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Volumn 41, Issue 2, 2011, Pages 392-402

Invariant NKT cells regulate experimental autoimmune uveitis through inhibition of Th17 differentiation

Author keywords

Autoimmunity; NKT cells; Th differentiation

Indexed keywords

CD1D ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 78851469543     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040569     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver, C. T., Hatton, R. D., Mangan, P. R. and Harrington, L. E., IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 2007. 25: 821-852.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 2
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions, and faults
    • Zhu, J. and Paul, W. E., CD4 T cells: fates, functions, and faults. Blood 2008. 112: 1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 3
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: the long and winding road
    • McGeachy, M. J. and Cua, D. J., Th17 cell differentiation: the long and winding road. Immunity 2008. 28: 445-453.
    • (2008) Immunity , vol.28 , pp. 445-453
    • McGeachy, M.J.1    Cua, D.J.2
  • 4
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7
  • 6
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M. and Cheroutre, H., Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007. 317: 256-260.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6    Cheroutre, H.7
  • 7
    • 33845910939 scopus 로고    scopus 로고
    • Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
    • Lohr, J., Knoechel, B., Wang, J. J., Villarino, A. V. and Abbas, A. K., Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 2006. 203: 2785-2791.
    • (2006) J. Exp. Med. , vol.203 , pp. 2785-2791
    • Lohr, J.1    Knoechel, B.2    Wang, J.J.3    Villarino, A.V.4    Abbas, A.K.5
  • 8
    • 49649101595 scopus 로고    scopus 로고
    • Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    • Stummvoll, G. H., DiPaolo, R. J., Huter, E. N., Davidson, T. S., Glass, D., Ward, J. M. and Shevach, E. M., Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J. Immunol. 2008. 181: 1908-1916.
    • (2008) J. Immunol. , vol.181 , pp. 1908-1916
    • Stummvoll, G.H.1    DiPaolo, R.J.2    Huter, E.N.3    Davidson, T.S.4    Glass, D.5    Ward, J.M.6    Shevach, E.M.7
  • 9
    • 34548734314 scopus 로고    scopus 로고
    • The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+regulatory T cells
    • O'Connor, R. A., Malpass, K. H. and Anderton, S. M., The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+regulatory T cells. J. Immunol. 2007. 179: 958-966.
    • (2007) J. Immunol. , vol.179 , pp. 958-966
    • O'Connor, R.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 10
    • 51549097819 scopus 로고    scopus 로고
    • Reprogrammed FoxP3+T regulatory cells become IL-17+antigen-specific autoimmune effectors in vitro and in vivo
    • Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J. et al., Reprogrammed FoxP3+T regulatory cells become IL-17+antigen-specific autoimmune effectors in vitro and in vivo. J. Immunol. 2008. 181: 3137-3147.
    • (2008) J. Immunol. , vol.181 , pp. 3137-3147
    • Radhakrishnan, S.1    Cabrera, R.2    Schenk, E.L.3    Nava-Parada, P.4    Bell, M.P.5    Van Keulen, V.P.6    Marler, R.J.7
  • 11
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25high Foxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen, H. J., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. and Joosten, I., Human CD25high Foxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008. 112: 2340-2352.
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 12
    • 27144435475 scopus 로고    scopus 로고
    • CD8bright CD56+T cells are cytotoxic effectors in patients with active Behcet's uveitis
    • Ahn, J. K., Chung, H., Lee, D. S., Yu, Y. S. and Yu, H. G., CD8bright CD56+T cells are cytotoxic effectors in patients with active Behcet's uveitis. J. Immunol. 2005. 175: 6133-6142.
    • (2005) J. Immunol. , vol.175 , pp. 6133-6142
    • Ahn, J.K.1    Chung, H.2    Lee, D.S.3    Yu, Y.S.4    Yu, H.G.5
  • 13
    • 0025105886 scopus 로고
    • The mouse as a model of experimental autoimmune uveoretinitis (EAU)
    • Caspi, R. R., Chan, C. C., Wiggert, B. and Chader, G. J., The mouse as a model of experimental autoimmune uveoretinitis (EAU). Curr. Eye. Res. 1990. 9: 169-174.
    • (1990) Curr. Eye. Res. , vol.9 , pp. 169-174
    • Caspi, R.R.1    Chan, C.C.2    Wiggert, B.3    Chader, G.J.4
  • 14
    • 0031570957 scopus 로고    scopus 로고
    • Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response
    • Sun, B., Rizzo, L. V., Sun, S. H., Chan, C. C., Wiggert, B., Wilder, R. L. and Caspi, R. R., Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J. Immunol. 1997. 159: 1004-1011.
    • (1997) J. Immunol. , vol.159 , pp. 1004-1011
    • Sun, B.1    Rizzo, L.V.2    Sun, S.H.3    Chan, C.C.4    Wiggert, B.5    Wilder, R.L.6    Caspi, R.R.7
  • 15
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • Amadi-Obi, A., Yu, C. R., Liu, X., Mahdi, R. M., Clarke, G. L., Nussenblatt, R. B., Gery, I. et al., TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 2007. 13: 711-718.
    • (2007) Nat. Med. , vol.13 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6    Gery, I.7
  • 16
    • 34247586615 scopus 로고    scopus 로고
    • Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype
    • Tang, J., Zhu, W., Silver, P. B., Su, S. B., Chan, C. C. and Caspi, R. R., Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J. Immunol. 2007. 178: 5578-5587.
    • (2007) J. Immunol. , vol.178 , pp. 5578-5587
    • Tang, J.1    Zhu, W.2    Silver, P.B.3    Su, S.B.4    Chan, C.C.5    Caspi, R.R.6
  • 17
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    • Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P. et al., Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 2008. 205: 799-810.
    • (2008) J. Exp. Med. , vol.205 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3    Cua, D.4    Chen, Z.5    Iwakura, Y.6    Bowman, E.P.7
  • 18
    • 17144374753 scopus 로고    scopus 로고
    • Toward an understanding of NKT cell biology: progress and paradoxes
    • Kronenberg, M., Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol. 2005. 23: 877-900.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 877-900
    • Kronenberg, M.1
  • 20
    • 13544262688 scopus 로고    scopus 로고
    • Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity
    • Oh, K., Kim, S., Park, S. H., Gu, H., Roopenian, D., Kim, Y. S. and Lee, D. S., Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity. J. Immunol. 2005. 174: 2030-2036.
    • (2005) J. Immunol. , vol.174 , pp. 2030-2036
    • Oh, K.1    Kim, S.2    Park, S.H.3    Gu, H.4    Roopenian, D.5    Kim, Y.S.6    Lee, D.S.7
  • 21
    • 0034799397 scopus 로고    scopus 로고
    • Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes
    • Sharif, S., Arreaza, G. A., Zucker, P., Mi, Q. S., Sondhi, J., Naidenko, O. V., Kronenberg, M. et al., Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 2001. 7: 1057-1062.
    • (2001) Nat. Med. , vol.7 , pp. 1057-1062
    • Sharif, S.1    Arreaza, G.A.2    Zucker, P.3    Mi, Q.S.4    Sondhi, J.5    Naidenko, O.V.6    Kronenberg, M.7
  • 22
    • 0034786013 scopus 로고    scopus 로고
    • The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
    • Hong, S., Wilson, M. T., Serizawa, I., Wu, L., Singh, N., Naidenko, O. V., Miura, T. et al., The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 2001. 7: 1052-1056.
    • (2001) Nat. Med. , vol.7 , pp. 1052-1056
    • Hong, S.1    Wilson, M.T.2    Serizawa, I.3    Wu, L.4    Singh, N.5    Naidenko, O.V.6    Miura, T.7
  • 23
    • 0035905471 scopus 로고    scopus 로고
    • Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis
    • Singh, A. K., Wilson, M. T., Hong, S., Olivares-Villagómez, D., Du, C., Stanic, A. K., Joyce, S. et al., Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 2001. 194: 1801-1811.
    • (2001) J. Exp. Med. , vol.194 , pp. 1801-1811
    • Singh, A.K.1    Wilson, M.T.2    Hong, S.3    Olivares-Villagómez, D.4    Du, C.5    Stanic, A.K.6    Joyce, S.7
  • 24
    • 53149111593 scopus 로고    scopus 로고
    • Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent manner
    • Mars, L. T., Gautron, A. S., Novak, J., Beaudoin, L., Diana, J., Liblau, R. S. and Lehuen, A., Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent manner. J. Immunol. 2008. 181: 2321-2329.
    • (2008) J. Immunol. , vol.181 , pp. 2321-2329
    • Mars, L.T.1    Gautron, A.S.2    Novak, J.3    Beaudoin, L.4    Diana, J.5    Liblau, R.S.6    Lehuen, A.7
  • 25
    • 33646553070 scopus 로고    scopus 로고
    • DX5+NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1
    • Hornung, M., Farkas, S. A., Sattler, C., Schlitt, H. J. and Geissler, E. K., DX5+NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1. Eur. J. Immunol. 2006. 36: 1210-1221.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1210-1221
    • Hornung, M.1    Farkas, S.A.2    Sattler, C.3    Schlitt, H.J.4    Geissler, E.K.5
  • 27
    • 0037097505 scopus 로고    scopus 로고
    • Cutting Edge: Va14-Ja281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice
    • Mars, L. T., Laloux, V., Goude, K., Desbois, S., Saoudi, A., Van Kaer, L., Lassmann, H. et al., Cutting Edge: Va14-Ja281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 2002. 168: 6007-6011.
    • (2002) J. Immunol. , vol.168 , pp. 6007-6011
    • Mars, L.T.1    Laloux, V.2    Goude, K.3    Desbois, S.4    Saoudi, A.5    Van Kaer, L.6    Lassmann, H.7
  • 28
    • 58149277740 scopus 로고    scopus 로고
    • Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses
    • Grajewski, R. S., Hansen, A. M., Agarwal, R. K., Kronenberg, M., Sidobre, S., Su, S. B., Silver, P. B. et al., Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J. Immunol. 2008. 181: 4791-4797.
    • (2008) J. Immunol. , vol.181 , pp. 4791-4797
    • Grajewski, R.S.1    Hansen, A.M.2    Agarwal, R.K.3    Kronenberg, M.4    Sidobre, S.5    Su, S.B.6    Silver, P.B.7
  • 29
    • 3042591658 scopus 로고    scopus 로고
    • NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease
    • Yamamura, T., Miyamoto, K., Illés, Z., Pál, E., Araki, M. and Miyake, S., NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease. Curr. Top. Med. Chem. 2004. 4: 561-567.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 561-567
    • Yamamura, T.1    Miyamoto, K.2    Illés, Z.3    Pál, E.4    Araki, M.5    Miyake, S.6
  • 30
    • 0035807302 scopus 로고    scopus 로고
    • A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells
    • Miyamoto, K., Miyake, S. and Yamamura, T., A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001. 413: 531-534.
    • (2001) Nature , vol.413 , pp. 531-534
    • Miyamoto, K.1    Miyake, S.2    Yamamura, T.3
  • 31
    • 0346458555 scopus 로고    scopus 로고
    • Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide
    • Chiba, A., Oki, S., Miyamoto, K., Hashimoto, H., Yamamura, T. and Miyake, S., Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum. 2004. 50: 305-313.
    • (2004) Arthritis Rheum. , vol.50 , pp. 305-313
    • Chiba, A.1    Oki, S.2    Miyamoto, K.3    Hashimoto, H.4    Yamamura, T.5    Miyake, S.6
  • 32
    • 13544252802 scopus 로고    scopus 로고
    • Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts
    • Novak, J., Beaudoin, L., Griseri, T. and Lehuen, A., Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J. Immunol. 2005. 174: 1954-1961.
    • (2005) J. Immunol. , vol.174 , pp. 1954-1961
    • Novak, J.1    Beaudoin, L.2    Griseri, T.3    Lehuen, A.4
  • 33
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M. and Weaver, C. T., Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005. 6: 1123-1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 34
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura, K., Kitani, A. and Strober, W., Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 2001. 194: 629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 35
    • 33746933828 scopus 로고    scopus 로고
    • TGF-beta-mediated suppression by CD4+CD25+T cells is facilitated by CTLA-4 signaling
    • Oida, T., Xu, L., Weiner, H. L., Kitani, A. and Strober, W., TGF-beta-mediated suppression by CD4+CD25+T cells is facilitated by CTLA-4 signaling. J. Immunol. 2006. 177: 2331-2339.
    • (2006) J. Immunol. , vol.177 , pp. 2331-2339
    • Oida, T.1    Xu, L.2    Weiner, H.L.3    Kitani, A.4    Strober, W.5
  • 36
    • 58149277740 scopus 로고    scopus 로고
    • Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses
    • Grajewski, R. S., Hansen, A. M., Agarwal, R. K., Kronenberg, M., Sidobre, S., Su, S. B., Silver, P. B. et al., Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J. Immunol. 2008. 181: 4791-4797.
    • (2008) J. Immunol. , vol.181 , pp. 4791-4797
    • Grajewski, R.S.1    Hansen, A.M.2    Agarwal, R.K.3    Kronenberg, M.4    Sidobre, S.5    Su, S.B.6    Silver, P.B.7
  • 37
    • 0033835732 scopus 로고    scopus 로고
    • Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice
    • Avichezer, D., Chan, C. C., Silver, P. B., Wiggert, B. and Caspi, R. R., Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp. Eye. Res. 2000. 71: 111-118.
    • (2000) Exp. Eye. Res. , vol.71 , pp. 111-118
    • Avichezer, D.1    Chan, C.C.2    Silver, P.B.3    Wiggert, B.4    Caspi, R.R.5
  • 38
    • 23944522338 scopus 로고    scopus 로고
    • Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions
    • Minami, K., Yanagawa, Y., Iwabuchi, K., Shinohara, N., Harabayashi, T., Nonomura, K. and Onoé, K., Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions. Blood 2005. 106: 1685-1693.
    • (2005) Blood , vol.106 , pp. 1685-1693
    • Minami, K.1    Yanagawa, Y.2    Iwabuchi, K.3    Shinohara, N.4    Harabayashi, T.5    Nonomura, K.6    Onoé, K.7
  • 39
    • 50949091429 scopus 로고    scopus 로고
    • Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines
    • Lees, J. R., Iwakura, Y. and Russell, J. H., Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines. J. Immunol. 2008. 180: 8066-8072.
    • (2008) J. Immunol. , vol.180 , pp. 8066-8072
    • Lees, J.R.1    Iwakura, Y.2    Russell, J.H.3
  • 40
    • 0038182547 scopus 로고    scopus 로고
    • Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis
    • Zamvil, S. S. and Steinman, L., Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis. Neuron 2003. 38: 685-688.
    • (2003) Neuron , vol.38 , pp. 685-688
    • Zamvil, S.S.1    Steinman, L.2
  • 41
    • 0035997391 scopus 로고    scopus 로고
    • Experimental autoimmune uveitides: multiple antigens, diverse diseases
    • Adamus, G. and Chan, C. C., Experimental autoimmune uveitides: multiple antigens, diverse diseases. Int. Rev. Immunol. 2002. 21: 209-229.
    • (2002) Int. Rev. Immunol. , vol.21 , pp. 209-229
    • Adamus, G.1    Chan, C.C.2


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