Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids

Toxicology and Applied Pharmacology

Volumn 180, Issue 1, 2002, Pages 43-55

  Islam, Zahidul ^a   Moon, Yu Seok ^a,b   Zhou, Hui Ren ^a   King, Louis E ^c   Fraker, Pamela J ^a,c   Pestka, James J ^a,b,d  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Michigan State University   (United States)

^d NONE   (United States)

Author keywords

Apoptosis; Corticosterone; Cyclooxygenase; Deoxynivalenol; IL 6; Lipopolysaccharide; Lymphocytes; Thymus; TNF ; Vomitoxin

Indexed keywords

CYCLOOXYGENASE 2; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ANTAGONIST; INDOMETACIN; INTERLEUKIN 6; MESSENGER RNA; MIFEPRISTONE; MYCOTOXIN; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; ROLIPRAM; TRICHOTHECENE; TUMOR NECROSIS FACTOR ALPHA; VOMITOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW; CONTROLLED STUDY; DNA DEGRADATION; DNA DETERMINATION; DRUG EFFECT; FLOW CYTOMETRY; FOOD POISONING; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; LYMPHOCYTE; LYMPHOID TISSUE; MALE; MOUSE; NONHUMAN; PEYER PATCH; THYMUS; TOXICITY TESTING; TOXIN ANALYSIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0036534738     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9374     Document Type: Article

References (63)

1. The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils
2. TNF-alpha-induced apoptosis in neonatal lymphocytes: TNFRp55 expression and downstream pathways of apoptosis
3. Glucocorticoids in T cell development and function
4. The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by corticosteroids but not tumor necrosis factor
5. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition
6. Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
7. Endotoxemia, encephalopathy, and mortality in cirrhotic patients
8. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess
9. Murine lymphocyte proliferation impaired by substituted neosolaniols and calonectrins: Fusarium metabolites associated with trichothecene biosynthesis
10. Immunomodulation by fungal toxins
11. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: A multicenter prospective study in intensive care units: French ICU Group for Severe Sepsis
12. Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclo-phosphamide-induced programmed cell death or apoptosis in human myeloid leukemia cells
13. Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma
14. Environmental and health studies of farm workers in Swedish swine confinement buildings
15. Chronic bronchitis and decreased forced expiratory flow rates in lifetime nonsmoking grain workers
16. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
17. Bacterial endotoxin isolated from a water spray air humidification system as a putative agent of occupation-related lung disease
18. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse
19. Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo
20. Sex steroids induce apoptosis of CD8+CD4+ double-positive thymocytes via TNF-alpha
21. Reproducibility in the quantification of mRNA levels by RT-PCR-ELISA and RT competitive-PCR-ELISA
22. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides
23. T-2 toxin induces thymic apoptosis in vivo in mice
24. Endotoxin and bacteria in portal blood
25. Role of tumor necrosis factor-alpha and glucocorticoid on lipopolysaccharide (LPS)-induced apoptosis of thymocytes
26. The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells
27. Impaired immune and acute-phase responses in interleukin-6-deficient mice
28. Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation
29. Induction of apoptosis in thymocytes by prostaglandin E2 in vivo
30. Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry
31. Microbial growth and accumulation in industrial metal-working fluids
32. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
33. In vivo induction of apoptosis in murine lymphocytes by bacterial lipopolysaccharides
34. Bacteriological and endotoxin studies in cases of ulcerative colitis submitted to surgery
35. The role of bacteria endotoxins in occupational diseases caused by inhaling vegetable dusts
36. Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells
37. Endotoxin activity of house dust extracts
38. TNF and Fas-induced apoptosis during negative selection in thymic nurse cells
39. Mice deficient for the 55 Kd tumor necrosis factor receptor are resistant to endotoxic shock yet succumb to L. monocytogenes infection
40. Quantitative relationships between the suppression of selected immunological parameters and the area under the corticosterone concentration vs time curve in B6C3F1 mice subjected to exogenous corticosterone or to restraint stress
41. DNA binding of the glucocorticoid receptor is not essential for survival
42. Quantitative RT-PCR for measuring gene expression
43. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
44. Toxicology of deoxynivalenol (vomitoxin)
45. Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse
46. The role of intestinal bacteria in the development of dietary cirrhosis in rats
47. Effects of PGE2 upon differentiation and programmed cell death of suspension cultured CD4-CD8- thymocytes
48. Molecular mechanisms of endotoxin activity
49. Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation
50. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes
51. Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice
52. Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin
53. Trichothecenes in food
54. Clinical significance of translocation
55. The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta
56. Current understanding of sepsis
57. Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies
58. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: Relationship to ERK, p38 MAPK, and SAPK/JNK activation
59. Regulation of Bifidobacterium bifidum surface molecules on apoptosis of murine thymocytes induced by LPS in vivo
60. In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide
61. Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs
62. Amplified proinflammatory cytokine expression and toxicity in mice co-exposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol)
63. Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): Differential toxin-induced hyporesponsiveness and recovery