Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

Biochemical Pharmacology

Volumn 81, Issue 4, 2011, Pages 471-477

  Petrie, John R ^a   Pearson, Ewan R ^b   Sutherland, Calum ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Beta cell; Diabetes; Gene; Insulin; Signalling

Indexed keywords

GLUCOSE; INSULIN;

ACCURACY; CALORIC INTAKE; CELL FUNCTION; DISEASE COURSE; DNA POLYMORPHISM; ENERGY EXPENDITURE; ENVIRONMENTAL FACTOR; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 78751575640     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.11.010     Document Type: Note

References (37)

1. R.A. Defronzo Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 58 2009 773 795
2. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053
3. B.F. Voight, L.J. Scott, V. Steinthorsdottir, A.P. Morris, C. Dina, and R.P. Welch Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Nat Genet 42 2010 579 589
4. E. Ingelsson, C. Langenberg, M.F. Hivert, I. Prokopenko, V. Lyssenko, and J. Dupuis Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans Diabetes 59 2010 1266 1275
5. J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, and A.U. Jackson New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 2010 105 116
6. H. Staiger, F. Machicao, A. Fritsche, and H.U. Haring Pathomechanisms of type 2 diabetes genes Endocr Rev 30 2009 557 585
7. D. Altshuler, J.N. Hirschhorn, M. Klannemark, C.M. Lindgren, M.C. Vohl, and J. Nemesh The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 2000 76 80
8. J. Rung, S. Cauchi, A. Albrechtsen, L. Shen, G. Rocheleau, and C. Cavalcanti-Proenca Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nat Genet 41 2009 1110 1115
9. T.M. Frayling, N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, and C.M. Lindgren A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 2007 889 894
10. H. Xu, M. Dembski, Q. Yang, D. Yang, A. Moriarty, and O. Tayber Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance J Biol Chem 278 2003 30187 30192
11. S. George, J.J. Rochford, C. Wolfrum, S.L. Gray, S. Schinner, and J.C. Wilson A family with severe insulin resistance and diabetes due to a mutation in AKT2 Science 304 2004 1325 1328
12. S. Dash, H. Sano, J.J. Rochford, R.K. Semple, G. Yeo, and C.S. Hyden A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia Proc Natl Acad Sci USA 106 2009 9350 9355
13. O. Rubio-Cabezas, V. Puri, I. Murano, V. Saudek, R.K. Semple, and S. Dash Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC EMBO Mol Med 1 2009 280 287
14. M. Stadler, G. Pacini, J. Petrie, A. Luger, and C. Anderwald Beta cell (dys)function in non-diabetic offspring of diabetic patients Diabetologia 52 2009 2435 2444
15. R.A. DeFronzo, R.C. Bonadonna, and E. Ferrannini Pathogenesis of NIDDM. A balanced overview Diabetes Care 15 1992 318 368
16. A.G. Tabak, M. Jokela, T.N. Akbaraly, E.J. Brunner, M. Kivimaki, and D.R. Witte Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study Lancet 373 2009 2215 2221
17. C. Weyer, C. Bogardus, D.M. Mott, and R.E. Pratley The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus J Clin Invest 104 1999 787 794
18. E. Ferrannini, A. Gastaldelli, Y. Miyazaki, M. Matsuda, A. Mari, and R.A. DeFronzo Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis J Clin Endocrinol Metab 90 2005 493 500
19. A. Gastaldelli, E. Ferrannini, Y. Miyazaki, M. Matsuda, and R.A. DeFronzo Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study Diabetologia 47 2004 31 39
20. S.A. Hills, B. Balkau, S.W. Coppack, J.M. Dekker, A. Mari, and A. Natali The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives Diabetologia 47 2004 566 570
21. E. Nerpin, U. Riserus, E. Ingelsson, J. Sundstrom, M. Jobs, and A. Larsson Insulin sensitivity measured with euglycemic clamp is independently associated with glomerular filtration rate in a community-based cohort Diabetes Care 31 2008 1550 1555
22. T. McLaughlin, F. Abbasi, C. Lamendola, and G. Reaven Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity Arch Int Med 167 2007 642 648
23. L.E. Wagenknecht, E.J. Mayer, M. Rewers, S. Haffner, J. Selby, and G.M. Borok The insulin resistance atherosclerosis study (IRAS) objectives, design, and recruitment results Ann Epidemiol 5 1995 464 472
24. N.D. Palmer, J.C. Mychaleckyj, C.D. Langefeld, J.T. Ziegler, A.H. Williams, and M. Bryer-Ash Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study Diabetes Res Clin Pract 87 2010 69 76
25. T.M. Wallace, J.C. Levy, and D.R. Matthews Use and abuse of HOMA modeling Diabetes Care 27 2004 1487 1495
26. N.J. Wareham, D.I. Phillips, C.D. Byrne, and C.N. Hales The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion Diabet Med 12 1995 931
27. A. Tura, A. Kautzky-Willer, and G. Pacini Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT Diabetes Res Clin Pract 72 2006 298 301
28. G.M. Reaven HOMA-beta in the UKPDS and ADOPT. Is the natural history of type 2 diabetes characterised by a progressive and inexorable loss of insulin secretory function? Maybe? Maybe not? Diab Vasc Dis Res 6 2009 133 138
29. A. Mari, and E. Ferrannini Beta-cell function assessment from modelling of oral tests: an effective approach Diabetes Obes Metab 10 Suppl. 4 2008 77 87
30. A. Mari, A. Tura, A. Natali, M. Laville, M. Laakso, and R. Gabriel Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance Diabetologia 53 2010 749 756
31. K. Bouzakri, H.A. Koistinen, and J.R. Zierath Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes Curr Diabetes Rev 1 2005 167 174
32. C. Sutherland, R.M. O'Brien, and D.K. Granner Gene regulation J. Pessin, A. Saltiel, Textbook of insulin action 2006 Landes Bioscience
33. S. Boura-Halfon, and Y. Zick Phosphorylation of IRS proteins, insulin action, and insulin resistance Am J Physiol Endocrinol Metab 296 2009 E581 E591
34. Y.L. Woods, J.R. Petrie, and C. Sutherland Dissecting insulin signaling pathways: individualised therapeutic targets for diagnosis and treatment of insulin resistant states Endocr, Metab Immune Disorders - Drug Targets 9 2009 187 198
35. S. Ikemoto, M. Takahashi, N. Tsunoda, K. Maruyama, H. Itakura, and O. Ezaki High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils Metabolism 45 1996 1539 1546
36. H. Lango, C.N. Palmer, A.D. Morris, E. Zeggini, A.T. Hattersley, and M.I. McCarthy Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk Diabetes 57 2008 3129 3135
37. C.J. Patel, J. Bhattacharya, and A.J. Butte An environment-wide association study (EWAS) on type 2 diabetes mellitus PLoS One 5 2010 e10746