Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

Nanotechnology

Volumn 22, Issue 4, 2011, Pages

  Gonzalez Mira, E ^a   Egea, M A ^a   Souto, E B ^b,c   Calpena, A C ^a   Garcia M L ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AVERAGE SIZE; CASTOR OIL; CENTRAL COMPOSITE; COMPOSITE DESIGNS; CRITICAL VARIABLES; CRYSTALLINITIES; DRUG CARRIER; ENCAPSULATION EFFICIENCY; FACTORIAL DESIGN; FLURBIPROFEN; HIGH PRESSURE HOMOGENIZATION; IN-VITRO; LIPID MATRIX; LIPID NANOPARTICLES; NANOSTRUCTURED LIPID CARRIERS; NARROW SIZE DISTRIBUTIONS; NEGATIVELY CHARGED SURFACES; OCULAR DELIVERY; OCULAR TISSUE; OPTIMIZATION STUDIES; PHYSICOCHEMICAL CHARACTERISTICS; POLYDISPERSITY INDICES; POSITIVE EFFECTS; STABILITY STUDY; SURFACTANT CONCENTRATIONS; SUSTAINED RELEASE; TOPICAL DELIVERY; TOTAL LIPIDS;

CONCENTRATION (PROCESS); DESIGN; DRUG PRODUCTS; ENCAPSULATION; HOMOGENIZATION METHOD; LIQUIDS; OPTIMIZATION; POLYDISPERSITY; STEARIC ACID; SURFACE ACTIVE AGENTS; VEGETABLE OILS;

EXPERIMENTS;

DRUG CARRIER; EYE DROPS; FLURBIPROFEN; LIPID; NANOMATERIAL; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL; ARTICLE; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECT; DRUG STABILITY; EYE; PARTICLE SIZE; RABBIT; TOPICAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG STABILITY; EYE; FLURBIPROFEN; LIPIDS; NANOSTRUCTURES; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; RABBITS;

EID: 79251585943     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/22/4/045101     Document Type: Article

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