Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells

Pflugers Archiv European Journal of Physiology

Volumn 461, Issue 1, 2011, Pages 191-202

  Lau, Yuen Ting ^a   Wong, Chun Kit ^a   Luo, Jialie ^b   Leung, Lok Hang ^c   Tsang, Pui Fong ^a   Bian, Zhao Xiang ^b   Tsang, Suk Ying ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Cell cycle; Excitability; Hyperpolarization activated channels; Ion channels; Stem cell

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CESIUM; CYCLIC NUCLEOTIDE GATED CHANNEL; CYCLIN B; HYERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 2; HYERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; CELL SYNCHRONIZATION; CELL VIABILITY; CONTROLLED STUDY; EMBRYONIC STEM CELL; HYPERPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CESIUM; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; CYCLIN B; EMBRYONIC STEM CELLS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; PYRIMIDINES;

EID: 78751642871     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0899-9     Document Type: Article

References (40)

1. Y Aponte CC Lien E Reisinger P Jonas 2006 Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus J Physiol 574 229 243 1:CAS:528:DC%2BD28XnsVyisrg%3D 10.1113/jphysiol.2005.104042 16690716 (Pubitemid 43905808)
2. AJ Barrow SM Wu 2009 Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors J Neurosci 29 5841 5853 1:CAS:528:DC%2BD1MXlvVGntr8%3D 10.1523/JNEUROSCI.5746-08.2009 19420251
3. J Bartek J Lukas 2001 Mammalian G1- and S-phase checkpoints in response to DNA damage Curr Opin Cell Biol 13 738 747 1:CAS:528:DC%2BD3MXotFWht70%3D 10.1016/S0955-0674(00)00280-5 11698191 (Pubitemid 33042735)
4. M Baruscotti A Bucchi D Difrancesco 2005 Physiology and pharmacology of the cardiac pacemaker ("funny") current Pharmacol Ther 107 59 79 1:CAS:528:DC%2BD2MXlt1Ghurc%3D 10.1016/j.pharmthera.2005.01.005 15963351 (Pubitemid 40800408)
5. A Behfar C Perez-Terzic RS Faustino DK Arrell DM Hodgson S Yamada M Puceat N Niederlander AE Alekseev LV Zingman A Terzic 2007 Cardiopoietic programming of embryonic stem cells for tumor-free heart repair J Exp Med 204 405 420 1:CAS:528:DC%2BD2sXitVektLY%3D 10.1084/jem.20061916 17283208 (Pubitemid 46294555)
6. M Biel C Wahl-Schott S Michalakis X Zong 2009 Hyperpolarization-activated cation channels: from genes to function Physiol Rev 89 847 885 1:CAS:528:DC%2BD1MXpslyjsLs%3D 10.1152/physrev.00029.2008 19584315
7. JJ Bolivar D Tapia G Arenas M Castanon-Arreola H Torres E Galarraga 2008 A hyperpolarization-activated, cyclic nucleotide-gated, (Ih-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells Am J Physiol Cell Physiol 294 C893 906 1:CAS:528:DC%2BD1cXkslOksbY%3D 10.1152/ajpcell.00616.2006 18199706 (Pubitemid 351507899)
8. J Chen JS Mitcheson M Tristani-Firouzi M Lin MC Sanguinetti 2001 The S4-S5 linker couples voltage sensing and activation of pacemaker channels Proc Natl Acad Sci USA 98 11277 11282 1:CAS:528:DC%2BD3MXnt1yqtL4%3D 10.1073/pnas.201250598 11553787 (Pubitemid 32928719)
9. R Felix A Sandoval D Sanchez JC Gomora JL De la Vega-Beltran CL Trevino A Darszon 2003 ZD7288 inhibits low-threshold Ca(2+) channel activity and regulates sperm function Biochem Biophys Res Commun 311 187 192 1:CAS:528:DC%2BD3sXot1Glt7g%3D 10.1016/j.bbrc.2003.09.197 14575712 (Pubitemid 37297905)
10. H Fujii-Yamamoto JM Kim K Arai H Masai 2005 Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells J Biol Chem 280 12976 12987 1:CAS:528:DC%2BD2MXislygsbw%3D 10.1074/jbc.M412224200 15659392
11. AE Gonzalez-Iglesias K Kretschmannova M Tomic SS Stojilkovic 2006 ZD7288 inhibits exocytosis in an HCN-independent manner and downstream of voltage-gated calcium influx in pituitary lactotrophs Biochem Biophys Res Commun 346 845 850 1:CAS:528:DC%2BD28XmtlWrsbY%3D 10.1016/j.bbrc.2006.05.194 16780797
12. YQ Jiang Q Sun HY Tu Y Wan 2008 Characteristics of HCN channels and their participation in neuropathic pain Neurochem Res 33 1979 1989 1:CAS:528:DC%2BD1cXhtFOjsbbL 10.1007/s11064-008-9717-6 18461446
13. L Jirmanova M Afanassieff S Gobert-Gosse S Markossian P Savatier 2002 Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells Oncogene 21 5515 5528 1:CAS:528:DC%2BD38XlvVylu74%3D 10.1038/sj.onc. 1205728 12165850 (Pubitemid 34983541)
14. N Kapur GA Mignery K Banach 2007 Cell cycle-dependent calcium oscillations in mouse embryonic stem cells Am J Physiol Cell Physiol 292 C1510 1518 1:CAS:528:DC%2BD2sXks1Gqu7w%3D 10.1152/ajpcell.00181.2006 17092997 (Pubitemid 46631736)
15. I Kehat D Kenyagin-Karsenti M Snir H Segev M Amit A Gepstein E Livne O Binah J Itskovitz-Eldor L Gepstein 2001 Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes J Clin Invest 108 407 414 1:CAS:528:DC%2BD3MXlvVGltLo%3D 11489934
16. J Leor S Gerecht S Cohen L Miller R Holbova A Ziskind M Shachar MS Feinberg E Guetta J Itskovitz-Eldor 2007 Human embryonic stem cell transplantation to repair the infarcted myocardium Heart 93 1278 1284 10.1136/hrt.2006.093161 17566061 (Pubitemid 47492921)
17. YL Li TP Tran R Muelleman HD Schultz 2008 Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization- activated channel Cardiovasc Res 79 715 721 1:CAS:528:DC%2BD1cXhtFChsrzL 10.1093/cvr/cvn141 18524809
18. N Liu M Lu X Tian Z Han 2007 Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells J Cell Physiol 211 279 286 1:CAS:528:DC%2BD2sXktVSrtrw%3D 10.1002/jcp.20978 17195167 (Pubitemid 46580081)
19. D Maric I Maric JL Barker 1998 Buoyant density gradient fractionation and flow cytometric analysis of embryonic rat cortical neurons and progenitor cells Methods 16 247 259 1:CAS:528:DyaK1MXhsFWit74%3D 10.1006/meth.1998.0682 10071064 (Pubitemid 29112275)
20. P Mistrik R Mader S Michalakis M Weidinger A Pfeifer M Biel 2005 The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides J Biol Chem 280 27056 27061 1:CAS:528:DC%2BD2MXmt1Ggt74%3D 10.1074/jbc.M502696200 15923185 (Pubitemid 41040742)
21. SY Ng CH Chin YT Lau J Luo CK Wong ZX Bian SY Tsang 2010 Role of voltage-gated potassium channels in the fate determination of embryonic stem cells J Cell Physiol 224 165 177 1:CAS:528:DC%2BC3cXlsVSrsb4%3D 20333647
22. J Nussbaum E Minami MA Laflamme JA Virag CB Ware A Masino V Muskheli L Pabon H Reinecke CE Murry 2007 Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response FASEB J 21 1345 1357 1:CAS:528:DC%2BD2sXltlamtr8%3D 10.1096/fj.06-6769com 17284483 (Pubitemid 46684837)
23. P Petkova-Kirova H Gagov U Krien D Duridanova T Noack R Schubert 2000 4-Aminopyridine affects rat arterial smooth muscle BK(Ca) currents by changing intracellular pH Br J Pharmacol 131 1643 1650 1:CAS:528:DC%2BD3MXjtVGltg%3D%3D 10.1038/sj.bjp.0703742 11139442
24. C Proenza D Angoli E Agranovich V Macri EA Accili 2002 Pacemaker channels produce an instantaneous current J Biol Chem 277 5101 5109 1:CAS:528: DC%2BD38XhsFCjsrw%3D 10.1074/jbc.M106974200 11741901 (Pubitemid 34968552)
25. C Proenza G Yellen 2006 Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents J Gen Physiol 127 183 190 1:CAS:528:DC%2BD28XhvVantbg%3D 10.1085/jgp.200509389 16446506 (Pubitemid 43177140)
26. RB Robinson SA Siegelbaum 2003 Hyperpolarization-activated cation currents: from molecules to physiological function Annu Rev Physiol 65 453 480 1:CAS:528:DC%2BD3sXjt1GltLg%3D 10.1146/annurev.physiol.65.092101.142734 12471170 (Pubitemid 38249163)
27. B Santoro DT Liu H Yao D Bartsch ER Kandel SA Siegelbaum GR Tibbs 1998 Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain Cell 93 717 729 1:CAS:528:DyaK1cXjsl2ksbo%3D 10.1016/S0092-8674(00)81434-8 9630217 (Pubitemid 28257579)
28. E Stead J White R Faast S Conn S Goldstone J Rathjen U Dhingra P Rathjen D Walker S Dalton 2002 Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities Oncogene 21 8320 8333 1:CAS:528: DC%2BD38XovVGnu7Y%3D 10.1038/sj.onc.1206015 12447695 (Pubitemid 35477872)
29. J Stieber G Stockl S Herrmann B Hassfurth F Hofmann 2005 Functional expression of the human HCN3 channel J Biol Chem 280 34635 34643 1:CAS:528:DC%2BD2MXhtVyksrrP 10.1074/jbc.M502508200 16043489 (Pubitemid 41504594)
30. RJ Swijnenburg M Tanaka H Vogel J Baker T Kofidis F Gunawan DR Lebl AD Caffarelli JL de Bruin EV Fedoseyeva RC Robbins 2005 Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium Circulation 112 I166 172 16159810
31. JA Thomson J Itskovitz-Eldor SS Shapiro MA Waknitz JJ Swiergiel VS Marshall JM Jones 1998 Embryonic stem cell lines derived from human blastocysts Science 282 1145 1147 1:CAS:528:DyaK1cXntleisLg%3D 10.1126/science.282.5391.1145 9804556
32. SY Tsang JC Moore RV Huizen CW Chan RA Li 2007 Ectopic expression of systemic RNA interference defective protein in embryonic stem cells Biochem Biophys Res Commun 357 480 486 1:CAS:528:DC%2BD2sXksFeiu7o%3D 10.1016/j.bbrc.2007.03.187 17434453 (Pubitemid 46603156)
33. A Varghese EM Tenbroek J Coles Jr DC Sigg 2006 Endogenous channels in HEK cells and potential roles in HCN ionic current measurements Prog Biophys Mol Biol 90 26 37 1:CAS:528:DC%2BD2MXht1OlsrvO 10.1016/j.pbiomolbio.2005.05.002 15979128 (Pubitemid 41721042)
34. S Vemana S Pandey HP Larsson 2008 Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels Am J Physiol Cell Physiol 295 C557 565 1:CAS:528:DC%2BD1cXhtVaktrzE 10.1152/ajpcell.00154.2008 18579800 (Pubitemid 352755768)
35. K Wang T Xue SY Tsang R Van Huizen CW Wong KW Lai Z Ye L Cheng KW Au J Zhang GR Li CP Lau HF Tse RA Li 2005 Electrophysiological properties of pluripotent human and mouse embryonic stem cells Stem Cells 23 1526 1534 1:CAS:528:DC%2BD28XmsA%3D%3D 10.1634/stemcells.2004-0299 16091557 (Pubitemid 41741001)
36. J White S Dalton 2005 Cell cycle control of embryonic stem cells Stem Cell Rev 1 131 138 1:CAS:528:DC%2BD28XhtVOjtL8%3D 10.1385/SCR:1:2:131 17142847 (Pubitemid 43074197)
37. C Wong T Stearns 2005 Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure BMC Cell Biol 6 6 10.1186/1471-2121-6-6 15713235 (Pubitemid 41357630)
38. T Xue HC Cho FG Akar SY Tsang SP Jones E Marban GF Tomaselli RA Li 2005 Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers Circulation 111 11 20 10.1161/01.CIR.0000151313.18547.A2 15611367 (Pubitemid 40070838)
39. E Yanagida S Shoji Y Hirayama F Yoshikawa K Otsu H Uematsu M Hiraoka T Furuichi S Kawano 2004 Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells Cell Calcium 36 135 146 1:CAS:528:DC%2BD2cXkvVCksL4%3D 10.1016/j.ceca.2004.01.022 15193861 (Pubitemid 38960623)
40. YM Zhang L Shang C Hartzell M Narlow L Cribbs SC Dudley Jr 2003 Characterization and regulation of T-type Ca2+ channels in embryonic stem cell-derived cardiomyocytes Am J Physiol Heart Circ Physiol 285 H2770 2779 1:CAS:528:DC%2BD2cXhsVCl 12919937