An equivalence principle for the incorporation of favorable mutations in asexual populations

Science

Volumn 311, Issue 5767, 2006, Pages 1615-1617

  Hegreness, Matthew ^a,b   Shoresh, Noam ^a   Hartl, Daniel ^b   Kishony, Roy ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; CELLS; DRUG DOSAGE; ESCHERICHIA COLI; FLUORESCENCE; GENETIC ENGINEERING; MICROORGANISMS; PARAMETER ESTIMATION;

ASEXUAL POPULATIONS; EVOLUTIONARY DYNAMICS; MUTATION-SELECTION PROCESS; MUTATIONS;

POPULATION STATISTICS;

CYAN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; YELLOW FLUORESCENT PROTEIN;

MUTATION;

ARTICLE; ASEXUAL REPRODUCTION; BACTERIAL CELL; CANCER CELL; CELL DIVISION; CELL MUTANT; CELL POPULATION; ESCHERICHIA COLI; EVOLUTIONARY ADAPTATION; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL;

ADAPTATION, BIOLOGICAL; BACTERIAL PROTEINS; ESCHERICHIA COLI; EVOLUTION; GENETICS, POPULATION; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MATHEMATICS; MODELS, GENETIC; MUTATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 33645076253     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122469     Document Type: Article

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30. We thank D. Huse for theoretical advice regarding the model; M. Elowitz for strains and suggestions; N. Barkai and R. Lenski for important comments; and U. Alon, D. Damian, A. DeLuna, M. Depristo, M. Desai, D. Fisher, L. Garwin, A. Murray, V. Savage, K. Vestigian, and D. Weinreich for discussions and comments on the manuscript. This work was supported by the Bauer Center for Genomics Research and by grants from the NSF and the Ellison Medical Foundation. M.H. dedicates this work to the memory of his mother, Kari Hegreness.