Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis

Toxicology and Applied Pharmacology

Volumn 239, Issue 3, 2009, Pages 297-305

  Mercer, Amy E ^a   Regan, Sophie L ^a   Hirst, Charlotte M ^a   Graham, Emma E ^a   Antoine, Daniel J ^a   Benson, Craig A ^a   Williams, Dominic P ^a   Foster, John ^b   Kenna, J Gerry ^b   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Apoptosis; Glutathione; Hepatotoxicity; Methapyrilene; Necrosis; Thiophene

Indexed keywords

CASPASE; CYTOCHROME C; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; METHAPYRILENE; THIOPHENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPHILIC STRESS; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER NECROSIS; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; NONHUMAN; OXIDATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TOXIC HEPATITIS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HEPATITIS, TOXIC; HEPATOCYTES; LIVER; MALE; METHAPYRILENE; NECROSIS; OXIDATION-REDUCTION; RATS; RATS, WISTAR; THIOPHENES;

RATTUS;

EID: 69049104063     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.05.027     Document Type: Article

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