Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract

African Journal of Biotechnology

Volumn 6, Issue 3, 2007, Pages 273-277

  Semiz, Asli ^a   Sen, Alaattin ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Chemoprotection; Cytochrome P450; Glutathione S transferases; Momordica charantia

Indexed keywords

CATALASE; CYTOCHROME P450; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MOMORDICA CHARANTIA EXTRACT; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; KIDNEY; LIVER; LIVER MICROSOME; LIVER PROTECTION; LIVER TOXICITY; LUNG; MALE; MOMORDICA CHARANTIA; NONHUMAN; RAT;

ANIMALIA; CUCUMIS; MOMORDICA CHARANTIA; RATTUS; RATTUS NORVEGICUS;

EID: 33846992288     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Abei H (1974). Catalase. In Method of Enzymatic Analysis. New York: Academic Press, pp: 673-684.
2. Aruoma OI (1994). Nutrition and health aspects of free radicals and antioxidants. Food Chem. Toxicol. 32: 671-683.
3. Beloin N, Gbeassor M, Akpagana K, Hudson J, de Soussa K, Koumaglo K, Arnason JT (2005). Ethnomedicinal uses of Momordica charantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity. J. Ethnopharmacol. 96: 49-55.
4. Burke MD, Mayer RT (1974). Ethoxyresorufin: Direct fluorometric assay of microsomal O-dealkylation which is preferentially induced by 3-methylcholanthrene. Drug Metab. Dispos. 2: 583-588.
5. Cohen G, Heikkila RE (1974). The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249: 2447-2452.
6. Erel O (2004). A novel automated method to measure total antioxidant response against potent free radical reactions. Clin. Biochem. 37: 112-119.
7. Goodwin JS, Brodwick M (1995). Diet, aging and cancer. Clin. Geriatr. Med. 11: 577-589.
8. Grover JK, Yadav SP (2004). Pharmacological actions and potential uses of Momordica charantia: a review. J. Ethnopharmacol. 93: 123-132.
9. Gurbuz I, Akyuz C, Yesilada E, Bilge S (2000). Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats. J. Ethnopharmacol. 71: 77-82.
10. Habig WH, Pabst MJ, Jakoby WB (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249: 7130-7139.
11. Halliwel B, Gutteridge JMC (1999). Free radicals in biology and medicine (3rd Ed.). Oxford: Oxford University Press.
12. Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30: 445-600.
13. Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR (2003). Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J. Agric. Food Chem. 51: 3302-3308.
14. Ioannides C, Lewis DF (2004). Cytochromes P450 in the bioactivation of chemicals. Curr. Top Med. Chem. 4: 1767-1788.
15. Jung SH, Lee YS, Lim SS, Lee S, Shin KH, Kim YS (2004). Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats. Arch. Pharm. Res. 27: 184-188.
16. Kehrer JP (1993). Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23: 21-48.
17. Kim KS, Lee S, Lee YS, Jung SH, Park Y, Shin KH, Kim BK (2003). Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea. J. Ethnopharmacol. 85: 69-72.
18. Lowry OH, Rosenburg NJ, Farr AL, Randall RJ (1951). Protein measurements with Folin-phenol reagent. J. Biol. Chem. 193: 265-275.
19. Marklund S, Marklund G (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474.
20. Nebert DW, Gonzalez FJ (1987). P-450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 56: 945-93.
21. Paglia ED, Valentine WN (1967). Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. J. Lab. Clin. Med. 70: 158-169.
22. Raman A, Lau C (1996). Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine. 2: 349-362.
23. Reitman S, Frankel S (1957). A colorimetric method for the determination of sGOT and sGPT. Am. J. Clin. Pathol. 28: 56-63.
24. Rice-Evans CA, Miller NJ, Paganga G (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20: 933-956.
25. Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC (1996). Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA 275: 447-451.
26. Scartezzini P, Speroni E (2000). Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 71: 23-43.
27. Sen A, Arinc E (2000). Further immunochemical and biocatalytic characterization of CYP1A1 from feral leaping mullet liver (Liza saliens) microsomes. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 126: 235-244.
28. Sen A, Kirikbakan A (2004). Biochemical characterization and distribution of glutathione S-transferases in leaping mullet (Liza saliens). Biochem. (Moscow) 69: 993-1000.
29. Shahidi F, Wanasundra PK (1992). Phenolic antioxidants. Crit. Rev. Food Sci. Nutr. 32: 67-103.
30. Snyder MJ, Maddison DR (1997). Molecular phylogeny of glutathione S-transferases. DNA Cell. Biol. 16: 1373-1384.
31. Stahelin HB, Gey KF, Eichholzer M, Ludin E, Bernasconi F, Thurneysen J, Brubacher G (1991). Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective basel study. Am. J. Epidemiol. 133: 766-775.
32. Steinberg D (1991). Antioxidants and atherosclerosis: a current assessment. Circulation 84: 1420-1425.
33. Steinmetz KA, Potter, JD (1996). Vegetables, fruit and cancer prevention: a review. J. Am. Diet Assoc. 96: 1027-1039.
34. Welihinda J, Karunanayake EH, Sheriff MH, Jayasinghe KS (1986). Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J. Ethnopharmacol. 17: 277-282.
35. Willett WC (1994). Micronutrients and cancer risk. Am. J. Clin. Nutr. 59: S265-S269.
36. Wroblewski F, La Due JS (1955). Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Biol. Med. 90: 210.
37. Zimniak P, Waxman DJ (1993). Liver cytochrome P450 metabolism of endogenous steroid hormones, bile acids, and fatty acids. In: Schenkman JB, Greim H, eds. Handbook of Experimental Pharmacology 105. Heidelberg; Springer-Verlag Press. pp: 123-144.