Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Chertov, Oleg ^a   Zhang, Ning ^a   Chen, Xin ^a   Oppenheim, Joost J ^a   Lubkowski, Jacek ^a   McGrath, Connor ^b   Sowder II, Raymond C ^c   Crise, Bruce J ^c   Malyguine, Anatoli ^c   Kutzler, Michele A ^d   Steele, Amber D ^d   Henderson, Earl E ^d   Rogers, Thomas J ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Target Structure Based Drug Discovery Group   (United States)

^c SAIC FREDERICK INC   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CYSTEINE; GLYCOPROTEIN GP 120; TRYPTOPHAN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE; PEPTIDE; PEPTIDE FRAGMENT;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; PEPTIDE SYNTHESIS; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS REPLICATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; SYNTHESIS; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CELLS, CULTURED; CHEMOKINES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HUMANS; MACROPHAGES; PEPTIDE FRAGMENTS; PEPTIDES; RECEPTORS, CXCR4; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 79251587133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014474     Document Type: Article

References (48)

1. Freed EO, Martin MA (1995) The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection. J Biol Chem 270: 23883-23886.
2. Capon DJ, Ward RH (1991) The CD4-gp120 interaction and AIDS pathogenesis. Ann Rev Immunol 9: 649-678.
3. Clayton LK, Sieh M, Pious DA, Reinherz EL (1989) Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature 339: 548-551.
4. Arthos J, Deen KC, Chaikin MA, Fornwald JA, Sathe G, et al. (1989) Identification of the residues in human CD4 critical for the binding of HIV. Cell 57: 469-481.
5. Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, et al. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393: 648-659.
6. Landau NR, Warton M, Littman DR (1988) The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature 334: 159-162.
7. Berger EA, Murphy PM, Farber JM (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Ann Rev Immunol 17: 657-700.
8. Helseth E, Olshevsky U, Gabuzda D, Ardman B, Haseltine W, et al. (1990) Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion. J Virol 64: 6314-6318.
9. Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC (1997) Atomic structure of the ectodomain from HIV-1 gp41. Nature 387: 426-430.
10. Dauber-Osguthorpe P, Roberts VA, Osguthorpe DJ, Wolff J, Genest M, et al. (1988) Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system. Proteins 4: 31-47.
11. Hagler AT, Huler E, Lifson S (1974) Energy functions for peptides and proteins. I. Derivation of a consistent force field including the hydrogen bond from amide crystals. J Am Chem Soc 96: 5319-5327.
12. Hagler AT, Osguthorpe DJ, Dauber-Osguthorpe P, Hempel JC (1985) Dynamics and conformational energetics of a peptide hormone: vasopressin. Science 227: 1309-1315.
13. Howard OM, Shirakawa AK, Turpin JA, Maynard A, Tobin GJ, et al. (1999) Aaturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function. J Biol Chem 274: 16228-16234.
14. Cole SW, Naliboff BD, Kemeny ME, Griswold MP, Fahey JL, et al. (2001) Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity. Proc Natl Acad Sci (USA) 98: 12695-12700.
15. Szabo, I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, et al. (2003) Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. J Leuk Biol 74: 1074-1082.
16. Zhang N, Inan S, Cowan A, Sun R, Wang JM, et al. (2005) A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci (USA) 102: 4536-4541.
17. Korber B (1998) Human retroviruses and AIDS, 1998: A compilation and analysis of nucleic acid and amino acid sequences. Los Alamos NM: Theoretical Biology and Biophysics Group T-10 Los Alamos National Laboratory.
18. Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, et al. (1994) High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. Science 263: 1762-1767.
19. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, et al. (1995) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major IVsuppressive factors produced by CD8+ T cells. Science 270: 1811-1815.
20. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, et al. (1996) CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 87: 745-756.
21. Hoxie JA, LaBranche CC, Endres MJ, Turner JD, Berson JF, et al. (1998) CD4- independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2. J Reproductive Immunol 41: 197-211.
22. McKnight A, Wilkinson D, Simmons G, Talbot S, Picard L, et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J Virol 71: 1692-1696.
23. Schols D, Struyf S, Van Damme J, Este JA, Henson G, et al. (1997) Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med 186: 1383-1388.
24. Hatse S, Princen K, Gerlach LO, Bridger G, Henson G, et al. (2001) Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Mol Pharmacol 60: 164-173.
25. Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, et al. (1999) Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. J Virol 73: 2752-2761.
26. Wu L, LaRosa G, Kassam N, Gordon CJ, Heath H, et al. (1997) Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J Exp Med 186: 1373-1381.
27. Olson WC, Rabut GE, Nagashima KA, Tran DN, Anselma DJ, et al. (1999) Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J Virol 73: 4145-4155.
28. Wu L, Gerard NP, Wyatt R, Choe H, Parolin C, et al. (1996) CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384: 179-183.
29. Hoffman TL, LaBranche CC, Zhang W, Canziani G, Robinson J, et al. (1999) Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci (USA) 96: 6359-6364.
30. Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, et al. (1997) CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 7: 112-121.
31. Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, et al. (1996) The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokinemediated blockade of infection. Nature Med 2: 1244-1247.
32. Hwang SS, Boyle TJ, Lyerly HK, Cullen BR (1991) Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253: 71-74.
33. Hung CS, Vander HN, Ratner L (1999) Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization. J Virol 73: 8216-8226.
34. Sakaida H, Hori T, Yonezawa A, Sato A, Isaka Y, et al. (1998) T-tropic human immunodeficiency virus type 1 (HIV-1)-derived V3 loop peptides directly bind to CXCR-4 and inhibit T-tropic HIV-1 infection. J Virol 72: 9763-9770.
35. Moulard M, Mabrouk K, Martin I, van RJ, Rochat H, Sabatier JM (1999) V3 loop-derived peptide SPC3 inhibits infection of CD4- and galactosylceramidecells by LAV-2/B. J Peptide Res 53: 647-655.
36. Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, et al. (1998) A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280: 1949-1953.
37. Sharon M, Kessler N, Levy R, Zolla-Pazner S, Gorlach M, et al. (2003) Alternative conformations of HIV-1 V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity. Structure 11: 225-236.
38. Clark-Lewis I, Schumacher C, Baggiolini M, Moser B (1991) Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities. J Biol Chem 266: 23128-23134.
39. Crump MP, Gong JH, Loetscher P, Rajarathnam K, Amara A, et al. (1997) Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J 16: 6996-7007.
40. Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hebert CA (1997) Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5. Biochem 36: 9642-9648.
41. Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, et al. (1999) Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J Biol Chem 274: 16077-16084.
42. Grainger DJ, Reckless J (2003) Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo. Biochem Pharmacol 65: 1027-1034.
43. Gozansky EK, Louis JM, Caffrey M, Clore GM (2005) Mapping the binding of the N-terminal extracellular tail of the CXCR4 receptor to stromal cell-derived factor-1alpha. J Mol Biol 345: 651-658.
44. Farzan M, Choe H, Martin KA, Sun Y, Sidelko M, et al. (1997) HUV-1 entry and macrophage inflammatory protein-1-b-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem 272: 6854-6857.
45. Fantuzzi L, Canini I, Belardelli F, Gessani S (2001) HIV-1 gp120 stimulates the production of b-chemokines in human peripheral blood monocytes through a CD4-independent mechanism. J Immunol 166: 5381-5387.
46. Choe W, Volsky DJ, Potash MJ (2001) Induction of rapid and extensive bchemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype. J Virol 75: 10738-10745.
47. Wetzel MA, Steele AD, Henderson EE, Rogers TJ (2002) The effect of X4 and R5 HIV-1 on C, C-C, and C-X-C chemokines during the early stages of infection in human PBMCs. Virol 292: 6-15.
48. Chertov O, Oppenheim JJ, Chen X, McGrath C, Sowder RC, et al. (2001) Methods and Compositions for Inhibiting HIV-Coreceptor Interactions. US Provisional Patent Application No 60/269,534, PCT/US02/05063.