Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 892-898

  Palin, Ronald ^a   Abernethy, Lynn ^a   Ansari, Nasrin ^b   Cameron, Kenneth ^a   Clarkson, Tom ^a   Dempster, Maureen ^a   Dunn, David ^b   Easson, Anna Marie ^a   Edwards, Darren ^a   MacLean, John ^a   Everett, Katy ^a   Feilden, Helen ^a   Ho, Koc Kan ^b   Kultgen, Steve ^b   Littlewood, Peter ^a   McArthur, Duncan ^a   McGregor, Deborah ^a   McLuskey, Hazel ^a   Neagu, Irina ^b   Neale, Stuart ^a   Nisbet, Lesley Anne ^a   Ohlmeyer, Michael ^b   Pham, Quynhchi ^b   Ratcliffe, Paul ^a   Rong, Yajing ^b   Roughton, Andrew ^b   Sammons, Melanie ^a   Swanson, Robert ^b   Tracey, Heather ^a   Walker, Glenn ^a   more..

^a MSD   (United Kingdom)

^b PHARMACOPEIA INC   (United States)

Author keywords

Antihyperalgesia; Hyperthermia; Isoxazoles; TRPV1 antagonist

Indexed keywords

ISOXAZOLE 3 CARBOXAMIDE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; HYPERALGESIA; HYPERTHERMIA; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMIDES; ANIMALS; ANTIHYPERTENSIVE AGENTS; CYCLOHEXANOLS; HYPERTHERMIA, INDUCED; ISOXAZOLES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

RATTUS;

EID: 78751646048     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.092     Document Type: Article

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