The whey fermentation product malleable protein matrix decreases triglyceride concentrations in subjects with hypercholesterolemia: A randomized placebo-controlled trial1

Journal of Dairy Science

Volumn 94, Issue 2, 2011, Pages 589-601

  Berthold, H K ^a   Schulte, D M ^b   Lapointe, J F ^c   Lemieux, P ^c   Krone, W ^c   Gouni Berthold, I ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c Technologie Biolactis   (Canada)

Author keywords

Hypercholesterolemia; Hypertriglyceridemia; Malleable protein matrix; Whey

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MILK PROTEIN; TRIACYLGLYCEROL; WHEY PROTEIN;

ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAIRY PRODUCT; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TREATMENT OUTCOME;

ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CULTURED MILK PRODUCTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; MILK PROTEINS; RISK FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES;

ANIMALIA; LACTOBACILLUS KEFIRANOFACIENS;

EID: 78751694077     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-3115     Document Type: Article

References (54)

1. Agerbaek M., Gerdes L.U., Richelsen B. Hypocholesterolaemic effect of a new fermented milk product in healthy middle-aged men. Eur. J. Clin. Nutr. 1995, 49:346-352.
2. Agerholm-Larsen L., Bell M.L., Grunwald G.K., Astrup A. The effect of a probiotic milk product on plasma cholesterol: A meta-analysis of short-term intervention studies. Eur. J. Clin. Nutr. 2000, 54:856-860.
3. Agerholm-Larsen L., Raben A., Haulrik N., Hansen A.S., Manders M., Astrup A. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur. J. Clin. Nutr. 2000, 54:288-297.
4. Beaulieu J., Dubuc R., Beaudet N., Dupont C., Lemieux P. Immunomodulation by a malleable matrix composed of fermented whey proteins and lactic acid bacteria. J. Med. Food 2007, 10:67-72.
5. Beaulieu J., Dupont C., Lemieux P. Anti-inflammatory potential of a malleable matrix composed of fermented whey proteins and lactic acid bacteria in an atopic dermatitis model. J. Inflamm. (Lond.) 2007, 4:6.
6. Beaulieu J., Girard D., Dupont C., Lemieux P. Inhibition of neutrophil infiltration by a malleable protein matrix of lactic acid bacteria-fermented whey proteins in vivo. Inflamm. Res. 2009, 58:133-138.
7. Beaulieu J., Millette E., Trottier E., Précourt L.-P., Dupont C., Lemieux P. Regulatory function of a malleable protein matrix as a novel fermented whey product on features defining the metabolic syndrome. J. Med. Food 2010, 13:509-519.
8. Berthold H.K., Unverdorben S., Degenhardt R., Bulitta M., Gouni-Berthold I. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: A randomized controlled trial. JAMA 2006, 295:2262-2269.
9. Bowen J., Noakes M., Clifton P.M. Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake. J. Clin. Endocrinol. Metab. 2006, 91:2913-2919.
10. Bowen J., Noakes M., Clifton P.M. Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages. Int. J. Obes. (Lond) 2007, 31:1696-1703.
11. Bowen J., Noakes M., Trenerry C., Clifton P.M. Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J. Clin. Endocrinol. Metab. 2006, 91:1477-1483.
12. Choi Y.S., Goto S., Ikeda I., Sugano M. Interaction of dietary protein, cholesterol and age on lipid metabolism of the rat. Br. J. Nutr. 1989, 61:531-543.
13. Denke M.A., Fox M.M., Schulte M.C. Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J. Nutr. 1993, 123:1047-1053.
14. Diepvens K., Haberer D., Westerterp-Plantenga M. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int. J. Obes. (Lond) 2008, 32:510-518.
15. Gandotra P., Miller M. The role of triglycerides in cardiovascular risk. Curr. Cardiol. Rep. 2008, 10:505-511.
16. Gomes A.M.P., Malcata F.X. Bifidobacterium spp. and Lactobacillus acidophilus: Biological, biochemical, technological and therapeutical properties relevant for use as probiotics. Trends Food Sci. Technol. 1999, 10:139-157.
17. Gouni-Berthold I., Krone W. Hypertriglyceridemia-Why, when and how should it be treated?. Z. Kardiol. 2005, 94:731-739.
18. Grundy S.M., Cleeman J.E., Merz C.N., Brewer H.B., Clark L.T., Hunninghake D.B., Pasternak R.C., Smith S.C., Stone N.J. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J. Am. Coll. Cardiol. 2004, 44:720-732. Coordinating Committee of the National Cholesterol Education Program.
19. Grundy S.M., Cleeman J.I., Daniels S.R., Donato K.A., Eckel R.H., Franklin B.A., Gordon D.J., Krauss R.M., Savage P.J., Smith S.C., Spertus J.A., Costa F. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735-2752.
20. Hartweg J., Farmer A.J., Holman R.R., Neil A. Potential impact of omega-3 treatment on cardiovascular disease in type 2 diabetes. Curr. Opin. Lipidol. 2009, 20:30-38.
21. Jacobs D.R., Gross M.D., Tapsell L.C. Food synergy: An operational concept for understanding nutrition. Am. J. Clin. Nutr. 2009, 89:1543S-1548S.
22. Jenkins D.J., Kendall C.W., Faulkner D., Vidgen E., Trautwein E.A., Parker T.L., Marchie A., Koumbridis G., Lapsley K.G., Josse R.G., Leiter L.A., Connelly P.W. A dietary portfolio approach to cholesterol reduction: Combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism 2002, 51:1596-1604.
23. Kawase M., Hashimoto H., Hosoda M., Morita H., Hosono A. Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J. Dairy Sci. 2000, 83:255-263.
24. Khaw K.T., Wareham N., Bingham S., Luben R., Welch A., Day N. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk. Ann. Intern. Med. 2004, 141:413-420.
25. Lapointe J.-F., Trottier E., Lemieux P. Modification of gene expression in mice by multiplex matrices of fermented whey proteins. Nutrafoods 2009, 8:41-51.
26. Lapré J.A., West C.E., Lovati M.R., Sirtori C.R., Beynen A.C. Dietary animal proteins and cholesterol metabolism in rats. Int. J. Vitam. Nutr. Res. 1989, 59:93-100.
27. Lichtenstein A.H., Appel L.J., Brands M., Carnethon M., Daniels S., Franch H.A., Franklin B., Kris-Etherton P., Harris W.S., Howard B., Karanja N., Lefevre M., Rudel L., Sacks F., van Horn L., Winston M., Wylie-Rosett J. Diet and lifestyle recommendations revision 2006: A scientific statement from the American Heart Association Nutrition Committee. Circulation 2006, 114:82-96.
28. Lichtenstein A.H., Deckelbaum R.J. AHA Science Advisory. Stanol/sterol ester-containing foods and blood cholesterol levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation 2001, 103:1177-1179.
29. Localio A.R., Berlin J.A., Ten Have T.R., Kimmel S.E. Adjustments for center in multicenter studies: An overview. Ann. Intern. Med. 2001, 135:112-123.
30. Major G.C., Chaput J.P., Ledoux M., St-Pierre S., Anderson G.H., Zemel M.B., Tremblay A. Recent developments in calcium-related obesity research. Obes. Rev. 2008, 9:428-445.
31. Marshall K. Therapeutic applications of whey protein. Altern. Med. Rev. 2004, 9:136-156.
32. Nagaoka K., Kanamaru Y., Kuzuya Y. Effects of whey protein and casein on the plasma and liver lipids in rats. Agric. Biol. Chem. 1991, 55:813-818.
33. Nagaoka K., Kanamaru Y., Kuzuya Y., Kojima S., Kuwata T. Comparative studies on the serum cholesterol lowering action of whey protein and soybean protein in rats. Biosci. Biotechnol. Biochem. 1992, 56:1484-1485.
34. Nagaoka S. Studies on regulation of cholesterol metabolism induced by dietary food constituents or xenobiotics. J. Jpn. Soc. Nutr. Food Sci. 1996, 49:303-313.
35. Nagaoka S., Futamura Y., Miwa K., Awano T., Yamauchi K., Kanamaru Y., Tadashi K., Kuwata T. Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin. Biochem. Biophys. Res. Commun. 2001, 281:11-17.
36. NCEP ATP-III. 2001. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486-2497.
37. O'Neill R.T. Statistical analyses of adverse event data from clinical trials. Special emphasis on serious events. Drug Inf. J. 1987, 21:9-20.
38. Pal S., Ellis V., Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br. J. Nutr. 2010, 104:716-723.
39. Pereira D.I., Gibson G.R. Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit. Rev. Biochem. Mol. Biol. 2002, 37:259-281.
40. Pichon L., Potier M., Tome D., Mikogami T., Laplaize B., Martin-Rouas C., Fromentin G. High-protein diets containing different milk protein fractions differently influence energy intake and adiposity in the rat. Br. J. Nutr. 2008, 99:739-748.
41. Pilvi T.K., Korpela R., Huttunen M., Vapaatalo H., Mervaala E.M. High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice. Br. J. Nutr. 2007, 98:900-907.
42. Richelsen B., Kristensen K., Pedersen S.B. Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins-A placebo-controlled and double blind study. Eur. J. Clin. Nutr. 1996, 50:811-815.
43. Rudkowska I. Functional foods for cardiovascular disease in women. Menopause Int. 2008, 14:63-69.
44. Rudkowska I. Functional foods for health: Focus on diabetes. Maturitas 2009, 62:263-269.
45. Rudkowska I., Jones P.J. Functional foods for the prevention and treatment of cardiovascular diseases: Cholesterol and beyond. Expert Rev. Cardiovasc. Ther. 2007, 5:477-490.
46. Sanders M.E. Considerations for use of probiotic bacteria to modulate human health. J. Nutr. 2000, 130(2S Suppl):384S-390S.
47. Sautier C., Dieng K., Flament C., Doucet C., Suquet J.P., Lemonnier D. Effects of whey protein, casein, soya-bean and sunflower proteins on the serum, tissue and faecal steroids in rats. Br. J. Nutr. 1983, 49:313-319.
48. Schaafsma G., Meuling W.J., van Dokkum W., Bouley C. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur. J. Clin. Nutr. 1998, 52:436-440.
49. St-Onge M.-P., Farnworth E.R., Jones P.J. Consumption of fermented and nonfermented dairy products: Effects on cholesterol concentrations and metabolism. Am. J. Clin. Nutr. 2000, 71:674-681.
50. Sun X., Zemel M.B. Calcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-agouti transgenic mice. J. Nutr. 2004, 134:3054-3060.
51. Taylor G.R., Williams C.M. Effects of probiotics and prebiotics on blood lipids. Br. J. Nutr. 1998, 80:S225-S230.
52. World Health Organization Uppsala Monitoring Center. 2010. Adverse reaction terminology (WHO-ART). http://www.umc-products.com/DynPage.aspx%3Fid=73589%26mn1=1107%26mn2=1664.
53. Xiao J.Z., Kondo S., Takahashi N., Miyaji K., Oshida K., Hiramatsu A., Iwatsuki K., Kokubo S., Hosono A. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J. Dairy Sci. 2003, 86:2452-2461.
54. Zhang X., Beynen A.C. Lowering effect of dietary milk-whey protein v. casein on plasma and liver cholesterol concentrations in rats. Br. J. Nutr. 1993, 70:139-146.