HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 5, 2011, Pages 1128-1135

  Geenen, Suzanne ^a,b   Michopoulos, Filippos ^b   Kenna, J Gerry ^b   Kolaja, Kyle L ^c   Westerhoff, Hans V ^a   Wilson, Ian ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Predictive Toxicology Screens and Emerging Technologies   (United States)

Author keywords

Biomarkers; Glutathione; Hepatotoxicity; HPLC MS MS; Ophthalmic acid; Oxidative stress

Indexed keywords

ASPARTATE AMINOTRANSFERASE; GLUTATHIONE DERIVATIVE; METHAPYRILENE; OPHTHALMIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CALIBRATION; CELL CULTURE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIVER CELL; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; DRUG-INDUCED LIVER INJURY; EPITHELIAL CELLS; HUMANS; LIMIT OF DETECTION; LIVER; MALE; METHAPYRILENE; OLIGOPEPTIDES; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 78751706621     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.038     Document Type: Article

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