Reconstitution of Scid mice with CD4+CD25- T cells leads to rapid colitis: An improved model for pharmacologic testing

International Immunopharmacology

Volumn 6, Issue 8, 2006, Pages 1341-1354

  Kjellev, Stine ^a,b   Lundsgaard, Dorthe ^a,b   Poulsen, Steen Seier ^c   Markholst, Helle ^a,b  

^a NOVO NORDISK A S   (Denmark)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Adoptive transfer; CD4+ T lymphocytes; Colitis; Cytokines; Disease models, animal; Epithelial proliferation; Inflammatory bowel disease

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR RECEPTOR 2;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CD4+ CD25- T LYMPHOCYTE; CELL INFILTRATION; CELL PROLIFERATION; CLINICAL FEATURE; COLITIS; COLON; COLON MUCOSA; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DISEASE COURSE; DISEASE SEVERITY; ENTERITIS; EXPERIMENTAL MODEL; FECES ANALYSIS; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; INFLAMMATION; LYMPHOID CELL; MOUSE; MUCUS; NONHUMAN; OCCULT BLOOD; PRIORITY JOURNAL; PROTEIN CONTENT; SCID MOUSE; T CELL DEPLETION; T LYMPHOCYTE; TH1 CELL; TISSUE HOMOGENATE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD11C; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; EPITHELIUM; FEMALE; GOBLET CELLS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C; MICE, SCID; OCCULT BLOOD; PEPTIDES; RECEPTORS, INTERLEUKIN-2;

EID: 33744968175     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.04.017     Document Type: Article

References (41)

1. Bouma G., and Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3 (2003) 521-533
2. Wirtz S., and Neurath M.F. Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease. Int J Colorectal Dis 15 (2000) 144-160
3. Morrissey P.J., Charrier K., Braddy S., Liggitt D., and Watson J.D. CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J Exp Med 178 (1993) 237-244
4. Powrie F., Leach M.W., Mauze S., Caddle L.B., and Coffman R.L. Phenotypically distinct subsets of cd4(+) t-cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int Immunol 5 (1993) 1461-1471
5. Leach M.W., Bean A.G., Mauze S., Coffman R.L., and Powrie F. Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells. Am J Pathol 148 (1996) 1503-1515
6. Claesson M.H., Rudolphi A., Kofoed S., Poulsen S.S., and Reimann J. Cd4(+) t-lymphocytes injected into severe combined immunodeficient (scid) mice lead to an inflammatory and lethal bowel-disease. Clin Exp Immunol 104 (1996) 491-500
7. Mudter J., Wirtz S., Galle P.R., and Neurath M.F. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology 70 (2002) 170-176
8. Ikenoue Y., Tagami T., and Murata M. Development and validation of a novel IL-10 deficient cell transfer model for colitis. Int Immunopharmacol 5 (2005) 993-1006
9. Mottet C., Uhlig H.H., and Powrie F. Cutting edge: cure of colitis by CD4(+) CD25(+) regulatory T cells. J Immunol 170 (2003) 3939-3943
10. Xu D.M., Liu H.Y., Komai-Koma M., Campbell C., McSharry C., Alexander J., et al. CD4(+)CD25(+) regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol 170 (2003) 394-399
11. Alyanakian M.A., You S., Damotte D., Gouarin C., Esling A., Garcia C., et al. Diversity of regulatory CD4+ T cells controlling distinct organ-specific autoimmune diseases. Proc Natl Acad Sci U S A 100 (2003) 15806-15811
12. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
13. Bancroft J.D., and Cook H.C. Manual of histological techniques (1984), Churchill Livingstone, New York
14. Hoffmann W., Jagla W., and Wiede A. Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol 16 (2001) 319-334
15. Poulsen S.S., Thulesen J., Hartmann B., Kissow H.L., Nexo E., and Thim L. Injected TFF1 and TFF3 bind to TFF2-immunoreactive cells in the gastrointestinal tract in rats. Regul Pept 115 (2003) 91-99
16. Pyke C., Romer J., Kallunki P., Lund L.R., Ralfkiaer E., Dano K., et al. The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. Am J Pathol 145 (1994) 782-791
17. Lindsay J., van Montfrans C., Brennan F., van Deventer S., Drillenburg P., Hodgson H., et al. IL-10 gene therapy prevents TNBS-induced colitis. Gene Ther 9 (2002) 1715-1721
18. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
19. Bradley P.P., Christensen R.D., and Rothstein G. Cellular and extracellular myeloperoxidase in pyogenic inflammation. Blood 60 (1983) 618-622
20. Cahill R.J., Foltz C.J., Fox J.G., Dangler C.A., Powrie F., and Schauer D.B. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun 65 (1997) 3126-3131
21. Claesson M.H., Bregenholt S., Bonhagen K., Thoma S., Moller P., Grusby M.J., et al. Colitis-inducing potency of CD4(+) T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype. J Immunol 162 (1999) 3702-3710
22. Bregenholt S. Cells and cytokines in the pathogenesis of inflammatory bowel disease: new insights from mouse T cell transfer models. Exp Clin Immunogenet 17 (2000) 115-129
23. MacDonald T.T. Epithelial proliferation in response to gastrointestinal inflammation. Ann N Y Acad Sci 664 (1992) 202-209
24. Mizoguchi E., Mizoguchi A., Takedatsu H., Cario E., de Jong Y.P., Ooi C.J., et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 122 (2002) 134-144
25. Leithauser F., Trobonjaca Z., Moller P., and Reimann J. Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer model. Lab Invest 81 (2001) 1339-1349
26. Hershberg R.M., and Mayer L.F. Antigen processing and presentation by intestinal epithelial cells - polarity and complexity. Immunol Today 21 (2000) 123-128
27. Hibi T., Ogata H., and Sakuraba A. Animal models of inflammatory bowel disease. J Gastroenterol 37 (2002) 409-417
28. Podolsky D.K., and Isselbacher K.J. Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis. Gastroenterology 87 (1984) 991-998
29. Raouf A.H., Tsai H.H., Parker N., Hoffman J., Walker R.J., and Rhodes J.M. Sulphation of colonic and rectal mucin in inflammatory bowel disease: reduced sulphation of rectal mucus in ulcerative colitis. Clin Sci (Lond) 83 (1992) 623-626
30. Pullan R.D., Thomas G.A., Rhodes M., Newcombe R.G., Williams G.T., Allen A., et al. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut 35 (1994) 353-359
31. Matsuo K., Ota H., Akamatsu T., Sugiyama A., and Katsuyama T. Histochemistry of the surface mucous gel layer of the human colon. Gut 40 (1997) 782-789
32. Einerhand A.W.C., Renes I.B., Makkink M.K., van der S.M., Buller H.A., and Dekker J. Role of mucins in inflammatory bowel disease: important lessons from experimental models. Eur J Gastroenterol Hepatol 14 (2002) 757-765
33. Rhodes J.M. Mucins and inflammatory bowel-disease. QJM 90 (1997) 79-82
34. Makkink M.K., Schwerbrock N.M.J., Mahler M., Boshuizen J.A., Renes I.B., Cornberg M., et al. Fate of goblet cells in experimental colitis. Dig Dis Sci 47 (2002) 2286-2297
35. Nakano S., Ohara S., Kubota T., Saigenji K., and Hotta K. Compensatory response of colon tissue to dextran sulfate sodium-induced colitis. J Gastroenterol 34 (1999) 207-214
36. McCormick D.A., Horton L.W., and Mee A.S. Mucin depletion in inflammatory bowel disease. J Clin Pathol 43 (1990) 143-146
37. Deplancke B., and Gaskins H.R. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr 73 (2001) 1131S-1141S
38. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115 (1998) 182-205
39. Powrie F., Leach M.W., Mauze S., Menon S., Caddle L.B., and Coffman R.L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1 (1994) 553-562
40. Panja A., Goldberg S., Eckmann L., Krishen P., and Mayer L. The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells. J Immunol 161 (1998) 3675-3684
41. Williams K.L., Fuller C.R., Dieleman L.A., DaCosta C.M., Haldeman K.M., Sartor R.B., et al. Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120 (2001) 925-937