
25
-
-
33645988531
-
Inflammation in epithelial skin tumours: Old stories and new ideas
-
Mueller MM. (2006). Inflammation in epithelial skin tumours: old stories and new ideas. Eur J Cancer 42: 735-744.
-
(2006)
Eur J Cancer
, vol.42
, pp. 735-744
-
-
Mueller, M.M.1
-
26
-
-
0027447467
-
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation
-
Patriotis C, Makris A, Bear SE, Tsichlis PN. (1993). Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci USA 90: 2251-2255.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2251-2255
-
-
Patriotis, C.1
Makris, A.2
Bear, S.E.3
Tsichlis, P.N.4
-
27
-
-
0027937795
-
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
-
Patriotis C, Makris A, Chernoff J, Tsichlis PN. (1994). Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci USA 91: 9755-9759.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9755-9759
-
-
Patriotis, C.1
Makris, A.2
Chernoff, J.3
Tsichlis, P.N.4
-
28
-
-
0022527161
-
Carcinogen- specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
-
Quintanilla M, Brown K, Ramsden M, Balmain A. (1986). Carcinogen- specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322: 78-80.
-
(1986)
Nature
, vol.322
, pp. 78-80
-
-
Quintanilla, M.1
Brown, K.2
Ramsden, M.3
Balmain, A.4
-
29
-
-
0033571747
-
Transgenic mice overexpressing protein kinase C delta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
-
Reddig PJ, Dreckschmidt NE, Ahrens H, Simsiman R, Tseng CP, Zou J et al. (1999). Transgenic mice overexpressing protein kinase C delta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 59: 5710-5718.
-
(1999)
Cancer Res
, vol.59
, pp. 5710-5718
-
-
Reddig, P.J.1
Dreckschmidt, N.E.2
Ahrens, H.3
Simsiman, R.4
Tseng, C.P.5
Zou, J.6
-
30
-
-
0024326408
-
Two binding sites for Ki67 related to quiescent and cycling cells in human epidermis
-
Rijzewijk JJ, van Erp PE, Bauer FW. (1989). Two binding sites for Ki67 related to quiescent and cycling cells in human epidermis. Acta Derm Venereol 69: 512-515.
-
(1989)
Acta Derm Venereol
, vol.69
, pp. 512-515
-
-
Rijzewijk, J.J.1
Van Erp, P.E.2
Bauer, F.W.3
-
31
-
-
0030059508
-
Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novelMAP kinase kinase kinase
-
Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP, Ley SC. (1996). Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novelMAP kinase kinase kinase. EMBO J 15: 817-826.
-
(1996)
EMBO J
, vol.15
, pp. 817-826
-
-
Salmeron, A.1
Ahmad, T.B.2
Carlile, G.W.3
Pappin, D.4
Narsimhan, R.P.5
Ley, S.C.6
-
32
-
-
70849124961
-
IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene- initiated mouse skin through inhibition of inflammation
-
Sharma SD, Meeran SM, Katiyar N, Tisdale GB, Yusuf N, Xu H et al. (2009). IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene- initiated mouse skin through inhibition of inflammation. Carcinogenesis 30: 1970-1977.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1970-1977
-
-
Sharma, S.D.1
Meeran, S.M.2
Katiyar, N.3
Tisdale, G.B.4
Yusuf, N.5
Xu, H.6
-
33
-
-
0033517331
-
Overexpression of the Tpl-2/Cot oncogene in human breast cancer
-
Sourvinos G, Tsatsanis C, Spandidos DA. (1999). Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Oncogene 18: 4968-4973.
-
(1999)
Oncogene
, vol.18
, pp. 4968-4973
-
-
Sourvinos, G.1
Tsatsanis, C.2
Spandidos, D.A.3
-
34
-
-
9644301015
-
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
-
Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A et al. (2004). A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest 114: 857-866.
-
(2004)
J Clin Invest
, vol.114
, pp. 857-866
-
-
Sugimoto, K.1
Ohata, M.2
Miyoshi, J.3
Ishizaki, H.4
Tsuboi, N.5
Masuda, A.6
-
36
-
-
0027953555
-
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
-
Tahara H, Zeh III HJ, Storkus WJ, Pappo I, Watkins SC, Gubler U et al. (1994). Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res 54: 182-189.
-
(1994)
Cancer Res
, vol.54
, pp. 182-189
-
-
Tahara, H.1
Zeh Iii, H.J.2
Storkus, W.J.3
Pappo, I.4
Watkins, S.C.5
Gubler, U.6
-
37
-
-
30744448978
-
Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus
-
Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN et al. (2006). Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol 176: 1244-1251.
-
(2006)
J Immunol
, vol.176
, pp. 1244-1251
-
-
Tomczak, M.F.1
Gadjeva, M.2
Wang, Y.Y.3
Brown, K.4
Maroulakou, I.5
Tsichlis, P.N.6
-
38
-
-
0032548117
-
Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB
-
Tsatsanis C, Patriotis C, Tsichlis PN. (1998). Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB. Oncogene 17: 2609-2618.
-
(1998)
Oncogene
, vol.17
, pp. 2609-2618
-
-
Tsatsanis, C.1
Patriotis, C.2
Tsichlis, P.N.3
-
39
-
-
0034199806
-
The role of oncogenic kinases in human cancer
-
Tsatsanis C, Spandidos DA. (2000). The role of oncogenic kinases in human cancer. Int J Mol Med 5: 583-590.
-
(2000)
Int J Mol Med
, vol.5
, pp. 583-590
-
-
Tsatsanis, C.1
Spandidos, D.A.2
-
40
-
-
42949137559
-
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
-
Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN et al. (2008). Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci USA 105: 2987-2992.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2987-2992
-
-
Tsatsanis, C.1
Vaporidi, K.2
Zacharioudaki, V.3
Androulidaki, A.4
Sykulev, Y.5
Margioris, A.N.6
-
41
-
-
34547562008
-
Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis
-
Van Acker GJ, Perides G, Weiss ER, Das S, Tsichlis PN, Steer ML. (2007). Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis. J Biol Chem 282: 22140-22149.
-
(2007)
J Biol Chem
, vol.282
, pp. 22140-22149
-
-
Van Acker, G.J.1
Perides, G.2
Weiss, E.R.3
Das, S.4
Tsichlis, P.N.5
Steer, M.L.6
-
42
-
-
0035872212
-
P27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells
-
Velasco-Sampayo A, Alemany S. (2001). p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells. J Immunol 166: 6084-6090.
-
(2001)
J Immunol
, vol.166
, pp. 6084-6090
-
-
Velasco-Sampayo, A.1
Alemany, S.2
-
43
-
-
58149288281
-
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
-
Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y et al. (2008). Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med 205: 2803-2812.
-
(2008)
J Exp Med
, vol.205
, pp. 2803-2812
-
-
Watford, W.T.1
Hissong, B.D.2
Durant, L.R.3
Yamane, H.4
Muul, L.M.5
Kanno, Y.6
-
44
-
-
0032076149
-
The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis
-
Yuspa SH. (1998). The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. J Dermatol Sci 17: 1-7.
-
(1998)
J Dermatol Sci
, vol.17
, pp. 1-7
-
-
Yuspa, S.H.1
|