Treatment of experimental status epilepticus in immature rats: Dissociation between anticonvulsant and antiepileptogenic effects

Pediatric Research

Volumn 59, Issue 2, 2006, Pages 237-243

  Suchomelova, Lucie ^a,b,c,d   Baldwin, Roger A ^b   Kubova, Hana ^c   Thompson, Kerry W ^a,b   Sankar, Raman ^a   Wasterlain, Claude G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; DIAZEPAM; LITHIUM; PILOCARPINE; TOPIRAMATE; ATROPINE; DRUG DERIVATIVE; FRUCTOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; EPILEPTOGENESIS; INCIDENCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; SEIZURE; ANIMAL; ELECTROENCEPHALOGRAPHY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; ATROPINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FRUCTOSE; PILOCARPINE; RATS; RATS, WISTAR; STATUS EPILEPTICUS;

EID: 33646712589     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000196333.16608.30     Document Type: Article

References (40)

1. DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, Penberthy L, Garnett L, Fortner CA, Ko D 1996 A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 46:1029-1035
2. DeLorenzo RJ, Towne AR, Pellock JM, Ko D 1992 Status epilepticus in children, adults, and the elderly. Epilepsia 33:S15-S25
3. Maytal J, Shinnar S, Moshe SL, Alvarez LA 1989 Low morbidity and mortality of status epilepticus in children. Pediatrics 83:323-331
4. Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hauser WA 1998 Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol 44:908-912
5. Sankar R, Shin DH, Liu H, Mazarati A, Pereira de Vasconcelos A, Wasterlain CG 1998 Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. J Neurosci 18:8382-8393
6. Sankar R, Shin D, Mazarati AM, Liu H, Katsumori H, Lezama R, Wasterlain CG 2000 Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity. Ann Neurol 48:580-589
7. Roch C, Leroy C, Nehlig A, Namer IJ 2002 Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model. Epilepsia 43:1129-1136
8. Kubova H, Mares P, Suchomelova L, Brozek G, Druga R, Pitkanen A 2004 Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis. Eur J Neurosci 19:3255-3265
9. Baram TZ, Dube CM, Chung G, Akhtar F 2004 Prolonged experimental febrile seizures in immature rats cause spontaneous behavioral and electrophysiological seizures during adulthood. Epilepsia 45:6
10. Sankar R, Rho JM 2004 Ontogeny of Molecular Targets of Antiepileptic Drugs: Impact on Drug Choice. In: Rho JM, Sankar R, Cavazos JE (eds) Epilepsy: Scientific Foundations of Clinical Practice. M Dekker, New York, pp 61-76
11. Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR 1990 A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 323:497-502
12. Temkin NR, Dikmen SS, Anderson GD, Wilensky AJ, Holmes MD, Cohen W, Newell DW, Nelson P, Awan A, Winn HR 1999 Valproate therapy for prevention of posttraumatic seizures: a randomized trial. J Neurosurg 91:593-600
13. Sasa M, Yan H, Nagayama T, Serikawa T 2003 Anti-epileptogenic properties of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia 44:175
14. Mikati MA, Holmes GL, Chronopoulos A, Hyde P, Thurber S, Gatt A, Liu Z, Werner S, Stafstrom CE 1994 Phenobarbital modifies seizure-related brain injury in the developing brain. Ann Neurol 36:425-433
15. Capella HM, Lemos T 2002 Effect on epileptogenesis of carbamazepine treatment during the silent period of the pilocarpine model of epilepsy. Epilepsia 43:110-111
16. Mazarati AM, Sofia RD, Wasterlain CG 2002 Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure 11:423-430
17. Mazarati A, Bragin A, Baldwin R, Shin D, Wilson C, Sankar R, Naylor D, Engel J, Wasterlain CG 2002 Epileptogenesis after self-sustaining status epilepticus. Epilepsia 43:74-80
18. Prasad A, Williamson JM, Bertram EH 2002 Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. Ann Neurol 51:175-181
19. Pitkanen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J 2005 Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. Epilepsy Res 63:27-42
20. Gottlieb A, Keydar I, Epstein HT 1977 Rodent brain growth stages: an analytical review. Biol Neonate 32:166-176
21. Haas KZ, Sperber EF, Moshe SL 1990 Kindling in developing animals: expression of severe seizures an enhanced development of bilateral foci. Brain Res Dev Brain Res 56:275-280
22. Racine R 1972 Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294
23. Priel MR dos SantosNF, Cavalheiro EA 1996 Developmental aspects of the pilocarpine model of epilepsy. Epilepsy Res 26:115-121
24. Rigoulot MA, Koning E, Ferrandon A, Nehlig A 2003 Neuroprotective properties of topiramate in the lithium- pilocarpine model of epilepsy. J Pharmacol Exp Ther 308:787-795
25. Koh S, Tibayan FD, Simpson JN, Jensen FE 2004 NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury. Epilepsia 45:569-575
26. Fujikawa DG 1995 Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia 36:186-195
27. Khalilov I, Holmes GL, Ben-Ari Y 2003 In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nat Neurosci 6:1079-1085
28. Walton NY, Treiman DM 1988 Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. Exp Neurol 101:267-275
29. Niebauer M, Gruenthal M 1999 Topiramate reduces neuronal injury after experimental status epilepticus. Brain Res 837:263-269
30. White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH 1997 Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res 28:167-179
31. Koh S, Jensen FE 2001 Topiramate blocks perinatal hypoxia-induced seizures in rat pups. Ann Neurol 50:366-372
32. Cha BH, Silveira DC, Liu X, Hu Y, Holmes GL 2002 Effect of topiramate following recurrent and prolonged seizures during early development. Epilepsy Res 51:217-232
33. Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, Dzietko M, Pesditschek S, Mai I, Dikranian K, Olney JW, Ikonomidou C 2002 Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci 99:15089-15094
34. Glier C, Dzietko M, Bittigau P, Jarosz B, Korobowicz E, Ikonomidou C 2004 Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 187:403-409
35. Yang Y, Shuaib A, Li Q, Siddiqui MM 1998 Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Res 804:169-176
36. Edmonds HL Jr.Jiang, YD, Zhang PY, Shank R 2001 Topiramate as a neuroprotectant in a rat model of global ischemia-induced neurodegeneration. Life Sci 69:2265-2277
37. Andre V, Ferrandon A, Marescaux C, Nehlig A 2001 Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. Epilepsy Res 47:99-117
38. Brandt C, Potschka H, Loscher W, Ebert U 2004 N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy. Neuroscience 118:727-740
39. Sankar R, Holmes GL 2004 Mechanisms of action for the commonly used antiepileptic drugs: relevance to antiepileptic drug-associated neurobehavioral adverse effects. J Child Neurol 19:S6-S14
40. Sanchez RM, Koh S, Rio C, Wang C, Lamperti ED, Sharma D, Corfas G, Jensen FE 2001 Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. J Neurosci 21:8154-8163