New bisquaternary isoquinolinium inhibitors of brain cholinesterases - Synthesis and anticholinesterase activity

Letters in Drug Design and Discovery

Volumn 7, Issue 1, 2010, Pages 1-4

  Binder, Jiri ^a   Paar, Martin ^a   Jun, Daniel ^b   Pohanka, Miroslav ^b   Hrabinova, Martina ^b   Opletalova, Veronika ^a   Kuca, Kamil ^b,c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c J E PURKINJE UNIVERSITY   (Czech Republic)

Author keywords

Alzheimer's disease; Anticholinergic; Cholinesterase; Inhibitor; Quaternary compounds; Quinolinium

Indexed keywords

CHOLINESTERASE INHIBITOR; ISOQUINOLINE DERIVATIVE;

AGING; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CHOLINESTERASE INHIBITION; DRUG ACTIVITY; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 77949664753     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570180811007010001     Document Type: Article

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