메뉴 건너뛰기




Volumn 88, Issue 1, 2011, Pages 1-8

The role of GH/IGF-I-mediated mechanisms in sex differences in cortical bone size in mice

Author keywords

Androgen; Bone formation and resorption; Estrogen; Growth hormone; IGF I

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GROWTH HORMONE; SEX HORMONE; SOMATOMEDIN C; STEROID RECEPTOR; TESTOSTERONE;

EID: 78951485139     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9436-2     Document Type: Review
Times cited : (26)

References (80)
  • 1
    • 33744750875 scopus 로고    scopus 로고
    • Bone strength: Current concepts
    • 10.1196/annals.1346.039 16831941
    • CH Turner 2006 Bone strength: current concepts Ann N Y Acad Sci 1068 429 446 10.1196/annals.1346.039 16831941
    • (2006) Ann N y Acad Sci , vol.1068 , pp. 429-446
    • Turner, C.H.1
  • 2
    • 33750305899 scopus 로고    scopus 로고
    • Bone geometry and skeletal fragility
    • 10.1007/s11914-006-0002-9 16822403
    • ML Bouxsein D Karasik 2006 Bone geometry and skeletal fragility Curr Osteoporos Rep 4 49 56 10.1007/s11914-006-0002-9 16822403
    • (2006) Curr Osteoporos Rep , vol.4 , pp. 49-56
    • Bouxsein, M.L.1    Karasik, D.2
  • 3
    • 67650309019 scopus 로고    scopus 로고
    • Bone modeling and remodeling
    • 1:CAS:528:DC%2BD1MXhtlSksLrK 19883366
    • E Seeman 2009 Bone modeling and remodeling Crit Rev Eukaryot Gene Expr 19 219 233 1:CAS:528:DC%2BD1MXhtlSksLrK 19883366
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , pp. 219-233
    • Seeman, E.1
  • 4
    • 0034751519 scopus 로고    scopus 로고
    • Clinical review 137. Sexual dimorphism in skeletal size, density, and strength
    • 1:CAS:528:DC%2BD3MXptVakur0%3D 10.1210/jc.86.10.4576 11600506
    • E Seeman 2001 Clinical review 137. Sexual dimorphism in skeletal size, density, and strength J Clin Endocrinol Metab 86 4576 4584 1:CAS:528: DC%2BD3MXptVakur0%3D 10.1210/jc.86.10.4576 11600506
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4576-4584
    • Seeman, E.1
  • 5
    • 78951490416 scopus 로고    scopus 로고
    • Skeletal development in childhood and adolescence
    • C.J. Rosen (eds). American Society for Bone and Mineral Research Washington, DC. 10.1002/9780470623992.ch14
    • Bachrach LK (2008) Skeletal development in childhood and adolescence. In: Rosen CJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. American Society for Bone and Mineral Research, Washington, DC, pp 74-79
    • (2008) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , pp. 74-79
    • Bachrach, L.K.1
  • 6
  • 7
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • 1:CAS:528:DC%2BD38XltlWjtrs%3D 10.1210/er.23.3.279 12050121
    • BL Riggs S Khosla LJ Melton 3rd 2002 Sex steroids and the construction and conservation of the adult skeleton Endocr Rev 23 279 302 1:CAS:528:DC%2BD38XltlWjtrs%3D 10.1210/er.23.3.279 12050121
    • (2002) Endocr Rev , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 8
    • 0034850215 scopus 로고    scopus 로고
    • Growth hormone and sex steroids. Interactions in puberty
    • 1:CAS:528:DC%2BD3MXnsVygu7g%3D 10.1016/S0889-8529(05)70200-0 11571929
    • N Mauras 2001 Growth hormone and sex steroids. Interactions in puberty Endocrinol Metab Clin North Am 30 529 544 1:CAS:528:DC%2BD3MXnsVygu7g%3D 10.1016/S0889-8529(05)70200-0 11571929
    • (2001) Endocrinol Metab Clin North Am , vol.30 , pp. 529-544
    • Mauras, N.1
  • 9
    • 0029831597 scopus 로고    scopus 로고
    • Growth hormones and sex steroid interactions at puberty
    • 1:CAS:528:DyaK28XmtVSnurs%3D 10.1016/S0889-8529(05)70346-7 8879992
    • PA Clark AD Rogol 1996 Growth hormones and sex steroid interactions at puberty Endocrinol Metab Clin North Am 25 665 681 1:CAS:528:DyaK28XmtVSnurs%3D 10.1016/S0889-8529(05)70346-7 8879992
    • (1996) Endocrinol Metab Clin North Am , vol.25 , pp. 665-681
    • Clark, P.A.1    Rogol, A.D.2
  • 10
    • 0028143713 scopus 로고
    • Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans: Mechanisms of androgen and estrogen action
    • 1:CAS:528:DyaK2MXhvFWisbY%3D 10.1016/1043-2760(94)P3204-K 18407221
    • DL Metzger JR Kerrigan AD Rogol 1994 Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans: mechanisms of androgen and estrogen action Trends Endocrinol Metab 5 290 296 1:CAS:528:DyaK2MXhvFWisbY%3D 10.1016/1043-2760(94)P3204-K 18407221
    • (1994) Trends Endocrinol Metab , vol.5 , pp. 290-296
    • Metzger, D.L.1    Kerrigan, J.R.2    Rogol, A.D.3
  • 11
    • 0025100986 scopus 로고
    • Insulin-like growth factors i and II are present in the skeletal tissues of ten vertebrates
    • 1:CAS:528:DyaK3cXhtlKr 10.1016/0026-0495(90)90154-5 2104643
    • CM Bautista S Mohan DJ Baylink 1990 Insulin-like growth factors I and II are present in the skeletal tissues of ten vertebrates Metabolism 39 96 100 1:CAS:528:DyaK3cXhtlKr 10.1016/0026-0495(90)90154-5 2104643
    • (1990) Metabolism , vol.39 , pp. 96-100
    • Bautista, C.M.1    Mohan, S.2    Baylink, D.J.3
  • 12
    • 0032954538 scopus 로고    scopus 로고
    • The effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific
    • 1:CAS:528:DyaK1MXjtFKrtbc%3D 10.1359/jbmr.1999.14.5.802 10320529
    • XZ Zhang DN Kalu B Erbas JL Hopper E Seeman 1999 The effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific J Bone Miner Res 14 802 809 1:CAS:528:DyaK1MXjtFKrtbc%3D 10.1359/jbmr.1999.14.5.802 10320529
    • (1999) J Bone Miner Res , vol.14 , pp. 802-809
    • Zhang, X.Z.1    Kalu, D.N.2    Erbas, B.3    Hopper, J.L.4    Seeman, E.5
  • 13
    • 0035196410 scopus 로고    scopus 로고
    • The skeletal structure of insulin-like growth factor I-deficient mice
    • 1:CAS:528:DC%2BD38XhtlShtg%3D%3D 10.1359/jbmr.2001.16.12.2320 11760848
    • D Bikle S Majumdar A Laib L Powell-Braxton C Rosen W Beamer E Nauman C Leary B Halloran 2001 The skeletal structure of insulin-like growth factor I-deficient mice J Bone Miner Res 16 2320 2329 1:CAS:528:DC%2BD38XhtlShtg%3D%3D 10.1359/jbmr.2001.16.12.2320 11760848
    • (2001) J Bone Miner Res , vol.16 , pp. 2320-2329
    • Bikle, D.1    Majumdar, S.2    Laib, A.3    Powell-Braxton, L.4    Rosen, C.5    Beamer, W.6    Nauman, E.7    Leary, C.8    Halloran, B.9
  • 14
    • 36348993763 scopus 로고    scopus 로고
    • Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion
    • 1:CAS:528:DC%2BD2sXhsVers77O 10.1210/en.2007-0608 17717052
    • KE Govoni JE Wergedal L Florin P Angel DJ Baylink S Mohan 2007 Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion Endocrinology 148 5706 5715 1:CAS:528:DC%2BD2sXhsVers77O 10.1210/en.2007-0608 17717052
    • (2007) Endocrinology , vol.148 , pp. 5706-5715
    • Govoni, K.E.1    Wergedal, J.E.2    Florin, L.3    Angel, P.4    Baylink, D.J.5    Mohan, S.6
  • 15
    • 0037371936 scopus 로고    scopus 로고
    • Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms
    • 1:CAS:528:DC%2BD3sXhslCqsbo%3D 10.1210/en.2002-220948 12586770
    • S Mohan C Richman R Guo Y Amaar LR Donahue J Wergedal DJ Baylink 2003 Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms Endocrinology 144 929 936 1:CAS:528:DC%2BD3sXhslCqsbo%3D 10.1210/en.2002-220948 12586770
    • (2003) Endocrinology , vol.144 , pp. 929-936
    • Mohan, S.1    Richman, C.2    Guo, R.3    Amaar, Y.4    Donahue, L.R.5    Wergedal, J.6    Baylink, D.J.7
  • 17
    • 34548062140 scopus 로고    scopus 로고
    • Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice
    • 1:CAS:528:DC%2BD2sXhtV2ns7zF 10.1152/physiolgenomics.00022.2007 17519362
    • KE Govoni SK Lee YS Chung RR Behringer JE Wergedal DJ Baylink S Mohan 2007 Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice Physiol Genomics 30 354 362 1:CAS:528:DC%2BD2sXhtV2ns7zF 10.1152/physiolgenomics.00022.2007 17519362
    • (2007) Physiol Genomics , vol.30 , pp. 354-362
    • Govoni, K.E.1    Lee, S.K.2    Chung, Y.S.3    Behringer, R.R.4    Wergedal, J.E.5    Baylink, D.J.6    Mohan, S.7
  • 18
    • 0027455584 scopus 로고
    • Growth hormone deficiency in "little" mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
    • 1:CAS:528:DyaK3sXhs1Kitg%3D%3D 10.1677/joe.0.1360091 7679139
    • LR Donahue WG Beamer 1993 Growth hormone deficiency in "little" mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4 J Endocrinol 136 91 104 1:CAS:528:DyaK3sXhs1Kitg%3D%3D 10.1677/joe.0.1360091 7679139
    • (1993) J Endocrinol , vol.136 , pp. 91-104
    • Donahue, L.R.1    Beamer, W.G.2
  • 19
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor i (Igf-1) and type 1 IGF receptor (Igf1r)
    • 1:CAS:528:DyaK2cXps12nsg%3D%3D 8402901
    • JP Liu J Baker AS Perkins EJ Robertson A Efstratiadis 1993 Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) Cell 75 59 72 1:CAS:528:DyaK2cXps12nsg%3D%3D 8402901
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 20
    • 0025320906 scopus 로고
    • A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    • 1:CAS:528:DyaK3cXktFyrsr0%3D 10.1038/345078a0 2330056
    • TM DeChiara A Efstratiadis EJ Robertson 1990 A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting Nature 345 78 80 1:CAS:528:DyaK3cXktFyrsr0%3D 10.1038/345078a0 2330056
    • (1990) Nature , vol.345 , pp. 78-80
    • Dechiara, T.M.1    Efstratiadis, A.2    Robertson, E.J.3
  • 22
    • 0037214288 scopus 로고    scopus 로고
    • The structural and hormonal basis of sex differences in peak appendicular bone strength in rats
    • 1:CAS:528:DC%2BD3sXltFKkug%3D%3D 10.1359/jbmr.2003.18.1.150 12510817
    • BT Kim L Mosekilde Y Duan XZ Zhang L Tornvig JS Thomsen E Seeman 2003 The structural and hormonal basis of sex differences in peak appendicular bone strength in rats J Bone Miner Res 18 150 155 1:CAS:528:DC%2BD3sXltFKkug%3D%3D 10.1359/jbmr.2003.18.1.150 12510817
    • (2003) J Bone Miner Res , vol.18 , pp. 150-155
    • Kim, B.T.1    Mosekilde, L.2    Duan, Y.3    Zhang, X.Z.4    Tornvig, L.5    Thomsen, J.S.6    Seeman, E.7
  • 23
    • 33645329097 scopus 로고    scopus 로고
    • Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: A study in the androgen receptor knockout mouse model
    • 1:CAS:528:DC%2BD28Xkt1Kqs7w%3D 10.1359/jbmr.060103 16598378
    • K Venken K De Gendt S Boonen J Ophoff R Bouillon JV Swinnen G Verhoeven D Vanderschueren 2006 Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model J Bone Miner Res 21 576 585 1:CAS:528:DC%2BD28Xkt1Kqs7w%3D 10.1359/jbmr.060103 16598378
    • (2006) J Bone Miner Res , vol.21 , pp. 576-585
    • Venken, K.1    De Gendt, K.2    Boonen, S.3    Ophoff, J.4    Bouillon, R.5    Swinnen, J.V.6    Verhoeven, G.7    Vanderschueren, D.8
  • 24
    • 77953471006 scopus 로고    scopus 로고
    • Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: Evidence from pubertal mouse models
    • 1:CAS:528:DC%2BC3cXksl2lurg%3D 10.1359/jbmr.090828 19888832
    • F Callewaert K Venken JJ Kopchick A Torcasio GH van Lenthe S Boonen D Vanderschueren 2010 Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models J Bone Miner Res 25 617 626 1:CAS:528:DC%2BC3cXksl2lurg%3D 10.1359/jbmr.090828 19888832
    • (2010) J Bone Miner Res , vol.25 , pp. 617-626
    • Callewaert, F.1    Venken, K.2    Kopchick, J.J.3    Torcasio, A.4    Van Lenthe, G.H.5    Boonen, S.6    Vanderschueren, D.7
  • 25
    • 57049132080 scopus 로고    scopus 로고
    • Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice
    • 1:CAS:528:DC%2BD1cXhsVWku77J 10.1152/ajpendo.90507.2008 18812464
    • KE Govoni JE Wergedal RB Chadwick AK Srivastava S Mohan 2008 Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice Am J Physiol Endocrinol Metab 295 E1172 E1180 1:CAS:528:DC%2BD1cXhsVWku77J 10.1152/ajpendo.90507.2008 18812464
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Govoni, K.E.1    Wergedal, J.E.2    Chadwick, R.B.3    Srivastava, A.K.4    Mohan, S.5
  • 26
    • 0025457129 scopus 로고
    • Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats
    • 1:CAS:528:DyaK3MXkt1ansLc%3D 10.1002/jor.1100080418 2355301
    • RT Turner GK Wakley KS Hannon 1990 Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats J Orthop Res 8 612 617 1:CAS:528:DyaK3MXkt1ansLc%3D 10.1002/jor.1100080418 2355301
    • (1990) J Orthop Res , vol.8 , pp. 612-617
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3
  • 27
    • 0041341792 scopus 로고    scopus 로고
    • Role of estrogen and androgen in pubertal skeletal physiology
    • 10.1002/mpo.10340 12868122
    • GR Frank 2003 Role of estrogen and androgen in pubertal skeletal physiology Med Pediatr Oncol 41 217 221 10.1002/mpo.10340 12868122
    • (2003) Med Pediatr Oncol , vol.41 , pp. 217-221
    • Frank, G.R.1
  • 28
    • 0035016058 scopus 로고    scopus 로고
    • The effects of oestrogens on linear bone growth
    • 1:CAS:528:DC%2BD3MXkt1Okur0%3D 10.1093/humupd/7.3.303 11392377
    • A Juul 2001 The effects of oestrogens on linear bone growth Hum Reprod Update 7 303 313 1:CAS:528:DC%2BD3MXkt1Okur0%3D 10.1093/humupd/7.3.303 11392377
    • (2001) Hum Reprod Update , vol.7 , pp. 303-313
    • Juul, A.1
  • 29
    • 33748787122 scopus 로고    scopus 로고
    • Modulation of growth hormone action by sex steroids
    • 1:CAS:528:DC%2BD28Xht1ehsrbJ 10.1111/j.1365-2265.2006.02676.x
    • UJ Meinhardt KK Ho 2006 Modulation of growth hormone action by sex steroids Clin Endocrinol (Oxf) 65 413 422 1:CAS:528:DC%2BD28Xht1ehsrbJ 10.1111/j.1365-2265.2006.02676.x
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 413-422
    • Meinhardt, U.J.1    Ho, K.K.2
  • 30
    • 0042414014 scopus 로고    scopus 로고
    • The regulation of pubertal growth
    • 1:CAS:528:DC%2BD3sXmvFGru70%3D 10.1159/000071222 12955014
    • DM Styne 2003 The regulation of pubertal growth Horm Res 60 22 26 1:CAS:528:DC%2BD3sXmvFGru70%3D 10.1159/000071222 12955014
    • (2003) Horm Res , vol.60 , pp. 22-26
    • Styne, D.M.1
  • 31
    • 0031120087 scopus 로고    scopus 로고
    • The role of estrogen in bone growth and maturation during childhood and adolescence
    • 1:CAS:528:DyaK2sXnt1ansbw%3D 10.1016/S0960-0760(97)80005-2 9365183
    • GB Cutler Jr 1997 The role of estrogen in bone growth and maturation during childhood and adolescence J Steroid Biochem Mol Biol 61 141 144 1:CAS:528:DyaK2sXnt1ansbw%3D 10.1016/S0960-0760(97)80005-2 9365183
    • (1997) J Steroid Biochem Mol Biol , vol.61 , pp. 141-144
    • Cutler Jr., G.B.1
  • 32
    • 32544438281 scopus 로고    scopus 로고
    • Clinical review. Sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion
    • 1:CAS:528:DC%2BD28XhsFKnt7o%3D 10.1210/jc.2005-1766 16303833
    • D Vanderschueren K Venken J Ophoff R Bouillon S Boonen 2006 Clinical review. Sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion J Clin Endocrinol Metab 91 378 382 1:CAS:528:DC%2BD28XhsFKnt7o%3D 10.1210/jc.2005-1766 16303833
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 378-382
    • Vanderschueren, D.1    Venken, K.2    Ophoff, J.3    Bouillon, R.4    Boonen, S.5
  • 33
    • 0030958817 scopus 로고    scopus 로고
    • Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats
    • 1:CAS:528:DyaK2sXjsValsL4%3D 10.1210/en.138.6.2301 9165015
    • D Vanderschueren E van Herck J Nijs AG Ederveen R De Coster R Bouillon 1997 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats Endocrinology 138 2301 2307 1:CAS:528: DyaK2sXjsValsL4%3D 10.1210/en.138.6.2301 9165015
    • (1997) Endocrinology , vol.138 , pp. 2301-2307
    • Vanderschueren, D.1    Van Herck, E.2    Nijs, J.3    Ederveen, A.G.4    De Coster, R.5    Bouillon, R.6
  • 37
    • 52549085934 scopus 로고    scopus 로고
    • Adrenarche: Postnatal adrenal zonation and hormonal and metabolic regulation
    • 1:CAS:528:DC%2BD1cXhtl2qtbnF 10.1159/000157871 18824863
    • A Belgorosky MS Baquedano G Guercio MA Rivarola 2008 Adrenarche: postnatal adrenal zonation and hormonal and metabolic regulation Horm Res 70 257 267 1:CAS:528:DC%2BD1cXhtl2qtbnF 10.1159/000157871 18824863
    • (2008) Horm Res , vol.70 , pp. 257-267
    • Belgorosky, A.1    Baquedano, M.S.2    Guercio, G.3    Rivarola, M.A.4
  • 38
    • 2142653123 scopus 로고    scopus 로고
    • Adrenarche and bone modeling and remodeling at the proximal radius: Weak androgens make stronger cortical bone in healthy children
    • 10.1359/jbmr.2003.18.8.1539 12929945
    • T Remer KR Boye M Hartmann CM Neu E Schoenau F Manz SA Wudy 2003 Adrenarche and bone modeling and remodeling at the proximal radius: weak androgens make stronger cortical bone in healthy children J Bone Miner Res 18 1539 1546 10.1359/jbmr.2003.18.8.1539 12929945
    • (2003) J Bone Miner Res , vol.18 , pp. 1539-1546
    • Remer, T.1    Boye, K.R.2    Hartmann, M.3    Neu, C.M.4    Schoenau, E.5    Manz, F.6    Wudy, S.A.7
  • 39
    • 0018926298 scopus 로고
    • Andrenarche and its relationship to the onset of puberty
    • 1:CAS:528:DyaL3cXktVCmsrs%3D 6445284
    • GB Cutler Jr DL Loriaux 1980 Andrenarche and its relationship to the onset of puberty Fed Proc 39 2384 2390 1:CAS:528:DyaL3cXktVCmsrs%3D 6445284
    • (1980) Fed Proc , vol.39 , pp. 2384-2390
    • Cutler Jr., G.B.1    Loriaux, D.L.2
  • 40
    • 59849125252 scopus 로고    scopus 로고
    • Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer
    • 1:CAS:528:DC%2BD1MXitVyisrg%3D 10.1016/j.jsbmb.2008.11.004 19073258
    • F Labrie L Cusan JL Gomez C Martel R Berube P Belanger A Belanger L Vandenput D Mellstrom C Ohlsson 2009 Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer J Steroid Biochem Mol Biol 113 52 56 1:CAS:528:DC%2BD1MXitVyisrg%3D 10.1016/j.jsbmb.2008.11.004 19073258
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 52-56
    • Labrie, F.1    Cusan, L.2    Gomez, J.L.3    Martel, C.4    Berube, R.5    Belanger, P.6    Belanger, A.7    Vandenput, L.8    Mellstrom, D.9    Ohlsson, C.10
  • 41
  • 42
    • 33746688477 scopus 로고    scopus 로고
    • Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes
    • 1:CAS:528:DC%2BD28XnvFaksLY%3D 10.1677/joe.1.06750 16837610
    • IK Johnsen M Slawik I Shapiro MF Hartmann SA Wudy BD Looyenga GD Hammer M Reincke F Beuschlein 2006 Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes J Endocrinol 190 47 57 1:CAS:528:DC%2BD28XnvFaksLY%3D 10.1677/joe.1.06750 16837610
    • (2006) J Endocrinol , vol.190 , pp. 47-57
    • Johnsen, I.K.1    Slawik, M.2    Shapiro, I.3    Hartmann, M.F.4    Wudy, S.A.5    Looyenga, B.D.6    Hammer, G.D.7    Reincke, M.8    Beuschlein, F.9
  • 43
    • 0343090553 scopus 로고
    • Effects of adrenalectomy and gonadectomy on growth and development in the rat
    • 1:STN:280:DyaF2M%2FjvFygsg%3D%3D 10.1210/endo-75-3-446 14235413
    • JA Grunt 1964 Effects of adrenalectomy and gonadectomy on growth and development in the rat Endocrinology 75 446 451 1:STN:280:DyaF2M%2FjvFygsg%3D%3D 10.1210/endo-75-3-446 14235413
    • (1964) Endocrinology , vol.75 , pp. 446-451
    • Grunt, J.A.1
  • 46
    • 0035157596 scopus 로고    scopus 로고
    • Estrogen receptor specificity in the regulation of the skeleton in female mice
    • 1:CAS:528:DC%2BD3MXosV2htrY%3D 10.1677/joe.0.1710229 11691642
    • MK Lindberg SL Alatalo JM Halleen S Mohan JA Gustafsson C Ohlsson 2001 Estrogen receptor specificity in the regulation of the skeleton in female mice J Endocrinol 171 229 236 1:CAS:528:DC%2BD3MXosV2htrY%3D 10.1677/joe.0.1710229 11691642
    • (2001) J Endocrinol , vol.171 , pp. 229-236
    • Lindberg, M.K.1    Alatalo, S.L.2    Halleen, J.M.3    Mohan, S.4    Gustafsson, J.A.5    Ohlsson, C.6
  • 48
    • 0032748023 scopus 로고    scopus 로고
    • Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    • 1:CAS:528:DyaK1MXmsVClsbw%3D 10.1172/JCI6730 10510330
    • SH Windahl O Vidal G Andersson JA Gustafsson C Ohlsson 1999 Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice J Clin Invest 104 895 901 1:CAS:528:DyaK1MXmsVClsbw%3D 10.1172/JCI6730 10510330
    • (1999) J Clin Invest , vol.104 , pp. 895-901
    • Windahl, S.H.1    Vidal, O.2    Andersson, G.3    Gustafsson, J.A.4    Ohlsson, C.5
  • 52
    • 47849126237 scopus 로고    scopus 로고
    • Bone morphometry strongly predicts cortical bone stiffness and strength, but not toughness, in inbred mouse models of high and low bone mass
    • 10.1359/jbmr.080311 18348694
    • R Voide GH van Lenthe R Muller 2008 Bone morphometry strongly predicts cortical bone stiffness and strength, but not toughness, in inbred mouse models of high and low bone mass J Bone Miner Res 23 1194 1203 10.1359/jbmr.080311 18348694
    • (2008) J Bone Miner Res , vol.23 , pp. 1194-1203
    • Voide, R.1    Van Lenthe, G.H.2    Muller, R.3
  • 53
    • 0242607246 scopus 로고    scopus 로고
    • Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population
    • 1:CAS:528:DC%2BD3sXmslSnsrs%3D 10.1359/jbmr.2003.18.8.1497 12929939
    • SK Volkman AT Galecki DT Burke MR Paczas MR Moalli RA Miller SA Goldstein 2003 Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population J Bone Miner Res 18 1497 1505 1:CAS:528:DC%2BD3sXmslSnsrs%3D 10.1359/jbmr.2003.18.8.1497 12929939
    • (2003) J Bone Miner Res , vol.18 , pp. 1497-1505
    • Volkman, S.K.1    Galecki, A.T.2    Burke, D.T.3    Paczas, M.R.4    Moalli, M.R.5    Miller, R.A.6    Goldstein, S.A.7
  • 54
    • 0030882782 scopus 로고    scopus 로고
    • Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor i axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
    • 1:CAS:528:DyaK2sXmslOhsbg%3D 10.1210/jc.82.10.3414 9329378
    • JD Veldhuis DL Metzger PM Martha Jr N Mauras JR Kerrigan B Keenan AD Rogol SM Pincus 1997 Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement J Clin Endocrinol Metab 82 3414 3420 1:CAS:528:DyaK2sXmslOhsbg%3D 10.1210/jc.82.10.3414 9329378
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3414-3420
    • Veldhuis, J.D.1    Metzger, D.L.2    Martha Jr., P.M.3    Mauras, N.4    Kerrigan, J.R.5    Keenan, B.6    Rogol, A.D.7    Pincus, S.M.8
  • 55
    • 5544328189 scopus 로고    scopus 로고
    • Estrogen regulation of growth hormone action
    • 1:CAS:528:DC%2BD2cXhtVSjtrnN 10.1210/er.2003-0035 15466938
    • KC Leung G Johannsson GM Leong KK Ho 2004 Estrogen regulation of growth hormone action Endocr Rev 25 693 721 1:CAS:528:DC%2BD2cXhtVSjtrnN 10.1210/er.2003-0035 15466938
    • (2004) Endocr Rev , vol.25 , pp. 693-721
    • Leung, K.C.1    Johannsson, G.2    Leong, G.M.3    Ho, K.K.4
  • 56
    • 0036146365 scopus 로고    scopus 로고
    • Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: Implications for efficacy and safety
    • 1:CAS:528:DC%2BD38XntVygsQ%3D%3D 10.1210/jc.87.1.90 11788629
    • P Cohen GM Bright AD Rogol AM Kappelgaard RG Rosenfeld 2002 Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety J Clin Endocrinol Metab 87 90 98 1:CAS:528:DC%2BD38XntVygsQ%3D%3D 10.1210/jc.87.1.90 11788629
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 90-98
    • Cohen, P.1    Bright, G.M.2    Rogol, A.D.3    Kappelgaard, A.M.4    Rosenfeld, R.G.5
  • 57
    • 0034452986 scopus 로고    scopus 로고
    • Gender difference in insulin-like growth factor i response to growth hormone (GH) treatment in GH-deficient adults: Role of sex hormone replacement
    • 1:CAS:528:DC%2BD3cXisFOqsr4%3D 10.1210/jc.85.3.1121 10720049
    • JP Span GF Pieters CG Sweep AR Hermus AG Smals 2000 Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement J Clin Endocrinol Metab 85 1121 1125 1:CAS:528:DC%2BD3cXisFOqsr4%3D 10.1210/jc.85.3.1121 10720049
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1121-1125
    • Span, J.P.1    Pieters, G.F.2    Sweep, C.G.3    Hermus, A.R.4    Smals, A.G.5
  • 59
    • 0030021410 scopus 로고    scopus 로고
    • Sex steroids, growth hormone, insulin-like growth factor-1: Neuroendocrine and metabolic regulation in puberty
    • 1:CAS:528:DyaK28XpvFSjtg%3D%3D 10.1159/000184763 8742123
    • N Mauras AD Rogol MW Haymond JD Veldhuis 1996 Sex steroids, growth hormone, insulin-like growth factor-1: neuroendocrine and metabolic regulation in puberty Horm Res 45 74 80 1:CAS:528:DyaK28XpvFSjtg%3D%3D 10.1159/000184763 8742123
    • (1996) Horm Res , vol.45 , pp. 74-80
    • Mauras, N.1    Rogol, A.D.2    Haymond, M.W.3    Veldhuis, J.D.4
  • 61
    • 19944431157 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice
    • 1:CAS:528:DC%2BD2MXotlWnug%3D%3D 10.1210/en.2004-0816 15550514
    • DA Salih S Mohan Y Kasukawa G Tripathi FA Lovett NF Anderson EJ Carter JE Wergedal DJ Baylink JM Pell 2005 Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice Endocrinology 146 931 940 1:CAS:528:DC%2BD2MXotlWnug%3D%3D 10.1210/en.2004-0816 15550514
    • (2005) Endocrinology , vol.146 , pp. 931-940
    • Salih, D.A.1    Mohan, S.2    Kasukawa, Y.3    Tripathi, G.4    Lovett, F.A.5    Anderson, N.F.6    Carter, E.J.7    Wergedal, J.E.8    Baylink, D.J.9    Pell, J.M.10
  • 62
    • 42449117625 scopus 로고    scopus 로고
    • Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice
    • 1:CAS:528:DC%2BD1cXht1GmsLvM 10.1210/en.2007-1068 18276763
    • VE DeMambro DR Clemmons LG Horton ML Bouxsein TL Wood WG Beamer E Canalis CJ Rosen 2008 Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice Endocrinology 149 2051 2061 1:CAS:528:DC%2BD1cXht1GmsLvM 10.1210/en.2007-1068 18276763
    • (2008) Endocrinology , vol.149 , pp. 2051-2061
    • Demambro, V.E.1    Clemmons, D.R.2    Horton, L.G.3    Bouxsein, M.L.4    Wood, T.L.5    Beamer, W.G.6    Canalis, E.7    Rosen, C.J.8
  • 63
    • 77956825522 scopus 로고    scopus 로고
    • Sex-specific regulation of body size and bone slenderness by the acid labile subunit
    • 10.1002/jbmr.94 20499371
    • HW Courtland V DeMambro J Maynard H Sun S Elis C Rosen S Yakar 2010 Sex-specific regulation of body size and bone slenderness by the acid labile subunit J Bone Miner Res 25 2059 2068 10.1002/jbmr.94 20499371
    • (2010) J Bone Miner Res , vol.25 , pp. 2059-2068
    • Courtland, H.W.1    Demambro, V.2    Maynard, J.3    Sun, H.4    Elis, S.5    Rosen, C.6    Yakar, S.7
  • 65
    • 27744431505 scopus 로고    scopus 로고
    • Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption
    • 1:CAS:528:DC%2BD2MXhtlWntrfN 10.1359/JBMR.050803 16294275
    • H Michael PL Harkonen HK Vaananen TA Hentunen 2005 Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption J Bone Miner Res 20 2224 2232 1:CAS:528:DC%2BD2MXhtlWntrfN 10.1359/JBMR.050803 16294275
    • (2005) J Bone Miner Res , vol.20 , pp. 2224-2232
    • Michael, H.1    Harkonen, P.L.2    Vaananen, H.K.3    Hentunen, T.A.4
  • 66
    • 0029798819 scopus 로고    scopus 로고
    • Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta
    • 1:CAS:528:DyaK28Xmt1Wmsrw%3D 10.1038/nm1096-1132 8837613
    • DE Hughes A Dai JC Tiffee HH Li GR Mundy BF Boyce 1996 Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta Nat Med 2 1132 1136 1:CAS:528:DyaK28Xmt1Wmsrw%3D 10.1038/nm1096-1132 8837613
    • (1996) Nat Med , vol.2 , pp. 1132-1136
    • Hughes, D.E.1    Dai, A.2    Tiffee, J.C.3    Li, H.H.4    Mundy, G.R.5    Boyce, B.F.6
  • 67
    • 1542301037 scopus 로고    scopus 로고
    • Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts
    • 1:CAS:528:DC%2BD2cXhvVOgtrw%3D 10.1677/jme.0.0320209 14766003
    • KM Wiren AR Toombs XW Zhang 2004 Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts J Mol Endocrinol 32 209 226 1:CAS:528:DC%2BD2cXhvVOgtrw%3D 10.1677/jme.0.0320209 14766003
    • (2004) J Mol Endocrinol , vol.32 , pp. 209-226
    • Wiren, K.M.1    Toombs, A.R.2    Zhang, X.W.3
  • 68
    • 3042541735 scopus 로고    scopus 로고
    • Targeted overexpression of androgen receptor in osteoblasts: Unexpected complex bone phenotype in growing animals
    • 1:CAS:528:DC%2BD2cXltFykt70%3D 10.1210/en.2003-1016 15131013
    • KM Wiren XW Zhang AR Toombs V Kasparcova MA Gentile S Harada KJ Jepsen 2004 Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals Endocrinology 145 3507 3522 1:CAS:528:DC%2BD2cXltFykt70%3D 10.1210/en.2003-1016 15131013
    • (2004) Endocrinology , vol.145 , pp. 3507-3522
    • Wiren, K.M.1    Zhang, X.W.2    Toombs, A.R.3    Kasparcova, V.4    Gentile, M.A.5    Harada, S.6    Jepsen, K.J.7
  • 69
    • 0033304663 scopus 로고    scopus 로고
    • Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line
    • 1:CAS:528:DyaK1MXns12htrs%3D 10.1210/en.140.12.5579 10579321
    • F Gori LC Hofbauer CA Conover S Khosla 1999 Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line Endocrinology 140 5579 5586 1:CAS:528:DyaK1MXns12htrs%3D 10.1210/en.140.12.5579 10579321
    • (1999) Endocrinology , vol.140 , pp. 5579-5586
    • Gori, F.1    Hofbauer, L.C.2    Conover, C.A.3    Khosla, S.4
  • 71
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • 1:CAS:528:DC%2BD1cXltlOhsr0%3D 10.1210/er.2007-0014 18057140
    • AE Kearns S Khosla PJ Kostenuik 2008 Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease Endocr Rev 29 155 192 1:CAS:528:DC%2BD1cXltlOhsr0%3D 10.1210/er.2007-0014 18057140
    • (2008) Endocr Rev , vol.29 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 72
    • 27744521675 scopus 로고    scopus 로고
    • Androgens and bone growth: It's location, location, location
    • 1:CAS:528:DC%2BD2MXhtFKntrnP 10.1016/j.coph.2005.06.003 16185926
    • KM Wiren 2005 Androgens and bone growth: it's location, location, location Curr Opin Pharmacol 5 626 632 1:CAS:528:DC%2BD2MXhtFKntrnP 10.1016/j.coph.2005.06.003 16185926
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 626-632
    • Wiren, K.M.1
  • 73
    • 0035017768 scopus 로고    scopus 로고
    • Mechanical strain and estrogen activate estrogen receptor alpha in bone cells
    • 1:CAS:528:DC%2BD3MXkt1Oqsrs%3D 10.1359/jbmr.2001.16.6.1045 11393781
    • HL Jessop M Sjoberg MZ Cheng G Zaman CP Wheeler-Jones LE Lanyon 2001 Mechanical strain and estrogen activate estrogen receptor alpha in bone cells J Bone Miner Res 16 1045 1055 1:CAS:528:DC%2BD3MXkt1Oqsrs%3D 10.1359/jbmr.2001.16. 6.1045 11393781
    • (2001) J Bone Miner Res , vol.16 , pp. 1045-1055
    • Jessop, H.L.1    Sjoberg, M.2    Cheng, M.Z.3    Zaman, G.4    Wheeler-Jones, C.P.5    Lanyon, L.E.6
  • 74
    • 34548500327 scopus 로고    scopus 로고
    • A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
    • 1:CAS:528:DC%2BD2sXpsFWltr8%3D 10.1074/jbc.M702231200 17609204
    • JI Aguirre LI Plotkin AR Gortazar MM Millan CA O'Brien SC Manolagas T Bellido 2007 A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction J Biol Chem 282 25501 25508 1:CAS:528:DC%2BD2sXpsFWltr8%3D 10.1074/jbc.M702231200 17609204
    • (2007) J Biol Chem , vol.282 , pp. 25501-25508
    • Aguirre, J.I.1    Plotkin, L.I.2    Gortazar, A.R.3    Millan, M.M.4    O'Brien, C.A.5    Manolagas, S.C.6    Bellido, T.7
  • 75
    • 34547620497 scopus 로고    scopus 로고
    • The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    • 1:CAS:528:DC%2BD2sXpt12ru7w%3D 10.1152/ajpendo.00189.2007 17535856
    • LK Saxon AG Robling AB Castillo S Mohan CH Turner 2007 The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta Am J Physiol Endocrinol Metab 293 E484 E491 1:CAS:528:DC%2BD2sXpt12ru7w%3D 10.1152/ajpendo.00189.2007 17535856
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Saxon, L.K.1    Robling, A.G.2    Castillo, A.B.3    Mohan, S.4    Turner, C.H.5
  • 76
    • 4444314796 scopus 로고    scopus 로고
    • The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    • 1:CAS:528:DC%2BD2cXntFOgt7s%3D 10.1677/joe.0.1820193 15283680
    • KC Lee H Jessop R Suswillo G Zaman LE Lanyon 2004 The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta J Endocrinol 182 193 201 1:CAS:528:DC%2BD2cXntFOgt7s%3D 10.1677/joe.0.1820193 15283680
    • (2004) J Endocrinol , vol.182 , pp. 193-201
    • Lee, K.C.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.E.5
  • 77
    • 0033791733 scopus 로고    scopus 로고
    • Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females
    • 1:CAS:528:DC%2BD3cXnvVKlt7Y%3D 10.1359/jbmr.2000.15.11.2169 11092397
    • E Damien JS Price LE Lanyon 2000 Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females J Bone Miner Res 15 2169 2177 1:CAS:528:DC%2BD3cXnvVKlt7Y%3D 10.1359/jbmr.2000.15.11. 2169 11092397
    • (2000) J Bone Miner Res , vol.15 , pp. 2169-2177
    • Damien, E.1    Price, J.S.2    Lanyon, L.E.3
  • 78
    • 0036128710 scopus 로고    scopus 로고
    • Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor i
    • 1:CAS:528:DC%2BD38XislCkurc%3D 10.1359/jbmr.2002.17.4.593 11924572
    • MZ Cheng SC Rawlinson AA Pitsillides G Zaman S Mohan DJ Baylink LE Lanyon 2002 Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I J Bone Miner Res 17 593 602 1:CAS:528:DC%2BD38XislCkurc%3D 10.1359/jbmr.2002.17.4.593 11924572
    • (2002) J Bone Miner Res , vol.17 , pp. 593-602
    • Cheng, M.Z.1    Rawlinson, S.C.2    Pitsillides, A.A.3    Zaman, G.4    Mohan, S.5    Baylink, D.J.6    Lanyon, L.E.7
  • 79
    • 45849143260 scopus 로고    scopus 로고
    • Hormonal aspects of the muscle-bone unit
    • 1:CAS:528:DC%2BD1cXnvVCqtLc%3D 18271680
    • I Zofkova 2008 Hormonal aspects of the muscle-bone unit Physiol Res 57 Suppl 1 S159 S169 1:CAS:528:DC%2BD1cXnvVCqtLc%3D 18271680
    • (2008) Physiol Res , vol.57 , Issue.SUPPL. 1
    • Zofkova, I.1
  • 80
    • 67651146640 scopus 로고    scopus 로고
    • Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue
    • 1:CAS:528:DC%2BD1MXpsV2rtLs%3D 10.1210/en.2008-1509 19264874
    • J Ophoff K Van Proeyen F Callewaert K De Gendt K De Bock A Vanden Bosch G Verhoeven P Hespel D Vanderschueren 2009 Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue Endocrinology 150 3558 3566 1:CAS:528: DC%2BD1MXpsV2rtLs%3D 10.1210/en.2008-1509 19264874
    • (2009) Endocrinology , vol.150 , pp. 3558-3566
    • Ophoff, J.1    Van Proeyen, K.2    Callewaert, F.3    De Gendt, K.4    De Bock, K.5    Vanden Bosch, A.6    Verhoeven, G.7    Hespel, P.8    Vanderschueren, D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.