메뉴 건너뛰기




Volumn 140, Issue 2, 2011, Pages 380-385.e2

GI GEMs: Genetically engineered mouse models of gastrointestinal disease

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BETA GLOBIN; CRE RECOMBINASE; CYCLIN D1; CYTOCHROME P450; ESTROGEN RECEPTOR; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMAD3 PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

EID: 79251590752     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.12.013     Document Type: Article
Times cited : (7)

References (93)
  • 1
    • 0036234199 scopus 로고    scopus 로고
    • Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
    • M.D. Bates, C.R. Erwin, and L.P. Sanford Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis Gastroenterology 122 2002 1467 1482
    • (2002) Gastroenterology , vol.122 , pp. 1467-1482
    • Bates, M.D.1    Erwin, C.R.2    Sanford, L.P.3
  • 2
    • 0036549015 scopus 로고    scopus 로고
    • Conditional mouse models of sporadic cancer
    • J. Jonkers, and A. Berns Conditional mouse models of sporadic cancer Nat Rev Cancer 2 2002 251 265
    • (2002) Nat Rev Cancer , vol.2 , pp. 251-265
    • Jonkers, J.1    Berns, A.2
  • 3
    • 0037169361 scopus 로고    scopus 로고
    • Cancer modeling in the modern era: Progress and challenges
    • T. Van Dyke, and T. Jacks Cancer modeling in the modern era: progress and challenges Cell 108 2002 135 144
    • (2002) Cell , vol.108 , pp. 135-144
    • Van Dyke, T.1    Jacks, T.2
  • 4
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • K.K. Frese, and D.A. Tuveson Maximizing mouse cancer models Nat Rev Cancer 7 2007 654 658
    • (2007) Nat Rev Cancer , vol.7 , pp. 654-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 5
    • 77952668256 scopus 로고    scopus 로고
    • Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models
    • A.M. Westbrook, A. Szakmary, and R.H. Schiestl Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models Mutat Res 705 2010 40 59
    • (2010) Mutat Res , vol.705 , pp. 40-59
    • Westbrook, A.M.1    Szakmary, A.2    Schiestl, R.H.3
  • 6
    • 0242568295 scopus 로고
    • Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus
    • R. Jaenisch Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus Proc Natl Acad Sci U S A 73 1976 1260 1264
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 1260-1264
    • Jaenisch, R.1
  • 7
    • 2642522640 scopus 로고
    • Genetic transformation of mouse embryos by microinjection of purified DNA
    • J.W. Gordon, G.A. Scangos, and D.J. Plotkin Genetic transformation of mouse embryos by microinjection of purified DNA Proc Natl Acad Sci U S A 77 1980 7380 7384
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 7380-7384
    • Gordon, J.W.1    Scangos, G.A.2    Plotkin, D.J.3
  • 8
    • 0000051454 scopus 로고
    • Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring
    • T.E. Wagner, P.C. Hoppe, and J.D. Jollick Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring Proc Natl Acad Sci U S A 78 1981 6376 6380
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6376-6380
    • Wagner, T.E.1    Hoppe, P.C.2    Jollick, J.D.3
  • 9
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human beta- globin gene in transgenic mice
    • F. Grosveld, G.B. van Assendelft, and D.R. Greaves Position-independent, high-level expression of the human beta- globin gene in transgenic mice Cell 51 1987 975 985
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1    Van Assendelft, G.B.2    Greaves, D.R.3
  • 10
    • 0024283304 scopus 로고
    • Transgenic animals
    • R. Jaenisch Transgenic animals Science 240 1988 1468 1474
    • (1988) Science , vol.240 , pp. 1468-1474
    • Jaenisch, R.1
  • 11
    • 0024796824 scopus 로고
    • Transgenic mice as probes into complex systems
    • D. Hanahan Transgenic mice as probes into complex systems Science 246 1989 1265 1275
    • (1989) Science , vol.246 , pp. 1265-1275
    • Hanahan, D.1
  • 12
    • 0015379899 scopus 로고
    • The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratoma cells
    • M.J. Evans The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratoma cells J Embryol Exp Morphol 28 1972 163 176
    • (1972) J Embryol Exp Morphol , vol.28 , pp. 163-176
    • Evans, M.J.1
  • 13
    • 0000727065 scopus 로고
    • Spontaneous testicular teratomas in an inbred strain of mice
    • L.C. Stevens, and C.C. Little Spontaneous testicular teratomas in an inbred strain of mice Proc Natl Acad Sci U S A 40 1954 1080 1087
    • (1954) Proc Natl Acad Sci U S A , vol.40 , pp. 1080-1087
    • Stevens, L.C.1    Little, C.C.2
  • 14
    • 0004531474 scopus 로고
    • Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse
    • L.C. Stevens Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse Dev Biol 2 1960 285 297
    • (1960) Dev Biol , vol.2 , pp. 285-297
    • Stevens, L.C.1
  • 15
    • 0016174481 scopus 로고
    • The effect of cells transferred into the mouse blastocyst on subsequent development
    • R.L. Brinster The effect of cells transferred into the mouse blastocyst on subsequent development J Exp Med 140 1974 1049 1056
    • (1974) J Exp Med , vol.140 , pp. 1049-1056
    • Brinster, R.L.1
  • 16
    • 0016801524 scopus 로고
    • Fate of teratocarcinoma cells injected into early mouse embryos
    • V.E. Papaioannou, M.W. McBurney, and R.L. Gardner Fate of teratocarcinoma cells injected into early mouse embryos Nature 258 1975 70 73
    • (1975) Nature , vol.258 , pp. 70-73
    • Papaioannou, V.E.1    McBurney, M.W.2    Gardner, R.L.3
  • 17
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 18
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • G.R. Martin Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc Natl Acad Sci U S A 78 1981 7634 7638
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 19
    • 0021358883 scopus 로고
    • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
    • A. Bradley, M. Evans, and M.H. Kaufman Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines Nature 309 1984 255 256
    • (1984) Nature , vol.309 , pp. 255-256
    • Bradley, A.1    Evans, M.2    Kaufman, M.H.3
  • 20
    • 0022461705 scopus 로고
    • Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
    • E. Robertson, A. Bradley, and M. Kuehn Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector Nature 323 1986 445 448
    • (1986) Nature , vol.323 , pp. 445-448
    • Robertson, E.1    Bradley, A.2    Kuehn, M.3
  • 21
    • 0001256353 scopus 로고
    • Transgenesis by means of blastocyst-derived embryonic stem cell lines
    • A. Gossler, T. Doetschman, and R. Korn Transgenesis by means of blastocyst-derived embryonic stem cell lines Proc Natl Acad Sci U S A 83 1986 9065 9069
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 9065-9069
    • Gossler, A.1    Doetschman, T.2    Korn, R.3
  • 22
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • O. Smithies, R.G. Gregg, and S.S. Boggs Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination Nature 317 1985 230 234
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3
  • 23
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • K.R. Thomas, and M.R. Capecchi Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells Cell 51 1987 503 512
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 24
    • 0023630807 scopus 로고
    • Targeted correction of a mutant HPRT gene in mouse embryonic stem cells
    • T. Doetschman, R.G. Gregg, and N. Maeda Targeted correction of a mutant HPRT gene in mouse embryonic stem cells Nature 330 1987 576 578
    • (1987) Nature , vol.330 , pp. 576-578
    • Doetschman, T.1    Gregg, R.G.2    Maeda, N.3
  • 25
    • 0024494423 scopus 로고
    • Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells
    • S. Thompson, A.R. Clarke, and A.M. Pow Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells Cell 56 1989 313 321
    • (1989) Cell , vol.56 , pp. 313-321
    • Thompson, S.1    Clarke, A.R.2    Pow, A.M.3
  • 26
    • 0024332217 scopus 로고
    • Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells
    • B.H. Koller, L.J. Hagemann, and T. Doetschman Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells Proc Natl Acad Sci U S A 86 1989 8927 8931
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8927-8931
    • Koller, B.H.1    Hagemann, L.J.2    Doetschman, T.3
  • 27
    • 0025681348 scopus 로고
    • Gene targeting in murine embryonic stem cells: Introduction of specific alterations into the mammalian genome
    • S.L. Mansour Gene targeting in murine embryonic stem cells: introduction of specific alterations into the mammalian genome Genet Anal Tech Appl 7 1990 219 227
    • (1990) Genet Anal Tech Appl , vol.7 , pp. 219-227
    • Mansour, S.L.1
  • 28
    • 0026689409 scopus 로고
    • Altering genes in animals by gene targeting
    • B.H. Koller, and O. Smithies Altering genes in animals by gene targeting Annu Rev Immunol 10 1992 705 730
    • (1992) Annu Rev Immunol , vol.10 , pp. 705-730
    • Koller, B.H.1    Smithies, O.2
  • 29
    • 0026764280 scopus 로고
    • Tissue- and site-specific DNA recombination in transgenic mice
    • P.C. Orban, D. Chui, and J.D. Marth Tissue- and site-specific DNA recombination in transgenic mice Proc Natl Acad Sci U S A 89 1992 6861 6865
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 30
    • 0029807339 scopus 로고    scopus 로고
    • Conditional gene targeting
    • K. Rajewsky, H. Gu, and R. Kuhn Conditional gene targeting J Clin Invest 98 1996 600 603
    • (1996) J Clin Invest , vol.98 , pp. 600-603
    • Rajewsky, K.1    Gu, H.2    Kuhn, R.3
  • 31
    • 0029022369 scopus 로고
    • Transcriptional activation by tetracyclines in mammalian cells
    • M. Gossen, S. Freundlieb, and G. Bender Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766 1769
    • (1995) Science , vol.268 , pp. 1766-1769
    • Gossen, M.1    Freundlieb, S.2    Bender, G.3
  • 32
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • R. Kuhn, F. Schwenk, and M. Aguet Inducible gene targeting in mice Science 269 1995 1427 1429
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3
  • 34
    • 0027485834 scopus 로고
    • Manipulation of transgenes by site-specific recombination: Use of Cre recombinase
    • B. Sauer Manipulation of transgenes by site-specific recombination: use of Cre recombinase Methods Enzymol 225 1993 890 900
    • (1993) Methods Enzymol , vol.225 , pp. 890-900
    • Sauer, B.1
  • 35
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • E.L. Jackson, N. Willis, and K. Mercer Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras Genes Dev 15 2001 3243 3248
    • (2001) Genes Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3
  • 36
    • 0037213351 scopus 로고    scopus 로고
    • Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis
    • G. Gu, J.R. Brown, and D.A. Melton Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis Mech Dev 120 2003 35 43
    • (2003) Mech Dev , vol.120 , pp. 35-43
    • Gu, G.1    Brown, J.R.2    Melton, D.A.3
  • 37
    • 2342550641 scopus 로고    scopus 로고
    • Transgenic tagging defining pancreatic pedigrees
    • P.L. Herrera Merino Transgenic tagging defining pancreatic pedigrees Ann N Y Acad Sci 1014 2004 38 49
    • (2004) Ann N y Acad Sci , vol.1014 , pp. 38-49
    • Herrera Merino, P.L.1
  • 38
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • P. Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain Nat Genet 21 1999 70 71
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 39
    • 0033608980 scopus 로고    scopus 로고
    • Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice
    • X. Mao, Y. Fujiwara, and S.H. Orkin Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice Proc Natl Acad Sci U S A 96 1999 5037 5042
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5037-5042
    • Mao, X.1    Fujiwara, Y.2    Orkin, S.H.3
  • 40
    • 0035170536 scopus 로고    scopus 로고
    • Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain
    • X. Mao, Y. Fujiwara, and A. Chapdelaine Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain Blood 97 2001 324 326
    • (2001) Blood , vol.97 , pp. 324-326
    • Mao, X.1    Fujiwara, Y.2    Chapdelaine, A.3
  • 41
    • 0029164598 scopus 로고
    • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
    • D. Metzger, J. Clifford, and H. Chiba Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase Proc Natl Acad Sci U S A 92 1995 6991 6995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6991-6995
    • Metzger, D.1    Clifford, J.2    Chiba, H.3
  • 42
    • 0032481124 scopus 로고    scopus 로고
    • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    • P.S. Danielian, D. Muccino, and D.H. Rowitch Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase Curr Biol 8 1998 1323 1326
    • (1998) Curr Biol , vol.8 , pp. 1323-1326
    • Danielian, P.S.1    Muccino, D.2    Rowitch, D.H.3
  • 43
    • 0025847620 scopus 로고
    • Recombinase-mediated gene activation and site-specific integration in mammalian cells
    • S. O'Gorman, D.T. Fox, and G.M. Wahl Recombinase-mediated gene activation and site-specific integration in mammalian cells Science 251 1991 1351 1355
    • (1991) Science , vol.251 , pp. 1351-1355
    • O'Gorman, S.1    Fox, D.T.2    Wahl, G.M.3
  • 44
    • 0032573147 scopus 로고    scopus 로고
    • Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo
    • K.P. Lam, and K. Rajewsky Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo Proc Natl Acad Sci U S A 95 1998 13171 13175
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13171-13175
    • Lam, K.P.1    Rajewsky, K.2
  • 45
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • L.A. Donehower, M. Harvey, and B.L. Slagle Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature 356 1992 215 221
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 46
    • 33749007676 scopus 로고    scopus 로고
    • Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
    • B. Evers, and J. Jonkers Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects Oncogene 25 2006 5885 5897
    • (2006) Oncogene , vol.25 , pp. 5885-5897
    • Evers, B.1    Jonkers, J.2
  • 47
    • 0030709433 scopus 로고    scopus 로고
    • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
    • W. Edelmann, K. Yang, and A. Umar Mutation in the mismatch repair gene Msh6 causes cancer susceptibility Cell 91 1997 467 477
    • (1997) Cell , vol.91 , pp. 467-477
    • Edelmann, W.1    Yang, K.2    Umar, A.3
  • 48
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 49
    • 33746388298 scopus 로고    scopus 로고
    • Deciphering cancer complexities in genetically engineered mice
    • K. Simin, R. Hill, and Y. Song Deciphering cancer complexities in genetically engineered mice Cold Spring Harb Symp Quant Biol 70 2005 283 290
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 283-290
    • Simin, K.1    Hill, R.2    Song, Y.3
  • 50
    • 0035116072 scopus 로고    scopus 로고
    • Molecular biology of Barrett's adenocarcinoma
    • B.P. Wijnhoven, H.W. Tilanus, and W.N. Dinjens Molecular biology of Barrett's adenocarcinoma Ann Surg 233 2001 322 337
    • (2001) Ann Surg , vol.233 , pp. 322-337
    • Wijnhoven, B.P.1    Tilanus, H.W.2    Dinjens, W.N.3
  • 51
    • 0036091028 scopus 로고    scopus 로고
    • Barrett's esophagus
    • G.W. Falk Barrett's esophagus Gastroenterology 122 2002 1569 1591
    • (2002) Gastroenterology , vol.122 , pp. 1569-1591
    • Falk, G.W.1
  • 52
    • 0031039244 scopus 로고    scopus 로고
    • The incidence of adenocarcinoma in Barrett's esophagus: A prospective study of 170 patients followed 4.8 years
    • D.J. Drewitz, R.E. Sampliner, and H.S. Garewal The incidence of adenocarcinoma in Barrett's esophagus: a prospective study of 170 patients followed 4.8 years Am J Gastroenterol 92 1997 212 215
    • (1997) Am J Gastroenterol , vol.92 , pp. 212-215
    • Drewitz, D.J.1    Sampliner, R.E.2    Garewal, H.S.3
  • 53
    • 0018129795 scopus 로고
    • Nitrosobenzylmethylamine, zinc deficiency and oesophageal cancer
    • L.Y. Fong, and P.M. Newberne Nitrosobenzylmethylamine, zinc deficiency and oesophageal cancer IARC Sci Publ 1978 503 513
    • (1978) IARC Sci Publ , pp. 503-513
    • Fong, L.Y.1    Newberne, P.M.2
  • 54
    • 0030975976 scopus 로고    scopus 로고
    • The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach
    • H. Nakagawa, T.C. Wang, and L. Zukerberg The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach Oncogene 14 1997 1185 1190
    • (1997) Oncogene , vol.14 , pp. 1185-1190
    • Nakagawa, H.1    Wang, T.C.2    Zukerberg, L.3
  • 55
    • 0036736803 scopus 로고    scopus 로고
    • A mouse model of human oral-esophageal cancer
    • O.G. Opitz, H. Harada, and Y. Suliman A mouse model of human oral-esophageal cancer J Clin Invest 110 2002 761 769
    • (2002) J Clin Invest , vol.110 , pp. 761-769
    • Opitz, O.G.1    Harada, H.2    Suliman, Y.3
  • 56
    • 0037226417 scopus 로고    scopus 로고
    • P53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice
    • L.Y. Fong, H. Ishii, and V.T. Nguyen p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice Cancer Res 63 2003 186 195
    • (2003) Cancer Res , vol.63 , pp. 186-195
    • Fong, L.Y.1    Ishii, H.2    Nguyen, V.T.3
  • 57
    • 0042674105 scopus 로고    scopus 로고
    • Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis
    • L.Y. Fong, R. Mancini, and H. Nakagawa Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis Cancer Res 63 2003 4244 4252
    • (2003) Cancer Res , vol.63 , pp. 4244-4252
    • Fong, L.Y.1    Mancini, R.2    Nakagawa, H.3
  • 58
    • 0033134231 scopus 로고    scopus 로고
    • Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux
    • M. Fein, J.H. Peters, and N. Baril Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux J Surg Res 83 1999 48 55
    • (1999) J Surg Res , vol.83 , pp. 48-55
    • Fein, M.1    Peters, J.H.2    Baril, N.3
  • 59
    • 14944339606 scopus 로고    scopus 로고
    • Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice
    • M. Lechpammer, X. Xu, and F.H. Ellis Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice Oncogene 24 2005 1683 1688
    • (2005) Oncogene , vol.24 , pp. 1683-1688
    • Lechpammer, M.1    Xu, X.2    Ellis, F.H.3
  • 60
    • 34250347652 scopus 로고    scopus 로고
    • Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer?: Inadequate evidence in Mongolian gerbils and inbred mice
    • D. Chen, B. Stenstrom, and C.M. Zhao Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice FEMS Immunol Med Microbiol 50 2007 184 189
    • (2007) FEMS Immunol Med Microbiol , vol.50 , pp. 184-189
    • Chen, D.1    Stenstrom, B.2    Zhao, C.M.3
  • 61
    • 0033960131 scopus 로고    scopus 로고
    • Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    • T.C. Wang, C.A. Dangler, and D. Chen Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer Gastroenterology 118 2000 36 47
    • (2000) Gastroenterology , vol.118 , pp. 36-47
    • Wang, T.C.1    Dangler, C.A.2    Chen, D.3
  • 62
    • 70349584124 scopus 로고    scopus 로고
    • Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models
    • H. Oshima, K. Oguma, and Y.C. Du Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models Cancer Sci 100 2009 1779 1785
    • (2009) Cancer Sci , vol.100 , pp. 1779-1785
    • Oshima, H.1    Oguma, K.2    Du, Y.C.3
  • 63
    • 77449146686 scopus 로고    scopus 로고
    • Conditional deletion of IkappaB-kinase-beta accelerates Helicobacterdependent gastric apoptosis, proliferation, and preneoplasia
    • W. Shibata, S. Takaishi, and S. Muthupalani Conditional deletion of IkappaB-kinase-beta accelerates Helicobacterdependent gastric apoptosis, proliferation, and preneoplasia Gastroenterology 138 2010 1022 1034
    • (2010) Gastroenterology , vol.138 , pp. 1022-1034
    • Shibata, W.1    Takaishi, S.2    Muthupalani, S.3
  • 64
    • 54549089856 scopus 로고    scopus 로고
    • Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    • S. Tu, G. Bhagat, and G. Cui Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice Cancer Cell 14 2008 408 419
    • (2008) Cancer Cell , vol.14 , pp. 408-419
    • Tu, S.1    Bhagat, G.2    Cui, G.3
  • 65
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • D. Hanahan Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes Nature 315 1985 115 122
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 66
    • 0038405066 scopus 로고    scopus 로고
    • Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
    • P.J. Grippo, P.S. Nowlin, and M.J. Demeure Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice Cancer Res 63 2003 2016 2019
    • (2003) Cancer Res , vol.63 , pp. 2016-2019
    • Grippo, P.J.1    Nowlin, P.S.2    Demeure, M.J.3
  • 67
    • 0035252589 scopus 로고    scopus 로고
    • A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
    • M. Wagner, F.R. Greten, and C.K. Weber A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease Genes Dev 15 2001 286 293
    • (2001) Genes Dev , vol.15 , pp. 286-293
    • Wagner, M.1    Greten, F.R.2    Weber, C.K.3
  • 68
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • S.R. Hingorani, E.F. Petricoin, and A. Maitra Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437 450
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 69
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • N. Bardeesy, K.H. Cheng, and J.H. Berger Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer Genes Dev 20 2006 3130 3146
    • (2006) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3
  • 70
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • O.J. De La, L.L. Emerson, and J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci U S A 105 2008 18907 18912
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18907-18912
    • De La, O.J.1    Emerson, L.L.2    Goodman, J.L.3
  • 71
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • N. Habbe, G. Shi, and R.A. Meguid Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice Proc Natl Acad Sci U S A 105 2008 18913 18918
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3
  • 72
    • 70350513347 scopus 로고    scopus 로고
    • Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras
    • S.Y. Gidekel Friedlander, G.C. Chu, and E.L. Snyder Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras Cancer Cell 16 2009 379 389
    • (2009) Cancer Cell , vol.16 , pp. 379-389
    • Gidekel Friedlander, S.Y.1    Chu, G.C.2    Snyder, E.L.3
  • 73
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 20 2004 781 810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 74
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • A.R. Moser, H.C. Pitot, and W.F. Dove A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse Science 247 1990 322 324
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 75
    • 0030614675 scopus 로고    scopus 로고
    • Intestinal neoplasia in the ApcMin mouse: Independence from the microbial and natural killer (beige locus) status
    • W.F. Dove, L. Clipson, and K.A. Gould Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status Cancer Res 57 1997 812 814
    • (1997) Cancer Res , vol.57 , pp. 812-814
    • Dove, W.F.1    Clipson, L.2    Gould, K.A.3
  • 76
    • 0037044114 scopus 로고    scopus 로고
    • Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation
    • M. Suzui, M. Okuno, and T. Tanaka Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation Cancer Lett 183 2002 31 41
    • (2002) Cancer Lett , vol.183 , pp. 31-41
    • Suzui, M.1    Okuno, M.2    Tanaka, T.3
  • 77
    • 32044447491 scopus 로고    scopus 로고
    • The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis
    • H.F. Yerushalmi, D.G. Besselsen, and N.A. Ignatenko The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis Mol Carcinog 45 2006 93 105
    • (2006) Mol Carcinog , vol.45 , pp. 93-105
    • Yerushalmi, H.F.1    Besselsen, D.G.2    Ignatenko, N.A.3
  • 78
    • 33749008552 scopus 로고    scopus 로고
    • Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice
    • N.M. Sodir, X. Chen, and R. Park Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice Cancer Res 66 2006 8430 8438
    • (2006) Cancer Res , vol.66 , pp. 8430-8438
    • Sodir, N.M.1    Chen, X.2    Park, R.3
  • 79
    • 60449086469 scopus 로고    scopus 로고
    • Mouse models of colon cancer
    • M.M. Taketo, and W. Edelmann Mouse models of colon cancer Gastroenterology 136 2009 780 798
    • (2009) Gastroenterology , vol.136 , pp. 780-798
    • Taketo, M.M.1    Edelmann, W.2
  • 80
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • S.J. Engle, J.B. Hoying, and G.P. Boivin Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis Cancer Res 59 1999 3379 3386
    • (1999) Cancer Res , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3
  • 81
    • 0037112436 scopus 로고    scopus 로고
    • Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    • S.J. Engle, I. Ormsby, and S. Pawlowski Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice Cancer Res 62 2002 6362 6366
    • (2002) Cancer Res , vol.62 , pp. 6362-6366
    • Engle, S.J.1    Ormsby, I.2    Pawlowski, S.3
  • 82
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Y. Zhu, J.A. Richardson, and L.F. Parada Smad3 mutant mice develop metastatic colorectal cancer Cell 94 1998 703 714
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3
  • 83
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • X. Yang, J.J. Letterio, and R.J. Lechleider Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta EMBO J 18 1999 1280 1291
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3
  • 84
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    • M.B. Datto, J.P. Frederick, and L. Pan Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction Mol Cell Biol 19 1999 2495 2504
    • (1999) Mol Cell Biol , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3
  • 85
    • 31544465904 scopus 로고    scopus 로고
    • Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice
    • L. Maggio-Price, P. Treuting, and W. Zeng Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice Cancer Res 66 2006 828 838
    • (2006) Cancer Res , vol.66 , pp. 828-838
    • Maggio-Price, L.1    Treuting, P.2    Zeng, W.3
  • 86
    • 33750565444 scopus 로고    scopus 로고
    • Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    • N.M. Munoz, M. Upton, and A. Rojas Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation Cancer Res 66 2006 9837 9844
    • (2006) Cancer Res , vol.66 , pp. 9837-9844
    • Munoz, N.M.1    Upton, M.2    Rojas, A.3
  • 87
    • 39749137048 scopus 로고    scopus 로고
    • Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    • S. Kaiser, Y.K. Park, and J.L. Franklin Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer Genome Biol 8 2007 R131
    • (2007) Genome Biol , vol.8 , pp. 131
    • Kaiser, S.1    Park, Y.K.2    Franklin, J.L.3
  • 88
    • 0029047954 scopus 로고
    • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    • M. Oshima, H. Oshima, and K. Kitagawa Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene Proc Natl Acad Sci U S A 92 1995 4482 4486
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4482-4486
    • Oshima, M.1    Oshima, H.2    Kitagawa, K.3
  • 89
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • K. Takaku, M. Oshima, and H. Miyoshi Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes Cell 92 1998 645 656
    • (1998) Cell , vol.92 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3
  • 90
    • 33745578957 scopus 로고    scopus 로고
    • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    • B.G. Kim, C. Li, and W. Qiao Smad4 signalling in T cells is required for suppression of gastrointestinal cancer Nature 441 2006 1015 1019
    • (2006) Nature , vol.441 , pp. 1015-1019
    • Kim, B.G.1    Li, C.2    Qiao, W.3
  • 91
    • 0029061801 scopus 로고
    • Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice
    • U. Rudolph, M.J. Finegold, and S.S. Rich Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice Nat Genet 10 1995 143 150
    • (1995) Nat Genet , vol.10 , pp. 143-150
    • Rudolph, U.1    Finegold, M.J.2    Rich, S.S.3
  • 92
    • 77955525325 scopus 로고    scopus 로고
    • Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis
    • M. Bennecke, L. Kriegl, and M. Bajbouj Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis Cancer Cell 18 2010 135 146
    • (2010) Cancer Cell , vol.18 , pp. 135-146
    • Bennecke, M.1    Kriegl, L.2    Bajbouj, M.3
  • 93
    • 33748988989 scopus 로고    scopus 로고
    • Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
    • O.J. Sansom, V. Meniel, and J.A. Wilkins Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo Proc Natl Acad Sci U S A 103 2006 14122 14127
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14122-14127
    • Sansom, O.J.1    Meniel, V.2    Wilkins, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.