Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: Implications for infantile neuronal ceroid lipofuscionosis (INCL)

Human Molecular Genetics

Volumn 10, Issue 1, 2001, Pages 69-75

  Lehtovirta, Maarit ^a   Kyttälä, Aija ^a   Eskelinen, Eeva Liisa ^b   Hess, Michael ^b   Heinonen, Outi ^a   Jalanko, Anu ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOME ENZYME; N4 (BETA N ACETYLGLUCOSAMINYL)ASPARAGINASE; PALMITOYL PROTEIN THIOESTERASE; SOMATOMEDIN B RECEPTOR;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASEMENT MEMBRANE; BRAIN CELL; BRAIN TISSUE; CARCINOMA CELL; CELL FRACTIONATION; CELL LOSS; CONFOCAL MICROSCOPY; DEGENERATIVE DISEASE; EMBRYO; ENZYME DEFICIENCY; ENZYME LOCALIZATION; ENZYME RELEASE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; LIPOFUSCINOSIS; LYSOSOME; MONKEY; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; SYNAPSE VESICLE; SYNAPTOSOME;

ANIMALS; BLOTTING, WESTERN; BRAIN; CACO-2 CELLS; CELL FRACTIONATION; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; LYSOSOMES; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; PHENOTYPE; SYNAPTIC VESICLES; SYNAPTOSOMES; THIOLESTER HYDROLASES; TRANSFECTION;

ANIMALIA;

EID: 0035167162     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Neuronal ceroid-lipofuscinoses in childhood
2. Neuronal ceroid-lipofuscinoses in childhood
3. Infantile type of so-called neuronal ceroid-lipofuscinosis. 1. A clinical study of 15 patients
4. Storage of saposins A and D in infantile neuronal ceroid-lipofuscinosis
5. Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis
6. Molecular genetics of palmitoyl-protein thioesterase deficiency in the U.S
7. Palmitoyl-protein thioesterase deficiency in a novel granular variant of LINCL
8. The molecular basis of GROD-storing neuronal ceroid lipofuscinoses in Scotland
9. Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: Correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase
10. In vitro depalmitoylation of neurospecific peptides: Implication for infantile neuronal ceroid lipofuscinosis
11. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis
12. Molecular cloning and expression of palmitoyl-protein thioesterase
13. Human palmitoyl protein thioesterase: Evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis
14. Lysosomal targeting of palmitoyl-protein thioesterase
15. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis
16. Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease
17. Localization and processing of CLN3, the protein associated to Batten disease: Where is it and what does it do?
18. The neuronal ceroid lipofuscinosis CLN8 membrane protein is resident of the endoplasmic reticulum
19. The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues
20. Developmental expression of palmitoyl protein thioesterase in normal mice
21. CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain
22. Expression of palmitoyl protein thioesterase in neurons
23. Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease
24. Mouse palmitoyl protein thioesterase: Gene structure and expression of cDNA
25. Possible role for fatty acyl-coenzyme A in intracellular protein transport
26. The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS
27. SNAP receptors implicated in vesicle targeting and fusion
28. Regulated vesicular fusion in neurons: Snapping together the details
29. A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43
30. Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells
31. SNAP-25 palmitoylation and plasma membrane targeting require a functional secretory pathway
32. Palmitoylation of cellular and viral proteins
33. Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons
34. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture
35. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
36. Trafficking itineraries of G proteincoupled receptors in epithelial cells do not predict receptor localization in neurons
37. Expression of heterologous proteins in cultured rat hippocampal neurons using the Semliki Forest virus vector
38. Application of cryoultramicrotomy to immunocytochemistry
39. The cytoskeletons of isolated, neuronal growth cones
40. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
41. Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain
42. Purification of lysosomal membrane proteins from human placenta
43. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
44. Human leucocyte aspartylglucosaminidase. Evidence for two different subunits in a more complex native structure