IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation

Carcinogenesis

Volumn 30, Issue 11, 2009, Pages 1970-1977

  Sharma, Som D ^a   Meeran, Syed M ^a   Katiyar, Nandan ^a   Tisdale, George B ^a   Yusuf, Nabiha ^a,b   Xu, Hui ^a   Elmets, Craig A ^a,b,c   Katiyar, Santosh K ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CYCLIN D1; CYCLINE; CYCLOOXYGENASE 2; DIMETHYLBENZ[A]ANTHRACENE; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CELL INFILTRATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN EDEMA; SKIN INFLAMMATION; SKIN TUMOR; WESTERN BLOTTING;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CYCLIN D1; CYCLOOXYGENASE 2; CYTOKINES; FEMALE; INFLAMMATION; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-6; MICE; MICE, KNOCKOUT; PROLIFERATING CELL NUCLEAR ANTIGEN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70849124961     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp228     Document Type: Article

References (42)

1. Housman,T.S. et al. (2003) Skin cancer is among the most costly of all cancers to treat for the Medicare population. J. Am. Acad. Dermatol., 48, 425-429.
2. DiGiovanni,J. (1992) Multistage carcinogenesis in mouse skin. Pharmacol. Ther., 54, 63-128.
3. Wolf,S.F. et al. (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol., 146, 3074-3081.
4. Colombo,M.P. et al. (1996) Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res., 56, 2531-2534.
5. Brunda,M.J. et al. (1993) Antitumor and antimetastatic activity of interleukin-12 against murine tumors. J. Exp. Med., 178, 1223-1230.
6. Brunda,M.J. (1994) Interleukin-12. J. Leukoc. Biol., 55, 280-288.
7. Zou,J.P. et al. (1995) Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells. Int. Immunol., 7, 1135-1145.
8. Robertson,M.J. et al. (1996) Interleukin-12: Basic biology and potential applications in cancer treatment. Oncologist, 1, 88-97.
9. Nastala,C.L. et al. (1994) Recombinant IL-12 administration induces tumor-regression in association with IFN-γ production. J. Immunol., 153, 1697-1706.
10. Wigginton,J.M. et al. (1996) Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma. J. Natl Cancer Inst., 88, 38-43.
11. Tahara,H. et al. (1994) Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res., 54, 182-189.
12. Mu,J. et al. (1995) Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res., 55, 4404-4408.
13. Halak,B.K. et al. (1999) Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site. Cancer Res., 59 911-917.
14. Meeran,S.M. et al. (2006) Interleukin-12-deficient mice are at greater risk of ultraviolet radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol. Cancer Ther., 5, 825-832.
15. Glick,A.B. et al. (1993) Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl Acad. Sci. USA, 90, 6076-6080.
16. Katiyar,S.K. et al. (1997) Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis, 18, 497-502.
17. Mittal,A. et al. (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24, 1379-1388.
18. O'Connell,J.F. et al. (1986) Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res., 46, 2863-2865.
19. Sharma,S.D. et al. (2007) Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice. Mol. Cancer Ther., 6, 995-1005.
20. Mantena,S.K. et al. (2006) Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis, 27, 1682-1691.
21. Katiyar,S.K. et al. (1999) Prevention of UVB-induced immunosuppression in mice by green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production. Carcinogenesis, 20, 2117-2124.
22. Meeran,S.M. et al. (2007) Interleukin-12-deficiency is permissive for angiogenesis in UV radiation-induced skin tumors. Cancer Res., 67, 3785-3793.
23. Mukhtar,H. et al. (1996) Photocarcinogenesis: Mechanisms, models and human health implications. Photochem. Photobiol., 63, 355-447.
24. Vanderveen,E.E. et al. (1986) Arachidonic acid metabolites in cutaneous carcinomas. Arch. Dermatol., 122, 407-412.
25. Katiyar,S.K. et al. (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen presenting cells and oxidative stress. J. Leukoc. Biol., 69, 719-726.
26. Meeran,S.M. et al. (2008) Interleukin-12-deficiency exacerbates inflammatory responses in UV-irradiated skin and skin tumors. J. Invest. Dermatol., 128, 2716-2727.
27. Langenbach,R. et al. (1999) Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis. Ann. N. Y. Acad. Sci., 889, 52-61.
28. Chapple,K.S. et al. (2000) Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am. J. Pathol., 156, 545-553.
29. Marks,F. et al. (1999) Metabolic targets of cancer chemoprevention: Interruption of tumor development by inhibitors of arachidonic acid metabolism. Recent Results Cancer Res., 151 45-67.
30. Williams,C.S. et al. (1999) The role of cyclooxygenases in inflammation, cancer, and development. Oncogene, 18, 7908-7916.
31. Buckman,S.Y. et al. (1998) COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer. Carcinogenesis, 19, 723-729.
32. Wilgus,T.A. et al. (2003) Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. Mol. Carcinog., 38, 49-58.
33. Pentland,A.P. et al. (1999) Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis, 20 1939-1944.
34. Scott,K.A. et al. (2003) An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors. Mol. Cancer Ther., 2, 445-451.
35. Tron,V.A. et al. (1988) Epidermal interleukin-1 is increased in cutaneous T-cell lymphoma. J. Invest. Dermatol., 90, 378-381.
36. Smith,C.W. et al. (1998) The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC. Clin. Exp. Metastasis, 16, 655-664.
37. Pang,L. et al. (1997) Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. Br. J. Pharmacol., 121, 579-587.
38. Meeran,S.M. et al. (2009) Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J. Invest. Dermatol., 129, 1258-1270.
39. Langrish,C.L. et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med., 201, 233-240.
40. Numasaki,M. et al. (2003) Interleukin-17 promotes angiogenesis and tumor growth. Blood, 101, 2620-2627.
41. Trinchieri,G. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol., 3, 133-146.
42. Jana,M. et al. (2009) IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. Mol. Immunol., 46, 773-783.