Congenic strains provide evidence that a mapped locus on chromosome 15 influences excitotoxic cell death

Genes, Brain and Behavior

Volumn 10, Issue 1, 2011, Pages 100-110

  Schauwecker, P E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

C57BL 6J; Excitotoxicity; FVB NJ; Hippocampus; Kainate; Quantitative trait locus; Seizure

Indexed keywords

KAINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CHROMOSOME 15; CONGENIC STRAIN; CONTROLLED STUDY; DENTATE HILUS; EXCITOTOXICITY; FEMALE; GENE MAPPING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HIPPOCAMPAL CA3 REGION; INTROGRESSION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; QUANTITATIVE TRAIT LOCUS; SEIZURE; TEMPORAL LOBE EPILEPSY;

ANIMALS; BEHAVIOR, ANIMAL; CELL COUNT; CELL DEATH; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; DNA; EPILEPSY, TEMPORAL LOBE; GENOTYPE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICROSATELLITE REPEATS; NEURONS; PHENOTYPE; SEIZURES;

MUS;

EID: 78751682353     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2010.00644.x     Document Type: Article

References (49)

1. Ben-Ari, Y. (1985) Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14, 375-403.
2. Ben-Ari, Y. & Cossart, R. (2000) Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci 23, 580-587.
3. Berger, M.L., Lefauconnier, J.M., Tremblay, E. & Ben-Ari, Y. (1986) Limbic seizures induced by systemically applied kainic acid: how much kainic acid reaches the brain? Adv Exp Med Biol 203, 199-209.
4. Boscia, F., Esposito, C.L., Di Crisci, A., de Franciscis, V., Annunziato, L. & Cerchia, L. (2009) GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signaling. PLoS One 4, e6486.
5. Cardon, L.R. & Bell, J.I. (2001) Association study designs for complex diseases. Nat Rev Genet 2, 91-99.
6. Choi, D.W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
7. Darvasi, A. (1997) Interval-specific congenic strains (ICSC): an experimental design for mapping a QTL into a 1-centimorgan interval. Mamm Genome 8, 163-167.
8. Darvasi, A. (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18, 19-24.
9. Depienne, C., Magnin, E., Bouteiller, D., Stevanin, G., Saint-Martin, C., Vidailhet, M., Apartis, E., Hirsch, E., LeGuern, E., Labauge, P. & Rumbach, L. (2010) Familial cortical myoclonic tremor with epilepsy: the third locus (FCMTE3) maps to 5p. Neurology 74, 2000-2003.
10. Ferraro, T.N., Golden, G.T., Smith, G.G. & Berrettini, W.H. (1995) Differential vulnerability to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice. Epilepsia 36, 301-307.
11. Fisher, R.S. (1989) Animal models of the epilepsies. Brain Res Rev 14, 245-278.
12. Franklin, K.B.J. & Paxinos, G. (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, New York.
13. Fujikawa, D.G. (1995) Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia 36, 186-195.
14. Fujikawa, D.G. (1996) The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus. Brain Res 725, 11-22.
15. Fujikawa, D.G., Daniels, A.H. & Kim, J.S. (1994) The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. Epilepsy Res 17, 207-219.
16. Galanopoulou, A., Vidaurre, J. & Moshe, S.L. (2002) Under what circumstances can seizures produce hippocampal injury: evidence for age-specific effects. Dev Neurosci 24, 355-363.
17. Holmes, G.L. (2002) Seizure-induced neuronal injury: animal data. Neurology 59, S3-S6.
18. Humpel, C., Hoffer, B., Strömberg, I., Bektesh, S., Collins, F. & Olson, L. (1994) Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainite-induced excitation. Neuroscience 59, 791-795.
19. Jankowsky, J.L., Derrick, B.E. & Patterson, P.H. (2000) Cytokine response to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques. Learn Mem 7, 400-412.
20. Jen, J.C., Wan, J., Palos, T.P., Howard, B.D. & Baloh, R.W. (2005) Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. Neurology 65, 529-534.
21. Lehtimäki, K.A., Peltola, J., Koskikallio, E., Keränen, T. & Honkaniemi, J. (2003) Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Mol Brain Res 110, 253-260.
22. Leite, J.P., Garcia-Cairsaco, N. & Cavalheiro, E.A. (2002) New insights from the use of pilocarpine and kainate models. Epilepsy Res 50, 93-103.
23. Lin, L.F., Doherty, D.H., Lile, J.D., Bektesh, S. & Collins, F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132.
24. Lorenzana, A., Chancer, Z. & Schauwecker, P.E. (2007) A quantitative trait locus on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility. Eur J Neurosci 25, 1998-2008.
25. Mackay, T.F.C. (2001) The genetic architecture of quantitative traits. Annu Rev Genet 35, 303-339.
26. Maeda, S., Kawamoto, A., Yatani, Y., Shirakawa, H., Nakagawa, T. & Kaneko, S. (2008) Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats. Mol Pain 4, 65.
27. McKhann, G.M., Wenzel, H.J., Robbins, C.A., Sosunov, A.A. & Schwartzkroin, P.A. (2003) Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology. Neuroscience 122, 551-561.
28. McLin, J.P. & Steward, O. (2006) Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur J Neurosci 24, 2191-2202.
29. Miller, S.A., Dykes, D.D. & Polesky, H.F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16, 1215.
30. Morrison, R.S., Wenzel, H.J., Kinoshita, Y., Robbins, C.A., Donehower, A. & Schwartzkroin, P.A. (1996) Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J Neurosci 16, 1337-1345.
31. Nadeau, J.H., Singer, J.B., Matin, A. & Lander, E.S. (2000) Analyzing complex genetic traits with chromosome substitution strains. Nat Genet 24, 221-225.
32. Nadler, J.V. & Evenson, D.A. (1983) Use of excitatory amino acids to make axon-sparing lesions of hypothalamus. Methods Enzymol 103, 393-400.
33. Olney, J.W. (1989) Excitatory amino acids and neuropsychiatric disorders. Biol Psychiatry 26, 505-525.
34. Olney, J.W., Collins, R.C. & Sloviter, R.S. (1986) Excitotoxic mechanisms of epileptic brain damage. Adv Neurol 44, 857-877.
35. Racine, R.J. (1972) Modification of seizure activity electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32, 281-294.
36. Santos, J.B. & Schauwecker, P.E. (2003) Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent. Epilepsia 44, 995-1002.
37. Schauwecker, P.E. & Steward, O. (1997) Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci U S A 94, 4103-4108.
38. Schauwecker, P.E., Ramirez, J.J. & Steward, O. (2000) Genetic dissection of the signals that induce synaptic reorganization. Exp Neurol 161, 139-152.
39. Schauwecker, P.E., Williams, R.W. & Santos, J.B. (2004) Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. J Comp Neurol 477, 96-107.
40. Schmued, L.C., Stowers, C.C., Scallet, A.C. & Xu, L. (2005) Fluoro-Jde C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035, 24-31.
41. Sidman, R.L., Angevine, J.B. & Taber Pierce, E. (1971) Atlas of the Mouse Brain and Spinal Cord. Harvard University Press, Cambridge, MA.
42. Sperk, G. (1994) Kainic acid seizures in the rat. Prog Neurobiol 42, 1-32.
43. Sperk, G., Lassmann, H., Baran, H., Kish, S.J., Seitelberger, F. & Hornykiewicz, O. (1983) Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10, 1301-1315.
44. Springer, J.E., Mu, X., Bergmann, L.W. & Trojanowski, J.Q. (1994) Expression of GDNF mRNA in rat and human nervous tissue. Exp Neurol 127, 167-170.
45. Sucholmelova, L., Baldwin, R.A., Kuvoba, H., Thompson, K.W., Sankar, R. & Wasterlain, C.G. (2006) Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. Pediatr Res 59, 237-243.
46. Turski, L., Cavalheiro, E.A., Czuczwar, S.J., Turski, W.A. & Kleinrok, Z. (1987) The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents. Pol J Pharmacol Pharm 39, 545-555.
47. Wakeland, E., Morel, L., Achey, K., Yui, M. & Longmate, J. (1997) Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol Today 18, 472-477.
48. Wenzel, H.J., Woolley, C.S., Robbins, C.A. & Schwartzkroin, P.A. (2000) Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats. Hippocampus 10, 244-260.
49. West, M.J., Slomianka, L. & Gundersen, H.J. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231, 482-497.