Evaluation of health aspects of kojic acid in food

Regulatory Toxicology and Pharmacology

Volumn 33, Issue 1, 2001, Pages 80-101

  Burdock, George A ^a   Soni, Madhusudan G ^a   Carabin, Ioana G ^a  

^a Burdock and Associates Inc   (United States)

Author keywords

Health effects; Kojic acid; Mycotoxins; Safety; Toxicity

Indexed keywords

IODINE; KOJIC ACID;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; ASPERGILLUS; CARCINOGENICITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DOG; EMBRYOTOXICITY; FOOD PROCESSING; MOUSE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SYNTHESIS; TERATOGENICITY; THYROID ADENOMA; THYROID FUNCTION; TOXICITY TESTING;

ACETOBACTER; ANIMALIA; ASPERGILLUS; ASPERGILLUS FLAVUS; GLYCINE MAX; MAMMALIA; PENICILLIUM;

EID: 0035081454     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2000.1442     Document Type: Article

References (160)

1. An immunoanalysis for kojic acid
2. High performance liqiuid chromatographic analysis of norsolorinic acid produced by Aspergillus parasiticus mutant
3. 14C]-1:3-dihydroxyacetone
4. The biosynthesis of kojic acid. 3. The incorporation of labelled small molecules into kojic acid
5. Evaluation of the genotoxic activity of some mycotoxins using Escherichia coli in the SOS spot test
6. Kojic acid: Synthesis and properties
7. Transport of L-proline by rat brain slices
8. Kojic acid as an insecticidal mycotoxin
9. Effect of mycotoxins and coumarins on the growth of Bacillus megaterium from spores
10. Photoinduction of strand scissions in DNA by kojic acid: Role of transition metal ions and oxygen free radical intermediates in the reaction
11. Photoinactivation of bacteriophage lambda by kojic acid and Fe(III): Role of oxygen radical intermediates in the reaction
12. Tumors of the thyroid gland
13. Mutagenicity of 1,2-dicarbonyl compounds: Maltol, kojic acid, diacetyl and related substances
14. Insecticidal fungal metabolites: Cyclopiazonic acid and kojic acid contribute to the toxicity of Aspergillus flavus to shee blowfly Lucilia cuprina
15. Antibacterial effect of some mycotoxins and fungal metabolites against strains of Bacillus thuringiensis (Berliner) sensitive or resistant to aflatoxin B1
16. Protrietes antibacteriennes et genotoxiques de 33 mycotoxines
17. Inhibition mechanism of kojic acid on polyphenol oxidase
18. Effect of some mycotoxins on reproduction in pregnant albino rats
19. Antifertility and cannibalistic properties of some mycotoxins in albino rats
20. Review: Nutrition and experimental carcinogenesis
21. The use of chemical peelings in the treatment of different cutaneous hyperpigmentations
22. Chemical induction of local reddening in strawberry fruits
23. The oxidation of glycine by D-amino acid oxidase in extracts of mammalian central nervous tissue
24. Effect of kojic acid phenylosazone on Trypanosoma cruzi
25. Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver
26. Toxicological and biochemical interactions of the fungal metabolites fuscaric acid and kojic acid with xenobiotics in Heliothis zea (F.) and Spodoptera frugiperda (J. E. Smith)
27. Synergism of aflatoxin B1 toxicity with the co-occurring fungal metabolite kojic acid in two caterpillars
28. Systematic analysis of mycotoxins by thin-layer chromatography
29. Occurrence of mycotoxins in cereals and animal feedstuffs in Natal, South Africa
30. Toxigenicity and toxins produced by fungi isolated from clinically positive pneumonic cases of buffalo calves
31. The stimulatory effect of kojic acid on the production of aflatoxin by isolates of Aspergillus flavus Link
32. Effect of melanin biosynthesis compounds on Gaeumannomyces species
33. Kojic acid production from cocoa juice by Aspergillus flavus entraped in calcium alginate
34. Effects of fungal metabolites on testosterone secretion in vitro
35. Chemical and physiological properties of kojic acid
36. High-performance liquid chromatographic determination of profiles of mycotoxins and other secondary metabolites
37. Classification of terverticillate penicillia based on profiles of mycotoxins and other secondary metabolites
38. Standardized high-performance liquid chromatography of 182 mycotoxins and other fungal metabolites based on alkylphenone retention indexes and UV-VIS spectra (diode array detection)
39. Changes in thyroid function during development of thyroid hyperplasia induced by kojic acid in F344 rats
40. 1 mice by oral administration of kojic acid
41. The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions
42. Antibiotic lactones and synthetic analogs. 1. Cardiotoxic effects on the isolated frog heart
43. Antibiotic lactones and synthetic analogs. II. Cardiotonic effects on the isolated frog heart
44. The individual and combined toxicity of kojic acid and aflatoxin in broiler chickens
45. Toxic effects of kojic acid in the diet of male broilers
46. Toxic effects of kojic acid and its lack of synergy with aflatoxin in male broilers
47. Analysis of Aspergillus mycotoxins by gas chromatography using fused silica capillary column
48. Comparative study of toxigenic and nontoxigenic strains of Aspergillus flavus
49. Dietary restriction and cancer
50. Thyroid follicular cells
51. Investigation of the anti-inflammatory properties of hydroxypyridinones
52. Thyroid follicular cell carcinogenesis: A review
53. Inhibitory effect of kojic acid contained cream in UV-induced pigmentationin human skin
54. Association of morphology and mycotoxin production with vegetative compatibility groups in Aspergillus flavus, A. parasiticus and A. tamarii
55. The initiator tRNA acceptance assay as a short-term test for carcinogens. 4. Results with 20 mycotoxins
56. Kojic acid metabolism by microorganisms. X. Kojic acid oxidase
57. Evaluation of certain food additives
58. Evaluation of certain food additives and contaminants
59. Production of kojic acid by Aspergillus effusus Tiraboschi
60. Effect of kojic acid on the oxiation of DL-DOPA norepinephrine and dopamine by mushroom tyrosinase
61. Effect of kojic acid on the oxidation of trihydroxyphenols by mushroom tyrosinase
62. Effect of kojic acid on the oxidation of N-acetyldopamine by mushroom tyrosinase
63. Effect of kojic acid on the oxidation of o-dihydroxyphenols by mushroom tyrosinase
64. 2 system
65. 2 system
66. Conditions for the production of aflatoxins and kojic acid by Aspergillus and Penicillium strains isolated from human skin layers
67. Protective action of iron-chelating agents (catechol, mimosine, deferoxamine, and kojic acid) against ischemia-reperfusion injury of isolated neonatal rabbit hearts
68. Diet overfeeding and moderate dietary restriction in control Sprague-Dawley rat. I. Effects of spontaneous neoplasm
69. The biosynthesis of kojic acid by Aspergillus flavus Link starins isolated from feed
70. Species of the genus Aspergillus Mich. producing kojic acid on mixed feeds and the role of this mycogoxin in animal pathology
71. The species composition of the micromycetes in feed and their role in animal kojic acid toxicosis
72. Koetoxicosis (kojic acid poisoning) in poultry
73. Desmutagenic effect of α-dicarbonyl and α-hydroxycarbonyl compounds against mutagenic heterocyclic amines
74. Studies on Passiflora incarnata dry extract. Part II. Central depressant effects of maltol analogs in mice
75. Mycotoxins in fermented food
76. Toxicity of Koji (Asp. oryzae)
77. Kojic acid fermentation. V. Effect of metabolic inhibitors
78. Kojic acid fermentation. VII. Mechanism of the conversion of glucose to kojic acid
79. Inhibitory effect of kojic acid upon oxidations mediated by liver and kidney
80. Adverse reactions to sulasoxole, sulfamethoxazole, and nitrofurantoin: Manifestations and reaction rates during 2,118 courses of therapy
81. Sensibilite de l'embryon de poulet a des mycotixines
82. Kojic acid as an inhibitor of tubercle bacilli
83. Substrate depletion during formation of aflatoxin and kojic acid on corn inoculated with Aspergillus flavus
84. Development of sensitive bacterial tests, exemplified by two mycotoxins
85. A test battery of bacterial toxicity assays and comparison with LD50 values
86. Treatment of melasa using kojic acid in a gel containing hydroquinone and glycolic acid
87. High production of kojic acid crystals by Aspergillus parasitiicus UNBF A12 in liquid medium
88. Study of the possibility of contamination of rice grain by mycotoxins under moderate climatic conditions
89. Formatin of mycotoxins during stroage of freshly harvested corn
90. In vitro effectiveness of several whitening cosmetic components in human melanocytes
91. Comparative hepatotoxicity of aluminum administered with maltol and kojic acid to mice
92. The capabilities of the Aspergillus flavus group to produce aflatoxins and kojic acid
93. Producing capability of kojic acid and aflatoxin by koji mould
94. Producing capability of kojic acid and aflatoxin by koji mould
95. Organomercury(II) complexes of kojic acid and maltol: Syntheis, characterization, and biological studies
96. Specific inhibition of elF-5A and collagen hydroxylation by a single agent: Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries
97. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implication for thyroid gland neoplasia: A review
98. Promoting effects of kojic acid due to serum TSH elevation resulting from reduced serum thyroid levels on development of thyroid proliferative lesions in rats initiated with N-bis(2-hydroxypropyl)-nitrosamine
99. Synthesis and iron(III) binding properties of 3-hydroxypyrid-4-ones derived from kojic acid
100. Design of novel hybrid vitamin C derivatives: Thermal stability and biological activity
101. The experimental development and metabolism of thyroid gland tumors
102. Toxicity and antibiotic activity of kojic acid produced by Aspergillus luteo-virescens
103. Toxigenic fungi isolated from Roquefort cheese
104. Toxigenic Aspergilli isolated from different sources in Egypt
105. UVB-induced pigmentation in hairless mice as an in vivo assay for topical skin-depigmenting activity
106. Contact allergy to kojic acid in skin care products
107. Mechanism of action of thioureylene antithyroid drugs: Factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats
108. Treatment of chloasma with kojic acid cream
109. Kojic acid scavenges free radicals while potentiating leukocyte functions including free radical generation
110. Gas-chromatographic analysis of the mycotoxins kojic acid, terreic acid, and terrein
111. Production of kojic acid from Aspergillus oryzae var. oryzae by membrane surface liquid culture
112. Quantitative structure-time-activity relationships (QSTAR): pH-dependent growth inhibition of Escherichia coli by ionizable and nonionizable kojic acid derivatives. Part II
113. Production of kojic acid by resuspended mycelia of Aspergillus flavus
114. Optimization of chick embryotoxicity bioassay for testing toxicity poteintial of fungal metabolites
115. Application of the chick embryotoxicity bioassay for the evaluation of mycotoxin toxicity
116. Separation of potential flavoring compounds by high-performance liquid chromatography
117. Detection of genotoxic properties of mycotoxins with the SOS chromotest
118. Isolation of a kojic acid producing fungus capable of using starch as a carbon source
119. Kojic acid production by Aspergillus flavus using gelatinized and hydrolyzed sago starch as carbon sources
120. The chemosterilizing activity of some mycotoxins and their influence on the development and survival of Spodoptera littoralis (Boisd.) (Lep., Noctuidae)
121. Kojic acid, a tyrosinase inhibitor from Aspergillus albus
122. Mycotoxins in feeds and ingredients and their origin
123. Allergic contact dermatitis from kojic acid
124. Sequential determination of thorium and rare earths with EDTA and kojic acid
125. Mutagenicity and dominant lethal test of kojic acid, Ames test, forward mutation in cultured Chinese hamster cells and dominant lethal test in mice
126. Inhibition of mammary carcinogenesis in rats, by dietary restriction
127. Assessment of beef flavor quality: A multidisciplinary approach
128. Cytochemical localization of a D-amino acid oxidizing enzyme in peroxisomes of Drosophila melanogaster
129. Mutagenicity and carcinogenicity of mycotoxins: DNA binding as a possible mode of action
130. Aflatoxin B1, BGY-flurorescence and kojic acid in maize kernels: An investigation on maize of Swiss origin
131. Observations on the thyroid gland in rats following the administration of sulfamethoxazole and trimethoprim
132. Detection of mutagenic activity of mycotoxins by Salmonella typhimurium/microsome assay and ultra-weak chemiluminescence
133. Inhibition of thyroid iodine uptake and organification in rats treated with kojic acid
134. Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after BHPN initiation
135. Dose-threshold for thyroid tumor-promoting effects of orally administered kojic acid in rats after initiation with N-bis(2-hydroxypropyl)nitrosamine
136. Inhibition study of tyrosinase from Aspergillus oryzae
137. The determination of kojic acid using the stopped-flow method
138. A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil
139. Inhibition of N-nitrosamine formation in a cured ground pork belly model system
140. Isolation and toxicity of molds from foods stored in homes
141. Trends in preparation and uses of fermented and acid-hydrolyzed soy sauce
142. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells
143. Kojic acid and its derivatives in cosmetics and health protection
144. Vyuziti kurechiho zarodku k predikci nekterych embryotoxickych ucinku mykotoxinu na savcich
145. Nineteen mycotoxins tested on chicken embryos
146. Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins
147. Production of kojic acid by Aspergillus candidus in three culture media
148. Mutagenicity studies of kojic acid
149. Hog cerebellar D-amino acid oxidase and its histochemical and immunofluorescent localization
150. Kojic acid - A convulsant
151. Koji acid, a new organic acid formed by Aspergillus oryzae
152. Synthesis and antitumor activity of tropolone derivatives
153. Synthesis and antitumor activity of tropolone derivatives