Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats

Food and Chemical Toxicology

Volumn 49, Issue 2, 2011, Pages 471-476

  Chusiri, Yaowares ^a,b   Wongpoomchai, Rawiwan ^a,b   Kakehashi, Anna ^a   Wei, Min ^a   Wanibuchi, Hideki ^a   Vinitketkumnuan, Usanee ^b   Fukushima, Shoji ^c  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Faculty of Medicine Chiang Mai University   (Thailand)

^c Japan Bioassay Research Center   (Japan)

Author keywords

GST P; Hepatocarcinogenesis; Kojic acid; Threshold

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CYCLINE; GLUTATHIONE TRANSFERASE; KOJIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FISCHER 344 RAT; LIVER CARCINOGENESIS; LIVER CELL; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; CARCINOGENS; CELL PROLIFERATION; GLUTATHIONE TRANSFERASE; LIVER NEOPLASMS; MALE; PYRONES; RATS; RATS, INBRED F344;

RATTUS;

EID: 78951485275     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.11.027     Document Type: Article

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