Combinatorial synthesis of heterocycles: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives

Journal of Combinatorial Chemistry

Volumn 2, Issue 4, 2000, Pages 378-381

  Gopalsamy, Ariamala ^a   Yang, Hui ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; QUINAZOLINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINES; DRUG DESIGN; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034220357     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc000017d     Document Type: Article

References (29)

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28. LC conditions: HP 1100, 23°C, 10 μL injected. Column: YMC-ODS-A 4.6 x 50, 5 μm. Gradient A: 0.05% TFA/water; B: 0.05% TFA/acetonitrile. Time 0 & 1 min: 98% A & 2% B. Time 7 min: 10% A & 90% B. Time 8 min: 10% A & 90% B. Time 8.9 min: 98% A & 2% B. Post time: 1 min. Flow rate: 2.5 mL/min. Detection: 215 and 254 nm, DAD.
29. Analysis of the crude product indicated the presence of unreacted methyl thioureas 12 as the only other major component.