T lymphocytes from malnourished infants are short-lived and dysfunctional cells

Immunobiology

Volumn 216, Issue 3, 2011, Pages 309-315

  Badr, Gamal ^a,b   Sayed, Douaa ^c   Alhazza, Ibrahim M ^a   Elsayh, Khalid I ^c   Ahmed, Emad A ^b   Alwasel, Saleh H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

^c Assiut University Faculty of Medicine   (Egypt)

Author keywords

Apoptosis; Flow cytometry; Infants; Malnutrition

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; FAS ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN KINASE B; SECONDARY LYMPHOID TISSUE CHEMOKINE; STAT5 PROTEIN; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CELL SURVIVAL; CELL VIABILITY; CHILD; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFANT; LYMPHOCYTE COUNT; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MALE; MALNUTRITION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CHEMOKINE CCL21; CHEMOKINE CXCL12; CHEMOTAXIS, LEUKOCYTE; FEMALE; FLOW CYTOMETRY; HUMANS; INFANT; INFANT NUTRITION DISORDERS; INTERLEUKINS; LYMPHOCYTE COUNT; MALE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CHEMOKINE; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79251594351     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.07.007     Document Type: Article

References (44)

1. Alam D.S. Prevention of low birthweight. Nestle Nutr. Workshop Ser. Pediatr. Program 2009, 63:209-221.
2. Ameho C., Adjei A., Yamauchi K., Harrison E., Kulkarni A., Sato S., et al. Modulation of age-related changes in immune functions of protein-deficient senescence-accelerated mice by dietary nucleoside-nucleotide mixture supplementation. Br. J. Nutr. 1997, 77:795-804.
3. Amesty V., Pereira N., García M., Núñez J., Cayama N., Villadiego N. Niveles séricos de citocinas proinflamatorias en niños con diferentes grados de desnutrición. Bol. Med. Hosp. Infant Mex. 2003, 60:14-21.
4. Barker D.J. Rise and fall of Western diseases. Nature 1989, 338:371-372.
5. Blades M.C, Manzo A., Ingegnoli F., et al. Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J. Immunol. 2002, 168:4308.
6. Broxmeyer H.E., Kohli L., Kim C.H., et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells. J. Leukocyte Biol. 2003, 73:630-638.
7. Cantrell D.A. Regulation and function of serine kinase networks in lymphocytes. Curr. Opin. Immunol. 2003, 15:294-298.
8. Chandra R.K. Nutrition and immunology: from the clinic to cellular biology and back again. Proc. Nutr. Soc. 1999, 58:681-683.
9. Das M., Stiehm E.R., Borut T., Feig S.A. Metabolic correlates of immune dysfunction in malnourished children. Am. J. Clin. Nutr. 1977, 12:1949-1952.
10. de Waal Malefyt R., Yssel H., Roncarolo M., Spits H., de Vries Jan E. Interleukin-10. Curr. Opin. Immunol. 1993, 4:314-320.
11. Day C.L., Kaufmann D.E., Kiepiela P., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354.
12. Doherty J., Golden M., Remick D., Griffin G. Production on interleukin-6 and tumour necrosis factor-alpha in vitro is reduced in whole blood of severely malnourished children. Clin. Sci. 1994, 83:347-351.
13. Dülger H., Arik M., Ramazan M., Tarakcioglu H., Noyan M., Balahoroglu R. Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. Mediators Inflamm. 2002, 11:363-365.
14. El-Hodhod M.A., Nassar M.F., Zaki M.M., Moustafa A. Apoptotic changes in lymphocytes of protein energy malnutrition children. Nutr. Res. 2005, 25:21-29.
15. Fluur C., De Milito A., Fry T.J., et al. Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J. Immunol. 2007, 178:5340-5350.
16. Gomez R., Ramos G.R., Frenk S., Gravioto J., Chavez R., Vazquez J. Mortality in second and third degree malnutrition. J. Trop. Pediatr. 1956, 2:77-83.
17. González-Martínez H., Rodríguez L., Nájera O., Cruz D., Miliar A., et al. Expression of cytokine mRNA in lymphocytes of malnourished children. J. Clin. Immunol. 2008, 28:593-599.
18. Heird W.C. Food Insecurity, Hunger and Undernutrition 2004, 167-173. WB Saunders Company, (Chapter 42). 17th ed. Nelson, R.E. Behrman, R.M. Kliegman, F.B. Jenson (Eds.).
19. Hetts S.W. To die or not to die: an overview of apoptosis and its role in disease. JAMA 1998, 279:300-307.
20. Hotchkiss R.S., Swanson P.E., Knudson C.M., et al. Over expression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J. Immunol. 1999, 162:4148-4156.
21. Islam Z., Moon Y.S., Zhou H.R., et al. Endotoxin potentiation of trichothecene induced lymphocyte apoptosis is mediated by up regulation of glucocorticoids. Toxicol. Appl. Pharmacol. 2002, 180:43-55.
22. Lašt'ovička J., Budinský V., Špíšek R., Bartůňková J. Assessment of lymphocyte proliferation: CFSE kills dividing cells and modulates expression of activation markers. Cell. Immunol. 2009, 256:79-85.
23. Levy D.E., Darnell J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002, 3:651-662.
24. Lofty O., Selenh W., Barbari M. Study of some changes of cellmediated immunity in protein energy malnutrition. J. Egypt Soc. Parasitol. 1998, 28:413-428.
25. Malavé I., Vethercourt M., Chacón R., Quiñones D., Rebrij C., Bolivar G. Production of interleukin-6 in cultures of peripheral blood mononuclear cells from children with primary protein-calorie malnutrition and from eutrophic control. Ann. Nutr. Metab. 1998, 42:266-273.
26. Mebius R.E. Organogenesis of lymphoid tissues. Nat. Rev. Immunol. 2003, 3:292-303.
27. Mengheri E., Nobili F., Crocchioni G., Lewis J.A. Protein starvation impairs the ability of activated lymphocytes to produce interferon gamma. J. Interferon Res. 1992, 12:17-21.
28. Mengshol J.A., Golden-Mason L., Castelblanco N., et al. Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 2009, 58:964-973.
29. Nagata S., Golstein P. The Fas death factor. Science 1995, 267:1449.
30. Nájera O., González C., et al. Flow cytometry study of lymphocyte subsets in malnourished and well nourished children with bacterial infections. Clin. Diagn. Lab. Immunol. 2004, 11:577-580.
31. Nájera O., González C., Toledo G., et al. Early activation of T, B and NK lymphocytes in infected malnourished and infected well-nourished children. J. Nutr. Immunol. 2001, 5:85-97.
32. Nathan C., Sporn M. Cytokines in context. J. Cell Biol. 1991, 113:981-986.
33. Nicholson J.F., Pesce M.A. Reference ranges for laboratory tests and procedures. Textbook of Pediatrics 2004, 2396-2427. WB Saunders Company. 17th ed. Nelson (Ed.).
34. Park J.H., Yu Q., Erman B., et al. Suppression of IL7R alpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004, 21:289-302.
35. Rodríguez L., González C., Flores L., Graniel J., Ortiz R. Assessment by flow cytometry of cytokine production in malnourished children. Clin. Diagn. Lab. Immunol. 2005, 12:502-507.
36. Sasson S.C., Zaunders J.J., Zanetti G., et al. Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in children with HIV-1 infection. J. Infect. Dis. 2006, 193:505-514.
37. Singer G.G., Abbas A.K. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994, 1:365.
38. Su L. PD-1+ T cells: exhausted and premature?. Blood 2007, 109:4593-4594.
39. Tisdale M. Cancer, anorexia and cachexia. Nutrition 2001, 17:438-442.
40. Van Parijs L., Biuckians, Abbas A.K. Functional roles of Fas and bcl-2 regulated apoptosis of T lymphocytes. J. Immunol. 1998, 160:2065-2071.
41. Vethencourt M., Pirela M., Sousa P., Acuña M., Cordero R., Baute L. Correlacion entre prealbúmina, proteína C reactiva e interleuquina-6 en niños desnutridos con o sin infección clínica. Arch. Lat. Nutr. 1994, 44:93-95.
42. Voll R.E., Herrmann M., Roth E.A., et al. Immunosuppressive effects of apoptotic cells. Nature 1997, 390:350-351.
43. von Freeden-Jeffry U., Vieira P., Lucian L.A., et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 1995, 181:1519-1526.
44. Zuniga F., Acosta Rodrigues E., Montes C., Gruppi A. Lymphocyte apoptosis associated to infections. Medicina 2002, 62:189-196.