FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways

Journal of Cellular Biochemistry

Volumn 112, Issue 2, 2011, Pages 453-462

  Liu, Ju Fang ^a   Fong, Yi Chin ^a,b   Chang, Kai Wei ^a   Kuo, Sheng Chu ^a   Chang, Chih Shiang ^a   Tang, Chih Hsin ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

chondrosarcoma; ER; GRP78; mitochondria; ROS

Indexed keywords

2 (FURANYL) 5 (PYRROLIDINYL) 1 (3,4,5 TRIMETHOXYBENZYL)BENZOIMIDAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CALCIUM ION; CALPAIN; CASPASE 3; CASPASE 9; FURAN DERIVATIVE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PYRROLIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARTILAGE CELL; CHONDROSARCOMA; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CHONDROSARCOMA; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79251606264     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22927     Document Type: Article

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