-
1
-
-
69949096728
-
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding
-
E. Beausoleil, C. Chauvignac, T. Taverne, S. Lacombe, L. Pognante, B. Leblond, D. Pallares, C. De Oliveira, F. Bachelot, R. Carton, H. Peillon, S. Coutadeur, V. Picard, N. Lambeng, L. Desire, and F. Schweighoffer Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding Bioorg. Med. Chem. Lett. 19 2009 5594 5598
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 5594-5598
-
-
Beausoleil, E.1
Chauvignac, C.2
Taverne, T.3
Lacombe, S.4
Pognante, L.5
Leblond, B.6
Pallares, D.7
De Oliveira, C.8
Bachelot, F.9
Carton, R.10
Peillon, H.11
Coutadeur, S.12
Picard, V.13
Lambeng, N.14
Desire, L.15
Schweighoffer, F.16
-
2
-
-
0033808151
-
Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition
-
C.S. Breivogel, and S.R. Childers Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition J. Pharmacol. Exp. Ther. 295 2000 328 336
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 328-336
-
-
Breivogel, C.S.1
Childers, S.R.2
-
3
-
-
41249100938
-
1 receptor
-
1 receptor Eur. J. Pharmacol. 584 2008 338 342
-
(2008)
Eur. J. Pharmacol.
, vol.584
, pp. 338-342
-
-
Chen, R.Z.1
Frassetto, A.2
Lao, J.Z.3
Huang, R.R.4
Xiao, J.C.5
Clements, M.J.6
Walsh, T.F.7
Hale, J.J.8
Wang, J.9
Tong, X.10
Fong, T.M.11
-
6
-
-
0027501457
-
Cannabinoid structure-activity relationships: Correlation of receptor binding and in vivo activities
-
D.R. Compton, K.C. Rice, B.R. De Costa, R.K. Razdan, L.S. Melvin, M.R. Johnson, and B.R. Martin Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities J. Pharmacol. Exp. Ther. 265 1993 218 226
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.265
, pp. 218-226
-
-
Compton, D.R.1
Rice, K.C.2
De Costa, B.R.3
Razdan, R.K.4
Melvin, L.S.5
Johnson, M.R.6
Martin, B.R.7
-
7
-
-
0027875020
-
Cannabinoids modulate potassium current in cultured hippocampal neurons
-
S.A. Deadwyler, R.E. Hampson, B.A. Bennett, T.A. Edwards, J. Mu, M.A. Pacheco, S.J. Ward, and S.R. Childers Cannabinoids modulate potassium current in cultured hippocampal neurons Recept. Channels 1 1993 121 134
-
(1993)
Recept. Channels
, vol.1
, pp. 121-134
-
-
Deadwyler, S.A.1
Hampson, R.E.2
Bennett, B.A.3
Edwards, T.A.4
Mu, J.5
Pacheco, M.A.6
Ward, S.J.7
Childers, S.R.8
-
8
-
-
0024263922
-
Determination and characterization of a cannabinoid receptor in rat brain
-
W.A. Devane, F.A. Dysarz III, M.R. Johnson, L.S. Melvin, and A.C. Howlett Determination and characterization of a cannabinoid receptor in rat brain Mol. Pharmacol. 34 1988 605 613
-
(1988)
Mol. Pharmacol.
, vol.34
, pp. 605-613
-
-
Devane, W.A.1
Iii, A.D.F.2
Johnson, M.R.3
Melvin, L.S.4
Howlett, A.C.5
-
11
-
-
0017383560
-
Fate of methoprene (isopropyl(2E, 4E)-11-methoxy-3, 7, 11-trimethyl-2, 4-dodecadienoate) in rats
-
D.R. Hawkins, K.T. Weston, L.F. Chasseaud, and E.R. Franklin Fate of methoprene (isopropyl(2E, 4E)-11-methoxy-3, 7, 11-trimethyl-2, 4-dodecadienoate) in rats J. Agric. Food Chem. 25 1977 398 403
-
(1977)
J. Agric. Food Chem.
, vol.25
, pp. 398-403
-
-
Hawkins, D.R.1
Weston, K.T.2
Chasseaud, L.F.3
Franklin, E.R.4
-
14
-
-
0025954862
-
Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
-
M. Herkenham, A.B. Lynn, M.R. Johnson, L.S. Melvin, B.R. de Costa, and K.C. Rice Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study J. Neurosci. 11 1991 563 583
-
(1991)
J. Neurosci.
, vol.11
, pp. 563-583
-
-
Herkenham, M.1
Lynn, A.B.2
Johnson, M.R.3
Melvin, L.S.4
De Costa, B.R.5
Rice, K.C.6
-
15
-
-
0027396592
-
Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins
-
D. Houston, and A. Howlett Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins Mol. Pharmacol. 43 1993 17 22
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 17-22
-
-
Houston, D.1
Howlett, A.2
-
16
-
-
0021966402
-
Cannabinoid inhibition of adenylate cyclase: Biochemistry of the response in neuroblastoma cell membranes
-
A.C. Howlett Cannabinoid inhibition of adenylate cyclase: Biochemistry of the response in neuroblastoma cell membranes Mol. Pharmacol. 27 1985 429 436
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 429-436
-
-
Howlett, A.C.1
-
17
-
-
0021722983
-
Cannabinoid inhibition of adenylate cyclase.: Pharmacology of the response in neuroblastoma cell membranes
-
A.C. Howlett, and R.M. Fleming Cannabinoid inhibition of adenylate cyclase.: Pharmacology of the response in neuroblastoma cell membranes Mol. Pharmacol. 26 1984 532 538
-
(1984)
Mol. Pharmacol.
, vol.26
, pp. 532-538
-
-
Howlett, A.C.1
Fleming, R.M.2
-
19
-
-
18444376760
-
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
-
A.C. Howlett, F. Barth, T.I. Bonner, G. Cabral, P. Casellas, W.A. Devane, C.C. Felder, M. Herkenham, K. Mackie, and B.R. Martin International Union of Pharmacology. XXVII. Classification of cannabinoid receptors Pharmacol. Rev. 54 2002 161 202
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
Devane, W.A.6
Felder, C.C.7
Herkenham, M.8
MacKie, K.9
Martin, B.R.10
-
22
-
-
33644934527
-
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory pre-synaptic sites in the hippocampus and cerebellum
-
Y. Kawamura, M. Fukaya, T. Maejima, T. Yoshida, E. Miura, M. Watanabe, T. Ohno-Shosaku, and M. Kano The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory pre-synaptic sites in the hippocampus and cerebellum J. Neurosci. 26 2006 2991 3001
-
(2006)
J. Neurosci.
, vol.26
, pp. 2991-3001
-
-
Kawamura, Y.1
Fukaya, M.2
Maejima, T.3
Yoshida, T.4
Miura, E.5
Watanabe, M.6
Ohno-Shosaku, T.7
Kano, M.8
-
23
-
-
0035053627
-
Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
-
A. Kreitzer, and W. Regehr Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells Neuron 29 2001 717 727
-
(2001)
Neuron
, vol.29
, pp. 717-727
-
-
Kreitzer, A.1
Regehr, W.2
-
24
-
-
3042751071
-
2+ currents by endocannabinoids released via postsynaptic mGluR activation at a Calyx synapse
-
2+ currents by endocannabinoids released via postsynaptic mGluR activation at a Calyx synapse J. Neurosci. 24 2004 5955 5965
-
(2004)
J. Neurosci.
, vol.24
, pp. 5955-5965
-
-
Kushmerick, C.1
Price, G.D.2
Taschenberger, H.3
Puente, N.4
Renden, R.5
Wadiche, J.I.6
Duvoisin, R.M.7
Von, G.P.8
Gersdorff, H.9
-
25
-
-
0033602129
-
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists
-
R. Lan, Q. Liu, P. Fan, S. Lin, S.R. Fernando, D. McCallion, R. Pertwee, and A. Makriyannis Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists J. Med. Chem. 42 1999 769 776
-
(1999)
J. Med. Chem.
, vol.42
, pp. 769-776
-
-
Lan, R.1
Liu, Q.2
Fan, P.3
Lin, S.4
Fernando, S.R.5
McCallion, D.6
Pertwee, R.7
Makriyannis, A.8
-
26
-
-
0000213557
-
Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C
-
S.K. Lee, W.G. Qing, W. Mar, L. Luyengi, R.G. Mehta, K. Kawanishi, H.H.S. Fong, C.W.W. Beecher, A.D. Kinghorn, and J.M. Pezzuto Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C J. Biol. Chem. 273 1998 19829 19833
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 19829-19833
-
-
Lee, S.K.1
Qing, W.G.2
Mar, W.3
Luyengi, L.4
Mehta, R.G.5
Kawanishi, K.6
Fong, H.H.S.7
Beecher, C.W.W.8
Kinghorn, A.D.9
Pezzuto, J.M.10
-
27
-
-
0026603679
-
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
-
K. Mackie, and B. Hille Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells Proc. Natl Acad. Sci. USA 89 1992 3825 3829
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 3825-3829
-
-
MacKie, K.1
Hille, B.2
-
28
-
-
0028823316
-
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
-
K. Mackie, Y. Lai, R. Westenbroek, and R. Mitchell Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor J. Neurosci. 15 1995 6552 6561
-
(1995)
J. Neurosci.
, vol.15
, pp. 6552-6561
-
-
MacKie, K.1
Lai, Y.2
Westenbroek, R.3
Mitchell, R.4
-
29
-
-
0242522905
-
1 receptor constitutes an agonist /inverse agonist binding region
-
1 receptor constitutes an agonist /inverse agonist binding region J. Med. Chem. 46 2003 5139 5152
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5139-5152
-
-
McAllister, S.D.1
Rizvi, G.2
Anavi-Goffer, S.3
Hurst, D.P.4
Barnett-Norris, J.5
Lynch, D.L.6
Reggio, P.H.7
Abood, M.E.8
-
30
-
-
43749096323
-
Activation of the endocannabinoid system by organophosphorus nerve agents
-
D.K. Nomura, J.L. Blankman, G.M. Simon, K. Fujioka, R.S. Issa, A.M. Ward, B.F. Cravatt, and J.E. Casida Activation of the endocannabinoid system by organophosphorus nerve agents Nat. Chem. Biol. 4 2008 373 378
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 373-378
-
-
Nomura, D.K.1
Blankman, J.L.2
Simon, G.M.3
Fujioka, K.4
Issa, R.S.5
Ward, A.M.6
Cravatt, B.F.7
Casida, J.E.8
-
31
-
-
0017613512
-
A simplification of the method of Lowry et al. which is more generally applicable
-
G.L. Peterson A simplification of the method of Lowry et al. which is more generally applicable Anal. Biochem. 83 1977 346 356
-
(1977)
Anal. Biochem.
, vol.83
, pp. 346-356
-
-
Peterson, G.L.1
-
32
-
-
0030709362
-
Interaction of brain cannabinoid receptors with guanine nucleotide binding protein; A radioligand binding study
-
F. Petitet, B. Jeantaud, M. Capet, and A. Doble Interaction of brain cannabinoid receptors with guanine nucleotide binding protein; a radioligand binding study Biochem. Pharmacol. 54 1997 1267 1270
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 1267-1270
-
-
Petitet, F.1
Jeantaud, B.2
Capet, M.3
Doble, A.4
-
34
-
-
67649856310
-
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
-
G. Riedel, P. Fadda, S. McKillop-Smith, R.G. Pertwee, B. Platt, and L. Robinson Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice Br. J. Pharmacol. 156 2009 1154 1166
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 1154-1166
-
-
Riedel, G.1
Fadda, P.2
McKillop-Smith, S.3
Pertwee, R.G.4
Platt, B.5
Robinson, L.6
-
35
-
-
0028129936
-
SR141716A a potent and selective antagonist of the brain cannabinoid receptor
-
M. Rinaldi-Carmona, F. Barth, M. Heaulme, D. Shire, B. Calandra, C. Congy, S. Martinez, J. Maruani, G. Neliat, D. Caput, P. Ferrara, P. Soubrie, J.C. Breliere, and G. Le Fur SR141716A a potent and selective antagonist of the brain cannabinoid receptor FEBS Lett. 350 1994 240 244
-
(1994)
FEBS Lett.
, vol.350
, pp. 240-244
-
-
Rinaldi-Carmona, M.1
Barth, F.2
Heaulme, M.3
Shire, D.4
Calandra, B.5
Congy, C.6
Martinez, S.7
Maruani, J.8
Neliat, G.9
Caput, D.10
Ferrara, P.11
Soubrie, P.12
Breliere, J.C.13
Le Fur, G.14
-
38
-
-
0017101659
-
Insect growth regulators and insect control: A critical appraisal
-
J.B. Siddall Insect growth regulators and insect control: A critical appraisal Environ. Health Perspect. 14 1976 119 126
-
(1976)
Environ. Health Perspect.
, vol.14
, pp. 119-126
-
-
Siddall, J.B.1
-
39
-
-
0034932996
-
Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells
-
I. Slalinova, E. Taborska, H. Bochorakova, and J. Slanina Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells Cell Biol. Toxicol. 17 2001 51 63
-
(2001)
Cell Biol. Toxicol.
, vol.17
, pp. 51-63
-
-
Slalinova, I.1
Taborska, E.2
Bochorakova, H.3
Slanina, J.4
-
40
-
-
0029866824
-
A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
-
Z.-H. Song, and T.I. Bonner A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2 Mol. Pharmacol. 49 1996 891 896
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 891-896
-
-
Song, Z.-H.1
Bonner, T.I.2
-
42
-
-
67650714118
-
Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists
-
G. Szabo, B. Varga, D. Payer-Lengyel, A. Szemzo, P. Erdelyi, K. Vukics, J. Szikra, E. Hegyi, M. Vastag, B. Kiss, J. Laszy, I. Gyertyn, and J. Fischer Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists J. Med. Chem. 2009 52 2009 4329 4337
-
(2009)
J. Med. Chem.
, vol.2009
, Issue.52
, pp. 4329-4337
-
-
Szabo, G.1
Varga, B.2
Payer-Lengyel, D.3
Szemzo, A.4
Erdelyi, P.5
Vukics, K.6
Szikra, J.7
Hegyi, E.8
Vastag, M.9
Kiss, B.10
Laszy, J.11
Gyertyn, I.12
Fischer, J.13
-
45
-
-
0030746408
-
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
-
W. Twitchell, S. Brown, and K. Mackie Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons J. Neurophysiol. 78 1997 43 50
-
(1997)
J. Neurophysiol.
, vol.78
, pp. 43-50
-
-
Twitchell, W.1
Brown, S.2
MacKie, K.3
-
46
-
-
0037103365
-
Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: Conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase
-
M. Van der Stelt, J.A. Van Kuik, M. Bari, G. Van Zadelhoff, B.R. Leeflang, G.A. Veldink, A. Finazzi-Agro, J.F.G. Vliegenthart, and M. Maccarrone Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase J. Med. Chem. 45 2002 3709 3720
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3709-3720
-
-
Van Der Stelt, M.1
Van Kuik, J.A.2
Bari, M.3
Van Zadelhoff, G.4
Leeflang, B.R.5
Veldink, G.A.6
Finazzi-Agro, A.7
Vliegenthart, J.F.G.8
MacCarrone, M.9
-
47
-
-
0036226664
-
2-selective agonists
-
2-selective agonists J. Pharmacol. Exp. Ther. 301 2002 679 689
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 679-689
-
-
Wiley, J.L.1
Beletskaya, I.D.2
Ng, E.W.3
Dai, Z.4
Crocker, P.J.5
Mahadevan, A.6
Razdan, R.K.7
Martin, B.R.8
-
48
-
-
0035967145
-
Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses
-
R.A. Wilson, and R.I. Nicoll Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses Nature 410 2001 588 592
-
(2001)
Nature
, vol.410
, pp. 588-592
-
-
Wilson, R.A.1
Nicoll, R.I.2
-
49
-
-
67650714102
-
Discovery of 2-[5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-ethyl-1H- pyrazol-3-yl]-1, 5, 5-trimethyl-1, 5-dihydroimidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice
-
C.H. Wu, M.S. Hung, J.S. Song, T.K. Yeh, M.C. Chou, C.M. Chu, J.J. Jan, M.T. Hsieh, S.L. Tseng, C.P. Chang, W.P. Hsieh, Y. Lin, Y.N. Yeh, W.L. Chung, C.W. Kuo, C.Y. Lin, H.S. Shy, Y.S. Chao, and K.S. Shia Discovery of 2-[5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-ethyl-1H-pyrazol-3-yl]-1, 5, 5-trimethyl-1, 5-dihydroimidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice J. Med. Chem. 52 2009 4496 4510
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4496-4510
-
-
Wu, C.H.1
Hung, M.S.2
Song, J.S.3
Yeh, T.K.4
Chou, M.C.5
Chu, C.M.6
Jan, J.J.7
Hsieh, M.T.8
Tseng, S.L.9
Chang, C.P.10
Hsieh, W.P.11
Lin, Y.12
Yeh, Y.N.13
Chung, W.L.14
Kuo, C.W.15
Lin, C.Y.16
Shy, H.S.17
Chao, Y.S.18
Shia, K.S.19
|