Search for a novel antioxidant antiinflammatory/ analgesic or anti-proliferative drug cucurbitacins hold the ace

Journal of Medicinal Plants Research

Volumn 4, Issue 25, 2010, Pages 2821-2826

  Bernard, Saba Adebowale ^a   Olayinka, Oridupa Ayorinde ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Analgesic; Anti inflammatory; Anti proliferative; Antioxidant; Cucurbitacins

Indexed keywords

23,24 DIHYDROCUCURBITACIN B; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIMITOTIC AGENT; ANTIOXIDANT; CUCURBITACIN; CUCURBITACIN A; CUCURBITACIN B; CUCURBITACIN D; CUCURBITACIN E; CUCURBITACIN GLYCOSIDE; CUCURBITACIN I; CUCURBITACIN Q; CUCURBITACIN R; FREE RADICAL; PLANT MEDICINAL PRODUCT; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TERPENOID; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CUCURBITA ANDREANA; CYTOTOXICITY; DOSE RESPONSE; DRUG DETERMINATION; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LIPID OXIDATION; MITOSIS INHIBITION; NONHUMAN; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SQUASH; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

CAYAPONIA TAYUYA; CUCURBITACEAE; GINKGO BILOBA; MEDICAGO SATIVA; TRITICUM AESTIVUM; VITACEAE;

EID: 79251582525     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Agil A, Miro M, Jimenez J, Aneiros J, Caracuel MD, Garcia-Granados A, Navarro MC (1999). Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium. Planta Med., 65: 673-675.
2. Agrawal SS, Paridhavi M (2007). Introduction to medicinal plants. In Herbal Drug. University Press Hyderabad 500 029 (A.P), India, pp. 1-3.
3. Behle RW (2001). Consumption of residue containing cucurbitacin feeding stimulant and reduced rates of carbaryl insecticide by western corn rootworm (Coleoptera: Chrysomelidae). J. Econ. Entomol. 94(6): 1428-1433.
4. Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (2003). Discovery of JSI-124 (cucurbitacin I), A selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Can. Res., 63: 1270-1279.
5. Boveris AD, Puntarulo S (1998). Free radical scavenging actions of natural antioxidants. Nutr. Res., 18: 1545-1557.
6. Bowman T, Yu H, Sebti S, Dalton W, Jove R (1999). Signal transducers and activators of transcription: Novel targets for anticancer therapeutics. Cancer Control, 6: 427-435.
7. Bowman T, Garcia R, Turkson J, Jove R (2000). STATs in oncogenesis. Saba and Oridupa 2825 Oncogene, 19: 2474-2488.
8. Bromberg J F, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE, Jr (1999). STAT3 as an oncogene. Cell, 98: 295-303.
9. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernandez-Luna JL, Nunez G, Dalton WS, Jove R (1999). Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity, 10: 105-115.
10. Cattel L, Balliano G, Caputo O, Viola F (1981). Biosynthesis of Cucurbitacins in Bryonia dioica Seedlings. Planta Med., 41(4): 328-336.
11. Che CT, Fang XD, Phoebe CH Jr, Kinghorn AD, Farnsworth NR, Yellin B, Hecht SM (1985). High-field 1H-NMR spectral analysis of some cucurbitacins. J. Natl. Prod., 48(3): 429-434.
12. Duncan KL, Duncan MD, Alley MC, Sausville EA (1996). Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells Biochem Pharmacol, 52(10) 1553-1560.
13. Duncan MD, Duncan KL (1997). Cucurbitacin E targets proliferating endothelia. J. Surg. Res., 69: 55-60.
14. Escandell J M B Recio M.C, Manez S, Giner R M, Nicola's M C, Rios J L (2007). Cucurbtiacin R reduces the inflammation and bone damage associated with Adjuvant Arthritis in Lewis rats by suppression of Tumor Necrosis Factor in T lymphocytes and macrophages. J. Pharmacol. Exp. Therapeut., 320: 581-590.
15. Escandell JM, Kaler P, Recio MC, Sasazuki T, Shirasawa S, Augenlicht L, Ríos JL, Klampfer L (2008). Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21. Biochem. Pharmacol., 76(2): 198-207.
16. Esterbauer, H. (1993). Cytotoxicity and genotoxicity of lipid oxidation products, Am. J. Clin. Nutr., 57: 779S-786S.
17. Gill NS, Garg M, Bansal R, Sood S, Muthuraman A, Bali M, Sharma PD (2009). Evaluation of antioxidant and antiulcer potential of Cucumis sativum L. seed extract in rats. Asian J. Clin. Nutr,1: 131-138.
18. Gill N, Bansal R, Garg M, Sood S, Muthuraman A, Bali M (2010). Evaluation of antioxidant, anti-inflammatory and analgesic potential of Citrullus lanatus seed extract in rodent model. Internet J. Nutr. Wellness, 9: 2.
19. Greige-Gerges H, Khalil RA, Mansour EA, Magdalou J, Chahine R, Ouaini N (2007). Cucurbitacins from Ecballium elaterium juice increase the binding of bilirubin and ibuprofen to albumin in human plasma. Chem. Biol. Interact., 169(1): 53-62.
20. Halliwell B, Gutteridge JM (1990). The antioxidants of human extracellular fluids. Arch. Biochem. Biophys., 280: 1-8.
21. Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP (2008). Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk. Res., 32(9): 1366-1373.
22. Jayaprakasam B, Seeram NP, Nair MG (2003). Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett., 189: 11-16.
23. Konoshima T, Takasaki M, Kozuka M, Nagao T, Okabe H, Irino N, Nakasumi T, Tokuda H, Nishino H (1995). Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and twostage carcinogenesis of skin tumor. II. Biol. Pharm. Bull., 18: 284-287.
24. Kumar S, Kumar D, Saroha K, Singh N, Vashishta B (2008). Antioxidand and free radical scavenging potential of Citrullus colocynthis (L.) Schard. methanolic fruit extract. Acta. Pharm., 58: 215-220.
25. Liu T, Zhang M, Zhang H, Sun C, Deng Y (2008). Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. Eur. Arch. Otorhinolaryngol., 265(10): 1225-1232.
26. Martin PA, Blackburn M, Schroder RF, Matsuo K, Li BWJ (2002). Stabilization of cucurbitacin E-glycoside, a feeding stimulant for diabroticite beetles, extracted from bitter Hawkesbury watermelon. Insect Sci., 2: 19.
27. Martin PA, Blackburn M (2003). Inhibition of seed germination by extracts of bitter Hawkesbury watermelon containing cucurbitacin, a feeding stimulant for corn rootworm (Coleoptera: Chrysomelidae). J. Econ. Entomol., 96(2): 441-445.
28. Marzouka B, Marzoukb Z, Halouib E, Feninab N, Bouraouic A, AouniaM (2010). Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J. Ethnopharmacol., 128: 15-19.
29. Musza LL, Speight P, McElhiney S, Barrow C J, Gillum AM, Cooper R, Killar LM (1994). Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides. J. Nat. Prod. (Lloydia), 57: 1498-1502.
30. Meng D, Qiang S, Lou L, Zhao W (2008). Cytotoxic cucurbitane-type triterpenoids from Elaeocarpus hainanensis. Planta Med., 74 (14): 1741-1744.
31. Niu G, Heller R, Catlett-Falcone R, Coppola D, Jaroszeski M, Dalton W, Jove R, Yu H (1999). Gene therapy with dominant-negative STAT3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res., 59: 5059-5063.
32. Noguchi N, Komuro E, Niki E, Wilson RL (1994). Action of cucurmin as an antioxidant against lipid peroxidation. J. Jap. Oil Chem. Soc., 43: 1045-1051.
33. Peters RR, Farias MR, Ribeiro-do-Valle RM (1997). Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata. Planta Med., 63(6): 525-528.
34. Peters RR, Saleh TF, Lora M, Patry C, de Brum-Fernandes AJ, Ribeirodo- Valle RM (1999). Anti-inflammtory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. Life Sci., 64(26): 2429-2437.
35. Peters RR, Baier Krepsky P, Siqueira-Junior JM, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M, Castro da Rocha FA, Ribeiro-do-Valle RM (2003). Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci., 73(17): 2185-2197.
36. Recio MC, Prieto M, Bonucelli M, Orsi C, Manez S, Giner RM, Cerda- Nicolas M, Rios JL (2004). Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med., 70: 414-420.
37. Semiz A, Sen A (2007). Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract. Afr. J. Biotechnol., 6: 273-277.
38. Siqueira JM, Peters RR, Gazola AC, Krepsky PB, Farias MR, Rae GA, de Brum-Femandes AJ, Ribeiro-do-Valle RM (2007). Antiinflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn. Life Sci., 80(15): 1382-1387.
39. Smit H F, van den Berg AJ, Kroes BH, Beukelman CJ, Quarles van Ufford HC, van Dijk H, Labadie RP (2000). Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora. J. Nat. Prod. (Lloydia), 63: 1300-1302.
40. Sturm S, Stuppner H (1998). Analysis of cucurbitacins in medicinal plants by high-pressure liquid chromatography-mass spectrum. Phytochem. Anal., 11(2): 121-127.
41. Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM (2005). Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity. Oncogene, 24(20): 3236-3245.
42. Tannin-Spitz T, Bergman M, Grossman S (2007). Cucurbitacin glucosides: Antioxidant and free-radical scavenging activities. Biochem. Biophys. Res. Commun., 364(1): 181-186.
43. Turkson J, Jove R (2000). STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene, 19: 6613-6626.
44. Vouldoukis I, Lacan D, Kamate C, Coste P, Calenda A, Mazier D (2004). Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity. J. Ethnopharmacol., 94: 67-75.
45. Wakimoto N, Yin D, O'Kelly J, Haritunians T, Karlan B, Said J, Xing H, Koeffler HP (2008). Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Sci., 99 (9): 1793-1797.
46. Witkowski A, Woynarowska B, Konopa J (1984). Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. J. Biochem. Pharmacol., 33(7): 995-1004.
47. Yamaguchi F, Yoshimura Y, Nakazawa H, Ariga T (1999). Free radical scavenging activity of grape seed extract and anti-oxidants by electron spin resonance spectrometry in an H(2)O(2)/NaOH/DMSO system. J. Agric. Food Chem., 47: 2544-2548.
48. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R (1995). Enhanced DNA-binding activity of a STAT3-related protein in cells transformed by the Src oncoprotein. Science (Wash. DC), 269: 81-83.
49. Zang, LY, Cosma G, Gardner H, Castranova V, Vallyathan V (2003). Effect of chlorogenic acid on hydroxyl radical. Mol. Cell Biochem., 247: 205-210.